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Volumn 10, Issue 5, 2008, Pages

Phosphorylated EGFR and PI3K/Akt signaling kinases are expressed in circulating tumor cells of breast cancer patients

Author keywords

[No Author keywords available]

Indexed keywords

AKT1 PROTEIN, HUMAN; EGFR PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; KERATIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RNA; TUMOR MARKER; TUMOR PROTEIN;

EID: 59449088408     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2149     Document Type: Article
Times cited : (126)

References (48)
  • 1
    • 6044259206 scopus 로고    scopus 로고
    • Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases
    • 10.1158/1078-0432.CCR-04-0378, 15501967
    • Allard WJ, Matera J, Miller MC, Repollet M, Connelly MC, Rao C, Tibbe AG, Uhr JW, Terstappen LW. Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases. Clin Cancer Res 2004, 10:6897-6904. 10.1158/1078-0432.CCR-04-0378, 15501967.
    • (2004) Clin Cancer Res , vol.10 , pp. 6897-6904
    • Allard, W.J.1    Matera, J.2    Miller, M.C.3    Repollet, M.4    Connelly, M.C.5    Rao, C.6    Tibbe, A.G.7    Uhr, J.W.8    Terstappen, L.W.9
  • 2
    • 33644981002 scopus 로고    scopus 로고
    • Circulating tumor cells: the 'leukemic phase' of solid cancers
    • 10.1016/j.molmed.2006.01.006, 16488189
    • Mocellin S, Keilholz U, Rossi CR, Nitti D. Circulating tumor cells: the 'leukemic phase' of solid cancers. Trends Mol Med 2006, 12:130-139. 10.1016/j.molmed.2006.01.006, 16488189.
    • (2006) Trends Mol Med , vol.12 , pp. 130-139
    • Mocellin, S.1    Keilholz, U.2    Rossi, C.R.3    Nitti, D.4
  • 3
    • 0029956813 scopus 로고    scopus 로고
    • Reverse transcriptase/polymerase chain reaction detection of cytokeratin-19 mRNA in bone marrow and blood of breast cancer patients
    • 10.1007/BF01209032, 8898979
    • Kruger W, Krzizanowski C, Holweg M, Stockschlader M, Kroger N, Jung R, Mross K, Jonat W, Zander AR. Reverse transcriptase/polymerase chain reaction detection of cytokeratin-19 mRNA in bone marrow and blood of breast cancer patients. J Cancer Res Clin Oncol 1996, 122:679-686. 10.1007/BF01209032, 8898979.
    • (1996) J Cancer Res Clin Oncol , vol.122 , pp. 679-686
    • Kruger, W.1    Krzizanowski, C.2    Holweg, M.3    Stockschlader, M.4    Kroger, N.5    Jung, R.6    Mross, K.7    Jonat, W.8    Zander, A.R.9
  • 5
    • 34047151778 scopus 로고    scopus 로고
    • Quantification of circulating tumour cells for the monitoring of adjuvant therapy in breast cancer: an increase in cell number at completion of therapy is a predictor of early relapse
    • 10.1016/j.breast.2006.12.005, 17291754
    • Lobodasch K, Frohlich F, Rengsberger M, Schubert R, Dengler R, Pachmann U, Pachmann K. Quantification of circulating tumour cells for the monitoring of adjuvant therapy in breast cancer: an increase in cell number at completion of therapy is a predictor of early relapse. Breast 2007, 16:211-218. 10.1016/j.breast.2006.12.005, 17291754.
    • (2007) Breast , vol.16 , pp. 211-218
    • Lobodasch, K.1    Frohlich, F.2    Rengsberger, M.3    Schubert, R.4    Dengler, R.5    Pachmann, U.6    Pachmann, K.7
  • 9
    • 33846252746 scopus 로고    scopus 로고
    • Mechanisms of egfr gene transcription modulation: relationship to cancer risk and therapy response
    • 10.1158/1078-0432.CCR-06-0626, 17189396
    • Brandt B, Meyer-Staeckling S, Schmidt H, Agelopoulos K, Buerger H. Mechanisms of egfr gene transcription modulation: relationship to cancer risk and therapy response. Clin Cancer Res 2006, 12:7252-7260. 10.1158/1078-0432.CCR-06-0626, 17189396.
