Dysregulation of the endothelial nitric oxide synthase-soluble guanylate cyclase pathway is normalized by insulin in the aorta of diabetic rat

Atherosclerosis

Volumn 181, Issue 1, 2005, Pages 69-73

  Zanetti, Michela ^a,c   Barazzoni, Rocco ^a   Stebel, Marco ^a   Roder, Elena ^a   Biolo, Gianni ^a   Baralle, Francisco E ^b   Cattin, Luigi ^a   Guarnieri, Gianfranco ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^c UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Diabetes; Guanylate cyclase; Nitric oxide

Indexed keywords

CYCLIC GMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANYLATE CYCLASE; INSULIN; STREPTOZOCIN;

ANIMAL MODEL; AORTA; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROGENESIS; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME REGULATION; INSULIN TREATMENT; MALE; METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; VASCULAR RING; VASODILATATION; WESTERN BLOTTING;

ANIMALS; AORTA, THORACIC; BLOTTING, WESTERN; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DIABETES MELLITUS, EXPERIMENTAL; ENZYME ACTIVATION; GUANYLATE CYCLASE; HYDRAZINES; INSULIN; MALE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; NITROGEN OXIDES; RATS; SOLUBILITY; VASODILATION;

EID: 20444413806     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2005.01.011     Document Type: Article

References (24)

1. A. Friebe, and D. Koesling Regulation of nitric oxide-sensitive guanylyl cyclase Circ Res 93 2003 96 105
2. F. Cosentino, K. Hishikawa, Z.S. Katusic, and T.F. Luscher High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells Circulation 96 1997 25 28
3. E. Salvolini, R.A. Rabini, D. Martarelli, N. Moretti, N. Cester, and L. Mazzanti A study on human umbilical cord endothelial cells: functional modifications by plasma from insulin-dependent diabetes mellitus patients Metabolism 48 1999 554 557
4. Y. Ding, N.D. Vaziri, R. Coulson, V.S. Kamanna, and D.D. Roth Effects of simulated hyperglycemia, insulin, and glucagons on endothelial nitric oxide synthase expression Am J Physiol 279 2000 E11 E17
5. X.L. Du, D. Edelstein, S. Dimmeler, Q. Ju, C. Sui, and M. Brownlee Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site J Clin Invest 108 2001 1341 1348
6. C.J. Meininger, R.S. Marinos, and K. Hatakeyama Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency Biochem J 349 2000 353 356
7. G. Mancusi, C. Hutter, S. Baumgartner-Parzer, K. Schmidt, W. Shutz, and V. Sexl High glucose incubation of human umbilical-vein endothelial cells does not alter expression and function either of G-protein alpha-subunits or endothelial nitric oxide synthase Biochem J 315 1996 281 287
8. S. Rojas, R. Rojas, L. Lamperti, P. Casanello, and L. Sobrevia Hyperglycemia inhibits thymidine incorporation and cell growth via protein kinase C, mitogen-activated protein kinases and nitric oxide in human umbilical vein endothelium Exp Physiol 88 2 2003 209 219
9. H.H. Ting, F.K. Timimi, K.S. Boles, S.J. Creager, P. Ganz, and M.A. Creager Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus J Clin Invest 97 1996 22 28
10. G.M. Pieper, and L.A. Dondlinger Plasma and vascular tissue arginine are decreased in diabetes: acute arginine supplementation restores endothelium-dependent relaxation by augmenting cGMP production J Pharmacol Exp Ther 283 1997 684 691
11. R.M. Weisbrod, M.L. Brown, and R.A. Cohen Effect of elevated glucose on cyclic GMP and eicosanoids produced by porcine aortic endothelium Arterioscler Thromb 13 1993 915 923
12. K. Kamata, N. Miyata, and Y. Kasuya Impairment of endothelium-dependent relaxation and change of levels of cyclic GMP in aorta from streptozotocin- induced diabetic rats Br J Pharmacol 97 1989 614 618
13. T. Abiru, Y. Watanabe, K. Kamata, N. Miyata, and Y. Kasuya Decrease in endothelium-dependent relaxation and levels of cyclic nucleotides in aorta from rabbits with alloxan-induced diabetes Res Commun Chem Pathol Pharmacol 68 1990 13 25
14. K. Witte, K. Jacke, and R. Stahrenberg Dysfunction of soluble guanylyl cyclase in aorta and kidney of Goto-Kakizaki rats: influence of age and diabetic state Nitric Oxide 6 2002 85 95
15. M.A. Miller, R.J. Morgan, C.S. Thompson, D.P. Mikhailidis, and J.Y. Jeremy Adenylate and guanylate cyclase activity in the penis and aorta of the diabetic rat: an in vitro study Br J Urol 1994 106 111
16. A. Papapetropoulos, G. Abou-Mohamed, N. Marezin, F. Murad, R.W. Caldwell, and J.D. Catravas Downregulation of nitrovasodilator-induced cyclic GMP accumulation in cells exposed to endotoxin or interleukin-1 beta Br J Pharmacol 118 1996 1359 1366
17. E. Courtois, M. Marques, A. Barrientos, S. Casado, and A. Lopez-Farre Lead-induced downregulation of soluble guanylate cyclase in isolated rat aortic segments mediated by reactive oxygen species and cyclooxygenase-2 J Am Soc Nephrol 14 2003 1464 1470
18. F. Cosentino, M. Eto, and P. De Paolis High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells Circulation 107 2003 1017 1023
19. C.A. Gunnett, D.D. Heistad, and F.M. Faraci Gene-targeted mice reveal a critical role for inducible nitric oxide synthase in vascular dysfunction during diabetes Stroke 34 2003 2970 2974
20. H. Gaenzer, G. Neumayr, and P. Marschang Effect of insulin therapy on endothelium-dependent dilation in type 2 diabetes mellitus Am J Cardiol 89 2002 431 434
21. G.M. Pieper Divergent actions of chronic insulin treatment in vivo versus treatment ex vivo on diabetic-induced endothelial dysfunction Life Sci 60 1997 371 376
22. P.D. Taylor, B.B. Oon, C.R. Thomas, and L. Poston Prevention by insulin treatment of endothelial dysfunction but not enhanced noradrenaline-induced contractility in mesenteric resistance arteries from streptozotocin-induced diabetes mellitus in rats Br J Pharmacol 111 1994 35 41
23. S. Vehkavaara, and H. Yki-Jarvinen 3.5 years of insulin therapy with insulin glargine improves in vivo endothelial function in type 2 diabetes Arterioscl Thromb Vasc Biol 24 2004 325 330
24. K. Kuboki, Z.Y. Jiang, and N. Takahara Regulation of endothelial constitutive nitric oxide gene expression in endothelial cells and in vivo: a specific vascular action of insulin Circulation 101 2000 676 681