-
1
-
-
80053497428
-
Prevalence of gout hyperuricemia in the us general population the national health nutrition examination survey 2007-2008
-
Zhu Y, Pandya BJ, Choi HK. Prevalence of gout and hyperuricemia in the US general population: The National Health and Nutrition Examination Survey 2007-2008. Arthritis Rheum 2011; 63:3136-3141
-
(2011)
Arthritis Rheum
, vol.63
, pp. 3136-3141
-
-
Zhu, Y.1
Pandya, B.J.2
Choi, H.K.3
-
2
-
-
38149052992
-
Estimates of the prevalence of arthritis and other rheumatic conditions in the united states: Part ii
-
for the national arthritis data workgroup
-
Lawrence RC, Felson DT, Helmick CG, et al., for the National Arthritis Data Workgroup. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II. Arthritis Rheum 2008; 58:26-35
-
(2008)
Arthritis Rheum
, vol.58
, pp. 26-35
-
-
Lawrence, R.C.1
Felson, D.T.2
Helmick, C.G.3
-
3
-
-
27744608003
-
Essential hypertension, progressive renal disease and uric acid a pathogenetic link
-
Johson RJ, Segal MS, Srinivas T, et al. Essential hypertension, progressive renal disease and uric acid: A pathogenetic link? J Am Soc Nephrol 2005; 16:1909-1919
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 1909-1919
-
-
Johson, R.J.1
Segal, M.S.2
Srinivas, T.3
-
4
-
-
32944468985
-
Gout-Associated uric acid crystals activate the nalp3 inflammasome
-
Martinon F, Petrilli V, Mayor A, et al. Gout-Associated uric acid crystals activate the NALP3 inflammasome. Nature 2006; 440:237-241
-
(2006)
Nature
, vol.440
, pp. 237-241
-
-
Martinon, F.1
Petrilli, V.2
Mayor, A.3
-
7
-
-
84872009400
-
Genetics of hyperuricemia and gout: Implications for the present and future
-
George R, Keenan R. Genetics of hyperuricemia and gout: Implications for the present and future. Curr Rheumatol Rep 2013; 15:309
-
(2013)
Curr Rheumatol Rep
, vol.15
, pp. 309
-
-
George, R.1
Keenan, R.2
-
10
-
-
77953478675
-
New agents for the treatment of gout and hyperuricemia: Febuxostat, puricase, and beyond
-
Schlesinger N. New agents for the treatment of gout and hyperuricemia: Febuxostat, puricase, and beyond. Curr Rheumatol Rep 2010; 12:130-134
-
(2010)
Curr Rheumatol Rep
, vol.12
, pp. 130-134
-
-
Schlesinger, N.1
-
11
-
-
0031795642
-
Regulation of renal urate excretion: A critical review
-
Maesaka JK, Fishbane S. Regulation of renal urate excretion: A critical review. Am J Kidney Dis 1998; 32:917-933
-
(1998)
Am J Kidney Dis
, vol.32
, pp. 917-933
-
-
Maesaka, J.K.1
Fishbane, S.2
-
12
-
-
0037114923
-
Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output
-
Perez-Ruiz F, Calabozo M, Erauskin GG, et al. Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output. Arthritis Care Res 2002; 47:610-613
-
(2002)
Arthritis Care Res
, vol.47
, pp. 610-613
-
-
Perez-Ruiz, F.1
Calabozo, M.2
Erauskin, G.G.3
-
14
-
-
0018320660
-
Uric acid excretion in patients with gout
-
Simkin PA. Uric acid excretion in patients with gout. Arthr Rheum 1979; 22:98-99
-
(1979)
Arthr Rheum
, vol.22
, pp. 98-99
-
-
Simkin, P.A.1
-
15
-
-
0037114923
-
Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output
-
Perez-Ruiz F, Calabozo M, Garcia Erauskin G, et al. Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output. Arthr Rheum 2002; 47:610-613
-
(2002)
Arthr Rheum
, vol.47
, pp. 610-613
-
-
Perez-Ruiz, F.1
Calabozo, M.2
Garcia Erauskin, G.3
-
16
-
-
84860306924
-
Decreased extra-renal urate excretion is a common cause of hyperuricemia
-
