메뉴 건너뛰기




Volumn 12, Issue 2, 2010, Pages 130-134

New agents for the treatment of gout and hyperuricemia: Febuxostat, puricase, and beyond

Author keywords

Gout; New agents; Treatment

Indexed keywords

ALLOPURINOL; ANTIGOUT AGENT; CANAKINUMAB; COLCHICINE; FEBUXOSTAT; INTERLEUKIN 1BETA; NONSTEROID ANTIINFLAMMATORY AGENT; OXIPURINOL; PEGLOTICASE; PLACEBO; RASBURICASE; RDEA 594; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RILONACEPT; TRIAMCINOLONE ACETONIDE; UNCLASSIFIED DRUG; URATE OXIDASE; Y 700;

EID: 77953478675     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-010-0093-2     Document Type: Review
Times cited : (22)

References (27)
  • 1
    • 74549125595 scopus 로고
    • Present status of the problem of "rheumatism": Review of recent American and english literature on "rheumatism" and arthritis (part 3)
    • Hench PS, Bauer W, Fletcher AA, et al.: Present status of the problem of "rheumatism": review of recent American and English literature on "rheumatism" and arthritis (part 3). Ann Intern Med 1935, 8:1673-1697.
    • (1935) Ann Intern Med , vol.8 , pp. 1673-1697
    • Hench, P.S.1    Bauer, W.2    Fletcher, A.A.3
  • 2
    • 0008553199 scopus 로고
    • Edited by Katzung BG. Norwalk, CT: Appleton and Lange
    • Katzung BG: Basic and Clinical Pharmacology. Edited by Katzung BG. Norwalk, CT: Appleton and Lange; 1995:536-559.
    • (1995) Basic and Clinical Pharmacology , pp. 536-559
    • Katzung, B.G.1
  • 3
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • Martinon F, Petrilli V, Mayor A, et al.: Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006, 440:237-241.
    • (2006) Nature , vol.440 , pp. 237-241
    • Martinon, F.1    Petrilli, V.2    Mayor, A.3
  • 4
    • 77953479379 scopus 로고    scopus 로고
    • Colchicine efficacy assessed by time to 50% reduction of pain is comparable in low dose and high dose regimens: Secondary analyses of the AGREE trial
    • This study highlights needed information about colchicine dosing in acute gout
    • Terkeltaub B, Furst DE, Bennett K, et al.: Colchicine efficacy assessed by time to 50% reduction of pain is comparable in low dose and high dose regimens: secondary analyses of the AGREE trial. Arthritis Rheum 2009, 59:S1108. This study highlights needed information about colchicine dosing in acute gout.
    • (2009) Arthritis Rheum , vol.59
    • Terkeltaub, B.1    Furst, D.E.2    Bennett, K.3
  • 5
    • 79960720836 scopus 로고    scopus 로고
    • Available at Accessed January
    • Colcrys.com: Highlights of prescribing information. Available at http://www.colcrys.com/assets/pdfCOLCRYS-Full-Prescribing-Information.pdf Accessed January 2010.
    • (2010) Highlights of Prescribing Information
  • 6
    • 84859787320 scopus 로고    scopus 로고
    • Available at Accessed January
    • US Food and Drug Administration: Highlights of prescribing information: Colocrys. Available at www.accessdata.fda.gov/drugsatfda-docs/label/2009/ 022351lbl.pdf. Accessed January 2010.
    • (2010) Highlights of Prescribing Information: Colocrys
  • 7
    • 0023178197 scopus 로고
    • Interleukin 1 (IL 1) as a mediator of crystal arthritis. Stimulation of T cell and synovial fibroblast mitogenesis by urate crystal-induced IL 1
    • Di Giovine FS, Malawista SE, Nuki G, Duff GW: Interleukin 1 (IL 1) as a mediator of crystal arthritis. Stimulation of T cell and synovial fibroblast mitogenesis by urate crystal-induced IL 1. J Immunol 1987, 138:3213-3218.
    • (1987) J Immunol , vol.138 , pp. 3213-3218
    • Di Giovine, F.S.1    Malawista, S.E.2    Nuki, G.3    Duff, G.W.4
  • 8
  • 9
    • 34047174085 scopus 로고    scopus 로고
    • A pilot study of IL-1 inhibition by anakinra in acute gout
    • This important pilot study demonstrated that IL-1 blockade is helpful in the treatment of acute gout
    • So A, De Smedt T, Revaz S, Tschopp J: A pilot study of IL-1 inhibition by anakinra in acute gout. Arthritis Res Ther 2007,12: R28. This important pilot study demonstrated that IL-1 blockade is helpful in the treatment of acute gout.
    • (2007) Arthritis Res Ther , vol.12
    • So, A.1    De Smedt, T.2    Revaz, S.3    Tschopp, J.4
  • 10
    • 70349402166 scopus 로고    scopus 로고
    • The IL-1 inhibitor rilonacept in treatment of chronic gouty arthritis: Results of a placebo-controlled, monosequence crossover, nonrandomized, single-blind pilot study
