Small macrocycles as highly active integrin α2β1 antagonists

ACS Medicinal Chemistry Letters

Volumn 5, Issue 2, 2014, Pages 193-198

  Halland, Nis ^a   Blum, Horst ^a   Buning, Christian ^a   Kohlmann, Markus ^a   Lindenschmidt, Andreas ^a  

^a Sanofi R and D   (Germany)

Author keywords

Integrin; macrocycle; metathesis; platelet collagen receptor; restricted conformation

Indexed keywords

ALPHA2BETA1 INTEGRIN ANTAGONIST; CARBOXYLIC ACID; CYTOCHROME P450 1A1; CYTOCHROME P450 3A4; FIRATEGRAST; HISTIDINE; IMIDAZOLE; MACROCYCLIC COMPOUND; NITROGEN; PICOLINIC ACID; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VALATEGRAST; VERY LATE ACTIVATION ANTIGEN 2;

ALLYLATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CLICK CHEMISTRY; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG HALF LIFE; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROLYSIS; IC 50; LIPOPHILICITY; NONHUMAN; PHARMACOPHORE; PHYSICAL CHEMISTRY; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; RAT; RING CLOSING METATHESIS; X RAY CRYSTALLOGRAPHY;

EID: 84894058300     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml4004556     Document Type: Article

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