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74549125595
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Present status of the problem of "rheumatism": Review of recent American and english literature on "rheumatism" and arthritis (part 3)
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Hench PS, Bauer W, Fletcher AA, et al.: Present status of the problem of "rheumatism": review of recent American and English literature on "rheumatism" and arthritis (part 3). Ann Intern Med 1935, 8:1673-1697.
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Hench, P.S.1
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Edited by Katzung BG. Norwalk, CT: Appleton and Lange
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Basic and Clinical Pharmacology
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Katzung, B.G.1
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32944468985
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Gout-associated uric acid crystals activate the NALP3 inflammasome
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Martinon F, Petrilli V, Mayor A, et al.: Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006, 440:237-241.
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Nature
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Martinon, F.1
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4
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77953479379
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Colchicine efficacy assessed by time to 50% reduction of pain is comparable in low dose and high dose regimens: Secondary analyses of the AGREE trial
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This study highlights needed information about colchicine dosing in acute gout
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Terkeltaub B, Furst DE, Bennett K, et al.: Colchicine efficacy assessed by time to 50% reduction of pain is comparable in low dose and high dose regimens: secondary analyses of the AGREE trial. Arthritis Rheum 2009, 59:S1108. This study highlights needed information about colchicine dosing in acute gout.
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Arthritis Rheum
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Terkeltaub, B.1
Furst, D.E.2
Bennett, K.3
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5
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79960720836
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Available at Accessed January
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Colcrys.com: Highlights of prescribing information. Available at http://www.colcrys.com/assets/pdfCOLCRYS-Full-Prescribing-Information.pdf Accessed January 2010.
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Highlights of Prescribing Information
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6
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84859787320
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Available at Accessed January
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US Food and Drug Administration: Highlights of prescribing information: Colocrys. Available at www.accessdata.fda.gov/drugsatfda-docs/label/2009/ 022351lbl.pdf. Accessed January 2010.
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Highlights of Prescribing Information: Colocrys
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7
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0023178197
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Interleukin 1 (IL 1) as a mediator of crystal arthritis. Stimulation of T cell and synovial fibroblast mitogenesis by urate crystal-induced IL 1
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Di Giovine FS, Malawista SE, Nuki G, Duff GW: Interleukin 1 (IL 1) as a mediator of crystal arthritis. Stimulation of T cell and synovial fibroblast mitogenesis by urate crystal-induced IL 1. J Immunol 1987, 138:3213-3218.
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Di Giovine, F.S.1
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Nuki, G.3
Duff, G.W.4
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9
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34047174085
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A pilot study of IL-1 inhibition by anakinra in acute gout
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This important pilot study demonstrated that IL-1 blockade is helpful in the treatment of acute gout
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So A, De Smedt T, Revaz S, Tschopp J: A pilot study of IL-1 inhibition by anakinra in acute gout. Arthritis Res Ther 2007,12: R28. This important pilot study demonstrated that IL-1 blockade is helpful in the treatment of acute gout.
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Arthritis Res Ther
, vol.12
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So, A.1
De Smedt, T.2
Revaz, S.3
Tschopp, J.4
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10
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70349402166
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The IL-1 inhibitor rilonacept in treatment of chronic gouty arthritis: Results of a placebo-controlled, monosequence crossover, nonrandomized, single-blind pilot study
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Terkeltaub R, Sundy JS, Schumacher HR et al.: The IL-1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, nonrandomized, single-blind pilot study. Ann Rheum Dis 2009, 68:1613-1617.
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Ann Rheum Dis
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Terkeltaub, R.1
Sundy, J.S.2
Schumacher, H.R.3
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11
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77953478223
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Canakinumab (ACZ885) vs. Triamcinolone actonide for treatment of acute gout in patients refractory or contraindicated to NSAIDs and/or colchicine. Late breaking abstract
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This important large study in acute gout demonstrated that IL-1 blockade is helpful, especially compared with triamcinolone in the treatment of acute gout
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So A, De Meulemeester M, Shamim T, et al.: Canakinumab (ACZ885) vs. triamcinolone actonide for treatment of acute gout in patients refractory or contraindicated to NSAIDs and/or colchicine. Late breaking abstract. Arthritis Rheum 2009, 60: LB4 p3660-1. This important large study in acute gout demonstrated that IL-1 blockade is helpful, especially compared with triamcinolone in the treatment of acute gout.
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(2009)
Arthritis Rheum
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, Issue.LB4
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So, A.1
De Meulemeester, M.2
Shamim, T.3
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12
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77957675498
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Placebo-controlled study of rilonacept for gout flare prophylaxis during initiation of urate-lowering therapy
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This important study demonstrates the use of IL-1 blockade in gout prophylaxis
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Schumacher HR, Sundy JS, Terkeltaub R, et al.: Placebo-controlled study of rilonacept for gout flare prophylaxis during initiation of urate-lowering therapy. Arthritis Rheum 2009, 59: S1096. This important study demonstrates the use of IL-1 blockade in gout prophylaxis.
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(2009)
Arthritis Rheum
, vol.59
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Schumacher, H.R.1
Sundy, J.S.2
Terkeltaub, R.3
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13
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10344260696
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Febuxostat (TMX-67), a novel, non-purine, selective inhibitor of xanthine oxidase, is safe and decreases serum urate in healthy volunteers
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Becker MA, Kisicki J, Khosravan R, et al.: Febuxostat (TMX-67), a novel, non-purine, selective inhibitor of xanthine oxidase, is safe and decreases serum urate in healthy volunteers. Nucleosides Nucleotides Nucleic Acids 2004, 23:1111-1116.
