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Volumn 723, Issue 1, 2014, Pages 181-184

The metabotropic glutamate receptors: Potential drug targets for the treatment of anxiety disorders?

Author keywords

Anxiety; Metabotropic glutamate receptors

Indexed keywords

1 AMINO 1,5 INDANDICARBOXYLIC ACID; 2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; ANXIOLYTIC AGENT; EGLUMETAD; FENOBAM; JNJ 16259685; LY 314582; LY 456236; LY 566332; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR ANTAGONIST; MSG 0039; PLACEBO; TALAGLUMETAD; UNCLASSIFIED DRUG;

EID: 84893798736     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.12.019     Document Type: Article
Times cited : (26)

References (42)
  • 1
    • 0034948146 scopus 로고    scopus 로고
    • Selective blockade of type-1 metabotropic glutamate receptors induces neuroprotection by enhancing gabaergic transmission
    • DOI 10.1006/mcne.2001.0992
    • G. Battaglia, V. Bruno, V. Pisani, D. Centoze, M. Vincenza, P. Calabresi, and F. Nicoletti Selective blockade of type-1 metabotropic glutamate receptors induces neuroprotection by enhancing gabaergic transmission Mol. Cell. Neurosci. 17 2001 1071 1083 (Pubitemid 32641875)
    • (2001) Molecular and Cellular Neuroscience , vol.17 , Issue.6 , pp. 1071-1083
    • Battaglia, G.1    Bruno, V.2    Pisani, A.3    Centonze, D.4    Catania, M.V.5    Calabresi, P.6    Nicoletti, F.7
  • 2
    • 26944475559 scopus 로고    scopus 로고
    • Metabotropic glutamate II receptor agonists in panic disorder: A double blind clinical trial with LY354740
    • DOI 10.1097/00004850-200511000-00001
    • V. Bergink, and H.G.M. Westernberger Metabotropic glutamate II receptors in panic disorder: a double blind clinical trial with LY354740 Int. Clin. Psychopharmacol. 20 2005 291 293 (Pubitemid 41475316)
    • (2005) International Clinical Psychopharmacology , vol.20 , Issue.6 , pp. 291-293
    • Bergink, V.1    Westenberg, H.G.M.2
  • 3
    • 49949084013 scopus 로고    scopus 로고
    • Behavioral characterization of the mGlu group II/III receptor antagonist LY-341495, in animal models of anxiety and depression
    • A.Y. Bespalov, M.M. van Gaalen, I.A. Sukhotina, K. Wicke, M. Mezler, H. Schoemaker, and G. Gross Behavioral characterization of the mGlu group II/III receptor antagonist LY-341495, in animal models of anxiety and depression Eur. J. Pharmacol. 592 2008 96 102
    • (2008) Eur. J. Pharmacol. , vol.592 , pp. 96-102
    • Bespalov, A.Y.1    Van Gaalen, M.M.2    Sukhotina, I.A.3    Wicke, K.4    Mezler, M.5    Schoemaker, H.6    Gross, G.7
  • 4
    • 3042685523 scopus 로고    scopus 로고
    • The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl] pyridine (MTEP) in rodent models of anxiety
    • DOI 10.1038/sj.npp.1300540
    • C.S. Busse, J. Brodkin, D. Tattersall, J.J. Anderson, N. Warren, and L. Tehrani et al. The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety Neuropsychopharmacology 29 2004 1971 1979 (Pubitemid 39486548)
    • (2004) Neuropsychopharmacology , vol.29 , Issue.11 , pp. 1971-1979
    • Busse, C.S.1    Brodkin, J.2    Tattersall, D.3    Andersen, J.J.4    Warren, N.5    Tehrani, L.6    Bristow, L.J.7    Varney, M.A.8    Cosford, N.D.P.9
  • 6
    • 0030995878 scopus 로고    scopus 로고
    • Pharmacology and functions of metabotropic glutamate receptors
    • P.J. Conn, and J.P. Pin Pharmacology and functions of metabotropic glutamate receptors Annu. Rev. Pharmacol. Toxicol. 37 1997 205 237 (Pubitemid 27238875)
    • (1997) Annual Review of Pharmacology and Toxicology , vol.37 , pp. 205-237
    • Conn, P.J.1    Pin, J.-P.2
  • 7
    • 79960021127 scopus 로고    scopus 로고
    • The age of anxiety: Role of animal models of anxiolytic action in drug discovery
