Acute exercise induce endothelial nitric oxide synthase phosphorylation via Akt and AMP-activated protein kinase in aorta of rats: Role of reactive oxygen species

International Journal of Cardiology

Volumn 167, Issue 6, 2013, Pages 2983-2988

  Barbosa, Viviane A ^a   Luciano, Thais F ^a   Marques, Scherolin O ^a   Vitto, Marcelo F ^a   Souza, Daniela R ^a   Silva, Luciano A ^a   Santos, João Paulo A ^b   Moreira, José C ^b   Dal Pizzol, Felipe ^a   Lira, Fabio S ^a   Pinho, Ricardo A ^a   De Souza, Claudio T ^a  

^a UNIVERSIDADE DO EXTREMO SUL CATARINENSE   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Aorta; eNOS phosphorylation; Exercise; Redox modulation

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ACETYLCYSTEINE; ADENYLATE KINASE; CHEMICAL COMPOUND; COMPOUND C; DICHLOROFLUORESCEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROGEN PEROXIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; UNCLASSIFIED DRUG; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD VESSEL FUNCTION; CHEMICAL ANALYSIS; CONTROLLED STUDY; DECAPITATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EX VIVO STUDY; EXCISION; EXERCISE; IMMUNOBLOTTING; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SWIMMING;

AORTA; ENOS PHOSPHORYLATION; EXERCISE; REDOX MODULATION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AORTA, THORACIC; MALE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PHYSICAL CONDITIONING, ANIMAL; PROTO-ONCOGENE PROTEINS C-AKT; RANDOM ALLOCATION; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 84883780569     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2012.08.050     Document Type: Article

References (39)

