Berberine protects against palmitate-induced endothelial dysfunction: Involvements of upregulation of AMPK and eNOS and downregulation of NOX4

Mediators of Inflammation

Volumn 2013, Issue , 2013, Pages

  Zhang, Ming ^a   Wang, Chun Mei ^b   Li, Jing ^a   Meng, Zhao Jie ^a   Wei, Sheng Nan ^a   Bucala, Richard ^c   Li, Yu Lin ^a   Chen, Li ^a  

^a JILIN UNIVERSITY   (China)

^b BEIHUA UNIVERSITY   (China)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BERBERINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MESSENGER RNA; NITRIC OXIDE; NOS3 PROTEIN, HUMAN; NOX4 PROTEIN, HUMAN; PALMITIC ACID; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ARTICLE; CELL CULTURE; CELL SURVIVAL; DOWN REGULATION; DRUG EFFECT; ENDOTHELIUM CELL; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION;

AMP-ACTIVATED PROTEIN KINASES; BERBERINE; CELL SURVIVAL; CELLS, CULTURED; DOWN-REGULATION; ENDOTHELIAL CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; NADPH OXIDASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PALMITIC ACID; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; UP-REGULATION;

EID: 84893849206     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2013/260464     Document Type: Article

References (26)

1. Rodríguez-Mañas L., Angulo J., Vallejo S., Peiró C., Sánchez-Ferrer A., Cercas E., López-Dóriga P., Sánchez-Ferrer C. F., Early and intermediate Amadori glycosylation adducts, oxidative stress, and endothelial dysfunction in the streptozotocin-induced diabetic rats vasculature. Diabetologia 2003 46 4 556 566 2-s2.0-0038632123 (Pubitemid 36577801)
2. Cacicedo J. M., Yagihashi N., Keaney J. F. Jr., Ruderman N. B., Ido Y., AMPK inhibits fatty acid-induced increases in NF- B transactivation in cultured human umbilical vein endothelial cells. Biochemical and Biophysical Research Communications 2004 324 4 1204 1209 2-s2.0-14344257169 10.1016/j.bbrc.2004.09. 177 (Pubitemid 40292150)
3. Ye-rong Y., Insulin resistance and abnormal function of vascular endothelium cell: is high blood free fatty acid play a key role? International Journal of Endocrinology and Metabolism 2006 26, article 3
4. Rask-Madsen C., King G. L., Vascular complications of diabetes: mechanisms of injury and protective factors. Cell Metabolism 2013 17 20 33
5. Inoguchi T., Li P., Umeda F., Yu H. Y., Kakimoto M., Imamura M., Aoki T., Etoh T., Hashimoto T., Naruse M., Sano H., Utsumi H., Nawata H., High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 2000 49 11 1939 1945 2-s2.0-0033765672
6. Kim F., Pham M., Luttrell I., Bannerman D. D., Tupper J., Thaler J., Hawn T. R., Raines E. W., Schwartz M. W., Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circulation Research 2007 100 11 1589 1596 2-s2.0-34250169823 10.1161/CIRCRESAHA.106.142851 (Pubitemid 46897262)
7. Park H. S., Chun J. N., Jung H. Y., Choi C., Bae Y. S., Role of NADPH oxidase 4 in lipopolysaccharide-induced proinflammatory responses by human aortic endothelial cells. Cardiovascular Research 2006 72 3 447 455 2-s2.0-33750519444 10.1016/j.cardiores.2006.09.012 (Pubitemid 44665857)
8. Leng S.-H., Lu F.-E., Xu L.-J., Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion. Acta Pharmacologica Sinica 2004 25 4 496 502 2-s2.0-1842708890 (Pubitemid 38470422)
9. Lee Y. S., Kim W. S., Kim K. H., Yoon M. J., Cho H. J., Shen Y., Ye J.-M., Lee C. H., Oh W. K., Kim C. T., Hohnen-Behrens C., Gosby A., Kraegen E. W., James D. E., Kim J. B., Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 2006 55 8 2256 2264 2-s2.0-33749336146 10.2337/db06-0006 (Pubitemid 44743622)
10. Wang F. L., Tang L. Q., Yang F., Zhu L. N., Cai M., Wei W., Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats. Molecular Biology Reports 2013 40 3 2405 2418 10.1007/s11033-012-2321-5
11. Yin J., Hu R., Chen M., Tang J., Li F., Yang Y., Chen J., Effects of berberine on glucose metabolism in vitro. Metabolism 2002 51 11 1439 1443 2-s2.0-0036833480
12. Tang L.-Q., Wei W., Chen L.-M., Liu S., Effects of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. Journal of Ethnopharmacology 2006 108 1 109 115 2-s2.0-33749327046 10.1016/j.jep.2006.04. 019 (Pubitemid 44498992)
