-
1
-
-
0030763857
-
Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning
-
1:CAS:528:DyaK2sXkvFCht74%3D 9241280 10.1038/ng0897-391
-
Yoshizawa T, Handa Y, Uematsu Y, Takeda S, Sekine K, Yoshihara Y, Kawakami T, Arioka K, Sato H, Uchiyama Y, Masushige S, Fukamizu A, Matsumoto T, Kato S (1997) Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet 16:391-396
-
(1997)
Nat Genet
, vol.16
, pp. 391-396
-
-
Yoshizawa, T.1
Handa, Y.2
Uematsu, Y.3
Takeda, S.4
Sekine, K.5
Yoshihara, Y.6
Kawakami, T.7
Arioka, K.8
Sato, H.9
Uchiyama, Y.10
Masushige, S.11
Fukamizu, A.12
Matsumoto, T.13
Kato, S.14
-
2
-
-
0030610422
-
Targeted ablation of the vitamin D receptor: An animal model of vitamin D-dependent rickets type II with alopecia
-
1:CAS:528:DyaK2sXlvVWls7Y%3D 9275211 10.1073/pnas.94.18.9831
-
Li YC, Pirro AE, Amling M, Delling G, Baron R, Bronson R, Demay MB (1997) Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci USA 94:9831-9835
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 9831-9835
-
-
Li, Y.C.1
Pirro, A.E.2
Amling, M.3
Delling, G.4
Baron, R.5
Bronson, R.6
Demay, M.B.7
-
3
-
-
0035818538
-
Duodenal calcium absorption in vitamin D receptor-knockout mice: Functional and molecular aspects
-
11687634 10.1073/pnas.231474698
-
Van Cromphaut SJ, Dewerchin M, Hoenderop JG, Stockmans I, Van Herck E, Kato S, Bindels RJ, Collen D, Carmeliet P, Bouillon R, Carmeliet G (2001) Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc Natl Acad Sci USA 98:13324-13329
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13324-13329
-
-
Van Cromphaut, S.J.1
Dewerchin, M.2
Hoenderop, J.G.3
Stockmans, I.4
Van Herck, E.5
Kato, S.6
Bindels, R.J.7
Collen, D.8
Carmeliet, P.9
Bouillon, R.10
Carmeliet, G.11
-
4
-
-
85047685376
-
Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D
-
1:CAS:528:DC%2BD38XlsVGitbg%3D 12089348
-
Erben RG, Soegiarto DW, Weber K, Zeitz U, Lieberherr M, Gniadecki R, Moller G, Adamski J, Balling R (2002) Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D. Mol Endocrinol 16:1524-1537
-
(2002)
Mol Endocrinol
, vol.16
, pp. 1524-1537
-
-
Erben, R.G.1
Soegiarto, D.W.2
Weber, K.3
Zeitz, U.4
Lieberherr, M.5
Gniadecki, R.6
Moller, G.7
Adamski, J.8
Balling, R.9
-
5
-
-
0034984919
-
Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets
-
1:CAS:528:DC%2BD3MXkslelt7g%3D 11416036
-
Dardenne O, Prud'homme J, Arabian A, Glorieux FH, St-Arnaud R (2001) Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets. Endocrinology 142:3135-3141
-
(2001)
Endocrinology
, vol.142
, pp. 3135-3141
-
-
Dardenne, O.1
Prud'Homme, J.2
Arabian, A.3
Glorieux, F.H.4
St-Arnaud, R.5
-
6
-
-
0035912707
-
Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: Evidence for skeletal, reproductive, and immune dysfunction
-
1:CAS:528:DC%2BD3MXkslWlsrY%3D 11416220 10.1073/pnas.131029498
-
Panda DK, Miao D, Tremblay ML, Sirois J, Farookhi R, Hendy GN, Goltzman D (2001) Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. Proc Natl Acad Sci USA 98:7498-7503
