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Volumn 39, Issue 2, 2014, Pages 301-314

Tau proteins harboring neurodegeneration-linked mutations impair kinesin translocation in vitro

Author keywords

Axonal transport; corticobasal degeneration; frontotemporal dementia with parkinsonism 17; kinesin; microtubules; motility; progressive supranuclear palsy; tau

Indexed keywords

KINESIN; PACLITAXEL; QUANTUM DOT; TAU PROTEIN; TUBULIN;

EID: 84893955408     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-131274     Document Type: Article
Times cited : (13)

References (69)
  • 1
    • 34548036227 scopus 로고    scopus 로고
    • Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
    • Ballatore C, Lee VM, Trojanowski JQ (2007) Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci 8, 663-672.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 663-672
    • Ballatore, C.1    Lee, V.M.2    Trojanowski, J.Q.3
  • 2
    • 0026001490 scopus 로고
    • The effect of tau antisense oligonucleotides on neurite formation of cultured cerebellar macroneurons
    • Caceres A, Potrebic S, Kosik KS (1991) The effect of tau antisense oligonucleotides on neurite formation of cultured cerebellar macroneurons. J Neurosci 11, 1515-1523.
    • (1991) J Neurosci , vol.11 , pp. 1515-1523
    • Caceres, A.1    Potrebic, S.2    Kosik, K.S.3
  • 3
    • 0028316882 scopus 로고
    • Sense and antisense transfection analysis of tau function: Tau influences net microtubule assembly, neurite outgrowth and neuritic stability
    • Esmaeli-Azad B, McCarty JH, Feinstein SC (1994) Sense and antisense transfection analysis of tau function: Tau influences net microtubule assembly, neurite outgrowth and neuritic stability. J Cell Sci 107(Pt 4), 869-879.
    • (1994) J Cell Sci , vol.107 , Issue.PART 4 , pp. 869-879
    • Esmaeli-Azad, B.1    McCarty, J.H.2    Feinstein, S.C.3
  • 4
    • 0034605045 scopus 로고    scopus 로고
    • Defects in axonal elongation and neuronal migration in mice with disrupted tau and map1b genes
    • Takei Y, Teng J, Harada A, Hirokawa N (2000) Defects in axonal elongation and neuronal migration in mice with disrupted tau and map1b genes. J Cell Biol 150, 989-1000.
    • (2000) J Cell Biol , vol.150 , pp. 989-1000
    • Takei, Y.1    Teng, J.2    Harada, A.3    Hirokawa, N.4
  • 5
    • 84863337843 scopus 로고    scopus 로고
    • Alzheimer mechanisms and therapeutic strategies
    • Huang Y, Mucke L (2012) Alzheimer mechanisms and therapeutic strategies. Cell 148, 1204-1222.
    • (2012) Cell , vol.148 , pp. 1204-1222
    • Huang, Y.1    Mucke, L.2
  • 11
    • 0033663879 scopus 로고    scopus 로고
    • A novel tau mutation (N296N) in familial dementia with swollen achromatic neurons and corticobasal inclusion bodies
    • Spillantini M, Yoshida H, Rizzini C, Lantos PL, Khan N, Rossor MN, Goedert M, Brown J (2000) A novel tau mutation (N296N) in familial dementia with swollen achromatic neurons and corticobasal inclusion bodies. Ann Neurol 48, 939-943.
    • (2000) Ann Neurol , vol.48 , pp. 939-943
    • Spillantini, M.1    Yoshida, H.2    Rizzini, C.3    Lantos, P.L.4    Khan, N.5    Rossor, M.N.6    Goedert, M.7    Brown, J.8
  • 12
    • 0024507707 scopus 로고
    • Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable Nterminal domains
    • Himmler A, Drechsel D, Kirschner MW, Martin DW, Jr. (1989) Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable Nterminal domains. Mol Cell Biol 9, 1381-1388.
    • (1989) Mol Cell Biol , vol.9 , pp. 1381-1388
    • Himmler, A.1    Drechsel, D.2    Kirschner, M.W.3    Martin Jr., D.W.4
  • 13
    • 0024641959 scopus 로고
    • Developmentally regulated expression of specific tau sequences
    • Kosik KS, Orecchio LD, Bakalis S, Neve RL (1989) Developmentally regulated expression of specific tau sequences. Neuron 2, 1389-1397.