    • J.F. Cryan, and F.F. Sweeney The age of anxiety: role of animal models of anxiolytic action in drug discovery Br. J. Pharmacol. 164 2011 1129 1161
    • (2011) Br. J. Pharmacol. , vol.164 , pp. 1129-1161
    • Cryan, J.F.1    Sweeney, F.F.2
  • 8
    • 43649087034 scopus 로고    scopus 로고
    • Efficacy and tolerability of an mGlu2/3 agonist in the treatment of generalized anxiety disorder
    • DOI 10.1038/sj.npp.1301531, PII 1301531
    • E. Dunayevich, J. Erickson, L. Levine, R. Landbloom, D.D. Schoepp, and G.D. Toellefson Efficacy and tolerability of an mGlu2/3 receptor agonist in the treatment of generalized anxiety disorder Neuropsychopharmacology 33 2008 1603 1610 (Pubitemid 351684700)
    • (2008) Neuropsychopharmacology , vol.33 , Issue.7 , pp. 1603-1610
    • Dunayevich, E.1    Erickson, J.2    Levine, L.3    Landbloom, R.4    Schoepp, D.D.5    Tollefson, G.D.6
  • 9
    • 0021075148 scopus 로고
    • Novel non-benzodiazepine anxiolytics
    • DOI 10.1016/0028-3908(83)90118-1
    • M.E. Goldberg, A.I. Salama, J.B. Patel, and J.B. Malick Novel non-benzodiazepine anxiolytics Neuropharmacology 22 1983 1499 1504 (Pubitemid 14175498)
    • (1983) Neuropharmacology , vol.22 , Issue.12 , pp. 1499-1504
    • Goldberg, M.E.1    Salama, A.I.2    Patel, J.B.3    Malick, J.B.4
  • 10
    • 0037240648 scopus 로고    scopus 로고
    • New molecular targets for antianxiety interventions
    • J.M. Gorman New molecule targets for antianxiety interventions J. Clin. Psychiatry 64 2003 28 35 (Pubitemid 36389869)
    • (2003) Journal of Clinical Psychiatry , vol.64 , Issue.SUPPL. 3 , pp. 28-35
    • Gorman, J.M.1
  • 11
    • 0041488670 scopus 로고    scopus 로고
    • Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans
    • DOI 10.1007/s00213-003-1444-8
    • C. Grillon, J. Cordova, L.R. Levine, and C.A. Morgan III Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans Psychopharmacology 168 2003 446 454 (Pubitemid 36994028)
    • (2003) Psychopharmacology , vol.168 , Issue.4 , pp. 446-454
    • Grillon, C.1    Cordova, J.2    Levine, L.R.3    Morgan III, C.A.4
  • 12
    • 84885480473 scopus 로고    scopus 로고
    • The metabotropic glutamate 2/3 receptor agonist LY379268 induces anxiety-like behavior at the highest dose tested in two rat models of anxiety
    • V. Grivas, A. Markou, and N. Pitsikas The metabotropic glutamate 2/3 receptor agonist LY379268 induces anxiety-like behavior at the highest dose tested in two rat models of anxiety Eur. J. Pharmacol. 715 2013 105 110
    • (2013) Eur. J. Pharmacol. , vol.715 , pp. 105-110
    • Grivas, V.1    Markou, A.2    Pitsikas, N.3
  • 13
    • 8144220483 scopus 로고    scopus 로고
    • Treatment-resistant posttraumatic stress disorder: Strategies for intervention
    • M.B. Hammer, S. Robert, and B.S. Fruech Treatment-resistant posttraumatic stress disorder: strategies for intervention CNS Spectr. 9 2004 740 752
    • (2004) CNS Spectr. , vol.9 , pp. 740-752
    • Hammer, M.B.1    Robert, S.2    Fruech, B.S.3
  • 14
    • 84855532130 scopus 로고    scopus 로고
    • Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: Focus on pharmacology and preclinical translational models
    • B.H. Harvey, and M. Shahid Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: focus on pharmacology and preclinical translational models Pharmacol. Biochem. Behav. 100 2012 775 800
    • (2012) Pharmacol. Biochem. Behav. , vol.100 , pp. 775-800
    • Harvey, B.H.1    Shahid, M.2
  • 15
    • 0036662898 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: Mediation through the Pyk2/Src-family kinase pathway in cortical neurons
    • V. Heidinger, P. Manzerra, Z.Q. Wang, U. Strasser, S.P. Yu, D.W. Choi, and M.M. Behrens Metabotropic glutamate receptor 1-indiuced upregulation of the NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons J. Neurosci. 22 2002 5452 5461 (Pubitemid 35386467)