    • (2006) Clin Cancer Res , vol.12 , pp. 7252-7260
    • Brandt, B.1    Meyer-Staeckling, S.2    Schmidt, H.3    Agelopoulos, K.4    Buerger, H.5
  • 12
    • 11144248359 scopus 로고    scopus 로고
    • Trastuzumab administration can effectively target chemotherapy-resistant cytokeratin-19 messenger RNA-positive tumor cells in the peripheral blood and bone marrow of patients with breast cancer
    • 10.1158/1078-0432.CCR-03-0094, 15623593
    • Bozionellou V, Mavroudis D, Perraki M, Papadopoulos S, Apostolaki S, Stathopoulos E, Stathopoulou A, Lianidou E, Georgoulias V. Trastuzumab administration can effectively target chemotherapy-resistant cytokeratin-19 messenger RNA-positive tumor cells in the peripheral blood and bone marrow of patients with breast cancer. Clin Cancer Res 2004, 10:8185-8194. 10.1158/1078-0432.CCR-03-0094, 15623593.
    • (2004) Clin Cancer Res , vol.10 , pp. 8185-8194
    • Bozionellou, V.1    Mavroudis, D.2    Perraki, M.3    Papadopoulos, S.4    Apostolaki, S.5    Stathopoulos, E.6    Stathopoulou, A.7    Lianidou, E.8    Georgoulias, V.9
  • 13
  • 14
    • 1642580489 scopus 로고    scopus 로고
    • Inhibition of proliferation and induction of apoptosis in breast cancer cells by the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ZD1839 ('Iressa') is independent of EGFR expression level
    • 10.1002/jcp.10411, 14603528
    • Campiglio M, Locatelli A, Olgiati C, Normanno N, Somenzi G, Vigano L, Fumagalli M, Menard S, Gianni L. Inhibition of proliferation and induction of apoptosis in breast cancer cells by the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ZD1839 ('Iressa') is independent of EGFR expression level. J Cell Physiol 2004, 198:259-268. 10.1002/jcp.10411, 14603528.
    • (2004) J Cell Physiol , vol.198 , pp. 259-268
    • Campiglio, M.1    Locatelli, A.2    Olgiati, C.3    Normanno, N.4    Somenzi, G.5    Vigano, L.6    Fumagalli, M.7    Menard, S.8    Gianni, L.9
  • 15
    • 33645688204 scopus 로고    scopus 로고
    • HER2-positive circulating tumor cells indicate poor clinical outcome in stage I to III breast cancer patients
    • 10.1158/1078-0432.CCR-05-2087, 16551854
    • Wulfing P, Borchard J, Buerger H, Heidl S, Zanker KS, Kiesel L, Brandt B. HER2-positive circulating tumor cells indicate poor clinical outcome in stage I to III breast cancer patients. Clin Cancer Res 2006, 12:1715-1720. 10.1158/1078-0432.CCR-05-2087, 16551854.
    • (2006) Clin Cancer Res , vol.12 , pp. 1715-1720
    • Wulfing, P.1    Borchard, J.2    Buerger, H.3    Heidl, S.4    Zanker, K.S.5    Kiesel, L.6    Brandt, B.7
  • 16
    • 0034992521 scopus 로고    scopus 로고
    • The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification
    • 10.1677/erc.0.0080011, 11350724
    • Prenzel N, Fischer OM, Streit S, Hart S, Ullrich A. The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. Endocr Relat Cancer 2001, 8:11-31. 10.1677/erc.0.0080011, 11350724.
    • (2001) Endocr Relat Cancer , vol.8 , pp. 11-31
    • Prenzel, N.1    Fischer, O.M.2    Streit, S.3    Hart, S.4    Ullrich, A.5
  • 17
    • 0034766736 scopus 로고    scopus 로고
    • Biology of HER2 and its importance in breast cancer
    • 10.1159/000055396, 11694782
    • Yarden Y. Biology of HER2 and its importance in breast cancer. Oncology 2001, 61:1-13. 10.1159/000055396, 11694782.