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Nucleosides Nucleotides Nucleic Acids
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Becker, M.A.1
Kisicki, J.2
Khosravan, R.3
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14
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29644447615
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The effect of mild and moderate hepatic impairment on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase
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Khosravan R, Grabowski BA, Mayer MD, et al.: The effect of mild and moderate hepatic impairment on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase. J Clin Pharmacol 2006, 46:88-102.
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J Clin Pharmacol
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Khosravan, R.1
Grabowski, B.A.2
Mayer, M.D.3
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15
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10344254333
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PK/PD and safety of a single dose of TMX-67 (febuxostat) in subjects with mild and moderate kidney disease (chronic kidney disease (CKD) stages 2 and 3)
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This noteworthy study demonstrated the pharmacokinetics, pharmacodynamics, and safety of febuxostat in patients with CKD 2 and 3
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Hoshide S, Takahashi Y, Ishikawa T, et al.: PK/PD and safety of a single dose of TMX-67 (febuxostat) in subjects with mild and moderate kidney disease (chronic kidney disease (CKD) stages 2 and 3). Nucleosides Nucleotides Nucleic Acids 2004, 23:1117-1118. This noteworthy study demonstrated the pharmacokinetics, pharmacodynamics, and safety of febuxostat in patients with CKD 2 and 3.
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(2004)
Nucleosides Nucleotides Nucleic Acids
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Hoshide, S.1
Takahashi, Y.2
Ishikawa, T.3
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16
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67650020121
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A phase 3 randomized, controlled, multicenter, double-blind trial comparing efficacy and safety of daily febuxostat and allopurinol in subjects with gout
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Becker MA, Schumacher HR Jr, Espinosa L, et al.: A phase 3 randomized, controlled, multicenter, double-blind trial comparing efficacy and safety of daily febuxostat and allopurinol in subjects with gout. Arthritis Rheum 2008, 58:4029-4029.
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Arthritis Rheum
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Becker, M.A.1
Schumacher Jr., H.R.2
Espinosa, L.3
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17
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Febuxostat compared with allopurinol in patients with hyperuricemia and gout
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Becker MA, Schumacher HR Jr, Wortmann RL, et al.: Febuxostat compared with allopurinol in patients with hyperuricemia and gout. N Engl J Med 2005, 353:2450-2461.
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Becker, M.A.1
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Wortmann, R.L.3
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18
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58749106802
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Febuxostat in the treatment of gout: 5-yr findings of the FOCUS efficacy and safety study
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Schumacher HR Jr, Becker MA, Lloyd E, et al.: Febuxostat in the treatment of gout: 5-yr findings of the FOCUS efficacy and safety study. Rheumatology 2009, 48:188-194.
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Rheumatology
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Schumacher Jr., H.R.1
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Lloyd, E.3
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20
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0035874512
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A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis
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Goldman SC, Holcenberg JS, Finklestein JZ, et al.: A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis. Blood 2001, 97:2998-3003.
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Goldman, S.C.1
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21
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Rasburicase treatment in severe tophaceous gout: A novel therapeutic option
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Moolenburgh JD, Reinders MK, Jansen TL: Rasburicase treatment in severe tophaceous gout: a novel therapeutic option. Clin Rheumatol 2006, 25:749-752.
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Clin Rheumatol
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Moolenburgh, J.D.1
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Rasburicase for tophaceous gout not treatable with allopurinol: An exploratory study
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Richette P, Briere C, Hoenen-Clavert V, et al.: Rasburicase for tophaceous gout not treatable with allopurinol: an exploratory study. J Rheumatol 2007, 34:2093-2098.
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J Rheumatol
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Richette, P.1
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68149164788
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Efficacy and safety of intravenous (IV) pegloticase (PGL) in subjects with treatment failure gout (TFG): Phase 3 results from GOUT1 and GOUT2
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This noteworthy study reviewed the use of pegloticase as urate-lowering therapy in patients with chronic severe gout
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Sundy JS, Baraf HS, Becker MA, et al.: Efficacy and safety of intravenous (IV) pegloticase (PGL) in subjects with treatment failure gout (TFG): phase 3 results from GOUT1 and GOUT2. Arthritis Rheum 2008, 58:S635. This noteworthy study reviewed the use of pegloticase as urate-lowering therapy in patients with chronic severe gout.
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(2008)
Arthritis Rheum
, vol.58
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Sundy, J.S.1
Baraf, H.S.2
Becker, M.A.3
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24
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Routine serum uric acid (SUA) monitoring predicts antibody-mediated loss of response and infusion reaction risk during pegloticase therapy
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Wright D, Sundy JS, Rosario-Jansen T: Routine serum uric acid (SUA) monitoring predicts antibody-mediated loss of response and infusion reaction risk during pegloticase therapy. Arthritis Rheum 2009, 59:S1104.
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Arthritis Rheum
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Wright, D.1
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25
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First application of computer-assisted analysis of digital photographs for assessing tophus response: Phase 3 studies of pegloticase in treatment failure gout
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Maroli AN, Waltrip R, Alton M, et al.: First application of computer-assisted analysis of digital photographs for assessing tophus response: phase 3 studies of pegloticase in treatment failure gout. Arthritis Rheum 2009, 59:S1 111.
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Arthritis Rheum
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Maroli, A.N.1
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Serum uric acid-lowering therapies: Where are we heading in management of hyperuricemia and the potential role of uricase
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Bomalaski JS, Clark MA: Serum uric acid-lowering therapies: where are we heading in management of hyperuricemia and the potential role of uricase. Curr Rheum Rep 2004, 6:240-247.
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84870005584
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Available at Accessed January
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Ardea Biosciences: Development pipeline: gout. Available at http://www.ardeabio.com/gout.html. Accessed January 2010.
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(2010)
Development Pipeline: Gout
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