    • (1989) Neuron , vol.2 , pp. 1389-1397
    • Kosik, K.S.1    Orecchio, L.D.2    Bakalis, S.3    Neve, R.L.4
  • 14
    • 0024498630 scopus 로고
    • Structure of the bovine tau gene: Alternatively spliced transcripts generate a protein family
    • Himmler A (1989) Structure of the bovine tau gene: Alternatively spliced transcripts generate a protein family. Mol Cell Biol 9, 1389-1396.
    • (1989) Mol Cell Biol , vol.9 , pp. 1389-1396
    • Himmler, A.1
  • 16
    • 84856056846 scopus 로고    scopus 로고
    • Mitochondrial transport in neurons: Impact on synaptic homeostasis and neurodegeneration
    • Sheng Z-H, Cai Q (2012) Mitochondrial transport in neurons: Impact on synaptic homeostasis and neurodegeneration. Nat Rev Neurosci 13, 77-93.
    • (2012) Nat Rev Neurosci , vol.13 , pp. 77-93
    • Sheng, Z.-H.1    Cai, Q.2
  • 18
    • 0037128935 scopus 로고    scopus 로고
    • Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
    • Stamer K, Vogel R, Thies E, Mandelkow E, Mandelkow EM (2002) Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J Cell Biol 156, 1051-1063.
    • (2002) J Cell Biol , vol.156 , pp. 1051-1063
    • Stamer, K.1    Vogel, R.2    Thies, E.3    Mandelkow, E.4    Mandelkow, E.M.5
  • 19
    • 0032476645 scopus 로고    scopus 로고
    • Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: Implications for Alzheimer's disease
    • Ebneth A, Godemann R, Stamer K, Illenberger S, Trinczek B, Mandelkow E (1998) Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: Implications for Alzheimer's disease. J Cell Biol 143, 777-794.
    • (1998) J Cell Biol , vol.143 , pp. 777-794
    • Ebneth, A.1    Godemann, R.2    Stamer, K.3    Illenberger, S.4    Trinczek, B.5    Mandelkow, E.6
  • 20
    • 0032799381 scopus 로고    scopus 로고
    • Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles
    • Trinczek B, Ebneth A, Mandelkow EM, Mandelkow E (1999) Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles. J Cell Sci 112(Pt 14), 2355-2367.
    • (1999) J Cell Sci , vol.112 , Issue.PART 14 , pp. 2355-2367
    • Trinczek, B.1    Ebneth, A.2    Mandelkow, E.M.3    Mandelkow, E.4
  • 21
    • 0345276565 scopus 로고    scopus 로고
    • Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses
    • Mandelkow EM, Stamer K, Vogel R, Thies E, Mandelkow E (2003) Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses. Neurobiol Aging 24, 1079-1085.
    • (2003) Neurobiol Aging , vol.24 , pp. 1079-1085
    • Mandelkow, E.M.1    Stamer, K.2    Vogel, R.3    Thies, E.4    Mandelkow, E.5
  • 23
    • 39549117998 scopus 로고    scopus 로고
    • Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice
    • Yuan A, Kumar A, Peterhoff C, Duff K, Nixon RA (2008) Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. J Neurosci 28, 1682-1687.
    • (2008) J Neurosci , vol.28 , pp. 1682-1687
    • Yuan, A.1    Kumar, A.2    Peterhoff, C.3    Duff, K.4    Nixon, R.A.5
  • 24
    • 34250317264 scopus 로고    scopus 로고
    • Tau binding to microtubules does not directly affect microtubule-based vesicle motility
    • Morfini G, Pigino G, Mizuno N, Kikkawa M, Brady ST (2007) Tau binding to microtubules does not directly affect microtubule-based vesicle motility. J Neurosci Res 85, 2620-2630.
    • (2007) J Neurosci Res , vol.85 , pp. 2620-2630
    • Morfini, G.1    Pigino, G.2    Mizuno, N.3    Kikkawa, M.4    Brady, S.T.5
  • 25
    • 0037119947 scopus 로고    scopus 로고
    • Single-molecule investigation of the interference between kinesin, tau and MAP2c
    • Seitz A, Kojima H, Oiwa K, Mandelkow EM, Song YH, Mandelkow E (2002) Single-molecule investigation of the interference between kinesin, tau and MAP2c. EMBO J 21, 4896-4905.
    • (2002) EMBO J , vol.21 , pp. 4896-4905
    • Seitz, A.1    Kojima, H.2    Oiwa, K.3    Mandelkow, E.M.4    Song, Y.H.5    Mandelkow, E.6
  • 27
    • 39749165656 scopus 로고    scopus 로고
    • Differential regulation of dynein and kinesin motor proteins by tau
    • Dixit R, Ross JL, Goldman YE, Holzbaur EL (2008) Differential regulation of dynein and kinesin motor proteins by tau. Science 319, 1086-1089.
