Dietary fatty acids in health and disease: Greater controversy, greater interest

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 17, Issue 2, 2014, Pages 111-115

  Calder, Philip C ^a,b   Deckelbaum, Richard J ^c  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^c Department of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIETARY FATS; FATTY ACIDS; HUMANS;

EID: 84894104118     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0000000000000038     Document Type: Review

References (45)

1. Micha R, Mozaffarian D. Saturated fat and cardiometabolic risk factors, coronary heart disease, stroke, and diabetes: a fresh look at the evidence. Lipids 2010; 45:893-905.
2. Calder PC. N-3 fatty acids and cardiovascular disease: evidence explained and mechanisms explored. Clin Sci 2004; 107:1-11.
3. Saravanan P, Davidson NC, Schmidt EB, Calder PC. Cardiovascular effects of marine omega-3 fatty acids. Lancet 2010; 376:540-550.
4. Calder PC. Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology? Br J Clin Pharmacol 2013; 75:645-662.
5. Calder PC. n-3 Fatty acids, inflammation and immunity: new mechanisms to explain old actions. Proc Nutr Soc 2013; 72:326-336.
6. Merendino N, Costantini L, Manzi L, et al. Dietary v-3 polyunsaturated fatty acids DHA: a potential adjuvant in the treatment of cancer. Biomed Res Int 2013; 2013:310186.
7. Vaughan VC, Hassing MR, Lewandowski PA. Marine polyunsaturated fatty acids and cancer therapy. Br J Cancer 2013; 108:486-492.
8. Karr JE, Alexander JE, Winningham RG. Omega-3 polyunsaturated fatty acids and cognition throughout the lifespan: a review. Nutr Neurosci 2011; 14: 216-225.
9. Sinn N, Milte C, Howe PR. Oiling the brain: a review of randomized controlled trials of omega-3 fatty acids in psychopathology across the lifespan. Nutrients 2010; 2:128-170.
10. Ramsden CE, Hibbeln JR, Majchrzak SF, Davis JM. n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. Br J Nutr 2010; 104:1586-1600.
11. Calder PC. The American Heart Association advisory on n-6 fatty acids: evidence based or biased evidence? Br J Nutr 2010; 104:1575-1576.
12. Calder PC, Deckelbaum RJ. Harmful, harmless or helpful? The n-6 fatty acid debate goes on. Curr Opin Clin Nutr Metab Care 2011; 14:113-114.
13. Galan P, Kesse-Guyot E, Czernichow S, et al., SU.FOL.OM3 Collaborative Group. Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial. Br Med J 2010; 341:c6273.
14. Kromhout D, Giltay EJ, Geleijnse JM, for the Alpha Omega Trial Group. n-3 fatty acids and cardiovascular events after myocardial infarction. N Engl J Med 2010; 363:2015-2026.
15. Rauch B, Schiele R, Schneider S, et al., OMEGA Study Group. OMEGA, a randomized, placebo controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction. Circulation 2010; 122:2152-2159.
16. Deckelbaum RJ, Calder PC. Different outcomes for omega-3 heart trials: why? Curr Opin Clin Nutr Metab Care 2012; 15:97-98.
17. Calder PC, Yaqoob P. Marine omega-3 fatty acids and coronary heart disease. Curr Opin Cardiol 2012; 27:412-419.
18. Ramsden CE, Zamora D, Leelarthaepin B, et al. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. Br Med J 2013; 346:e8707.
19. Calder PC. Old study sheds new light on the fatty acids and cardiovascular health debate. Br Med J 2013; 346:f493.
20. ORIGIN Trial Investigators. Bosch J, Gerstein HC, Dagenais GR, et al. n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia. N Engl J Med 2012; 367:309-318.
21. Roncaglioni MC, Tombesi M, Avanzini F, et al. n-3 fatty acids in patients with multiple cardiovascular risk factors. N Engl J Med 2013; 368:1800-1808.
22. Calder P. Limited impact of omega-3 fatty acids in patients with multiple cardiovascular risk factors. Evid Based Med 2013. [Epub ahead of print]. doi: 10.1136/eb-2013-101440.
23. Poole CD, Halcox JP, Jenkins-Jones S, et al. Omega-3 Fatty acids and mortality outcome in patients with and without type 2 diabetes after myocardial infarction: a retrospective, matched-cohort study. Clin Ther 2013; 35:40-51.