    • (2001) Oncology , vol.61 , pp. 1-13
    • Yarden, Y.1
  • 18
    • 0141530936 scopus 로고    scopus 로고
    • HER2-mediated effects on EGFR endosomal sorting: analysis of biophysical mechanisms
    • 1303497, 14507736
    • Hendriks BS, Wiley HS, Lauffenburger D. HER2-mediated effects on EGFR endosomal sorting: analysis of biophysical mechanisms. Biophys J 2003, 85:2732-2745. 1303497, 14507736.
    • (2003) Biophys J , vol.85 , pp. 2732-2745
    • Hendriks, B.S.1    Wiley, H.S.2    Lauffenburger, D.3
  • 19
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • 10.1016/1040-8428(94)00144-I, 7612182
    • Salomon DS, Brandt R, Ciardiello F, Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 1995, 19:183-232. 10.1016/1040-8428(94)00144-I, 7612182.
    • (1995) Crit Rev Oncol Hematol , vol.19 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciardiello, F.3    Normanno, N.4
  • 20
    • 0030990317 scopus 로고    scopus 로고
    • Prognostic significance of c-erbB-2/neu amplification and epidermal growth factor receptor (EGFR) in primary breast cancer and their relation to estradiol receptor (ER) status
    • 10.1016/S0009-8981(97)06542-X, 9204213
    • Torregrosa D, Bolufer P, Lluch A, Lopez JA, Barragan E, Ruiz A, Guillem V, Munarriz B, Garcia CJ. Prognostic significance of c-erbB-2/neu amplification and epidermal growth factor receptor (EGFR) in primary breast cancer and their relation to estradiol receptor (ER) status. Clin Chim Acta 1997, 262:99-119. 10.1016/S0009-8981(97)06542-X, 9204213.
    • (1997) Clin Chim Acta , vol.262 , pp. 99-119
    • Torregrosa, D.1    Bolufer, P.2    Lluch, A.3    Lopez, J.A.4    Barragan, E.5    Ruiz, A.6    Guillem, V.7    Munarriz, B.8    Garcia, C.J.9
  • 21
    • 0033063774 scopus 로고    scopus 로고
    • The epidermal growth factor receptor and its inhibition in cancer therapy
    • 10.1016/S0163-7258(98)00045-X, 10454201
    • Woodburn JR. The epidermal growth factor receptor and its inhibition in cancer therapy. Pharmacol Ther 1999, 82:241-250. 10.1016/S0163-7258(98)00045-X, 10454201.
    • (1999) Pharmacol Ther , vol.82 , pp. 241-250
    • Woodburn, J.R.1
  • 22
    • 33846817495 scopus 로고    scopus 로고
    • Targeting TACE-dependent EGFR ligand shedding in breast cancer
    • 1764856, 17218988, 10.1172/JCI29518
    • Kenny PA, Bissell MJ. Targeting TACE-dependent EGFR ligand shedding in breast cancer. J Clin Invest 2007, 117:337-345. 1764856, 17218988, 10.1172/JCI29518.
    • (2007) J Clin Invest , vol.117 , pp. 337-345
    • Kenny, P.A.1    Bissell, M.J.2
  • 23
    • 23444460828 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression correlates with poor survival in patients who have breast carcinoma treated with doxorubicin-based neoadjuvant chemotherapy
    • 10.1002/cncr.21217, 15981280
    • Buchholz TA, Tu X, Ang KK, Esteva FJ, Kuerer HM, Pusztai L, Cristofanilli M, Singletary SE, Hortobagyi GN, Sahin AA. Epidermal growth factor receptor expression correlates with poor survival in patients who have breast carcinoma treated with doxorubicin-based neoadjuvant chemotherapy. Cancer 2005, 104:676-681. 10.1002/cncr.21217, 15981280.
    • (2005) Cancer , vol.104 , pp. 676-681
    • Buchholz, T.A.1    Tu, X.2    Ang, K.K.3    Esteva, F.J.4    Kuerer, H.M.5    Pusztai, L.6    Cristofanilli, M.7    Singletary, S.E.8    Hortobagyi, G.N.9    Sahin, A.A.10
  • 26
    • 34249059285 scopus 로고    scopus 로고
    • Phosphorylation of FAK, PI-3K, and impaired actin organization in CK-positive micrometastatic breast cancer cells
    • 1869618, 17515959, 10.2119/2006-00083.Kallergi
    • Kallergi G, Mavroudis D, Georgoulias V, Stournaras C. Phosphorylation of FAK, PI-3K, and impaired actin organization in CK-positive micrometastatic breast cancer cells. Mol Med 2007, 13:79-88. 1869618, 17515959, 10.2119/2006-00083.Kallergi.
