Inhibition of cough-reflex sensitivity by benzonatate and guaifenesin in acute viral cough

Respiratory Medicine

Volumn 103, Issue 6, 2009, Pages 902-906

  Dicpinigaitis, Peter V ^a   Gayle, Yvonne E ^a   Solomon, Gail ^b   Gilbert, Richard D ^c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b RECKITT BENCKISER   (United Kingdom)

^c TKL RESEARCH INC   (United States)

Author keywords

Antitussive; Benzonatate; Capsaicin; Common cold; Cough; Guaifenesin

Indexed keywords

BENZONATATE; CAPSAICIN; GUAIFENESIN; PLACEBO;

ACUTE DISEASE; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; CROSSOVER PROCEDURE; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG POTENTIATION; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REFLEX; TREATMENT RESPONSE; UPPER RESPIRATORY TRACT INFECTION; VIRAL RESPIRATORY TRACT INFECTION;

ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; ADULT; ANTITUSSIVE AGENTS; BUTYLAMINES; CAPSAICIN; COMMON COLD; COUGH; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FEMALE; GUAIFENESIN; HUMANS; MALE; MIDDLE AGED; REFLEX; SENSORY SYSTEM AGENTS;

EID: 67349264549     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2008.12.008     Document Type: Article

References (17)

1. Burt C.W., and Schappert S.M. Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 1999-2000. Vital Health Stat 13 157 (2004) 1-70
2. Schroeder K., and Fahey T. Systematic review of randomised controlled trials of over-the-counter medicines for acute cough in adults. Br Med J 324 (2002) 329-331
3. Bolser D.C. Cough suppressant and pharmacologic protussive therapy: ACCP evidence-based clinical practice guidelines. Chest 129 (2006) 238S-249S
4. Eccles R., Morris S., and Jawad M. Lack of effect of codeine in the treatment of cough associated with acute upper respiratory tract infection. J Clin Pharm Ther 17 (1992) 175-180
5. Freestone C., and Eccles R. Assessment of the antitussive efficacy of codeine in cough associated with common cold. J Pharm Pharmacol 49 (1997) 1045-1049
6. Chung K.F. Currently available cough suppressants for chronic cough. Lung 186 Suppl. 1 (2008) S82-S87
7. Ayres P.J.W. Experimental and clinical methodologies in efficacy of expectorants using the example of guaifenesin. In: Loew D., and Rietbrock N. (Eds). Phytopharmaka III (1997), Steinkopff Verlag, Darmstadt, Germany 151-160
8. United States Dept. of Health and Human Services. Expectorant drug products for over-the-counter human use: final monograph (1989), Federal Register 54, Washington, DC p. 8494-509
9. Dicpinigaitis P.V., and Gayle Y.E. Effect of guaifenesin on cough reflex sensitivity. Chest 124 (2003) 2178-2181
10. Banner A.S. Pharmacologic treatment of cough. In: Leff A.R. (Ed). Pulmonary and critical care pharmacology and therapeutics (2002), McGraw-Hill, New York 673-679
11. Ziment I. Agents that affect mucus and cough. In: Witek T.J., and Schacter E.N. (Eds). Pharmacology and therapeutics in respiratory care (1994), WB Saunders, Philadelphia 239-257
12. Dicpinigaitis P.V. Short and long-term reproducibility of capsaicin cough challenge testing. Pulm Pharmacol Ther 16 (2003) 61-65
13. Dicpinigaitis P.V., and Alva R.V. Safety of capsaicin cough challenge testing. Chest 128 (2005) 196-202
14. Morice A.H., Fontana G.A., Belvisi M.G., et al. European Respiratory Society guidelines on the assessment of cough. Eur Respir J 29 (2007) 1256-1276
15. Empey D.W., Laitinen L.A., Jacobs L., Gold W.M., and Nadel J.A. Mechanism of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Respir Dis 113 (1976) 131-139
16. O'Connell F., Thomas V.E., Studham J.M., Pride N.B., and Fuller R.W. Capsaicin cough sensitivity increases during upper respiratory tract infection. Respir Med 90 (1996) 279-286
17. Dicpinigaitis P.V., Spinner L., Santhyadka G., and Negassa A. Effect of tiotropium on cough reflex sensitivity in acute viral cough. Lung 186 (2008) 369-374