13. Hao M., Li S.-Y., Sun C.-K., Jingyu-Xu J.-X., Lin Y., Liu K.-X., Wang L., Li C.-X., Zhou Q., Du J.-L., Li H., Amelioration effects of berberine on diabetic microendothelial injury model by the combination of high glucose and advanced glycation end products in vitro. European Journal of Pharmacology 2011 654 3 320 325 2-s2.0-79951670729 10.1016/j.ejphar.2010.12.030
14. Svedberg J., Bjorntorp P., Smith U., Lonnroth P., Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes. Diabetes 1990 39 5 570 574 2-s2.0-0025296906 (Pubitemid 20223782)
15. Wang S.-X., Xiong X.-M., Song T., Liu L.-Y., Protective effects of cariporide on endothelial dysfunction induced by high glucose. Acta Pharmacologica Sinica 2005 26 3 329 333 2-s2.0-15244344538 10.1111/j.1745-7254. 2005.00042.x (Pubitemid 40388069)
16. Huang J., Wu L., Tashiro S.-I., Onodera S., Ikejima T., Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways. Journal of Pharmacological Sciences 2008 107 4 370 379 2-s2.0-50149087699 10.1254/jphs.08044FP
17. Barbosa V. A., Luciano T. F., Marques S. O., Vitto M. F., Souza D. R., Silva L. A., Santos J. P., Moreira J. C., Dal-Pizzol F., Lira F. S., Pinho R. A., De Souza C. T., Acute exercise induce endothelial nitric oxide synthase phosphorylation via Akt and AMP-activated protein kinase in aorta of rats: role of reactive oxygen species. International Journal of Cardiology 2013 167 6 2983 2988 10.1016/j.ijcard.2012.08.050
18. Zanetti M., Barazzoni R., Stebel M., Roder E., Biolo G., Baralle F. E., Cattin L., Guarnieri G., Dysregulation of the endothelial nitric oxide synthase-soluble guanylate cyclase pathway is normalized by insulin in the aorta of diabetic rat. Atherosclerosis 2005 181 1 69 73 2-s2.0-20444413806 10.1016/j.atherosclerosis.2005.01.011 (Pubitemid 40804695)
19. Yu Y.-R., Li H.-L., Zhang X.-X., Effects of free fatty acids on nitric oxide synthase activity and mRNA expression in endothelial cell of SD rat aorta. Journal of Sichuan University 2008 39 2 193 196 2-s2.0-41449117794
20. Guo W.-X., Yang Q.-D., Liu Y.-H., Xie X.-Y., Wang-Miao W.-M., Niu R.-C., Palmitic and linoleic acids impair endothelial progenitor cells by inhibition of Akt/eNOS pathway. Archives of Medical Research 2008 39 4 434 442 2-s2.0-41049108669 10.1016/j.arcmed.2008.02.001 (Pubitemid 351423431)
21. Morrow V. A., Foufelle F., Connell J. M. C., Petrie J. R., Gould G. W., Salt I. P., Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells. Journal of Biological Chemistry 2003 278 34 31629 31639 2-s2.0-0041355355 10.1074/jbc.M212831200 (Pubitemid 37048341)
22. Sena C. M., Pereira A. M., Seica R., Endothelial dysfunction-a major mediator of diabetic vascular disease. Biochimica et Biophysica Acta 2013 1832 12 2216 2231 10.1016/j.bbadis.2013.08.006
23. Kim J.-E., Kim Y.-W., Lee I. K., Kim J. Y., Kang Y. J., Park S.-Y., AMP-activated protein kinase activation by 5-aminoimidazole-4-carboxamide- 1- β -D-ribofuranoside (AICAR) inhibits palmitate-induced endothelial cell apoptosis through reactive oxygen species suppression. Journal of Pharmacological Sciences 2008 106 3 394 403 2-s2.0-41549084644 10.1254/jphs.FP0071857 (Pubitemid 351468592)
24. Ceolotto G., Gallo A., Papparella I., Franco L., Murphy E., Iori E., Pagnin E., Fadini G. P., Albiero M., Semplicini A., Avogaro A., Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism. Arteriosclerosis, Thrombosis, and Vascular Biology 2007 27 12 2627 2633 2-s2.0-36348948505 10.1161/ATVBAHA.107.155762 (Pubitemid 350158915)
25. Song P., Zou M.-H., Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems. Free Radical Biology and Medicine 2012 52 9 1607 1619 2-s2.0-84858983392 10.1016/j.freeradbiomed.2012.01.025
26. Li H.-M., Wang Y.-Y., Wang H.-D., Cao W.-J., Yu X.-H., Lu D.-X., Qi R.-B., Hu C.-F., Yan Y.-X., Berberine protects against lipopolysaccharide- induced intestinal injury in mice via alpha 2 adrenoceptor-independent mechanisms. Acta Pharmacologica Sinica 2011 32 11 1364 1372 2-s2.0-80755175187 10.1038/aps.2011.102