    • (2007) Mol Med , vol.13 , pp. 79-88
    • Kallergi, G.1    Mavroudis, D.2    Georgoulias, V.3    Stournaras, C.4
  • 27
    • 0742323734 scopus 로고    scopus 로고
    • Circulating tumour cells in breast cancer
    • 10.1016/S1470-2045(04)01381-6, 14761811
    • Ring A, Smith IE, Dowsett M. Circulating tumour cells in breast cancer. Lancet Oncol 2004, 5:79-88. 10.1016/S1470-2045(04)01381-6, 14761811.
    • (2004) Lancet Oncol , vol.5 , pp. 79-88
    • Ring, A.1    Smith, I.E.2    Dowsett, M.3
  • 29
    • 0035892346 scopus 로고    scopus 로고
    • ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpression
    • 10.1002/ijc.1557, 11745477
    • Anderson NG, Ahmad T, Chan K, Dobson R, Bundred NJ. ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of EGFR-positive cancer cell lines with or without erbB2 overexpression. Int J Cancer 2001, 94:774-782. 10.1002/ijc.1557, 11745477.
    • (2001) Int J Cancer , vol.94 , pp. 774-782
    • Anderson, N.G.1    Ahmad, T.2    Chan, K.3    Dobson, R.4    Bundred, N.J.5
  • 30
    • 33747610198 scopus 로고    scopus 로고
    • Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine
    • 10.1124/mol.106.023333, 16782806
    • Liang K, Lu Y, Li X, Zeng X, Glazer RI, Mills GB, Fan Z. Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine. Mol Pharmacol 2006, 70:1045-1052. 10.1124/mol.106.023333, 16782806.
    • (2006) Mol Pharmacol , vol.70 , pp. 1045-1052
    • Liang, K.1    Lu, Y.2    Li, X.3    Zeng, X.4    Glazer, R.I.5    Mills, G.B.6    Fan, Z.7
  • 31
    • 0037962085 scopus 로고    scopus 로고
    • Distinct signaling pathways regulate differential opioid effects on actin cytoskeleton in malignant MCF7 and nonmalignant MCF12A human breast epithelial cells
    • 10.1016/S0014-4827(03)00210-6, 12878162
    • Kallergi G, Tsapara A, Kampa M, Papakonstanti EA, Krasagakis K, Castanas E, Stournaras C. Distinct signaling pathways regulate differential opioid effects on actin cytoskeleton in malignant MCF7 and nonmalignant MCF12A human breast epithelial cells. Exp Cell Res 2003, 288:94-109. 10.1016/S0014-4827(03)00210-6, 12878162.
    • (2003) Exp Cell Res , vol.288 , pp. 94-109
    • Kallergi, G.1    Tsapara, A.2    Kampa, M.3    Papakonstanti, E.A.4    Krasagakis, K.5    Castanas, E.6    Stournaras, C.7
  • 32
    • 35848947564 scopus 로고    scopus 로고
    • Activation of FAK/PI3K/Rac1 signaling controls actin reorganization and inhibits cell motility in human cancer cells
    • 10.1159/000110458, 17982280
    • Kallergi G, Agelaki S, Markomanolaki H, Georgoulias V, Stournaras C. Activation of FAK/PI3K/Rac1 signaling controls actin reorganization and inhibits cell motility in human cancer cells. Cell Physiol Biochem 2007, 20:977-986. 10.1159/000110458, 17982280.
    • (2007) Cell Physiol Biochem , vol.20 , pp. 977-986
    • Kallergi, G.1    Agelaki, S.2    Markomanolaki, H.3    Georgoulias, V.4    Stournaras, C.5
  • 34
    • 21044458905 scopus 로고    scopus 로고
    • Methods for isolating circulating epithelial cells and criteria for their classification as carcinoma cells
    • 10.1080/14653240510027082, 16040397
    • Fehm T, Solomayer EF, Meng S, Tucker T, Lane N, Wang J, Gebauer G. Methods for isolating circulating epithelial cells and criteria for their classification as carcinoma cells. Cytotherapy 2005, 7:171-185. 10.1080/14653240510027082, 16040397.