    • Terkeltaub R, Sundy JS, Schumacher HR et al.: The IL-1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, nonrandomized, single-blind pilot study. Ann Rheum Dis 2009, 68:1613-1617.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1613-1617
    • Terkeltaub, R.1    Sundy, J.S.2    Schumacher, H.R.3
  • 11
    • 77953478223 scopus 로고    scopus 로고
    • Canakinumab (ACZ885) vs. Triamcinolone actonide for treatment of acute gout in patients refractory or contraindicated to NSAIDs and/or colchicine. Late breaking abstract
    • This important large study in acute gout demonstrated that IL-1 blockade is helpful, especially compared with triamcinolone in the treatment of acute gout
    • So A, De Meulemeester M, Shamim T, et al.: Canakinumab (ACZ885) vs. triamcinolone actonide for treatment of acute gout in patients refractory or contraindicated to NSAIDs and/or colchicine. Late breaking abstract. Arthritis Rheum 2009, 60: LB4 p3660-1. This important large study in acute gout demonstrated that IL-1 blockade is helpful, especially compared with triamcinolone in the treatment of acute gout.
    • (2009) Arthritis Rheum , vol.60 , Issue.LB4 , pp. 3660-1
    • So, A.1    De Meulemeester, M.2    Shamim, T.3
  • 12
    • 77957675498 scopus 로고    scopus 로고
    • Placebo-controlled study of rilonacept for gout flare prophylaxis during initiation of urate-lowering therapy
    • This important study demonstrates the use of IL-1 blockade in gout prophylaxis
    • Schumacher HR, Sundy JS, Terkeltaub R, et al.: Placebo-controlled study of rilonacept for gout flare prophylaxis during initiation of urate-lowering therapy. Arthritis Rheum 2009, 59: S1096. This important study demonstrates the use of IL-1 blockade in gout prophylaxis.
    • (2009) Arthritis Rheum , vol.59
    • Schumacher, H.R.1    Sundy, J.S.2    Terkeltaub, R.3
  • 13
    • 10344260696 scopus 로고    scopus 로고
    • Febuxostat (TMX-67), a novel, non-purine, selective inhibitor of xanthine oxidase, is safe and decreases serum urate in healthy volunteers
    • Becker MA, Kisicki J, Khosravan R, et al.: Febuxostat (TMX-67), a novel, non-purine, selective inhibitor of xanthine oxidase, is safe and decreases serum urate in healthy volunteers. Nucleosides Nucleotides Nucleic Acids 2004, 23:1111-1116.
    • (2004) Nucleosides Nucleotides Nucleic Acids , vol.23 , pp. 1111-1116
    • Becker, M.A.1    Kisicki, J.2    Khosravan, R.3
  • 14
    • 29644447615 scopus 로고    scopus 로고
    • The effect of mild and moderate hepatic impairment on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase
    • Khosravan R, Grabowski BA, Mayer MD, et al.: The effect of mild and moderate hepatic impairment on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase. J Clin Pharmacol 2006, 46:88-102.
    • (2006) J Clin Pharmacol , vol.46 , pp. 88-102
    • Khosravan, R.1    Grabowski, B.A.2    Mayer, M.D.3
  • 15
    • 10344254333 scopus 로고    scopus 로고
    • PK/PD and safety of a single dose of TMX-67 (febuxostat) in subjects with mild and moderate kidney disease (chronic kidney disease (CKD) stages 2 and 3)
    • This noteworthy study demonstrated the pharmacokinetics, pharmacodynamics, and safety of febuxostat in patients with CKD 2 and 3
    • Hoshide S, Takahashi Y, Ishikawa T, et al.: PK/PD and safety of a single dose of TMX-67 (febuxostat) in subjects with mild and moderate kidney disease (chronic kidney disease (CKD) stages 2 and 3). Nucleosides Nucleotides Nucleic Acids 2004, 23:1117-1118. This noteworthy study demonstrated the pharmacokinetics, pharmacodynamics, and safety of febuxostat in patients with CKD 2 and 3.
    • (2004) Nucleosides Nucleotides Nucleic Acids , vol.23 , pp. 1117-1118
    • Hoshide, S.1    Takahashi, Y.2    Ishikawa, T.3
  • 16
    • 67650020121 scopus 로고    scopus 로고
    • A phase 3 randomized, controlled, multicenter, double-blind trial comparing efficacy and safety of daily febuxostat and allopurinol in subjects with gout
    • Becker MA, Schumacher HR Jr, Espinosa L, et al.: A phase 3 randomized, controlled, multicenter, double-blind trial comparing efficacy and safety of daily febuxostat and allopurinol in subjects with gout. Arthritis Rheum 2008, 58:4029-4029.
    • (2008) Arthritis Rheum , vol.58 , pp. 4029-4029
    • Becker, M.A.1    Schumacher Jr., H.R.2    Espinosa, L.3
  • 17
    • 28944437578 scopus 로고    scopus 로고
    • Febuxostat compared with allopurinol in patients with hyperuricemia and gout