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 7498-7503
-
-
Panda, D.K.1
Miao, D.2
Tremblay, M.L.3
Sirois, J.4
Farookhi, R.5
Hendy, G.N.6
Goltzman, D.7
-
7
-
-
33845309125
-
Vitamin D resistance
-
1:CAS:528:DC%2BD28Xht12ksb%2FM 17161336 10.1016/j.beem.2006.09.008
-
Bouillon R, Verstuyf A, Mathieu C, Van Cromphaut S, Masuyama R, Dehaes P, Carmeliet G (2006) Vitamin D resistance. Best Pract Res Clin Endocrinol Metab 20:627-645
-
(2006)
Best Pract Res Clin Endocrinol Metab
, vol.20
, pp. 627-645
-
-
Bouillon, R.1
Verstuyf, A.2
Mathieu, C.3
Van Cromphaut, S.4
Masuyama, R.5
Dehaes, P.6
Carmeliet, G.7
-
8
-
-
78650705554
-
Molecular mechanisms for regulation of intestinal calcium absorption by vitamin D and other factors
-
1:CAS:528:DC%2BC3cXhs1Srt7vJ 3235806 21182397 10.3109/10408363.2010. 536429
-
Fleet JC, Schoch RD (2010) Molecular mechanisms for regulation of intestinal calcium absorption by vitamin D and other factors. Crit Rev Clin Lab Sci 47:181-195
-
(2010)
Crit Rev Clin Lab Sci
, vol.47
, pp. 181-195
-
-
Fleet, J.C.1
Schoch, R.D.2
-
9
-
-
18744366041
-
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts
-
1:CAS:528:DC%2BD38XpslClsL8%3D 12479813 10.1016/S1534-5807(02)00369-6
-
Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J, Wagner EF, Mak TW, Kodama T, Taniguchi T (2002) Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 3:889-901
-
(2002)
Dev Cell
, vol.3
, pp. 889-901
-
-
Takayanagi, H.1
Kim, S.2
Koga, T.3
Nishina, H.4
Isshiki, M.5
Yoshida, H.6
Saiura, A.7
Isobe, M.8
Yokochi, T.9
Inoue, J.10
Wagner, E.F.11
Mak, T.W.12
Kodama, T.13
Taniguchi, T.14
-
10
-
-
23844515714
-
NFAT and osterix cooperatively regulate bone formation
-
1:CAS:528:DC%2BD2MXmvFemsL0%3D 16041384 10.1038/nm1270
-
Koga T, Matsui Y, Asagiri M, Kodama T, de Crombrugghe B, Nakashima K, Takayanagi H (2005) NFAT and osterix cooperatively regulate bone formation. Nat Med 11:880-885
-
(2005)
Nat Med
, vol.11
, pp. 880-885
-
-
Koga, T.1
Matsui, Y.2
Asagiri, M.3
Kodama, T.4
De Crombrugghe, B.5
Nakashima, K.6
Takayanagi, H.7
-
11
-
-
33845539490
-
Regulation of osteoclast differentiation and function by the CaMK-CREB pathway
-
1:CAS:528:DC%2BD28Xht1OntbnE 17128269 10.1038/nm1515
-
Sato K, Suematsu A, Nakashima T, Takemoto-Kimura S, Aoki K, Morishita Y, Asahara H, Ohya K, Yamaguchi A, Takai T, Kodama T, Chatila TA, Bito H, Takayanagi H (2006) Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med 12:1410-1416
-
(2006)
Nat Med
, vol.12
, pp. 1410-1416
-
-
Sato, K.1
Suematsu, A.2
Nakashima, T.3
Takemoto-Kimura, S.4
Aoki, K.5
Morishita, Y.6
Asahara, H.7
Ohya, K.8
Yamaguchi, A.9
Takai, T.10
Kodama, T.11
Chatila, T.A.12
Bito, H.13
Takayanagi, H.14
-
12
-
-
14044249546
-
Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts
-
1:CAS:528:DC%2BD2MXhvFKhsrw%3D 15695591 10.1073/pnas.0406874102
-
Komarova SV, Pereverzev A, Shum JW, Sims SM, Dixon SJ (2005) Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. Proc Natl Acad Sci USA 102:2643-2648
