Danazol induces prolonged survival of fully allogeneic cardiac grafts and maintains the generation of regulatory CD4 + cells in mice

Transplant International

Volumn 25, Issue 3, 2012, Pages 357-365

  Uchiyama, Masateru ^a,b   Jin, Xiangyuan ^b,c   Zhang, Qi ^b   Hirai, Toshihito ^d   Bashuda, Hisashi ^a   Watanabe, Toshiaki ^b   Amano, Atsushi ^a   Niimi, Masanori ^b  

^a JUNTENDO UNIVERSITY HOSPITAL   (Japan)

^b TEIKYO UNIVERSITY   (Japan)

^c HARBIN MEDICAL UNIVERSITY   (China)

^d TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

cardiac transplantation; danazol; immunomodulation; mouse; regulatory cells; testosterone derivative

Indexed keywords

DANAZOL; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; TRANSCRIPTION FACTOR FOXP3;

ADOPTIVE TRANSFER; ALLOTRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFECT; FLOW CYTOMETRY; GRAFT SURVIVAL; HEART GRAFT; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; MALE; MIXED LEUKOCYTE CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SINGLE DRUG DOSE; SURVIVAL TIME; UPREGULATION;

ADOPTIVE TRANSFER; ANIMALS; BIOLOGICAL MARKERS; CYTOKINES; DANAZOL; DRUG ADMINISTRATION SCHEDULE; FLOW CYTOMETRY; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOSUPPRESSIVE AGENTS; MALE; MICE; MICE, INBRED C57BL; T-LYMPHOCYTES, REGULATORY;

EID: 84862820127     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2011.01427.x     Document Type: Article

References (45)

