Effectiveness of nicotinic agonists as desensitizers at presynaptic α4β2-and α4α5β2-Nicotinic acetylcholine receptors

Nicotine and Tobacco Research

Volumn 16, Issue 3, 2014, Pages 297-305

  Wageman, Charles R ^a   Marks, Michael J ^a   Grady, Sharon R ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; DOPAMINE; DOPAMINERGIC NEURONS; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MICE, MUTANT STRAINS; NICOTINE; NICOTINIC AGONISTS; PYRIDINES; RECEPTORS, NICOTINIC; SMOKING CESSATION;

EID: 84894043881     PISSN: 14622203     EISSN: 1469994X     Source Type: Journal    
DOI: 10.1093/ntr/ntt146     Document Type: Article

References (38)

1. Bailey, C. D., De Biasi, M., Fletcher, P. J., & Lambe, E. K. (2010). The nicotinic acetylcholine receptor alpha5 subunit plays a key role in attention circuitry and accuracy. The Journal of Neuroscience, 30, 9241-9252. doi:10.1523/ JNEUROSCI.2258-10.2010
2. Barik, J., & Wonnacott, S. (2009). Molecular and cellular mechanisms of action of nicotine in the CNS. Handbook of Experimental Pharmacology, 192, 173-207. doi:10.1007/978-3-540-69248-5_7
3. Berrettini, W. H., & Doyle, G. A. (2012). The CHRNA5-A3-B4 gene cluster in nicotine addiction. Molecular Psychiatry, 17, 856-866. doi:10.1038/mp.2011.122
4. Brody, A. L., Mandelkern, M. A., London, E. D., Olmstead, R. E., Farahi, J., Scheibal, D., ..., Mukhin, A. G. (2006). Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors. Archives of General Psychiatry, 63, 907-915. doi:10.1001/archpsyc.63.8.907
5. Brown, R. W., Collins, A. C., Lindstrom, J. M., & Whiteaker, P. (2007). Nicotinic alpha5 subunit deletion locally reduces high-affinity agonist activation without altering nicotinic receptor numbers. Journal of Neurochemistry, 103, 204- 215. doi:10.1111/j.1471-4159.2007.04700.x
6. Buccafusco, J. J., Beach, J. W., & Terry, A. V., Jr. (2009). Desensitization of nicotinic acetylcholine receptors as a strategy for drug development. The Journal of Pharmacology and Experimental Therapeutics, 328, 364-370. doi:10.1124/ jpet.108.145292
7. Champtiaux, N., Gotti, C., Cordero-Erausquin, M., David, D. J., Przybylski, C., Lena, C., ..., Changeux, J. P. (2003). Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. The Journal of N euroscience, 23, 7820-7829.
8. De Biasi, M., & Dani, J. A. (2011). Reward, addiction, withdrawal to nicotine. Annual Review of Neuroscience, 34, 105-130. doi:10.1146/annurev-neuro-061010-113734
9. Exley, R., McIntosh, J. M., Marks, M. J., Maskos, U., & Cragg, S. J. (2012). Striatal a5 nicotinic receptor subunit regulates dopamine transmission in dorsal striatum. The Journal of Neuroscience, 32, 2352-2356. doi:10.1523/ JNEUROSCI.4985-11.2012
10. Faessel, H. M., Gibbs, M. A., Clark, D. J., Rohrbacher, K., Stolar, M., & Burstein, A. H. (2006). Multiple-dose pharmacokinetics of the selective nicotinic receptor partial agonist, varenicline, in healthy smokers. Journal of Clinical Pharmacology, 46, 1439-1448. doi:10.1177/0091270006292624
11. * nicotinic receptors. The Journal of Neuroscience, 25, 11396-11411. doi:10.1523/ jneurosci.3597-05.2005
12. *-and alpha 7-nicotine acetylcholine receptors. Neuropharmacology, 58, 1054-1066. doi:10.1016/j.neuropharm.2010.01.013
13. Grady, S. R., Salminen, O., McIntosh, J. M., Marks, M. J., & Collins, A. C. (2010). Mouse striatal dopamine nerve terminals express alpha4alpha5beta2 and two stoichiometric forms of alpha4beta2*-nicotinic acetylcholine receptors. Journal of Molecular Neuroscience, 40, 91-95. doi:10.1007/ s12031-009-9263-y
14. Grady, S. R., Wageman, C. R., Patzlaff, N. E., & Marks, M. J. (2012). Low concentrations of nicotine differentially desensitize nicotinic acetylcholine receptors that include a5 or a6 subunits and that mediate synaptosomal neurotransmitter release. Neuropharmacology, 62, 1935-1943. doi:10.1016/j.neuropharm.2011.12.026
15. Hulihan-Giblin, B. A., Lumpkin, M. D., & Kellar, K. J. (1990). Acute effects of nicotine on prolactin release in the rat: Agonist and antagonist effects of a single injection of nicotine. The Journal of Pharmacology and Experimental Therapeutics, 252, 15-20.
16. Hurst, R., Rollema, H., & Bertrand, D. (2013). Nicotinic acetylcholine receptors: From basic science to therapeutics. Pharmacology & Therapeutics, 137, 22-54. doi:10.1016/j. pharmthera.2012.08.012
17. Hussmann, G. P., Turner, J. R., Lomazzo, E., Venkatesh, R., Cousins, V., Xiao, Y., ..., Kellar, K. J. (2012). Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain. The Journal of Pharmacology and Experimental Therapeutics, 343, 441- 450. doi:10.1124/jpet.112.198085
18. Jarvik, M. E., Madsen, D. C., Olmstead, R. E., Iwamoto-Schaap, P. N., Elins, J. L., & Benowitz, N. L. (2000). Nicotine blood levels and subjective craving for cigarettes. Pharmacology, Biochemistry, and Behavior, 66, 553-558.