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 2643-2648
-
-
Komarova, S.V.1
Pereverzev, A.2
Shum, J.W.3
Sims, S.M.4
Dixon, S.J.5
-
13
-
-
80052229506
-
Calcemic actions of vitamin D: Effects on the intestine, kidney and bone
-
1:CAS:528:DC%2BC3MXhtFSru7jO 21872798 10.1016/j.beem.2011.05.008
-
Lieben L, Carmeliet G, Masuyama R (2011) Calcemic actions of vitamin D: effects on the intestine, kidney and bone. Best Pract Res Clin Endocrinol Metab 25:561-572
-
(2011)
Best Pract Res Clin Endocrinol Metab
, vol.25
, pp. 561-572
-
-
Lieben, L.1
Carmeliet, G.2
Masuyama, R.3
-
14
-
-
28444440235
-
2+ channel TRPV5 is essential for proper osteoclastic bone resorption
-
16291808 10.1073/pnas.0505789102
-
2+ channel TRPV5 is essential for proper osteoclastic bone resorption. Proc Natl Acad Sci USA 102:17507-17512
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17507-17512
-
-
Van Der Eerden, B.C.1
Hoenderop, J.G.2
De Vries, T.J.3
Schoenmaker, T.4
Buurman, C.J.5
Uitterlinden, A.G.6
Pols, H.A.7
Bindels, R.J.8
Van Leeuwen, J.P.9
-
15
-
-
62949178699
-
Intestinal vitamin D receptor is required for normal calcium and bone metabolism in mice
-
e1311-1312
-
Xue Y, Fleet JC (2009) Intestinal vitamin D receptor is required for normal calcium and bone metabolism in mice. Gastroenterology 136:1317-1327, e1311-1312
-
(2009)
Gastroenterology
, vol.136
, pp. 1317-1327
-
-
Xue, Y.1
Fleet, J.C.2
-
16
-
-
84866705387
-
Villin promoter-mediated transgenic expression of transient receptor potential cation channel, subfamily V, member 6 (TRPV6) increases intestinal calcium absorption in wild-type and vitamin D receptor knockout mice
-
1:CAS:528:DC%2BC38XhtlKjt7%2FM 3430830 22589201 10.1002/jbmr.1662
-
Cui M, Li Q, Johnson R, Fleet JC (2012) Villin promoter-mediated transgenic expression of transient receptor potential cation channel, subfamily V, member 6 (TRPV6) increases intestinal calcium absorption in wild-type and vitamin D receptor knockout mice. J Bone Miner Res 27:2097-2107
-
(2012)
J Bone Miner Res
, vol.27
, pp. 2097-2107
-
-
Cui, M.1
Li, Q.2
Johnson, R.3
Fleet, J.C.4
-
17
-
-
0022462199
-
Long-term nocturnal calcium infusions can cure rickets and promote normal mineralization in hereditary resistance to 1,25-dihydroxyvitamin D
-
1:STN:280:DyaL287ps1Ohtw%3D%3D 424571 3009551 10.1172/JCI112483
-
Balsan S, Garabedian M, Larchet M, Gorski AM, Cournot G, Tau C, Bourdeau A, Silve C, Ricour C (1986) Long-term nocturnal calcium infusions can cure rickets and promote normal mineralization in hereditary resistance to 1,25-dihydroxyvitamin D. J Clin Invest 77:1661-1667
-
(1986)
J Clin Invest
, vol.77
, pp. 1661-1667
-
-
Balsan, S.1
Garabedian, M.2
Larchet, M.3
Gorski, A.M.4
Cournot, G.5
Tau, C.6
Bourdeau, A.7
Silve, C.8
Ricour, C.9
-
18
-
-
0032780531
-
The vitamin D receptor and the syndrome of hereditary 1,25-dihydroxyvitamin D-resistant rickets
-
1:CAS:528:DyaK1MXisFygsrg%3D 10204116
-