    • (2005) Cytotherapy , vol.7 , pp. 171-185
    • Fehm, T.1    Solomayer, E.F.2    Meng, S.3    Tucker, T.4    Lane, N.5    Wang, J.6    Gebauer, G.7
  • 35
    • 33846815517 scopus 로고    scopus 로고
    • Significance, detection and markers of disseminated breast cancer cells
    • 10.1677/ERC-06-0001, 17158753
    • Lacroix M. Significance, detection and markers of disseminated breast cancer cells. Endocr Relat Cancer 2006, 13:1033-1067. 10.1677/ERC-06-0001, 17158753.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 1033-1067
    • Lacroix, M.1
  • 36
    • 34347353063 scopus 로고    scopus 로고
    • Circulating tumor cells (CTC) detection: Clinical impact and future directions
    • Paterlini-Brechot P, Benali NL. Circulating tumor cells (CTC) detection: Clinical impact and future directions. Cancer Lett 2007,
    • (2007) Cancer Lett
    • Paterlini-Brechot, P.1    Benali, N.L.2
  • 38
    • 0032437669 scopus 로고    scopus 로고
    • Detection of cancer cells in peripheral blood of breast cancer patients using reverse transcription-polymerase chain reaction for epidermal growth factor receptor
    • Leitzel K, Lieu B, Curley E, Smith J, Chinchilli V, Rychlik W, Lipton A. Detection of cancer cells in peripheral blood of breast cancer patients using reverse transcription-polymerase chain reaction for epidermal growth factor receptor. Clin Cancer Res 1998, 4:3037-3043.
    • (1998) Clin Cancer Res , vol.4 , pp. 3037-3043
    • Leitzel, K.1    Lieu, B.2    Curley, E.3    Smith, J.4    Chinchilli, V.5    Rychlik, W.6    Lipton, A.7
  • 39
    • 33750145581 scopus 로고    scopus 로고
    • The relevance of RT-PCR detection of disseminated tumour cells is hampered by the expression of markers regarded as tumour-specific in activated lymphocytes
    • 10.1016/j.ejca.2006.05.036, 16978860
    • Kowalewska M, Chechlinska M, Markowicz S, Kober P, Nowak R. The relevance of RT-PCR detection of disseminated tumour cells is hampered by the expression of markers regarded as tumour-specific in activated lymphocytes. Eur J Cancer 2006, 42:2671-2674. 10.1016/j.ejca.2006.05.036, 16978860.
    • (2006) Eur J Cancer , vol.42 , pp. 2671-2674
    • Kowalewska, M.1    Chechlinska, M.2    Markowicz, S.3    Kober, P.4    Nowak, R.5
  • 40
    • 0029682494 scopus 로고    scopus 로고
    • Human breast cancer progression can be regulated by dominant trans-acting factors in somatic cell hybridization studies
    • Safarians S, Sternlicht MD, Yamanishi DT, Love SM, Barsky SH. Human breast cancer progression can be regulated by dominant trans-acting factors in somatic cell hybridization studies. Cancer Res 1996, 56:3560-3569.
    • (1996) Cancer Res , vol.56 , pp. 3560-3569
    • Safarians, S.1    Sternlicht, M.D.2    Yamanishi, D.T.3    Love, S.M.4    Barsky, S.H.5
  • 42
    • 9144251561 scopus 로고    scopus 로고
    • Nonendocrine pathways and endocrine resistance: observations with antiestrogens and signal transduction inhibitors in combination
    • 10.1158/1078-0432.CCR-031206, 14734490
    • Nicholson RI, Hutcheson IR, Knowlden JM, Jones HE, Harper ME, Jordan N, Hiscox SE, Barrow D, Gee JM. Nonendocrine pathways and endocrine resistance: observations with antiestrogens and signal transduction inhibitors in combination. Clin Cancer Res 2004, 10:346S-354S. 10.1158/1078-0432.CCR-031206, 14734490.