Kimiyoshi I, et al. Decreased extra-renal urate excretion is a common cause of hyperuricemia. Nat Commun 2012; 3:1-7
-
(2012)
Nat Commun
, vol.3
, pp. 1-7
-
-
Kimiyoshi, I.1
-
17
-
-
47649130363
-
A benefit-risk assessment of benzbromarone in the treatment of gout
-
Lee M, Graham G, Williams K, Day R. A benefit-risk assessment of benzbromarone in the treatment of gout. Drug Safety 2008; 31:643-665
-
(2008)
Drug Safety
, vol.31
, pp. 643-665
-
-
Lee, M.1
Graham, G.2
Williams, K.3
Day, R.4
-
18
-
-
58449135143
-
Efficacy and tolerability drugs in gout: A randomized controlled trial of benzbromarone verus probenecid after failure of allopurinol
-
Reinders MK, van Roon EN, Jansen TL, et al. Efficacy and tolerability drugs in gout: A randomized controlled trial of benzbromarone verus probenecid after failure of allopurinol. Ann Rheum Dis 2009; 68:51-56
-
(2009)
Ann Rheum Dis
, vol.68
, pp. 51-56
-
-
Reinders, M.K.1
Van Roon, E.N.2
Jansen, T.L.3
-
19
-
-
38149106573
-
Pharmacokinetic and pharmacodynamics interaction between allopurinol and probenecid in healthy subjects
-
Stocker SL, Williams KM, McLachlan AJ, et al. Pharmacokinetic and pharmacodynamics interaction between allopurinol and probenecid in healthy subjects. Clin Pharmacokinet 2008; 47:111-118
-
(2008)
Clin Pharmacokinet
, vol.47
, pp. 111-118
-
-
Stocker, S.L.1
Williams, K.M.2
McLachlan, A.J.3
-
20
-
-
34547623014
-
Biochemical effectiveness of allopurinol and allopurinol-probenecid in previously benzbromarone-Treated gout patients
-
Reinders M, van Roon E, Houtman P, et al. Biochemical effectiveness of allopurinol and allopurinol-probenecid in previously benzbromarone-Treated gout patients. Clin Rheumatol 2007; 26:1459-1465
-
(2007)
Clin Rheumatol
, vol.26
, pp. 1459-1465
-
-
Reinders, M.1
Van Roon, E.2
Houtman, P.3
-
21
-
-
0037161834
-
Molecular identification of a renal urate anion exchanger that regulates blood urate levels
-
Enomoto A, Kimura H, Chairoungdua A, et al. Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 2002; 417:447-452
-
(2002)
Nature
, vol.417
, pp. 447-452
-
-
Enomoto, A.1
Kimura, H.2
Chairoungdua, A.3
-
22
-
-
84865578333
-
Drug transport by organic anion transporters (OATs
-
Burckhardt G. Drug transport by organic anion transporters (OATs). Pharmacol Ther 2012; 136:106-130
-
(2012)
Pharmacol Ther
, vol.136
, pp. 106-130
-
-
Burckhardt, G.1
-
23
-
-
37349008492
-
The glut9 gene is associated with serum uric acid levels in sardinia and chianti cohorts
-
Li S, Sanna S, Maschio A, et al. The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet 2007; 3:e194
-
(2007)
PLoS Genet
, vol.3
-
-
Li, S.1
Sanna, S.2
Maschio, A.3
-
24
-
-
57149083672
-
Mutations in the slc2a9 gene cause hyperuricosuria and hyperuricemia in the dog
-
Bannasch D, Safra N, Young A, et al. Mutations in the SLC2A9 gene cause hyperuricosuria and hyperuricemia in the dog. PLoS Genet 2008; 4:e1000246
-
(2008)
PLoS Genet
, vol.4
-
-
Bannasch, D.1
Safra, N.2
Young, A.3
-
25
-
-
0013809106
-
Role of the intestinal tract in the elimination of uric acid
-
Sorensen L. Role of the intestinal tract in the elimination of uric acid. Arth Rheum 1965; 8:694-706
-
(1965)
Arth Rheum
, vol.8
, pp. 694-706
-
-
Sorensen, L.1
-
26
-
-
1242335471
-
The mrp-related and bcrp/ abcg2 multidrug resistance proteins: Biology, substrate specificity and regulation
-
Haimeur A, Conseil G, Deeley RG, Cole SP. The MRP-related and BCRP/ ABCG2 multidrug resistance proteins: Biology, substrate specificity and regulation. Curr Drug Metab 2004; 5:21-53
