Breaking the dogma of the metal-coordinating carboxylate group in integrin ligands: Introducing hydroxamic acids to the MIDAS to tune potency and selectivity

Angewandte Chemie - International Edition

Volumn 48, Issue 24, 2009, Pages 4436-4440

  Heckmann, Dominik ^a   Laufer, Burkhardt ^a   Marinelli, Luciana ^b   Limongelli, Vittorio ^b   Novellino, Ettore ^b   Zahn, Grit ^c   Stragies, Roland ^c   Kessler, Horst ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c Jerini AG   (Germany)

Author keywords

Antitumor agents; Hydroxamic acids; Integrin ligands; Molecular modeling; Structureactivity relationship

Indexed keywords

ADHESION SITES; ANTITUMOR AGENTS; ASPARTATE RESIDUE; ASPARTATES; BINDING ACTIVITIES; CARBOXYL GROUPS; CARBOXYLATE GROUPS; HYDROXAMIC ACIDS; INTEGRIN LIGANDS; INTEGRIN RECEPTORS; ISOSTERIC; STRUCTUREACTIVITY RELATIONSHIP;

BINDING ENERGY; BINDING SITES; CARBOXYLATION; MOLECULAR MODELING; ORGANIC ACIDS;

LIGANDS;

CARBOXYLIC ACID; HYDROXAMIC ACID; INTEGRIN; LIGAND; METAL;

BINDING SITE; CHEMISTRY; COMPUTER SIMULATION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CARBOXYLIC ACIDS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HYDROXAMIC ACIDS; INTEGRINS; LIGANDS; METALS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 70349973413     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200900206     Document Type: Article

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