    • (2002) Journal of Neuroscience , vol.22 , Issue.13 , pp. 5452-5461
    • Heidinger, V.1    Manzerra, P.2    Wang, X.Q.3    Strasser, U.4    Yu, S.-P.5    Choi, D.W.6    Behrens, M.M.7
  • 16
    • 33845745734 scopus 로고    scopus 로고
    • Effects of metabotropic glutamate 2/3 receptor antagonists in the stress-induced hyperthermia test in singly housed mice
    • DOI 10.1007/s00213-006-0618-6
    • M. Iijima, T. Shimazaki, A. Ito, and S. Chaki Effects of metabotropic glutamate 2/3 receptor antagonists in the stress-induced hypothermia test in singly housed mice Psychopharmacology 190 2007 233 239 (Pubitemid 46011183)
    • (2007) Psychopharmacology , vol.190 , Issue.2 , pp. 233-239
    • Iijima, M.1    Shimazaki, T.2    Ito, A.3    Chaki, S.4
  • 17
    • 33747892054 scopus 로고    scopus 로고
    • Effects of the mGluR2/3 agonist LY379268 on ketamine-evoked behaviours and neurochemical changes in the dentate gyrus of the rat
    • DOI 10.1016/j.pbb.2006.05.021, PII S0091305706001663
    • G. Imre, A. Salomons, M. Jongsma, D.S. Fokkema, J.A. Den Boer, and G.J. Ter Horst Effects of the mGluR2/3 agonist LY379268 on ketamine-evoked behaviours and neurochemical changes in the dentate gyrus of the rat Pharmacol. Biochem. Behav. 84 2006 392 399 (Pubitemid 44292240)
    • (2006) Pharmacology Biochemistry and Behavior , vol.84 , Issue.3 , pp. 392-399
    • Imre, G.1    Salomons, A.2    Jongsma, M.3    Fokkema, D.S.4    Den Boer, J.A.5    Ter Horst, G.J.6
  • 19
    • 17744390351 scopus 로고    scopus 로고
    • 2/3 receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: Preliminary results
    • DOI 10.1007/s00213-004-2025-1
    • M. Kellner, C. Muhtz, K. Stark, A. Yassouridis, J. Arlt, and K. Wiedemann Effects of a metabotropic glutamate2/3 receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results Psychopharmacology 179 2005 310 315 (Pubitemid 40576719)
    • (2005) Psychopharmacology , vol.179 , Issue.1 , pp. 310-315
    • Kellner, M.1    Muhtz, C.2    Stark, K.3    Yassouridis, A.4    Arlt, J.5    Wiedemann, K.6
  • 20
  • 21
    • 0038017205 scopus 로고    scopus 로고
    • The mGlu2/3 receptor agonist, LY354740 reduces panic anxiety induced bya CO2 challenge in patients diagnosed with panic disorders
    • L. Levine, B. Gaydos, D. Shehhan, A. Goddard, J. Feighner, W.Z. Potter, and D.D. Schoepp The mGlu2/3 receptor agonist, LY354740 reduces panic anxiety induced bya CO2 challenge in patients diagnosed with panic disorders Neuropharmacology 43 2002 294 295
    • (2002) Neuropharmacology , vol.43 , pp. 294-295
    • Levine, L.1    Gaydos, B.2    Shehhan, D.3    Goddard, A.4    Feighner, J.5    Potter, W.Z.6    Schoepp, D.D.7
  • 22
    • 33846177868 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor targets for neuropsychiatric disorders
    • DOI 10.1016/j.ddstr.2006.10.018, PII S1740677306000842
    • A.M. Linden, and D.D. Schoepp Metabotropic glutamate receptor targets for neuropsychiatric disorders Drug Discov. Today: Ther. Strateg. 3 2006 507 517 (Pubitemid 46076174)
    • (2006) Drug Discovery Today: Therapeutic Strategies , vol.3 , Issue.4 , pp. 507-517
    • Linden, A.-M.1    Schoepp, D.D.2
  • 23
    • 1642266343 scopus 로고    scopus 로고
    • Anxiolytic activity of the MGLU2/3 receptor agonist LY354740 on the elevated plus maze is associated with the suppression of stress-induced c-Fos in the hippocampus and increases in c-Fos induction in several other stress-sensitive brain regions
    • DOI 10.1038/sj.npp.1300321
