Targeting voltage gated sodium channels NaV1.7, Na V1.8, and NaV1.9 for treatment of pathological cough

Lung

Volumn 192, Issue 1, 2014, Pages 15-20

  Muroi, Yukiko ^a   Undem, Bradley J ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

C fiber; Sodium channel; Vagus

Indexed keywords

ANIMALS; ANTITUSSIVE AGENTS; COUGH; DRUG DESIGN; HUMANS; MOLECULAR TARGETED THERAPY; NAV1.7 VOLTAGE-GATED SODIUM CHANNEL; NAV1.8 VOLTAGE-GATED SODIUM CHANNEL; NAV1.9 VOLTAGE-GATED SODIUM CHANNEL; NEURONS, AFFERENT; REFLEX; SODIUM CHANNEL BLOCKERS;

EID: 84894089580     PISSN: 03412040     EISSN: 14321750     Source Type: Journal    
DOI: 10.1007/s00408-013-9533-x     Document Type: Article

References (38)

1. Catterall WA, Raman IM, Robinson HP, Sejnowski TJ, Paulsen O (2012) The Hodgkin-Huxley heritage: from channels to circuits. J Neurosci 32(41):14064-14073
2. Catterall WA (2012) Voltage-gated sodium channels at 60: structure, function and pathophysiology. J Physiol 590(Pt 11):2577-2589
3. Hansson L, Midgren B, Karlsson JA (1994) Effects of inhaled lignocaine and adrenaline on capsaicin-induced cough in humans. Thorax 49(11):1166-1168
4. Trochtenberg S (1994) Nebulized lidocaine in the treatment of refractory cough. Chest 105(5):1592-1593
5. Howard P, Cayton RM, Brennan SR, Anderson PB (1977) Lignocaine aerosol and persistent cough. Br J Dis Chest 71(1):19-24
6. Chong CF, Chen CC, Ma HP, Wu YC, Chen YC, Wang TL (2005) Comparison of lidocaine and bronchodilator inhalation treatments for cough suppression in patients with chronic obstructive pulmonary disease. Emerg Med J 22(6):429-432
7. Dicpinigaitis PV, Gayle YE, Solomon G, Gilbert RD (2009) Inhibition of cough-reflex sensitivity by benzonatate and guaifenesin in acute viral cough. Respir Med 103(6):902-906
8. Canning BJ, Mazzone SB, Meeker SN, Mori N, Reynolds SM, Undem BJ (2004) Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs. J Physiol 557:543-558
9. Fox AJ, Barnes PJ, Urban L, Dray A (1993) An in vitro study of the properties of single vagal afferents innervating guinea-pig airways. J Physiol 469:21-35
10. Carr MJ, Kollarik M, Meeker SN, Undem BJ (2003) A role for TRPV1 in bradykinin-induced excitation of vagal airway afferent nerve terminals. J Pharmacol Exp Ther 304:1275-1279
11. Chuaychoo B, Lee MG, Kollarik M, Pullmann R Jr, Undem BJ (2006) Evidence for both adenosine A1 and A2A receptors activating single vagal sensory C-fibres in guinea pig lungs. J Physiol 575(Pt 2):481-490
12. Coleridge JCG, Coleridge HM (1984) Afferent vagal C-fiber innervation of the lungs and airways and its functional significance. Rev Physiol Biochem Pharmacol 99:1-110
13. Taylor-Clark T, Undem BJ (2006) Transduction mechanisms in airway sensory nerves. J Appl Physiol 101(3):950-959
14. Undem BJ, Chuaychoo B, Lee MG, Weinreich D, Myers AC, Kollarik M (2004) Subtypes of vagal afferent C-fibres in guinea-pig lungs. J Physiol 556(pt 3):905-917
15. Duarte AG, Myers AC (2012) Cough reflex in lung transplant recipients. Lung 190(1):23-27
16. Kwong K, Carr MJ, Gibbard A, Savage TJ, Singh K, Jing J, Meeker S, Undem BJ (2008) Voltage-gated sodium channels in nociceptive versus non-nociceptive nodose vagal sensory neurons innervating guinea pig lungs. J Physiol 586(5):1321-1336
17. Muroi Y, Ru F, Kollarik M, Canning BJ, Hughes SA, Walsh S, Sigg M, Carr MJ, Undem BJ (2011) Selective silencing of Na(V)1.7 decreases excitability and conduction in vagal sensory neurons. J Physiol 589(Pt 23):5663-5676