    • Becker MA, Schumacher HR Jr, Wortmann RL, et al.: Febuxostat compared with allopurinol in patients with hyperuricemia and gout. N Engl J Med 2005, 353:2450-2461.
    • (2005) N Engl J Med , vol.353 , pp. 2450-2461
    • Becker, M.A.1    Schumacher Jr., H.R.2    Wortmann, R.L.3
  • 18
    • 58749106802 scopus 로고    scopus 로고
    • Febuxostat in the treatment of gout: 5-yr findings of the FOCUS efficacy and safety study
    • Schumacher HR Jr, Becker MA, Lloyd E, et al.: Febuxostat in the treatment of gout: 5-yr findings of the FOCUS efficacy and safety study. Rheumatology 2009, 48:188-194.
    • (2009) Rheumatology , vol.48 , pp. 188-194
    • Schumacher Jr., H.R.1    Becker, M.A.2    Lloyd, E.3
  • 20
    • 0035874512 scopus 로고    scopus 로고
    • A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis
    • Goldman SC, Holcenberg JS, Finklestein JZ, et al.: A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis. Blood 2001, 97:2998-3003.
    • (2001) Blood , vol.97 , pp. 2998-3003
    • Goldman, S.C.1    Holcenberg, J.S.2    Finklestein, J.Z.3
  • 21
    • 33746463120 scopus 로고    scopus 로고
    • Rasburicase treatment in severe tophaceous gout: A novel therapeutic option
    • Moolenburgh JD, Reinders MK, Jansen TL: Rasburicase treatment in severe tophaceous gout: a novel therapeutic option. Clin Rheumatol 2006, 25:749-752.
    • (2006) Clin Rheumatol , vol.25 , pp. 749-752
    • Moolenburgh, J.D.1    Reinders, M.K.2    Jansen, T.L.3
  • 22
    • 35148881765 scopus 로고    scopus 로고
    • Rasburicase for tophaceous gout not treatable with allopurinol: An exploratory study
    • Richette P, Briere C, Hoenen-Clavert V, et al.: Rasburicase for tophaceous gout not treatable with allopurinol: an exploratory study. J Rheumatol 2007, 34:2093-2098.
    • (2007) J Rheumatol , vol.34 , pp. 2093-2098
    • Richette, P.1    Briere, C.2    Hoenen-Clavert, V.3
  • 23
    • 68149164788 scopus 로고    scopus 로고
    • Efficacy and safety of intravenous (IV) pegloticase (PGL) in subjects with treatment failure gout (TFG): Phase 3 results from GOUT1 and GOUT2
    • This noteworthy study reviewed the use of pegloticase as urate-lowering therapy in patients with chronic severe gout
    • Sundy JS, Baraf HS, Becker MA, et al.: Efficacy and safety of intravenous (IV) pegloticase (PGL) in subjects with treatment failure gout (TFG): phase 3 results from GOUT1 and GOUT2. Arthritis Rheum 2008, 58:S635. This noteworthy study reviewed the use of pegloticase as urate-lowering therapy in patients with chronic severe gout.
    • (2008) Arthritis Rheum , vol.58
    • Sundy, J.S.1    Baraf, H.S.2    Becker, M.A.3
  • 24
    • 77953477599 scopus 로고    scopus 로고
    • Routine serum uric acid (SUA) monitoring predicts antibody-mediated loss of response and infusion reaction risk during pegloticase therapy
    • Wright D, Sundy JS, Rosario-Jansen T: Routine serum uric acid (SUA) monitoring predicts antibody-mediated loss of response and infusion reaction risk during pegloticase therapy. Arthritis Rheum 2009, 59:S1104.
    • (2009) Arthritis Rheum , vol.59
    • Wright, D.1    Sundy, J.S.2    Rosario-Jansen, T.3
  • 25
    • 79952360840 scopus 로고    scopus 로고
    • First application of computer-assisted analysis of digital photographs for assessing tophus response: Phase 3 studies of pegloticase in treatment failure gout
    • Maroli AN, Waltrip R, Alton M, et al.: First application of computer-assisted analysis of digital photographs for assessing tophus response: phase 3 studies of pegloticase in treatment failure gout. Arthritis Rheum 2009, 59:S1 111.
    • (2009) Arthritis Rheum , vol.59
    • Maroli, A.N.1    Waltrip, R.2    Alton, M.3
  • 26
    • 4644275038 scopus 로고    scopus 로고
    • Serum uric acid-lowering therapies: Where are we heading in management of hyperuricemia and the potential role of uricase
    • Bomalaski JS, Clark MA: Serum uric acid-lowering therapies: where are we heading in management of hyperuricemia and the potential role of uricase. Curr Rheum Rep 2004, 6:240-247.
    • (2004) Curr Rheum Rep , vol.6 , pp. 240-247
    • Bomalaski, J.S.1    Clark, M.A.2
  • 27
    • 84870005584 scopus 로고    scopus 로고
    • Available at Accessed January
    • Ardea Biosciences: Development pipeline: gout. Available at http://www.ardeabio.com/gout.html. Accessed January 2010.
    • (2010) Development Pipeline: Gout


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.