1. A. Chatterjee, S.M. Black, and J.D. Catravas Endothelial nitric oxide (NO) and its pathophysiologic regulation Vascul Pharmacol 49 4-6 2008 134 140
2. C. Goto, K. Nishioka, and T. Umemura Acute moderate-intensity exercise induces vasodilation through an increase in nitric oxide bioavailiability in humans Am J Hypertens 20 8 2007 825 830
3. W. Shen, X. Zhang, G. Zhao, M.S. Wolin, W. Sessa, and T.H. Hintze Nitric oxide production and NO synthase gene expression contribute to vascular regulation during exercise Med Sci Sports Exerc 27 8 1995 1125 1134
4. Q.J. Zhang, S.L. McMillin, J.M. Tanner, M. Palionyte, E.D. Abel, and J.D. Symons Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases J Physiol 587 pt15 2009 3911 3920
5. S.R. Thomas, K. Chen, and J.F. Keaney Jr. Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway J Biol Chem 277 8 2002 6017 6024
6. H. Cai, Z. Li, M.E. Davis, W. Kanner, D.G. Harrison, and S.C. Dudley Jr. Akt dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide Mol Pharmacol 63 2 2003 325 331
7. K. Fisher-Wellman, and R.J. Bloomer Acute exercise and oxidative stress: a 30 year history Dyn Med 8 s.n 2009 1
8. N.E. Zanchi, L.R. Bechara, L.Y. Tanaka, V. Debbas, T. Bartholomeu, and P.R. Ramires Moderate exercise training decreases aortic superoxide production in myocardial infarcted rats Eur J Appl Physiol 104 6 2008 1045 1052
9. M.J. Frederico, S.L. Justo, and G. Da Luz Exercise training provides cardioprotection via a reduction in reactive oxygen species in rats submitted to myocardial infarction induced by isoproterenol Free Radic Res 43 10 2009 957 964
10. L.A. Silva, C.A. Pinho, L.G. Rocha, T. Tuon, P.C. Silveira, and R.A. Pinho Effect of different models of physical exercise on oxidative stress markers in mouse liver Appl Physiol Nutr Metab 34 1 2009 60 65
11. H.M. Alessio Exercise-induced oxidative stress Med Sci Sports Exerc 25 2 1993 218 224
12. J. Bejma, and L.L. Ji Aging and acute exercise enhance free radical generation in rat skeletal muscle J Appl Physiol 87 1 1999 465 470
13. J.C. Quindry, W.L. Stone, J. King, and C.E. Broeder The effects of acute exercise on neutrophils and plasma oxidative stress Med Sci Sports Exerc 35 7 2003 1139 1145
14. D.M. Bailey, L. Lawrenson, and J. McEneny Electron paramagnetic spectroscopic evidence of exercise-induced free radical accumulation in human skeletal muscle Free Radic Res 41 2 2007 182 190
15. L.L. Ji, M.C. Gomez-Cabrera, and J. Vina Exercise and hormesis: activation of cellular antioxidant signaling pathway Ann N Y Acad Sci 1067 s.n 2006 425 435
16. Z. Radak, H.Y. Chung, E. Koltai, A.W. Taylor, and S. Goto Exercise, oxidative stress and hormesis Ageing Res Rev 7 1 2008 34 42
17. J.R. Stone, and T. Collins The role of hydrogen peroxide in endothelial proliferative responses Endothelium 9 4 2002 231 238
18. E. Schroder, and P. Eaton Hydrogen peroxide as an endogenous mediator and exogenous tool in cardiovascular research: issues and considerations Curr Opin Pharmacol 8 2 2008 153 159
19. T. Nishikawa, D. Kukidome, and K. Sonoda Impact of mitochondrial ROS production on diabetic vascular complications Diabetes Res Clin Pract 77 1 2007 41 45
20. Z. Hu, J. Chen, Q. Wei, and Y. Xia Bidirectional actions of hydrogen peroxide on endothelial nitric-oxide synthase phosphorylation and function: co-commitment and interplay of Akt and AMPK J Biol Chem 283 37 2008 25256 25263
21. B.Y. Jin, J.L. Sartoretto, V.N. Gladyshev, and T. Michel Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells Proc Natl Acad Sci U S A 106 41 2009 17343 17348
22. J.J. Poderoso, M.C. Carreras, and C. Lisdero Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles Arch Biochem Biophys 328 1996 85 92
23. C.P. LeBel, H. Ischiropoulos, and S.C. Bondy Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress Chem Res Toxicol 5 2 1992 227 231
24. O.H. Lowry, N.G. Rosebough, A.L. Farr, and R.J. Randall Protein measurement with the folin phenol reagent J Biol Chem 193 1 1951 265 275
25. S. Di Francescomarino, A. Sciartilli, V. Di Valerio, A. Di Baldassarre, and S. Gallina The effect of physical exercise on endothelial function Sports Med 39 10 2009 797 812
26. D. Fulton, J.P. Gratton, and T.J. McCabe Regulation of endothelium-derived nitric oxide production by the protein kinase Akt Nature 399 6736 1999 597 601
27. S. Dimmeler, I. Fleming, B. Fisslthaler, C. Hermann, R. Busse, and A.M. Zeiher Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation Nature 399 6736 1999 601 605
28. I. Fleming, and R. Busse Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase Am J Physiol 284 1 2003 1 12
29. S.C. Stein, A. Woods, N.A. Jones, M.D. Davison, and D. Carling The regulation of AMP activated protein kinase by phosphorylation Biochem J 345 pt.3 2000 437 443
30. Z.P. Chen, K.I. Mitchelhill, and B.J. Michell AMP-activated protein kinase phosphorylation of endothelial NO synthase FEBS Lett 443 3 1999 285 289
31. A. Smolenski, C. Bachmann, and K. Reinhard Analysis and regulation of vasodilator-stimulated phosphoprotein serine 239 phosphorylation in vitro and in intact cells using a phosphospecific monoclonal antibody J Biol Chem 273 32 1998 20029 20035
32. M. Oelze, H. Mollnau, and N. Hoffmann Vasodilator-stimulated phosphoprotein serine 239 phosphorylation as a sensitive monitor of defective nitric oxide/cGMP signaling and endothelial dysfunction Circ Res 87 11 2000 999 1005
33. M.M. Tarpey, and I. Fridovich Methods of detection of vascular reactive species: nitric oxide, superoxide, hydrogen peroxide, and peroxynitrite Circ Res 89 3 2001 224 236
34. F. Goirand, M. Solar, and Y. Athea Activation of AMP kinase alpha1 subunit induces aortic vasorelaxation in mice J Physiol 581 pt.3 2007 1163 1171
35. M. Schleicher, J. Yu, and T. Murata The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo Sci Signal 2 82 2009 ra41
36. P.F. Davies Flow-mediated endothelial mechanotransduction Physiol Rev 75 3 1995 519 551
37. G.R. Guy, J. Cairns, S.B. Ng, and Y.H. Tan Inactivation of a redox-sensitive protein phosphatase during the early events of tumor necrosis factor/interleukin-1 signal transduction J Biol Chem 268 3 1993 2141 2148
38. B.J. Goldstein, K. Mahadev, X. Wu, L. Zhu, and H. Motoshima Role of insulin-induced reactive oxygen species in the insulin signaling pathway Antioxid Redox Signal 7 7-8 2005 1021 1031
39. 2 J Biol Chem 277 23 2002 20336 20342