Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines

Journal of Medicinal Chemistry

Volumn 57, Issue 3, 2014, Pages 651-668

  Lam, Thanh ^a   Hilgers, Mark T ^a   Cunningham, Mark L ^a   Kwan, Bryan P ^a   Nelson, Kirk J ^a   Brown Driver, Vickie ^a   Ong, Voon ^a   Trzoss, Michael ^a   Hough, Grayson ^a   Shaw, Karen Joy ^a   Finn, John ^a  

^a Trius Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; ANTI-BACTERIAL AGENTS; BENZIMIDAZOLES; DRUG RESISTANCE, BACTERIAL; FOLIC ACID ANTAGONISTS; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; QUINAZOLINES; SEPSIS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 84894060349     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401204g     Document Type: Article

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