Malloy PJ, Pike JW, Feldman D (1999) The vitamin D receptor and the syndrome of hereditary 1,25-dihydroxyvitamin D-resistant rickets. Endocr Rev 20:156-188
-
(1999)
Endocr Rev
, vol.20
, pp. 156-188
-
-
Malloy, P.J.1
Pike, J.W.2
Feldman, D.3
-
19
-
-
0000524953
-
Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice
-
1:CAS:528:DyaK1cXmsVGms7Y%3D 9751523
-
Li YC, Amling M, Pirro AE, Priemel M, Meuse J, Baron R, Delling G, Demay MB (1998) Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology 139:4391-4396
-
(1998)
Endocrinology
, vol.139
, pp. 4391-4396
-
-
Li, Y.C.1
Amling, M.2
Pirro, A.E.3
Priemel, M.4
Meuse, J.5
Baron, R.6
Delling, G.7
Demay, M.B.8
-
20
-
-
0035115164
-
Dietary phosphorus restriction reverses the impaired bone mineralization in vitamin D receptor knockout mice
-
1:CAS:528:DC%2BD3MXltFWntw%3D%3D 11145614
-
Masuyama R, Nakaya Y, Tanaka S, Tsurukami H, Nakamura T, Watanabe S, Yoshizawa T, Kato S, Suzuki K (2001) Dietary phosphorus restriction reverses the impaired bone mineralization in vitamin D receptor knockout mice. Endocrinology 142:494-497
-
(2001)
Endocrinology
, vol.142
, pp. 494-497
-
-
Masuyama, R.1
Nakaya, Y.2
Tanaka, S.3
Tsurukami, H.4
Nakamura, T.5
Watanabe, S.6
Yoshizawa, T.7
Kato, S.8
Suzuki, K.9
-
21
-
-
10744224186
-
Dietary calcium and phosphorus ratio regulates bone mineralization and turnover in vitamin D receptor knockout mice by affecting intestinal calcium and phosphorus absorption
-
1:CAS:528:DC%2BD3sXlsFGktLw%3D 12854831 10.1359/jbmr.2003.18.7.1217
-
Masuyama R, Nakaya Y, Katsumata S, Kajita Y, Uehara M, Tanaka S, Sakai A, Kato S, Nakamura T, Suzuki K (2003) Dietary calcium and phosphorus ratio regulates bone mineralization and turnover in vitamin D receptor knockout mice by affecting intestinal calcium and phosphorus absorption. J Bone Miner Res 18:1217-1226
-
(2003)
J Bone Miner Res
, vol.18
, pp. 1217-1226
-
-
Masuyama, R.1
Nakaya, Y.2
Katsumata, S.3
Kajita, Y.4
Uehara, M.5
Tanaka, S.6
Sakai, A.7
Kato, S.8
Nakamura, T.9
Suzuki, K.10
-
22
-
-
84860585876
-
Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization
-
1:CAS:528:DC%2BC38Xmsl2js7k%3D 3336970 22523068 10.1172/JCI45890
-
Lieben L, Masuyama R, Torrekens S, Van Looveren R, Schrooten J, Baatsen P, Lafage-Proust MH, Dresselaers T, Feng JQ, Bonewald LF, Meyer MB, Pike JW, Bouillon R, Carmeliet G (2012) Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization. J Clin Invest 122:1803-1815
-
(2012)
J Clin Invest
, vol.122
, pp. 1803-1815
-
-
Lieben, L.1
Masuyama, R.2
Torrekens, S.3
Van Looveren, R.4
Schrooten, J.5
Baatsen, P.6
Lafage-Proust, M.H.7
Dresselaers, T.8
Feng, J.Q.9
Bonewald, L.F.10
Meyer, M.B.11
Pike, J.W.12
Bouillon, R.13
Carmeliet, G.14
-
23
-
-
0030684749
-
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
-
1:CAS:528:DyaK2sXjs1ejtr4%3D 9182763 10.1016/S0092-8674(00)80258-5
-
Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755-764
-
(1997)
Cell
, vol.89
, pp. 755-764
-
-
Komori, T.1
Yagi, H.2
Nomura, S.3
Yamaguchi, A.4
Sasaki, K.5
Deguchi, K.6
