Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse

Genes and Development

Volumn 16, Issue 9, 2002, Pages 1060-1065

  Kalamarides, Michel ^a   Niwa Kawakita, Michiko ^b   Leblois, Hélène ^a   Abramowski, Vincent ^c   Perricaudet, Michel ^a   Janin, Anne ^a   Thomas, Gilles ^b   Gutmann, David H ^c   Giovannini, Marco ^d  

^a FONDATION JEAN DAUSSET CEPH   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c INSERM   (France)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenoviral vector; Conditional knockout mice; Cre loxP; Meningioma; NF2; Tumor suppressor gene

Indexed keywords

CRE RECOMBINASE; PROTEIN P53;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ARACHNOID; CANCER GENETICS; EXON; GENE; GENE INACTIVATION; HEMIZYGOSITY; MENINGIOMA; MOUSE; NEUROFIBROMATOSIS; NEWBORN; NF2 GENE; NONHUMAN; PRIORITY JOURNAL;

ADENOVIRIDAE; ANIMALS; ARACHNOID; GENE SILENCING; GENETIC VECTORS; HOMOZYGOTE; MENINGEAL NEOPLASMS; MENINGIOMA; MICE; MICE, MUTANT STRAINS; NEOPLASMS, EXPERIMENTAL; NEUROFIBROMIN 2; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; ARACHNOIDEA; RODENTIA;

EID: 0036571383     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.226302     Document Type: Article

References (23)

1. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
2. A genetic study of type 2 neurofibromatosis in the United Kingdom. II. Guidelines for genetic counselling
3. Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein
4. Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2
5. Loss of merlin expression in sporadic meningiomas, ependymomas and schwannomas
6. Loss of DAL-1, a protein 4.1-related tumor suppressor, is an important early event in the pathogenesis of meningiomas
7. Genetic background alters the spectrum of tumors that develop in p53-deficient mice
8. The impact of developmental stage, route of administration and the immune system on adenovirus-mediated gene transfer
9. World Health Organization classification of tumors
10. Meningiomas
11. Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors
12. Intracranial injection of human meningioma cells in athymic mice: An orthotopic model for meningioma growth
13. A morphologic classification of brain tumors found in several strains of mice
14. Merlin, DAL-1, and progesterone receptor expression in clinicopathologic subsets of meningioma: A correlative immunohistochemical study of 175 cases
15. Expression patterns of the p53 tumor suppressor gene and the mdm2 protooncogene in human meningiomas
16. Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects
17. Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene
18. Meningioangiomatosis is associated with neurofibromatosis 2 but not with somatic alterations of the NF2 gene
19. Widespread long-term gene transfer to mouse skeletal muscles and heart
20. Immunohistochemical localization of cell adhesion molecule epithelial cadherin in human arachnoid villi and meningiomas
21. Analysis of cell cycle regulators: p16INK4A, pRb, and CDK4 in low- and highgrade meningiomas
22. Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene
23. Quantitative effects of Nf1 inactivation on in vivo hematopoiesis