18. Raymond CK, Castle J, Garrett-Engele P, Armour CD, Kan Z, Tsinoremas N, Johnson JM (2004) Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia. J Biol Chem 279(44):46234-46241
19. Lai J, Porreca F, Hunter JC, Gold MS (2004) Voltage-gated sodium channels and hyperalgesia. Annu Rev Pharmacol Toxicol 44:371-397
20. Priest BT, Kaczorowski GJ (2007) Subtype-selective sodium channel blockers promise a new era of pain research. Proc Natl Acad Sci USA 104(20):8205-8206
21. Nardi A, Damann N, Hertrampf T, Kless A (2013) Advances in targeting voltage-gated sodium channels with small molecules. ChemMedChem 7(10):1712-1740
22. Farrag KJ, Costa SK, Docherty RJ (2002) Differential sensitivity to tetrodotoxin and lack of effect of prostaglandin E2 on the pharmacology and physiology of propagated action potentials. Br J Pharmacol 135(6):1449-1456
23. Canning BJ, Mori N (2010) Encoding of the cough reflex in anesthetized guinea pigs. Am J Physiol Regul Integr Comp Physiol 300(2):R369-R377
24. Mazzone SB, Reynolds SM, Mori N, Kollarik M, Farmer DG, Myers AC, Canning BJ (2009) Selective expression of a sodium pump isozyme by cough receptors and evidence for its essential role in regulating cough. J Neurosci 29(43):13662-13671
25. V1.7 shRNA silencing in guinea pig nodose ganglia. Am J Physiol Regul Integr Comp Physiol 304:R1017-R1023
26. Stamboulian S, Choi JS, Ahn HS, Chang YW, Tyrrell L, Black JA, Waxman SG, Dib-Hajj SD (2010) ERK1/2 mitogen-activated protein kinase phosphorylates sodium channel Na(v)1.7 and alters its gating properties. J Neurosci 30(5):1637-1647
27. V1.9 in a distinct population of dorsal root ganglia innervating the rat knee joint in a model of chronic inflammatory joint pain. Eur J Pain 12(5):564-572
28. V1.7 gene underlie congenital indifference to pain in multiple human populations. Clin Genet 71(4):311-319
29. V1.7 cause anosmia. Nature 472(7342):186-190
30. Schild JH, Clark JW, Hay M, Mendelowitz D, Andresen MC, Kunze DL (1994) A- and C-type rat nodose sensory neurons: model interpretations of dynamic discharge characteristics. J Neurophysiol 71(6):2338-2358
31. Gold MS (1999) Tetrodotoxin-resistant Na+ currents and inflammatory hyperalgesia. Proc Natl Acad Sci USA 96(14):7645-7649
32. Kwong K, Lee LY (2002) PGE2 sensitizes cultured pulmonary vagal sensory neurons to chemical and electrical stimuli. J Appl Physiol 93(4):1419-1428
33. Maher SA, Birrell MA, Belvisi MG (2009) Prostaglandin E2 mediates cough via the EP3 receptor: implications for future disease therapy. Am J Respir Crit Care Med 180(10):923-928
34. V1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci USA 104(20):8520-8525
35. Amaya F, Wang H, Costigan M, Allchorne AJ, Hatcher JP, Egerton J, Stean T, Morisset V, Grose D, Gunthorpe MJ, Chessell IP, Tate S, Green PJ, Woolf CJ (2006) The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity. J Neurosci 26(50):12852-12860
36. O'Neill J, McMahon SB, Undem BJ (2013) Chronic cough and pain: Janus faces in sensory neurobiology? Pulm Pharmacol Ther 26:476-485
37. Rush AM, Waxman SG (2004) PGE2 increases the tetrodotoxin-resistant Nav1.9 sodium current in mouse DRG neurons via G-proteins. Brain Res 1023(2):264-271
38. V1.9 is required for inflammation-based urinary bladder dysfunction. Neurosci Lett 452(1):28-32