Shimizu, Y.7
Bronson, R.T.8
Gao, Y.H.9
Inada, M.10
Sato, M.11
Okamoto, R.12
Kitamura, Y.13
Yoshiki, S.14
Kishimoto, T.15
-
24
-
-
0037340051
-
Parathyroid hormone bone anabolic action requires Cbfa1/Runx2-dependent signaling
-
1:CAS:528:DC%2BD3sXitlOiur8%3D 12554794 10.1210/me.2002-0225
-
Krishnan V, Moore TL, Ma YL, Helvering LM, Frolik CA, Valasek KM, Ducy P, Geiser AG (2003) Parathyroid hormone bone anabolic action requires Cbfa1/Runx2-dependent signaling. Mol Endocrinol 17:423-435
-
(2003)
Mol Endocrinol
, vol.17
, pp. 423-435
-
-
Krishnan, V.1
Moore, T.L.2
Ma, Y.L.3
Helvering, L.M.4
Frolik, C.A.5
Valasek, K.M.6
Ducy, P.7
Geiser, A.G.8
-
25
-
-
57149120511
-
Modulation of mouse RANKL gene expression by Runx2 and vitamin D3
-
1:CAS:528:DC%2BD1cXhsFWgt7%2FJ 18814144 10.1002/jcb.21929
-
Kitazawa R, Mori K, Yamaguchi A, Kondo T, Kitazawa S (2008) Modulation of mouse RANKL gene expression by Runx2 and vitamin D3. J Cell Biochem 105:1289-1297
-
(2008)
J Cell Biochem
, vol.105
, pp. 1289-1297
-
-
Kitazawa, R.1
Mori, K.2
Yamaguchi, A.3
Kondo, T.4
Kitazawa, S.5
-
26
-
-
0038754646
-
Stimulation of osteoclast formation by 1,25-dihydroxyvitamin D requires its binding to vitamin D receptor (VDR) in osteoblastic cells: Studies using VDR knockout mice
-
1:CAS:528:DyaK1MXntl2lug%3D%3D 9927335
-
Takeda S, Yoshizawa T, Nagai Y, Yamato H, Fukumoto S, Sekine K, Kato S, Matsumoto T, Fujita T (1999) Stimulation of osteoclast formation by 1,25-dihydroxyvitamin D requires its binding to vitamin D receptor (VDR) in osteoblastic cells: studies using VDR knockout mice. Endocrinology 140:1005-1008
-
(1999)
Endocrinology
, vol.140
, pp. 1005-1008
-
-
Takeda, S.1
Yoshizawa, T.2
Nagai, Y.3
Yamato, H.4
Fukumoto, S.5
Sekine, K.6
Kato, S.7
Matsumoto, T.8
Fujita, T.9
-
27
-
-
0033303655
-
Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: Formal histomorphometric and biomechanical analyses
-
1:CAS:528:DyaK1MXmvFemsLY%3D 10537122
-
Amling M, Priemel M, Holzmann T, Chapin K, Rueger JM, Baron R, Demay MB (1999) Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology 140:4982-4987
-
(1999)
Endocrinology
, vol.140
, pp. 4982-4987
-
-
Amling, M.1
Priemel, M.2
Holzmann, T.3
Chapin, K.4
Rueger, J.M.5
Baron, R.6
Demay, M.B.7
-
28
-
-
0037384951
-
Correction of the abnormal mineral ion homeostasis with a high-calcium, high-phosphorus, high-lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1)
-
1:CAS:528:DC%2BD3sXislenu7Y%3D 12689675 10.1016/S8756-3282(03)00023-1
-
Dardenne O, Prud'homme J, Hacking SA, Glorieux FH, St-Arnaud R (2003) Correction of the abnormal mineral ion homeostasis with a high-calcium, high-phosphorus, high-lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1). Bone 32:332-340
-
(2003)
Bone
, vol.32
, pp. 332-340
-
-
Dardenne, O.1
Prud'Homme, J.2
Hacking, S.A.3
Glorieux, F.H.4
St-Arnaud, R.5
-
29
-
-
1942469303
-
Inactivation of the 25-hydroxyvitamin D 1α-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis
-