-
(2004)
Curr Drug Metab
, vol.5
, pp. 21-53
-
-
Haimeur, A.1
Conseil, G.2
Deeley, R.G.3
Cole, S.P.4
-
27
-
-
77952845866
-
Common defects of abcg2, a highcapacity urate exporter, cause gout: A function-based genetic analysis in a japanese population
-
5rall
-
Maatsuo H, Takada T, Ichida K, et al. Common defects of ABCG2, a highcapacity urate exporter, cause gout: A function-based genetic analysis in a Japanese population. Sci Transi Med 2009; 1:5rall
-
(2009)
Sci Transi Med
, vol.1
-
-
Maatsuo, H.1
Takada, T.2
Ichida, K.3
-
28
-
-
77953187009
-
Uric acid transport and diseases
-
So A, Thorens B. Uric acid transport and diseases. J Clin Invest 2011; 120:1791-1799
-
(2011)
J Clin Invest
, vol.120
, pp. 1791-1799
-
-
So, A.1
Thorens, B.2
-
29
-
-
84867866650
-
Renal transport of uric acid: Evolving concepts and uncertainties
-
Bobulescu I, Moe O. Renal transport of uric acid: Evolving concepts and uncertainties. Adv Chronic Kidney Dis 2012; 19:358-371
-
(2012)
Adv Chronic Kidney Dis
, vol.19
, pp. 358-371
-
-
Bobulescu, I.1
Moe, O.2
-
30
-
-
0025773672
-
Effects of pyrazinamide, probenecid, and benzbromarone on renal excretion of oxypurinol
-
Yamamoto T, Moriwaki Y, Takahashi S, et al. Effects of pyrazinamide, probenecid, and benzbromarone on renal excretion of oxypurinol. Ann Rheum Dis 1991; 50:631-633
-
(1991)
Ann Rheum Dis
, vol.50
, pp. 631-633
-
-
Yamamoto, T.1
Moriwaki, Y.2
Takahashi, S.3
-
31
-
-
33847139479
-
Organic anion transporters of the SLC22 family: Biopharmaceutical, physiological, and pathological roles
-
Rizwan AN, Burckhardt G. Organic anion transporters of the SLC22 family: Biopharmaceutical, physiological, and pathological roles. Pharm Res 2007; 24:450-470
-
(2007)
Pharm Res
, vol.24
, pp. 450-470
-
-
Rizwan, A.N.1
Burckhardt, G.2
-
32
-
-
55249096942
-
Plasma urate level is directly regulated by a voltage-driven urate efflux transporter uratv1 (slc2a9) in humans
-
Anzai N, Ichida K, Jutabha P, et al. Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans. J Biol chem 2008; 283:26834-26838
-
(2008)
J Biol chem
, vol.283
, pp. 26834-26838
-
-
Anzai, N.1
Ichida, K.2
Jutabha, P.3
-
33
-
-
79151484250
-
Rdea594 a potent urat1 inhibitor without affecting other important renal transporters oat1 oat3 abstract
-
Yeh L, Shen Z, Kerr B, et al. RDEA594: A potent URAT1 inhibitor without affecting other important renal transporters, OAT1 and OAT3 [abstract]. Ann Rheum Dis 2009; 68 (Suppl 3); 320
-
(2009)
Ann Rheum Dis
, vol.68
, Issue.SUPPL. 3
, pp. 320
-
-
Yeh, L.1
Shen, Z.2
Kerr, B.3
-
35
-
-
79151481493
-
Gout therapeutics: New drugs for an old disease
-
Burns CM, Wortmann RL. Gout therapeutics: New drugs for an old disease. Lancet 2011; 377:165-177
-
(2011)
Lancet
, vol.377
, pp. 165-177
-
-
Burns, C.M.1
Wortmann, R.L.2
-
36
-
-
84873029291
-
Lesinurad (rdea594), a novel investigational uricosuric agent for hyperuricemia and gout, blocks transport of uric acid induced by hydrochlorothiazide [abstract
-
Tan PK, Hyndman D, Liu S, et al. Lesinurad (RDEA594), a novel investigational uricosuric agent for hyperuricemia and gout, blocks transport of uric acid induced by hydrochlorothiazide [abstract]. Ann Rheum Dis 2011; 70 (Suppl 3); 187
-
(2011)
Ann Rheum Dis
, vol.70
, Issue.SUPPL. 3
, pp. 187
-
-
Tan, P.K.1
Hyndman, D.2
Liu, S.3
-
37
-
-
84894062610
-
-
