An agonistic anti-BTLA mAb (3C10) induced generation of IL-10-dependent regulatory CD4+ T cells and prolongation of murine cardiac allograft

Transplantation

Volumn 97, Issue 3, 2014, Pages 301-309

  Uchiyama, Masateru ^a,b,c   Jin, Xiangyuan ^c,d   Matsuda, Hironori ^b   Bashuda, Hisashi ^b   Imazuru, Tomohiro ^a   Shimokawa, Tomoki ^a   Yagita, Hideo ^b   Niimi, Masanori ^c  

^a TEIKYO UNIVERSITY HOSPITAL   (Japan)

^b JUNTENDO UNIVERSITY HOSPITAL   (Japan)

^c TEIKYO UNIVERSITY   (Japan)

^d HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

BTLA; Cardiac transplantation; Mouse; Regulatory cells

Indexed keywords

ALLOGRAFTS; ANIMALS; ANTIBODIES, MONOCLONAL; CELL PROLIFERATION; CYTOKINES; FLOW CYTOMETRY; HEART TRANSPLANTATION; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-10; INTERLEUKIN-2; LEUKOCYTES; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED CBA; RECEPTORS, IMMUNOLOGIC; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES, REGULATORY;

EID: 84894093003     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000438204.96723.8b     Document Type: Article

References (44)