1:CAS:528:DC%2BD2cXivF2qu7k%3D 14739296 10.1074/jbc.M310271200
-
Panda DK, Miao D, Bolivar I, Li J, Huo R, Hendy GN, Goltzman D (2004) Inactivation of the 25-hydroxyvitamin D 1α-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis. J Biol Chem 279:16754-16766
-
(2004)
J Biol Chem
, vol.279
, pp. 16754-16766
-
-
Panda, D.K.1
Miao, D.2
Bolivar, I.3
Li, J.4
Huo, R.5
Hendy, G.N.6
Goltzman, D.7
-
30
-
-
67649877960
-
Hyperparathyroidism
-
1:CAS:528:DC%2BD1MXotl2ks7k%3D 19595349 10.1016/S0140-6736(09)60507-9
-
Fraser WD (2009) Hyperparathyroidism. Lancet 374:145-158
-
(2009)
Lancet
, vol.374
, pp. 145-158
-
-
Fraser, W.D.1
-
31
-
-
33747792713
-
Parathyroid hormone controls receptor activator of NF-κB ligand gene expression via a distant transcriptional enhancer
-
1:CAS:528:DC%2BD28XovFyhu7s%3D 1592840 16914731 10.1128/MCB.00356-06
-
Fu Q, Manolagas SC, O'Brien CA (2006) Parathyroid hormone controls receptor activator of NF-κB ligand gene expression via a distant transcriptional enhancer. Mol Cell Biol 26:6453-6468
-
(2006)
Mol Cell Biol
, vol.26
, pp. 6453-6468
-
-
Fu, Q.1
Manolagas, S.C.2
O'Brien, C.A.3
-
32
-
-
33747787316
-
Activation of receptor activator of NF-kappaB ligand gene expression by 1,25-dihydroxyvitamin D3 is mediated through multiple long-range enhancers
-
1:CAS:528:DC%2BD28XovFyhu7g%3D 1592822 16914732 10.1128/MCB.00353-06
-
Kim S, Yamazaki M, Zella LA, Shevde NK, Pike JW (2006) Activation of receptor activator of NF-kappaB ligand gene expression by 1,25-dihydroxyvitamin D3 is mediated through multiple long-range enhancers. Mol Cell Biol 26:6469-6486
-
(2006)
Mol Cell Biol
, vol.26
, pp. 6469-6486
-
-
Kim, S.1
Yamazaki, M.2
Zella, L.A.3
Shevde, N.K.4
Pike, J.W.5
-
33
-
-
37549006425
-
Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass
-
1:CAS:528:DC%2BD1cXjtVyhtQ%3D%3D 17932217 10.1210/en.2007-0734
-
Galli C, Zella LA, Fretz JA, Fu Q, Pike JW, Weinstein RS, Manolagas SC, O'Brien CA (2008) Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass. Endocrinology 149:146-153
-
(2008)
Endocrinology
, vol.149
, pp. 146-153
-
-
Galli, C.1
Zella, L.A.2
Fretz, J.A.3
Fu, Q.4
Pike, J.W.5
Weinstein, R.S.6
Manolagas, S.C.7
O'Brien, C.A.8
-
34
-
-
84874593853
-
Vitamin D receptor in osteoblasts is a negative regulator of bone mass control
-
1:CAS:528:DC%2BC3sXjsF2rsb4%3D 23389957 10.1210/en.2012-1542
-
Yamamoto Y, Yoshizawa T, Fukuda T, Shirode-Fukuda Y, Yu T, et al (2013) Vitamin D receptor in osteoblasts is a negative regulator of bone mass control. Endocrinology 154:1008-1020
-
(2013)
Endocrinology
, vol.154
, pp. 1008-1020
-
-
Yamamoto, Y.1
Yoshizawa, T.2
Fukuda, T.3
Shirode-Fukuda, Y.4
Yu, T.5
-
35
-
-
0033810453
-
Increased formation and decreased resorption of bone in mice with elevated vitamin D receptor in mature cells of the osteoblastic lineage
-
1:CAS:528:DC%2BD3MXhtF2rs7c%3D 11023975 10.1096/fj.99-1075com
-