    • (2008) Science , vol.319 , pp. 1086-1089
    • Dixit, R.1    Ross, J.L.2    Goldman, Y.E.3    Holzbaur, E.L.4
  • 28
    • 0023905288 scopus 로고
    • The primary structure and heterogeneity of tau protein from mouse brain
    • Lee G, Cowan N, Kirschner M (1988) The primary structure and heterogeneity of tau protein from mouse brain. Science 239, 285-288.
    • (1988) Science , vol.239 , pp. 285-288
    • Lee, G.1    Cowan, N.2    Kirschner, M.3
  • 30
    • 0028175215 scopus 로고
    • Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau
    • Goode BL, Feinstein SC (1994) Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau. J Cell Biol 124, 769-782.
    • (1994) J Cell Biol , vol.124 , pp. 769-782
    • Goode, B.L.1    Feinstein, S.C.2
  • 31
    • 0024094998 scopus 로고
    • Tau proteins: The molecular structure and mode of binding on microtubules
    • Hirokawa N, Shiomura Y, Okabe S (1988) Tau proteins: The molecular structure and mode of binding on microtubules. J Cell Biol 107, 1449-1459.
    • (1988) J Cell Biol , vol.107 , pp. 1449-1459
    • Hirokawa, N.1    Shiomura, Y.2    Okabe, S.3
  • 32
    • 0026046950 scopus 로고
    • Tau protein binds to microtubules through a flexible array of distributed weak sites
    • Butner KA, KirschnerMW(1991) Tau protein binds to microtubules through a flexible array of distributed weak sites. J Cell Biol 115, 717-730.
    • (1991) J Cell Biol , vol.115 , pp. 717-730
    • Butner, K.A.1    Kirschner, M.W.2
  • 33
    • 0029098802 scopus 로고
    • Kinetic stabilization of microtubule dynamics at steady state by tau and microtubule-binding domains of tau
    • Panda D, Goode BL, Feinstein SC, Wilson L (1995) Kinetic stabilization of microtubule dynamics at steady state by tau and microtubule-binding domains of tau. Biochemistry 34, 11117-11127.
    • (1995) Biochemistry , vol.34 , pp. 11117-11127
    • Panda, D.1    Goode, B.L.2    Feinstein, S.C.3    Wilson, L.4
  • 34
    • 0026729767 scopus 로고
    • Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons
    • Chen J, Kanai Y, Cowan NJ, Hirokawa N (1992) Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons. Nature 360, 674-677.
    • (1992) Nature , vol.360 , pp. 674-677
    • Chen, J.1    Kanai, Y.2    Cowan, N.J.3    Hirokawa, N.4
  • 36
    • 0032509226 scopus 로고    scopus 로고
    • Changes in microtubule protofilament number induced by Taxol binding to an easily accessible site. Internal microtubule dynamics
    • Diaz JF, Valpuesta JM, Chacon P, Diakun G, Andreu JM (1998) Changes in microtubule protofilament number induced by Taxol binding to an easily accessible site. Internal microtubule dynamics. J Biol Chem 273, 33803-33810.
    • (1998) J Biol Chem , vol.273 , pp. 33803-33810
    • Diaz, J.F.1    Valpuesta, J.M.2    Chacon, P.3    Diakun, G.4    Andreu, J.M.5
  • 37
    • 0042924434 scopus 로고    scopus 로고
    • Differential regulation of microtubule dynamics by three-and four-repeat tau: Implications for the onset of neurodegenerative disease
    • Panda D, Samuel JC, Massie M, Feinstein SC, Wilson L (2003) Differential regulation of microtubule dynamics by three-and four-repeat tau: Implications for the onset of neurodegenerative disease. Proc Natl Acad Sci U S A 100, 9548-9553.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 9548-9553
    • Panda, D.1    Samuel, J.C.2    Massie, M.3    Feinstein, S.C.4    Wilson, L.5
  • 38
    • 0028908695 scopus 로고
    • Substoichiometric binding of taxol suppresses microtubule dynamics
    • Derry WB, Wilson L, Jordan MA (1995) Substoichiometric binding of taxol suppresses microtubule dynamics. Biochemistry 34, 2203-2211.