24. Bucher HC, Hengstler P, Schindler C, Meier G. N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials. Am J Med 2002; 112:298-304.
25. Kwak SM, Myung SK, Lee YJ, Seo HG, Korean Meta-analysis Study Group. Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials. Arch Intern Med 2012; 172:686-694.
26. Rizos EC, Ntzani EE, Bika E, et al. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. J Am Med Assoc 2012; 308:1024-1033.
27. Estruch R, Ros E, Salas-SalvadoJ, et al., PREDIMED Study Investigators. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013; 368:1279-1290.
28. Sala-Vila A, Romero-Mamani ES, Gilabert R, et al. Changes in ultrasoundassessed carotid intima-media thickness and plaque with a Mediterranean diet: a substudy of the PREDIMED trial. Arterioscler Thromb Vasc Bio 2013. (in press).
29. Roodhart JM, Daenen LG, Stigter EC, et al. Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids. Cancer Cell 2011; 20:370-383.
30. Yam D, Peled A, Shinitzky M. Suppression of tumor growth and metastasis by dietary fish oil combined with vitamins E and C and cisplatin. Cancer Chemother Pharmacol 2001; 47:34-40.
31. Murphy RA, Mourtzakis M, Chu QS, et al. Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer. Cancer 2011; 117:3774-3780.
32. Brasky TM, Darke AK, Song X, et al. Plasma phospholipid fatty acids and prostate cancer risk in the SELECT trial. J Natl Cancer Inst 2013; 105:1132-1141.
33. Dahm CC, Gorst-Rasmussen A, Crowe FL, et al. Fatty acid patterns and risk of prostate cancer in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr 2012; 96:1354-1361.
34. Sorongon-Legaspi MK, Chua M, Sio MC, Morales M Jr. Blood level omega-3 Fatty acids as risk determinant molecular biomarker for prostate cancer. Prostate Cancer 2013; 2013:875615.
35. Chua ME, Sio MC, Sorongon MC, Dy JS. Relationship of dietary intake of omega-3 and omega-6 Fatty acids with risk of prostate cancer development: a meta-analysis of prospective studies and review of literature. Prostate Cancer 2012; 2012:826254.
36. Bosire C, Stampfer MJ, Subar AF, et al. Index-based dietary patterns and the risk of prostate cancer in the NIH-AARP diet and health study. Am J Epidemiol 2013; 177:504-513.
37. Browning LM, Walker CG, Mander AP, et al. Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish. Am J Clin Nutr 2013; 96:748-758.
38. Ifere GO, Desmond R, Demark-Wahnefried W, Nagy TR. Apolipoprotein E gene polymorphism influences aggressive behavior in prostate cancer cells by deregulating cholesterol homeostasis. Int J Oncol 2013; 43:1002-1010.
39. Samieri C, Lorrain S, Buaud B, et al. Relationship between diet and plasma long-chain n-3 PUFAs in older people: impact of apolipoprotein E genotype. J Lipid Res 2013; 54:2559-2567.
40. Calder PC, Deckelbaum RJ. Intravenous fish oil in hospitalized adult patients: reviewing the reviews. Curr Opin Clin Nutr Metab Care 2013; 16:119-123.
41. Wei C, Hua J, Bin C, Klassen K. Impact of lipid emulsion containing fish oil on outcomes in surgical patients: systematic review of randomized controlled trials from Europe and Asia. Nutrition 2010; 26:474-481.
42. Chen B, Zhou Y, Yang P, et al. Safety and efficacy of fish oil-enriched parenteral nutrition regimen on postoperative patients undergoing major abdominal surgery: a meta-analysis of randomized controlled trials. JPEN J Parenter Enteral Nutr 2010; 34:387-394.
43. Pradelli L, Mayer K, Muscaritoli M, Heller AR. N-3 fatty acid-enriched parenteral nutrition regimens in elective surgical and ICU patients: a metaanalysis. Crit Care 2012; 16:R184.
44. Palmer AJ, Ho CKM, Ajibola O, Avenell A. The role of v-3 fatty acid supplemented parenteral nutrition in critical illness in adults: a systematic review and meta-analysis. Crit Care Med 2013; 41:300-309.
45. Manzanares W, Dhaliwal R, Jurewitsch B, et al. Parenteral fish oil lipid emulsions in the critically ill: a systematic review and meta-analysis. JPEN J Parenter Enteral Nutr 2014; 38:20-28.