Gardiner EM, Baldock PA, Thomas GP, Sims NA, Henderson NK, Hollis B, White CP, Sunn KL, Morrison NA, Walsh WR, Eisman JA (2000) Increased formation and decreased resorption of bone in mice with elevated vitamin D receptor in mature cells of the osteoblastic lineage. FASEB J 14:1908-1916
-
(2000)
FASEB J
, vol.14
, pp. 1908-1916
-
-
Gardiner, E.M.1
Baldock, P.A.2
Thomas, G.P.3
Sims, N.A.4
Henderson, N.K.5
Hollis, B.6
White, C.P.7
Sunn, K.L.8
Morrison, N.A.9
Walsh, W.R.10
Eisman, J.A.11
-
36
-
-
33749237867
-
Vitamin D action and regulation of bone remodeling: Suppression of osteoclastogenesis by the mature osteoblast
-
1:CAS:528:DC%2BD28XhtFekt7zL 16995817 10.1359/jbmr.060714
-
Baldock PA, Thomas GP, Hodge JM, Baker SU, Dressel U, O'Loughlin PD, Nicholson GC, Briffa KH, Eisman JA, Gardiner EM (2006) Vitamin D action and regulation of bone remodeling: suppression of osteoclastogenesis by the mature osteoblast. J Bone Miner Res 21:1618-1626
-
(2006)
J Bone Miner Res
, vol.21
, pp. 1618-1626
-
-
Baldock, P.A.1
Thomas, G.P.2
Hodge, J.M.3
Baker, S.U.4
Dressel, U.5
O'Loughlin, P.D.6
Nicholson, G.C.7
Briffa, K.H.8
Eisman, J.A.9
Gardiner, E.M.10
-
37
-
-
21644452584
-
Osteoblasts lacking the vitamin D receptor display enhanced osteogenic potential in vitro
-
1:CAS:528:DC%2BD2MXmvFCl 15517598 10.1002/jcb.20313
-
Sooy K, Sabbagh Y, Demay MB (2005) Osteoblasts lacking the vitamin D receptor display enhanced osteogenic potential in vitro. J Cell Biochem 94:81-87
-
(2005)
J Cell Biochem
, vol.94
, pp. 81-87
-
-
Sooy, K.1
Sabbagh, Y.2
Demay, M.B.3
-
38
-
-
0038125598
-
Calcium signalling: Dynamics, homeostasis and remodelling
-
1:CAS:528:DC%2BD3sXltVWmsr8%3D 12838335 10.1038/nrm1155
-
Berridge MJ, Bootman MD, Roderick HL (2003) Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 4:517-529
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 517-529
-
-
Berridge, M.J.1
Bootman, M.D.2
Roderick, H.L.3
-
39
-
-
0043267987
-
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
-
1:CAS:528:DC%2BD3sXls1aqsbs%3D 12879072 10.1038/nature01807
-
Watanabe H, Vriens J, Prenen J, Droogmans G, Voets T, Nilius B (2003) Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature 424:434-438
-
(2003)
Nature
, vol.424
, pp. 434-438
-
-
Watanabe, H.1
Vriens, J.2
Prenen, J.3
Droogmans, G.4
Voets, T.5
Nilius, B.6
-
40
-
-
0347719316
-
Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4
-
1:CAS:528:DC%2BD2cXjvFaksQ%3D%3D 14691263 10.1073/pnas.0303329101
-
Vriens J, Watanabe H, Janssens A, Droogmans G, Voets T, Nilius B (2004) Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Proc Natl Acad Sci USA 101:396-401
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 396-401
-
-
Vriens, J.1
Watanabe, H.2
Janssens, A.3
Droogmans, G.4
Voets, T.5
Nilius, B.6
-
41
-
-
27644497526
-
Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium
-
1:CAS:528:DC%2BD2MXhtFCitr%2FE 16179585 10.1161/01.RES.0000187474.47805. 30
-
Vriens J, Owsianik G, Fisslthaler B, Suzuki M, Janssens A, Voets T, Morisseau C, Hammock BD, Fleming I, Busse R, Nilius B (2005) Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium. Circ Res 97:908-915