    • (1995) Biochemistry , vol.34 , pp. 2203-2211
    • Derry, W.B.1    Wilson, L.2    Jordan, M.A.3
  • 39
    • 14744280774 scopus 로고    scopus 로고
    • Long-range cooperative binding of kinesin to a microtubule in the presence of ATP
    • Muto E, Sakai H, Kaseda K (2005) Long-range cooperative binding of kinesin to a microtubule in the presence of ATP. J Cell Biol 168, 691-696.
    • (2005) J Cell Biol , vol.168 , pp. 691-696
    • Muto, E.1    Sakai, H.2    Kaseda, K.3
  • 41
    • 0345118121 scopus 로고    scopus 로고
    • Complex formation with kinesin motor domains affects the structure of microtubules
    • Krebs A, Goldie KN, Hoenger A (2004) Complex formation with kinesin motor domains affects the structure of microtubules. J Mol Biol 335, 139-153.
    • (2004) J Mol Biol , vol.335 , pp. 139-153
    • Krebs, A.1    Goldie, K.N.2    Hoenger, A.3
  • 42
    • 84875903817 scopus 로고    scopus 로고
    • Mechanical properties of doubly stabilized microtubule filaments
    • Hawkins TL, Sept D, Mogessie B, Straube A, Ross JL (2013) Mechanical properties of doubly stabilized microtubule filaments. Biophys J 104, 1517-1528.
    • (2013) Biophys J , vol.104 , pp. 1517-1528
    • Hawkins, T.L.1    Sept, D.2    Mogessie, B.3    Straube, A.4    Ross, J.L.5
  • 43
    • 83355163345 scopus 로고    scopus 로고
    • The Nucleotidebinding state of microtubules modulates kinesin processivity and the ability of tau to inhibit kinesin-mediated transport
    • McVicker DP, Chrin LR, Berger CL (2012) The Nucleotidebinding state of microtubules modulates kinesin processivity and the ability of tau to inhibit kinesin-mediated transport. J Biol Chem 286, 42873-42880.
    • (2012) J Biol Chem , vol.286 , pp. 42873-42880
    • McVicker, D.P.1    Chrin, L.R.2    Berger, C.L.3
  • 44
    • 78650217997 scopus 로고    scopus 로고
    • Tau isoform-specific modulation of kinesin-driven microtubule gliding rates and trajectories as determined with tau-stabilized microtubules
    • Peck A, Sargin ME, LaPointe NE, Rose K, Manjunath BS, Feinstein SC, Wilson L (2011) Tau isoform-specific modulation of kinesin-driven microtubule gliding rates and trajectories as determined with tau-stabilized microtubules. Cytoskeleton 68, 44-55.
    • (2011) Cytoskeleton , vol.68 , pp. 44-55
    • Peck, A.1    Sargin, M.E.2    LaPointe, N.E.3    Rose, K.4    Manjunath, B.S.5    Feinstein, S.C.6    Wilson, L.7
  • 45
    • 77955288077 scopus 로고    scopus 로고
    • Preparation of microtubule protein and purified tubulin from bovine brain by cycles of assembly and disassembly and phosphocellulose chromatography
    • Wilson L, Correia, JJ, eds. Elsevier Inc., Amsterdam
    • Miller HP, Wilson L (2010) Preparation of microtubule protein and purified tubulin from bovine brain by cycles of assembly and disassembly and phosphocellulose chromatography. In Methods in Cell Biology,Wilson L, Correia, JJ, eds. Elsevier Inc., Amsterdam, pp. 3-15.
    • (2010) Methods in Cell Biology , pp. 3-15
    • Miller, H.P.1    Wilson, L.2
  • 47
    • 17144409371 scopus 로고    scopus 로고
    • Three-and four-repeat tau regulate the dynamic instability of two distinct microtubule subpopulations in qualitatively different manners. Implications for neurodegeneration
    • Levy SF, Leboeuf AC, Massie MR, Jordan MA, Wilson L, Feinstein SC (2005) Three-and four-repeat tau regulate the dynamic instability of two distinct microtubule subpopulations in qualitatively different manners. Implications for neurodegeneration. J Biol Chem 280, 13520-13528.
    • (2005) J Biol Chem , vol.280 , pp. 13520-13528
    • Levy, S.F.1    Leboeuf, A.C.2    Massie, M.R.3    Jordan, M.A.4    Wilson, L.5    Feinstein, S.C.6
  • 49
    • 0030874883 scopus 로고    scopus 로고
    • The directional preference of kinesin motors is specified by an element outside of the motor catalytic domain
    • Case RB, Pierce DW, Hom-Booher N, Hart CL, Vale RD (1997) The directional preference of kinesin motors is specified by an element outside of the motor catalytic domain. Cell 90, 959-966.