    • A.M. Linden, S.J. Greene, M. Bergeron, and D.D. Schoepp Anxiolytic activity of the MGLU2/3 receptor agonist LY354740 on the elevated plus maze is associated with the suppression of stress-induced c-Fos in the hippocampus and increases in c-Fos induction in several other stress-sensitive brain regions Neuropsychopharmacology 29 2004 502 513 (Pubitemid 38365926)
    • (2004) Neuropsychopharmacology , vol.29 , Issue.3 , pp. 502-513
    • Linden, A.-M.1    Greene, S.J.2    Bergeron, M.3    Schoepp, D.D.4
  • 25
    • 84893806181 scopus 로고    scopus 로고
    • The neurobiology of anxious states
    • M.J. Millan The neurobiology of anxious states Prog. Neurobiol. 70 83 2003 244
    • (2003) Prog. Neurobiol. , vol.70 , Issue.83 , pp. 244
    • Millan, M.J.1
  • 28
    • 34347241277 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs
    • DOI 10.1016/j.pharmthera.2007.04.007, PII S0163725807000848
    • A. Palucha, and A. Pilc Metabotropic glutamate receptors ligands as possible anxiolytic and antidepressant drugs Pharmacol. Ther. 115 2007 116 147 (Pubitemid 46992810)
    • (2007) Pharmacology and Therapeutics , vol.115 , Issue.1 , pp. 116-147
    • Palucha, A.1    Pilc, A.2
  • 29
    • 0019957859 scopus 로고
    • Treatment of anxiety using fenobam (a nonbenzodiazepine) in a double-blind standard (diazepam) placebo-controlled study
    • J.C. Pecknold, D.J. McClure, L. Appeltauer, L. Wrzesinski, and T.J. Allan Treatment of anxiety with fenobam (a nonbenzodiazepine) in a double-blind standard (diazepam) placebo-controlled study Clin. Psychopharmacol. 2 1982 129 133 (Pubitemid 12025672)
    • (1982) Journal of Clinical Psychopharmacology , vol.2 , Issue.2 , pp. 129-133
    • Pecknold, J.C.1    McClure, D.J.2    Appeltauer, L.3
  • 30
    • 44949104175 scopus 로고    scopus 로고
    • Presynaptic glutamate receptors: Physiological functions and mechanisms of action
    • P.S. Pinheiro, and C. Mulle Presynaptic glutamate receptors: physiological functions and mechanisms of action Nat. Rev. Neurosci. 9 2008 423 436
    • (2008) Nat. Rev. Neurosci. , vol.9 , pp. 423-436
    • Pinheiro, P.S.1    Mulle, C.2
  • 32
    • 48049095987 scopus 로고    scopus 로고
    • Pharmacological effects of the metabotropic glutamate receptor 1 antagonist compared with those of the metabotropic
    • Glutamate receptor 5 antagonist and metabotropic glutamate receptor 2/3 agonists in rodents: Detailed investigations with a selective allosteric metabotropic glutamate receptor 1 antagonist FTIDC [4-[1-(2-Fluoropyridine-3-yl) -5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H) -carboxamide]
    • A. Satow, S. Maehara, S. Ise, H. Hikichi, M. Fukushima, G. Suzuki, T. Kimura, T. Tanaka, S. Ito, H. Kawamoto, and H. Ohta Pharmacological effects of the metabotropic glutamate receptor 1 antagonist compared with those of the metabotropic glutamate receptor 5 antagonist and metabotropic glutamate receptor 2/3 agonists in rodents: detailed investigations with a selective allosteric metabotropic glutamate receptor 1 antagonist FTIDC [4-[1-(2-Fluoropyridine-3-yl) -5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H) -carboxamide] J. Pharmacol. Exp. Ther. 326 2008 577 586
    • (2008) J. Pharmacol. Exp. Ther. , vol.326 , pp. 577-586
    • Satow, A.1    Maehara, S.2    Ise, S.3    Hikichi, H.4    Fukushima, M.5    Suzuki, G.6    Kimura, T.7    Tanaka, T.8    Ito, S.9    Kawamoto, H.10    Ohta, H.11
  • 33
    • 0034811597 scopus 로고    scopus 로고
    • Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system
    • D.D. Schoepp Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system J. Pharmacol. Exp. Ther. 200 2001 12 20 (Pubitemid 32905113)
    • (2001) Journal of Pharmacology and Experimental Therapeutics , vol.299 , Issue.1 , pp. 12-20
    • Schoepp, D.D.1
  • 34
    • 0011900802 scopus 로고    scopus 로고
    • Preclinical pharmacology of mGlu2/3 receptor agonists: Novel agents for schizophrenia?