Inc. Lesinurad and Febuxostat Combination Extension Study in Gout, Sponsor: Ardea Biosciences, Inc. Lesinurad Monotherapy in Gout Subjects Intolerant to Xanthine Oxidase Inhibitors (LIGHT), Sponsor: Ardea Biosciences, Inc. ClinicalTrials.gov Accessed 7 January 2014]
-
Lesinurad and Allopurinol Combination Extension Study in Gout, Sponsor: Ardea Biosciences, Inc. Lesinurad and Febuxostat Combination Extension Study in Gout, Sponsor: Ardea Biosciences, Inc. Lesinurad Monotherapy in Gout Subjects Intolerant to Xanthine Oxidase Inhibitors (LIGHT), Sponsor: Ardea Biosciences, Inc. ClinicalTrials.gov: Http://clinicaltrials.gov/ct2/results? term=lesinurad&Search=Search. [Accessed 7 January 2014]
-
Lesinurad and Allopurinol Combination Extension Study in Gout, Sponsor: Ardea Biosciences
-
-
-
38
-
-
80054098279
-
Efficacy and safety of lesiurad (RDEA594), a novel uricosuric agent, given in combination with allopurinol in allopurinol-refractory gout patients: Randomized, double-blind, placebocontrolled, Phase 2B study [abstract
-
Perez-Ruiz F, Sundy J, Krishnan E, et al. Efficacy and safety of lesiurad (RDEA594), a novel uricosuric agent, given in combination with allopurinol in allopurinol-refractory gout patients: Randomized, double-blind, placebocontrolled, Phase 2B study [abstract]. Ann Rheum Dis 2011; 70 (Suppl 3); 104
-
(2011)
Ann Rheum Dis
, vol.70
, Issue.SUPPL. 3
, pp. 104
-
-
Perez-Ruiz, F.1
Sundy, J.2
Krishnan, E.3
-
39
-
-
80054098279
-
Lesinurad (rdea594), a novel uricosuric agent, in combination with febuxostat shows significant additive urate lowering effects in gout patients with 100% response achieved for all combination dose regimens [abstract
-
Fleischmann R, Shen Z, Yeh L-T, et al. Lesinurad (RDEA594), a novel uricosuric agent, in combination with febuxostat shows significant additive urate lowering effects in gout patients with 100% response achieved for all combination dose regimens [abstract]. Ann Rheum Dis 2011; 70 (Suppl 3); 188
-
(2011)
Ann Rheum Dis
, vol.70
, Issue.SUPPL. 3
, pp. 188
-
-
Fleischmann, R.1
Shen, Z.2
Yeh, L.-T.3
-
40
-
-
84872689925
-
Rdea3170 a novel high affinity urat1 inhibitor binds to central domain within urat1
-
Miner J, Tan P. RDEA3170 a novel high affinity URAT1 inhibitor binds to central domain within URAT1. Ann Rheum Dis 2012; 71:446
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 446
-
-
Miner, J.1
Tan, P.2
-
41
-
-
84894055801
-
-
ACR Poster Session A Session: Metabolic and Crystal Arthropathies- Therapeutics and Outcomes I: Monday, November 8 2010 Atlanta GA
-
Mandal A, Emerling D, Serafini T. Tranilast inhibits urate transport mediated by URAT1 and GLUT9. American College of Rheumatology Annual Scientific Meeting. ACR Poster Session A; Session: Metabolic and Crystal Arthropathies-Therapeutics and Outcomes I: Monday, November 8, 2010, Atlanta, GA, 2010
-
(2010)
Tranilast inhibits urate transport mediated by URAT1 and GLUT9 American College of Rheumatology Annual Scientific Meeting
-
-
Mandal, A.1
Emerling, D.2
Serafini, T.3
-
42
-
-
0038325699
-
Effects of combination treatment using antihyperuricaemic agents with fenofibrate and/or losartan on uric acid metabolism
-
Takahashi S, Moriwaki Y, Yamamoto T, et al. Effects of combination treatment using antihyperuricaemic agents with fenofibrate and/or losartan on uric acid metabolism. Ann Rheum Dis 2003; 62:572-575
-
(2003)
Ann Rheum Dis
, vol.62
, pp. 572-575
-
-
Takahashi, S.1
Moriwaki, Y.2
Yamamoto, T.3
|