    • (1997) Cell , vol.90 , pp. 959-966
    • Case, R.B.1    Pierce, D.W.2    Hom-Booher, N.3    Hart, C.L.4    Vale, R.D.5
  • 50
    • 0019849247 scopus 로고
    • Taxol induces microtubule assembly at low temperature
    • Thompson WC, Wilson L, Purich DL (1981) Taxol induces microtubule assembly at low temperature. Cell Motil 1, 445-454.
    • (1981) Cell Motil , vol.1 , pp. 445-454
    • Thompson, W.C.1    Wilson, L.2    Purich, D.L.3
  • 51
    • 51549097934 scopus 로고    scopus 로고
    • Intramolecular strain coordinates kinesin stepping behavior along microtubules
    • Yildiz A, Tomishige M, Gennerich A, Vale RD (2008) Intramolecular strain coordinates kinesin stepping behavior along microtubules. Cell 134, 1030-1041.
    • (2008) Cell , vol.134 , pp. 1030-1041
    • Yildiz, A.1    Tomishige, M.2    Gennerich, A.3    Vale, R.D.4
  • 52
    • 34447250290 scopus 로고    scopus 로고
    • Bending dynamics of fluctuating biopolymers probed by automated high-resolution filament tracking
    • Brangwynne CP, Koenderink GH, Barry E, Dogic Z, MacKintosh FC,Weitz DA (2007) Bending dynamics of fluctuating biopolymers probed by automated high-resolution filament tracking. Biophys J 93, 346-359.
    • (2007) Biophys J , vol.93 , pp. 346-359
    • Brangwynne, C.P.1    Koenderink, G.H.2    Barry, E.3    Dogic, Z.4    MacKintosh, F.C.5    Weitz, D.A.6
  • 53
    • 84858054734 scopus 로고    scopus 로고
    • Spectral analysis methods for the robust measurement of the flexural rigidity of biopolymers
    • Valdman D, Atzberger Paul J, Yu D, Kuei S, Valentine Megan T (2012) Spectral analysis methods for the robust measurement of the flexural rigidity of biopolymers. Biophy J 102, 1144-1153.
    • (2012) Biophy J , vol.102 , pp. 1144-1153
    • Valdman, D.1    Atzberger Paul, J.2    Yu, D.3    Kuei, S.4    Valentine Megan, T.5
  • 54
    • 0022365608 scopus 로고
    • The distribution of tau in the mammalian central nervous system
    • Binder LI, Frankfurter A, Rebhun LI (1985) The distribution of tau in the mammalian central nervous system. J Cell Biol 101, 1371-1378.
    • (1985) J Cell Biol , vol.101 , pp. 1371-1378
    • Binder, L.I.1    Frankfurter, A.2    Rebhun, L.I.3
  • 55
    • 0022395021 scopus 로고
    • Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors
    • Drubin DG, Feinstein SC, Shooter EM, KirschnerMW(1985) Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors. J Cell Biol 101, 1799-1807.
    • (1985) J Cell Biol , vol.101 , pp. 1799-1807
    • Drubin, D.G.1    Feinstein, S.C.2    Shooter, E.M.3    Kirschner, M.W.4
  • 56
    • 0027273502 scopus 로고
    • Porters versus rowers: A unified stochastic model of motor proteins
    • Leibler S, Huse DA (1993) Porters versus rowers: A unified stochastic model of motor proteins. J Cell Biol 121, 1357-1368.
    • (1993) J Cell Biol , vol.121 , pp. 1357-1368
    • Leibler, S.1    Huse, D.A.2
  • 58
    • 0028820411 scopus 로고
    • Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules
    • Trinczek B, Biernat J, Baumann K, Mandelkow EM, Mandelkow E (1995) Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules. Mol Biol Cell 6, 1887-1902.
    • (1995) Mol Biol Cell , vol.6 , pp. 1887-1902
    • Trinczek, B.1    Biernat, J.2    Baumann, K.3    Mandelkow, E.M.4    Mandelkow, E.5
  • 59
    • 0024675418 scopus 로고
    • The microtubule binding domain of tau protein
    • Lee G, Neve RL, Kosik KS (1989) The microtubule binding domain of tau protein. Neuron 2, 1615-1624.