1. Dmowski WP,. Danazol. A synthetic steroid with diverse biologic effects. J Reprod Med 1990; 35: 69.
2. Odukoya OA, Bansal A, Wilson AP, Weetman AP, Cooke ID,. Serum-soluble CD23 in patients with endometriosis and the effect of treatment with danazol and leuprolide acetate depot injection. Hum Reprod 1995; 10: 942.
3. Ota H, Igarashi S, Hayakawa M, Matsui T, Tanaka H, Tanaka T,. Effect of danazol on the immunocompetent cells in the eutopic endometrium in patients with endometriosis: a multicenter cooperative study. Fertil Steril 1996; 65: 545.
4. Kusakabe K, Morishima S, Nakamuta N, Li ZL, Otsuki Y,. Effect of danazol on NK cells and cytokines in the mouse uterus. J Reprod Dev 2007; 53: 87.
5. Jaime-Pérez JC, Colunga-Pedraza PR, Gõmez-Ramírez CD, et al. Danazol as first-line therapy for aplastic anemia. Ann Hematol 2011; 90: 523.
6. Kojima S, Hibi S, Kosaka Y, et al. Immunosuppressive therapy using antithymocyte globulin, cyclosporine, and danazol with or without human granulocyte colony-stimulating factor in children with acquired aplastic anemia. Blood 2000; 96: 2049.
7. Escrich E, Solanas M, Bailly C, Ruiz de Villa MC, Saez S,. Effects of an androgenic derivative on the development of chemically-induced mammary carcinogenesis in the rat. Anticancer Res 1994; 14: 539.
8. Kondo H, Iseki T, Goto S, Takaso T, Ohto M, Okuda K,. Danazol therapy in idiopathic thrombocytopenic purpura: the efficacy of low-medium dose therapy. Int J Hematol 1992; 55: 293.
9. Ahn YS, Harrington WJ, Simon SR, Mylvaganam R, Pall LM, So AG,. Danazol for the treatment of idiopathic thrombocytopenic purpura. N Engl J Med 1983; 308: 1396.
10. Kotlarek-Haus S, Podolak-Dawidziak M,. Danazol in chronic idiopathic thrombocytopenic purpura resistant to corticosteroids. Folia Haematol Int Mag Klin Morphol Blutforsch 1987; 114: 768.
11. Mori H, Nakagawa M, Itoh N, Wada K, Tamaya T,. Danazol suppresses the production of interleukin-1 beta and tumor necrosis factor by human monocytes. Am J Reprod Immunol 1990; 24: 45.
12. Ahn YS, Rocha R, Mylvaganam R, Garcia R, Duncan R, Harrington WJ,. Long-term danazol in autoimmune; thrombocytopenia; unmaintained remission and age-dependent response in women. Ann Intern Med 1989; 111: 723.
13. Cervera H, Jara LJ, Pizarro S, et al. Danazol for sys-temic lupus erythematosus with refractory autoimmune thrombocytopenia or Evan's Syndrome. J Rheumatol 1995; 22: 1867.
14. West SG, Johnson SC,. Danazol for the treatment of refractory autoimmune thrombocytopenia in systemic lupus erythematosus. Ann Intern Med 1988; 108: 703.
15. Dasgupta B, Grahame R,. Treatment with danazol for refractory thrombocytopenia in rheumatoid arthritis. Br J Rheumatol 1989; 28: 550.
16. Hill JA, Barbieri RL, Anderson DJ,. Immunosuppressive effects of danazol in vitro. Fertil Steril 1987; 48: 414.
17. Niimi M,. The technique for heterotopic cardiac transplantation in mice: experience of 3000 operations by one surgeon. J Heart Lung Transplant 2001; 20: 1123.
18. + regulatory T cells to the paracortical areas of peripheral lymph nodes through high endothelial venules. J Leukoc Biol 2007; 82: 1230.
19. Akiyama Y, Shirasugi N, Uchida N, et al. B7/CTLA4 pathway is essential for generating regulatory cells after intratracheal delivery of alloantigen in mice. Transplantation 2002; 74: 732.
20. Perros P, Weightman DR,. Measurement of cell proliferation by enzyme-linked immunosorbent assay (ELISA) using a monoclonal antibody to bromodeoxyuridine. Cell Prolif 1991; 24: 517.
21. Tomino Y, Sakai H, Miura M, Suga T, Endoh M, Nomoto Y,. Effect of danazol on solubilization of immune deposits in patients with IgA nephropathy. Am J Kidney Dis 1984; 4: 135.
22. Lee YJ, Horstman LL, Ahn YS,. Danazol for Henoch-Schonlein purpura. Ann Intern Med 1993; 118: 827.
23. Tomono Y, Sakai H, Hanzawa S, Ohno J, Kitajima T, Sakai O,. Clinical effect of danazol in patients with IgA nephropathy. Jpn J Med 1987; 26: 162.
24. Inoue F, Zhang Q, Akiyoshi T, et al. Prolongation of survival of fully allogeneic cardiac grafts and generation of regulatory cells by a histamine receptor 2 antagonist. Transplantation 2007; 84: 1288.
25. Aramaki O, Takayama T, Yokoyama T, et al. High dose of antithrombin III induces indefinite survival of fully allogeneic cardiac grafts and generates regulatory cells. Transplantation 2003; 75: 217.
26. + regulatory cells. J Thorac Cardiovasc Surg 2005; 130: 1167.
27. Wang G, Zhong A, Wang S, Dong N, Sun Z, Xia J,. Retinoic acid attenuates acute heart rejection by increasing regulatory T cell and repressing differentiation of Th17 cell in the presence of TGF-β. Transpl Int 2010; 23: 986.
28. Yu J, Ren X, Yan F, et al. Alloreactive natural killer cells promote haploidentical hematopoietic stem cell transplantation by expansion of recipient-derived CD4(+)CD25(+)regulatory T cells. Transpl Int 2011; 24: 201.
29. Heng Y, Ma Y, Yin H, et al. Adoptive transfer of FTY720-treated immature BMDCs significantly prolonged cardiac allograft survival. Transpl Int 2010; 23: 1259.
30. Xia J, Chen J, Shao W, et al. Suppressing memory T cell activation induces islet allograft tolerance in alloantigen-primed mice. Transpl Int 2010; 23: 1154.
31. Newell KA, Larsen CP, Kirk AD,. Transplant tolerance: converging on a moving target. Transplantation 2006; 81: 1.
32. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 1999; 162: 5317.
33. Wood KJ, Sakaguchi S,. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003; 3: 199.
34. Brunner SM, Schiechl G, Falk W, Schlitt HJ, Geissler EK, Fichtner-Feigl S,. Interleukin-33 prolongs allograft survival during chronic cardiac rejection. Transpl Int 2011; 24: 1027.
35. Lei J, He F, Wu M, Zheng X, Chen X, Chen Z,. Administration of anti-interleukin-6 monoclonal antibody prolongs cardiac allograft survival. Transpl Int 2010; 23: 1271.
36. Wan YY, Flavell RA,. The roles for cytokines in the generation and maintenance of regulatory T cells. Immunol Rev 2006; 212: 114.
37. Aramaki O, Inoue F, Takayama T, et al. Interleukin-10 but not transforming growth factor-beta is essential for generation and suppressor function of regulatory cells induced by intratracheal delivery of alloantigen. Transplantation 2005; 79: 568.
38. Dalal M, Kim S, Voskuhl R,. Testosterone ameliorates experimental autoimmune encephalomyelitis and induces a T helper 2 bias in autoantigen-specific T lymphocyte response. J Immunol 1997; 159: 3.
39. Mori H, Sawairi M, Itoh N, et al. Effects of sex steroids on immunoglobulin M production by Epstein-Barr virus-transformed B-cell line SKW6-CL4. J In Vitro Fert Embryo Transf 1991; 8: 329.
40. Mylvaganam R, Ahn YS, Garcia RO, Kim CI, Harrington WJ,. Very low dose danazol in idiopathic thrombocytopenic purpura and its role as an immune modulator. Am J Med Sci 1989; 298: 215.
41. Cutolo M, Wilder R,. Different roles for androgens and estrogens in the susceptibility to autoimmune rheumatic diseases. Rheum Dis Clin North Am 2000; 26: 825.
42. Malkin CJ, Pugh PJ, Jones RD, Jones TH, Channer KS,. Testosterone as a protective factor against atherosclerosis-immunomodulation and influence upon plaque development and stability. J Endocrinol 2003; 178: 373.
43. Rettew JA, Huet-Hudson YM, Marriot I,. Testosterone reduce macrophage expression in the mouse of toll-like receptor 4, a trigger for inflammation and innate immunity. Biol Reprod 2008; 78: 432.
44. Hirasawa K, Enosawa S,. Effects of sex steroid hormones on sex-associated differences in the survival time of allogeneic skin grafts in rats. Evidence that testosterone enhances and estradiol reverses the immunosuppressive activity of cyclosporine. Transplantation 1990; 50: 637.
45. Fijak M, Schneider E, Klug J, et al. Testosterone replacement effectively inhibits the development of experimental autoimmune orchitis in rats: evidence for a direct role of testosterone on regulatory T cell expansion. J Immunol 2011; 186: 5162.