Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5171-5176

  Li, Xiaoming ^a   Hilgers, Mark ^a   Cunningham, Mark ^a   Chen, Zhiyong ^a   Trzoss, Michael ^a   Zhang, Junhu ^a   Kohnen, Lucy ^a   Lam, Thanh ^a   Creighton, Chris ^a   Gc, Kedar ^a   Nelson, Kirk ^a   Kwan, Bryan ^a   Stidham, Mark ^a   Brown Driver, Vickie ^a   Shaw, Karen J ^a   Finn, John ^a  

^a Trius Therapeutics   (United States)

Author keywords

Antibacterial; DHFR; Inhibitor; Selectivity; Staphylococcus aureus

Indexed keywords

2,4 DIAMINOQUINAZOLINE DERIVATIVE; 7 ARYL 2,4 DIAMINOQUINAZOLINE DERIVATIVE; ANTIINFECTIVE AGENT; ICLAPRIM; METHOTREXATE; PIRITREXIM; TRIMETHOPRIM; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM POSITIVE BACTERIUM; NONHUMAN; PROCESS OPTIMIZATION;

ANTI-BACTERIAL AGENTS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUINAZOLINES; STAPHYLOCOCCUS AUREUS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 80051936025     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.059     Document Type: Article

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