    • (1989) Neuron , vol.2 , pp. 1615-1624
    • Lee, G.1    Neve, R.L.2    Kosik, K.S.3
  • 61
    • 61349120799 scopus 로고    scopus 로고
    • FTDP-17 mutations in tau alter the regulation of microtubule dynamics-an "Alternative Core" model for normal and pathological tau action
    • LeBoeuf AC, Levy SF, Gaylord M, Bhattacharya A, Singh AK, Jordan MA, Wilson L, Feinstein SC (2008) FTDP-17 mutations in tau alter the regulation of microtubule dynamics-an "Alternative Core" model for normal and pathological tau action. J Biol Chem 283, 36406-36415.
    • (2008) J Biol Chem , vol.283 , pp. 36406-36415
    • LeBoeuf, A.C.1    Levy, S.F.2    Gaylord, M.3    Bhattacharya, A.4    Singh, A.K.5    Jordan, M.A.6    Wilson, L.7    Feinstein, S.C.8
  • 62
    • 33744952341 scopus 로고    scopus 로고
    • FTDP-17 mutations compromise the ability of tau to regulate microtubule dynamics in cells
    • Bunker JM, Kamath K, Wilson L, Jordan MA, Feinstein SC (2006) FTDP-17 mutations compromise the ability of tau to regulate microtubule dynamics in cells. J Biol Chem 281, 11856-11863.
    • (2006) J Biol Chem , vol.281 , pp. 11856-11863
    • Bunker, J.M.1    Kamath, K.2    Wilson, L.3    Jordan, M.A.4    Feinstein, S.C.5
  • 63
    • 0034624014 scopus 로고    scopus 로고
    • Structural and functional differences between 3-repeat and 4-repeat tau isoforms. Implications for normal tau function and the onset of neurodegenetative disease
    • Goode BL, Chau M, Denis PE, Feinstein SC (2000) Structural and functional differences between 3-repeat and 4-repeat tau isoforms. Implications for normal tau function and the onset of neurodegenetative disease. J Biol Chem 275, 38182-38189.
    • (2000) J Biol Chem , vol.275 , pp. 38182-38189
    • Goode, B.L.1    Chau, M.2    Denis, P.E.3    Feinstein, S.C.4
  • 64
  • 65
    • 0027058857 scopus 로고
    • Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau
    • Drechsel DN, Hyman AA, Cobb MH, Kirschner MW (1992) Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau. Mol Biol Cell 3, 1141-1154.
    • (1992) Mol Biol Cell , vol.3 , pp. 1141-1154
    • Drechsel, D.N.1    Hyman, A.A.2    Cobb, M.H.3    Kirschner, M.W.4
  • 66
    • 0037413708 scopus 로고    scopus 로고
    • Repeat motifs of tau bind to the insides of microtubules in the absence of taxol
    • Kar S, Fan J, Smith MJ, Goedert M, Amos LA (2003) Repeat motifs of tau bind to the insides of microtubules in the absence of taxol. EMBO J 22, 70-77.
    • (2003) EMBO J , vol.22 , pp. 70-77
    • Kar, S.1    Fan, J.2    Smith, M.J.3    Goedert, M.4    Amos, L.A.5
  • 67
    • 0029063397 scopus 로고
    • Structure of tubulin at 6.5 A and location of the taxolbinding site
    • Nogales E, Wolf SG, Khan IA, Luduena RF, Downing KH (1995) Structure of tubulin at 6.5 A and location of the taxolbinding site. Nature 375, 424-427.
    • (1995) Nature , vol.375 , pp. 424-427
    • Nogales, E.1    Wolf, S.G.2    Khan, I.A.3    Luduena, R.F.4    Downing, K.H.5
  • 69
    • 84863230105 scopus 로고    scopus 로고
    • The microtubule-stabilizing agent, epothilone d, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice
    • Zhang B, Carroll J, Trojanowski JQ, Yao Y, Iba M, Potuzak JS, Hogan A-ML, Xie SX, Ballatore C, Smith AB, Lee VM-Y, Brunden KR (2012) The microtubule-stabilizing agent, epothilone d, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J Neurosci 32, 3601-3611.
    • (2012) J Neurosci , vol.32 , pp. 3601-3611
    • Zhang, B.1    Carroll, J.2    Trojanowski, J.Q.3    Yao, Y.4    Iba, M.5    Potuzak, J.S.6    Hogan, A.-M.L.7    Xie, S.X.8    Ballatore, C.9    Smith, A.B.10    Lee, V.M.-Y.11    Brunden, K.R.12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.