19. Kuryatov, A., Berrettini, W., & Lindstrom, J. (2011). Acetylcholine receptor (AChR) alpha5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (alpha4beta2)(2)alpha5 AChR function. Molecular Pharmacology, 79, 119-125. doi:10.1124/mol.110.066357
20. Levin, E. D., Rezvani, A. H., Xiao, Y., Slade, S., Cauley, M., Wells, C., ..., Kellar, K. J. (2010). Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats. The Journal of Pharmacology and Experimental Therapeutics, 332, 933-939. doi:10.1124/jpet.109.162073
21. Lukas, R. J., Changeux, J. P., Le Novere, N., Albuquerque, E. X., Balfour, D. J., Berg, D. K., ..., Wonnacott, S. (1999). International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. Pharmacological Reviews, 51, 397-401.
22. Lüscher, C., & Malenka, R. C. (2011). Drug-evoked synaptic plasticity in addiction: From molecular changes to circuit remodeling. Neuron, 69, 650-663. doi:10.1016/j. neuron.2011.01.017
23. Mao, D., Perry, D. C., Yasuda, R. P., Wolfe, B. B., & Kellar, K. J. (2008). The alpha4beta2alpha5 nicotinic cholinergic receptor in rat brain is resistant to up-regulation by nicotine in vivo. Journal of Neurochemistry, 104, 446-456. doi:10.1111/j.1471-4159.2007.05011.x
24. Marks, M. J., Whiteaker, P., Calcaterra, J., Stitzel, J. A., Bullock, A. E., Grady, S. R., ..., Collins, A. C. (1999). Two pharmacologically distinct components of nicotinic receptormediated rubidium efflux in mouse brain require the beta2 subunit. The Journal of Pharmacology and Experimental Therapeutics, 289, 1090-1103.
25. Marks, M. J., Whiteaker, P., & Collins, A. C. (2006). Deletion of the alpha7, beta2, or beta4 nicotinic receptor subunit genes identifies highly expressed subtypes with relatively low affinity for [3H]epibatidine. Molecular Pharmacology, 70, 947-959. doi:10.1124/mol.106.025338
26. Maskos, U. (2010). Role of endogenous acetylcholine in the control of the dopaminergic system via nicotinic receptors. Journal of Neurochemistry, 114, 641-646. doi:10.1111/j.1471-4159.2010.06798.x
27. Miner, L. L., & Collins, A. C. (1988). Effect of nicotine pretreatment on nicotine-induced seizures. Pharmacology, Biochemistry, and Behavior, 29, 375-380.
28. Pennock, R. L., Dicken, M. S., & Hentges, S. T. (2012). Multiple inhibitory G-protein-coupled receptors resist acute desensitization in the presynaptic but not postsynaptic compartments of neurons. The Journal of Neuroscience, 32, 10192-10200. doi:10.1523/jneurosci.1227-12.2012
29. Penton, R. E., Quick, M. W., & Lester, R. A. (2011). Short-and long-lasting consequences of in vivo nicotine treatment on hippocampal excitability. The Journal of Neuroscience, 31, 2584-2594. doi:10.1523/JNEUROSCI.4362-10.2011
30. Picciotto, M. R., Addy, N. A., Mineur, Y. S., & Brunzell, D. H. (2008). It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood. Progress in Neurobiology, 84, 329-342. doi:10.1016/j. pneurobio.2007.12.005
31. Pidoplichko, V. I., DeBiasi, M., Williams, J. T., & Dani, J. A. (1997). Nicotine activates and desensitizes midbrain dopamine neurons. Nature, 390, 401-404. doi:10.1038/37120
32. Poorthuis, R. B., Bloem, B., Verhoog, M. B., & Mansvelder, H. D. (2013). Layer-specific interference with cholinergic signaling in the prefrontal cortex by smoking concentrations of nicotine. The Journal of Neuroscience, 33, 4843-4853. doi:10.1523/jneurosci.5012-12.2013
33. Rose, J. E., Mukhin, A. G., Lokitz, S. J., Turkington, T. G., Herskovic, J., Behm, F. M., ..., Garg, P. K. (2010). Kinetics of brain nicotine accumulation in dependent and nondependent smokers assessed with PET and cigarettes containing 11C-nicotine. Proceedings of the National Academy of Sciences of the United States of America, 107, 5190-5195. doi:10.1073/pnas.0909184107
34. Salminen, O., Murphy, K. L., McIntosh, J. M., Drago, J., Marks, M. J., Collins, A. C., & Grady, S. R. (2004). Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice. Molecular Pharmacology, 65, 1526-1535. doi:10.1124/mol.65.6.1526
35. Sharp, B. M., & Beyer, H. S. (1986). Rapid desensitization of the acute stimulatory effects of nicotine on rat plasma adrenocorticotropin and prolactin. The Journal of Pharmacology and Experimental Therapeutics, 238, 486-491.
36. Vardya, I., Drasbek, K. R., Gibson, K. M., & Jensen, K. (2010). Plasticity of postsynaptic, but not presynaptic, GABAB receptors in SSADH deficient mice. Experimental Neurology, 225, 114-122. doi:10.1016/j. expneurol.2010.05.022
37. Wetherington, J. P., & Lambert, N. A. (2002). Differential desensitization of responses mediated by presynaptic and postsynaptic A1 adenosine receptors. The Journal of Neuroscience, 22, 1248-1255.
38. Whiteaker, P., Jimenez, M., McIntosh, J. M., Collins, A. C., & Marks, M. J. (2000). Identification of a novel nicotinic binding site in mouse brain using [(125)I]-epibatidine. British Journal of Pharmacology, 131, 729-739. doi:10.1038/ sj.bjp.0703616