    • (2004) Clin Cancer Res , vol.10
    • Nicholson, R.I.1    Hutcheson, I.R.2    Knowlden, J.M.3    Jones, H.E.4    Harper, M.E.5    Jordan, N.6    Hiscox, S.E.7    Barrow, D.8    Gee, J.M.9
  • 43
    • 0035266243 scopus 로고    scopus 로고
    • ErbB2 overexpression on occult metastatic cells in bone marrow predicts poor clinical outcome of stage I-III breast cancer patients
    • Braun S, Schlimok G, Heumos I, Schaller G, Riethdorf L, Riethmuller G, Pantel K. ErbB2 overexpression on occult metastatic cells in bone marrow predicts poor clinical outcome of stage I-III breast cancer patients. Cancer Res 2001, 61:1890-1895.
    • (2001) Cancer Res , vol.61 , pp. 1890-1895
    • Braun, S.1    Schlimok, G.2    Heumos, I.3    Schaller, G.4    Riethdorf, L.5    Riethmuller, G.6    Pantel, K.7
  • 44
    • 33846202907 scopus 로고    scopus 로고
    • Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs
    • 10.1158/1078-0432.CCR-06-0646, 17189395
    • Ono M, Kuwano M. Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs. Clin Cancer Res 2006, 12:7242-7251. 10.1158/1078-0432.CCR-06-0646, 17189395.
    • (2006) Clin Cancer Res , vol.12 , pp. 7242-7251
    • Ono, M.1    Kuwano, M.2
  • 45
    • 33749316418 scopus 로고    scopus 로고
    • The epidermal growth factor receptor pathway: a model for targeted therapy
    • 10.1158/1078-0432.CCR-05-1554, 17000658
    • Scaltriti M, Baselga J. The epidermal growth factor receptor pathway: a model for targeted therapy. Clin Cancer Res 2006, 12:5268-5272. 10.1158/1078-0432.CCR-05-1554, 17000658.
    • (2006) Clin Cancer Res , vol.12 , pp. 5268-5272
    • Scaltriti, M.1    Baselga, J.2
  • 46
    • 25844468319 scopus 로고    scopus 로고
    • Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer
    • 10.1677/erc.1.01005, 16113104
    • Gee JM, Robertson JF, Gutteridge E, Ellis IO, Pinder SE, Rubini M, Nicholson RI. Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer. Endocr Relat Cancer 2005, 12:S99-S111. 10.1677/erc.1.01005, 16113104.
    • (2005) Endocr Relat Cancer , vol.12
    • Gee, J.M.1    Robertson, J.F.2    Gutteridge, E.3    Ellis, I.O.4    Pinder, S.E.5    Rubini, M.6    Nicholson, R.I.7
  • 47
    • 0027309375 scopus 로고
    • Relationship between EGF-R, c-erbB-2 protein expression and Ki67 immunostaining in breast cancer and hormone sensitivity
    • 10.1016/S0959-8049(05)80215-1, 8098946
    • Nicholson RI, McClelland RA, Finlay P, Eaton CL, Gullick WJ, Dixon AR, Robertson JF, Ellis IO, Blamey RW. Relationship between EGF-R, c-erbB-2 protein expression and Ki67 immunostaining in breast cancer and hormone sensitivity. Eur J Cancer 1993, 29A:1018-1023. 10.1016/S0959-8049(05)80215-1, 8098946.
    • (1993) Eur J Cancer , vol.29 A , pp. 1018-1023
    • Nicholson, R.I.1    McClelland, R.A.2    Finlay, P.3    Eaton, C.L.4    Gullick, W.J.5    Dixon, A.R.6    Robertson, J.F.7    Ellis, I.O.8    Blamey, R.W.9
  • 48
    • 0033986270 scopus 로고    scopus 로고
    • Lack of effect of adjuvant chemotherapy on the elimination of single dormant tumor cells in bone marrow of high-risk breast cancer patients
    • Braun S, Kentenich C, Janni W, Hepp F, de WJ, Willgeroth F, Sommer H, Pantel K. Lack of effect of adjuvant chemotherapy on the elimination of single dormant tumor cells in bone marrow of high-risk breast cancer patients. J Clin Oncol 2000, 18:80-86.
    • (2000) J Clin Oncol , vol.18 , pp. 80-86
    • Braun, S.1    Kentenich, C.2    Janni, W.3    Hepp, F.4    de, W.J.5    Willgeroth, F.6    Sommer, H.7    Pantel, K.8


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