Intramolecular isopeptide but not internal thioester bonds confer proteolytic and significant thermal stability to the S. pyogenes pilus adhesin Spy0125

Proteins: Structure, Function and Bioinformatics

Volumn 82, Issue 3, 2014, Pages 517-527

  Walden, Miriam ^a   Crow, Allister ^a,b   Nelson, Miles D ^a   Banfield, Mark J ^a  

^a NORWICH RESEARCH PARK   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Circular dichroism; Internal thioester bonds; Intramolecular isopeptide bonds; Protein stability; S. pyogenes pili; X ray crystallography

Indexed keywords

ADHESIN; INTRAMOLECULAR ISOPEPTIDE; ISOPROTEIN; THIOESTER; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM PILUS; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; MUTANT; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DENATURATION; PROTEIN STABILITY; STREPTOCOCCUS PYOGENES; THERMOSTABILITY; WILD TYPE;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STREPTOCOCCUS PYOGENES;

CIRCULAR DICHROISM; INTERNAL THIOESTER BONDS; INTRAMOLECULAR ISOPEPTIDE BONDS; PROTEIN STABILITY; S. PYOGENES PILI; X-RAY CRYSTALLOGRAPHY;

ADHESINS, BACTERIAL; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; FIMBRIAE, BACTERIAL; MODELS, MOLECULAR; PROTEIN STABILITY; STREPTOCOCCUS PYOGENES;

EID: 84893817196     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24420     Document Type: Article

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