Protective effects of cariporide on endothelial dysfunction induced by high glucose

Acta Pharmacologica Sinica

Volumn 26, Issue 3, 2005, Pages 329-333

  Wang, Shuang Xi ^a   Xiong, Xiao Ming ^a   Song, Tao ^a   Liu, Li Ying ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Endothelium; Glucose; Malondialdehyde; Nitric oxide; Sodium hydrogen antiporter; Superoxide dismutase

Indexed keywords

ACETYLCHOLINE; CARIPORIDE; GLUCOSE; MALONALDEHYDE; MANNITOL; NITRIC OXIDE; NITROPRUSSIDE SODIUM; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG STRUCTURE; ENDOTHELIUM LESION; ENZYME ACTIVITY; GLUCOSE INTAKE; INCUBATION TIME; MALE; NONHUMAN; RAT; THORACIC AORTA; VASCULAR RING;

ANIMALS; AORTA, THORACIC; ENDOTHELIUM, VASCULAR; GLUCOSE; GUANIDINES; MALE; MALONDIALDEHYDE; NITRIC OXIDE; RATS; RATS, SPRAGUE-DAWLEY; SULFONES; SUPEROXIDE DISMUTASE; VASODILATION;

EID: 15244344538     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2005.00042.x     Document Type: Article

References (20)

1. Najemnik C, Sinzinger H, Kritz H. Endothelial dysfunction, atherosclerosis and diabetes. Acta Med Austriaca 1999; 26: 148-53.
2. Guo X, Liu WL, Chen LW, Guo ZG. High glucose impairs endothelium- dependent relaxation in rabbit aorta. Acta Pharmacol Sin 2000; 21: 169-73.
3. Pieper GM. Enhanced, unaltered and impaired nitric oxide-mediated endothelium-dependent relaxation in experimental diabetes mellitus: importance of disease duration. Diabetologia 1999; 42: 204-13.
4. Friesen NT, Buchau AS, Schott-Ohly P, Lgssiar A, Gleichmann H. Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL/6 mice are associated with diabetes induced by multiple low doses of streptozotocin. Diabetologia 2004; 47: 676-85.
5. Matteucci E, Giampietro. Sodium/hydrogen exchange activity in type 1 diabetes mellitus: the never-ending story. Diabetes Nutr Metab 2001; 14: 225-33.
6. + exchange in glomerular mesangial cells. Am J Physiol Renal Physiol 2000; 278: F91-6.
7. + exchanger inhibitor cariporide on the injury of vascular endothelial function induced by hypercholesterolemia. Bull Hu-nan Med Univ 2002; 27: 13-6.
8. Ma FX, Liu LY, Xiong XM. Protective effects of lovastatin on vascular endothelium injured by low density lipoprotein. Acta Pharmacol Sin 2003; 24: 1027-32.
9. Tesfamariam B, Brown ML, Cohen RA. Elevated glucose impaired endothelium-dependent relaxation by activating protein kinase C. J Clin Invest 1991; 87: 1643-8.
10. Xu B, Rao MR. High concentration of glucose inhibits endothelium- dependent vasorelaxation of rabbit aortic artery. Acta Pharmacol Sin 2001; 22: 861-4.
11. 2-induced apoptosis in bovine aortic endothelial cells. Acta Pharmacol Sin 2000; 21: 41-5.
12. + exchange inhibition. Circ Res 2000; 87: 1133-40.
13. Telejko B, Tomasiak M, Stelmach H, Kinalska I. Platelet sodium-proton exchanger and phospholipid-dependent procoagulant activity in patients with type 2 diabetes. Metabolism 2003; 52: 102-6.
14. + antiport activity and gene expression in cultured vascular smooth muscle cells. Role of protein kinase C. J Clin Invest 1994; 93: 2623-31.
15. + exchanger, NHE-1, in vascular myocytes from Wistar-Kyoto and spontaneously hypertensive rats. Metabolism 1996; 45: 114-9.
16. Scholz W, Albus U, Counillon L, Gogelein H, Lang HJ, Linz W, et al. Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc Res 1995; 29: 260-8.
17. + exchange inhibitor, inhibits the mitochondrial death pathway. Circulation 2003; 108: 2275-81.
18. Cutaia M, Kroczynski J, Tollefson K. pH-dependent oxidant production following inhibition of the mitochondrial electron transport chain in pulmonary endothelial cells. Endothelium 2002; 9: 109-21.
19. + exchanger modulates the fibrogenic effect of oxidative stress in rat hepatic stellate cells. J Hepatol 1999; 30: 868-75.
20. 2+ overload and prolonged acidosis on reperfusion. Circulation 2000; 101: 2749-55.