    • D.D. Schoepp, and G.J. Marek Preclinical pharmacology of mGlu2/3 receptor agonists: novel agents for schizophrenia? Curr. Drug Targets CNS Neurol. Disord. 1 2002 215 225
    • (2002) Curr. Drug Targets CNS Neurol. Disord. , vol.1 , pp. 215-225
    • Schoepp, D.D.1    Marek, G.J.2
  • 35
    • 0002897958 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors - Immunocytochemical and in situ hybridization analysis
    • O.P. Ottersen, J Storm-Mathisen, Elsevier Science Amsterdam
    • R. Shigemoto, and N. Mizuno Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analysis O.P. Ottersen, J Storm-Mathisen, Handbook of Chemical Neuroanatomy 2000 Elsevier Science Amsterdam 63 98
    • (2000) Handbook of Chemical Neuroanatomy , pp. 63-98
    • Shigemoto, R.1    Mizuno, N.2
  • 36
    • 4644372048 scopus 로고    scopus 로고
    • Anxiolytic-like activity of MSG0039, a potent group II metabotropic glutamate receptor antagonist, in a marble-burying behaviour test
    • S. Shimazaki, M. Iijima, and S. Chaki Anxiolytic-like activity of MSG0039, a potent group II metabotropic glutamate receptor antagonist, in a marble-burying behaviour test Eur. J. Pharmacol. 501 2004 21 125
    • (2004) Eur. J. Pharmacol. , vol.501 , pp. 21-125
    • Shimazaki, S.1    Iijima, M.2    Chaki, S.3
  • 39
    • 8144223698 scopus 로고    scopus 로고
    • Optimizing treatment in social phobia: A review of treatment resistance
    • M. Van Ameringen, C. Mancini, B. Pipe, and M. Bennett Optimizing treatment in social phobia: a review of treatment resistance CNS Spectr. 9 2004 753 762 (Pubitemid 39473445)
    • (2004) CNS Spectrums , vol.9 , Issue.10 , pp. 753-762
    • Van Ameringen, M.1    Mancini, C.2    Pipe, B.3    Bennett, M.4
  • 40
    • 20944438126 scopus 로고    scopus 로고
    • The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: A comparison of efficacy and side-effect profiles
    • DOI 10.1007/s00213-005-2143-4
    • G.B. Varty, M. Grilli, A. Forlani, S. Freduzzi, M.E. Grzelak, D.H. Guthrie, R.A. Hodgson, S.X. Lu, E. Nicolussi, A.J. Pond, E.M. Parker, J.C. Hunter, G.A. Higgins, A. Regianni, and R. Bertorelli The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist LY456236, in rodents: a comparison of efficacy and side-effects profiles Psychopharmacology 179 2005 207 217 (Pubitemid 40576708)
    • (2005) Psychopharmacology , vol.179 , Issue.1 , pp. 207-217
    • Varty, G.B.1    Grilli, M.2    Forlani, A.3    Fredduzzi, S.4    Grzelak, M.E.5    Guthrie, D.H.6    Hodgson, R.A.7    Lu, S.X.8    Nicolussi, E.9    Pond, A.J.10    Parker, E.M.11    Hunter, J.C.12    Higgins, G.A.13    Reggiani, A.14    Bertorelli, R.15
  • 41
    • 64949091023 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors in the tripartite synapse as a target for new psychotropic drugs
    • J.M. Wieronska, and A. Pilc Metabotropic glutamate receptors in the tripartite synapse as a target for new psychotropic drugs Neurochem. Int. 55 2009 85 97
    • (2009) Neurochem. Int. , vol.55 , pp. 85-97
    • Wieronska, J.M.1    Pilc, A.2
  • 42
    • 80054098333 scopus 로고    scopus 로고
    • On the mechanism of anti-hyperthermic effects of LY379268 and LY487379 group II mGlu receptor activators, in the stress-induced hypothermia in singly housed mice
    • J.M. Wieronska, K. Stanchowicz, P. Branski, A. Patucha-Poniewiera, and A. Pilc On the mechanism of anti-hyperthermic effects of LY379268 and LY487379 group II mGlu receptor activators, in the stress-induced hypothermia in singly housed mice Neuropharmacology 62 2012 322 331
    • (2012) Neuropharmacology , vol.62 , pp. 322-331
    • Wieronska, J.M.1    Stanchowicz, K.2    Branski, P.3    Patucha-Poniewiera, A.4    Pilc, A.5


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