1. Sakamoto S, Shigeta T, Fukuda A, et al. The role of liver transplantation for congenital extrahepatic portosystemic shunt. Transplantation 2012; 93: 1282.
2. Krämer BK, Klinger M, Vítko S, et al. Tacrolimus-based, steroid-free regimens in renal transplantation: 3-year follow-up of the ATLAS trial. Transplantation 2012; 94: 492.
3. Montgomery JR, Berger JC, Warren DS, et al. Outcomes of ABO-incompatible kidney transplantation in the United States. Transplantation 2012; 93: 603.
4. Li J, Zhu H, Wang S, et al. Blockade of NKG2D synergized with CTLA4-Ig in promoting long-term graft survival in murine models of cardiac transplantation. Transplantation 2012; 93: 356.
5. Graves SS, Stone DM, Loretz C, et al. Antagonistic and agonistic anti-canine CD28 monoclonal antibodies: tools for allogeneic transplantation. Transplantation 2011; 91: 833.
6. del Rio ML, Kurtz J, Perez-Martinez C, et al. B-and T-lymphocyte attenuator targeting protects against the acute phase of graft versus host reaction by inhibiting donor anti-host cytotoxicity. Transplantation 2011; 92: 1085.
7. Zhang T, Fresnay S, Welty E, et al. Selective CD28 blockade attenuates acute and chronic rejection of murine cardiac allografts in a CTLA-4-dependent manner. Am J Transplant 2011; 11: 1599.
8. Harding FA, McArthur JG, Gross JA, et al. CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 1992; 356: 607.
9. Lenschow DJ, Walunas TL, Bluestone JA. CD28/B7 system of T cell costimulation. Annu Rev Immunol 1996; 14: 233.
10. Schwartz RH. A cell culture model for T lymphocyte clonal anergy. Science 1990; 248: 1349.
11. Ozkaynak E, Gao W, Shemmeri N, et al. Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection. Nat Immunol 2001; 2: 591.
12. Ozkaynak E, Wang L, Goodearl A, et al. Programmed death-1 targeting can promote allograft survival. J Immunol 2002; 169: 6546.
13. Wang L, Fraser CC, Kikly K, et al. B7-H3 promotes acute and chronic allograft rejection. Eur J Immunol 2005; 35: 428.
14. Ito T, Ueno T, Clarkson MR, et al. Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo. J Immunol 2005; 174: 6648.
15. Sandner SE, Clarkson MR, Salama AD, et al. Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. J Immunol 2005; 174: 3408.
16. Watanabe N, Gavrieli M, Sedy JR, et al. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol 2003; 4: 670.
17. + T cells. J Immunol 2005; 174: 3377.
18. Hobo W, Norde WJ, Schaap N, et al. B and T lymphocyte attenuator mediates inhibition of tumor-reactive CD8+ T cells in patients after allogeneic stem cell transplantation. J Immunol 2012; 189: 39.
19. Sedy JR, Gavrieli M, Potter KG, et al. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat Immunol 2005; 6: 90.
20. Krieg C, Han P, Stone R, et al. Functional analysis of B and T lymphocyte attenuator engagement on CD4+and CD8+ T cells. J Immunol 2005; 175: 6420.
21. Deppong C, Juehne TI, Hurchla M, et al. Cutting edge: B and T lymphocyte attenuator and programmed death receptor-1 inhibitory receptors are required for termination of acute allergic airway inflammation. J Immunol 2006; 176: 3909.
22. Stewart S, Winters GL, Fishbein MC, et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant 2005; 24: 1710.
23. Billingham ME, Cary NR, Hammond ME, et al. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group. The International Society for Heart Transplantation. J Heart Transplant 1990; 9: 587.
24. Tao R, Wang L, Han R, et al. Differential effects of B and T lymphocyte attenuator and programmed death-1 on acceptance of partially versus fully MHC-mismatched cardiac allografts. J Immunol 2005; 75: 5774.
25. del Rio ML, Jones ND, Buhler L, et al. Selective blockade of herpes-virus entry mediator-B and T lymphocyte attenuator pathway ameliorates acute graft-versus-host reaction. J Immunol 2012; 188: 4885.
26. Newell KA, Larsen CP, Kirk AD. Transplant tolerance: converging on a moving target. Transplantation 2006; 81: 1.
27. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 1999; 162: 5317.
28. Jiang S, Lechler RI. Regulatory T cells in the control of transplantation tolerance and autoimmunity. Am J Transplant 2003; 3: 516.
29. Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003; 3: 199.
30. + cells in mice. Transpl Int 2012; 25: 357.
31. Inoue F, Zhang Q, Akiyoshi T, et al. Prolongation of survival of fully allogeneic cardiac grafts and generation of regulatory cells by a his-tamine receptor 2 antagonist. Transplantation 2007; 84: 1288.
32. Aramaki O, Takayama T, Yokoyama T, et al. High dose of anti-thrombin III induces indefinite survival of fully allogeneic cardiac grafts and generates regulatory cells. Transplantation 2003; 75: 217.
33. + regulatory cells. J Thorac Cardiovasc Surg 2005; 130: 1167.
34. + cells. J Cardiothorac Surg 2012; 7: 26.
35. + regulatory T cells. Am J Transplant 2008; 8: 1639.
36. Truong W, Plester JC, Hancock WW, et al. Combined coinhibitory and costimulatory modulation with anti-BTLA and CTLA4Ig facilitates tolerance in murine islet allografts. Am J Transplant 2007; 7: 2663.
37. Zhang Q, Nakai T, Iwami D, et al. Induction of regulatory T cells and indefinite survival of fully allogeneic cardiac grafts by ursodeoxycholic acid in mice. Transplantation 2009; 88: 1360.
38. Akiyoshi T, Zhang Q, Inoue F, et al. Induction of indefinite survival of fully mismatched cardiac allografts and generation of regulatory cells by sarpogrelate hydrochloride. Transplantation 2006; 82: 1051.
39. Iwami D, Zhang Q, Aramaki O, et al. Purified eicosapentaenoic acid induces prolonged survival of cardiac allografts and generates regulatory T cells. Am J Transplant 2009; 9: 1294.
40. Wan YY, Flavell RA. The roles for cytokines in the generation and maintenance of regulatory T cells. Immunol Rev 2006; 212: 114.
41. Hara M, Kingsley CI, Niimi M, et al. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol 2001; 166: 3789.
42. Niimi M. The technique for heterotopic cardiac transplantation in mice: experience of 3000 operations by one surgeon. J Heart Lung Transplant 2001; 20: 1123.
43. Ishida W, Fukuda K, Kajisako M, et al. B and T lymphocyte attenuator regulates the development of antigen-induced experimental conjunctivitis. Graefes Arch Clin Exp Ophthalmol 2012; 250: 289.
44. Akiyama Y, Shirasugi N, Uchida N, et al. B7/CTLA4 pathway is essential for generating regulatory cells after intratracheal delivery of alloantigen in mice. Transplantation 2002; 74: 732.