-
(2005)
Circ Res
, vol.97
, pp. 908-915
-
-
Vriens, J.1
Owsianik, G.2
Fisslthaler, B.3
Suzuki, M.4
Janssens, A.5
Voets, T.6
Morisseau, C.7
Hammock, B.D.8
Fleming, I.9
Busse, R.10
Nilius, B.11
-
42
-
-
0038604287
-
Impaired pressure sensation in mice lacking TRPV4
-
1:CAS:528:DC%2BD3sXksF2it7s%3D 12692122 10.1074/jbc.M302561200
-
Suzuki M, Mizuno A, Kodaira K, Imai M (2003) Impaired pressure sensation in mice lacking TRPV4. J Biol Chem 278:22664-22668
-
(2003)
J Biol Chem
, vol.278
, pp. 22664-22668
-
-
Suzuki, M.1
Mizuno, A.2
Kodaira, K.3
Imai, M.4
-
43
-
-
48349103354
-
Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia
-
1:CAS:528:DC%2BD1cXptVKku7g%3D 3525077 18587396 10.1038/ng.166
-
Rock MJ, Prenen J, Funari VA, Funari TL, Merriman B, Nelson SF, Lachman RS, Wilcox WR, Reyno S, Quadrelli R, Vaglio A, Owsianik G, Janssens A, Voets T, Ikegawa S, Nagai T, Rimoin DL, Nilius B, Cohn DH (2008) Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia. Nat Genet 40:999-1003
-
(2008)
Nat Genet
, vol.40
, pp. 999-1003
-
-
Rock, M.J.1
Prenen, J.2
Funari, V.A.3
Funari, T.L.4
Merriman, B.5
Nelson, S.F.6
Lachman, R.S.7
Wilcox, W.R.8
Reyno, S.9
Quadrelli, R.10
Vaglio, A.11
Owsianik, G.12
Janssens, A.13
Voets, T.14
Ikegawa, S.15
Nagai, T.16
Rimoin, D.L.17
Nilius, B.18
Cohn, D.H.19
-
44
-
-
77952748007
-
Novel and recurrent TRPV4 mutations and their association with distinct phenotypes within the TRPV4 dysplasia family
-
Dai J, Kim OH, Cho TJ, Schmidt-Rimpler M, Tonoki H, et al (2010) Novel and recurrent TRPV4 mutations and their association with distinct phenotypes within the TRPV4 dysplasia family. J Med Genet 47:704-709
-
(2010)
J Med Genet
, vol.47
, pp. 704-709
-
-
Dai, J.1
Kim, O.H.2
Cho, T.J.3
Schmidt-Rimpler, M.4
Tonoki, H.5
-
45
-
-
75749129360
-
Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C
-
1:CAS:528:DC%2BD1MXhs1SktbvL 3272392 20037588 10.1038/ng.508
-
Auer-Grumbach M, Olschewski A, Papic L, Kremer H, McEntagart ME, et al (2010) Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C. Nat Genet 42:160-164
-
(2010)
Nat Genet
, vol.42
, pp. 160-164
-
-
Auer-Grumbach, M.1
Olschewski, A.2
Papic, L.3
Kremer, H.4
McEntagart, M.E.5
-
46
-
-
75749083221
-
Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4
-
1:CAS:528:DC%2BD1MXhs1Skur7F 3786192 20037587 10.1038/ng.509
-
Deng HX, Klein CJ, Yan J, Shi Y, Wu Y, Fecto F, Yau HJ, Yang Y, Zhai H, Siddique N, Hedley-Whyte ET, Delong R, Martina M, Dyck PJ, Siddique T (2010) Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4. Nat Genet 42:165-169
-
(2010)
Nat Genet
, vol.42
, pp. 165-169
-
-
Deng, H.X.1
Klein, C.J.2
Yan, J.3
Shi, Y.4
Wu, Y.5
Fecto, F.6
Yau, H.J.7
Yang, Y.8
Zhai, H.9
Siddique, N.10
Hedley-Whyte, E.T.11
Delong, R.12
Martina, M.13
Dyck, P.J.14
Siddique, T.15
-
47
-
-
75749139617
-
Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C
-
1:CAS:528:DC%2BD1MXhs1Skur%2FM 2812627 20037586 10.1038/ng.512
-
Landoure G, Zdebik AA, Martinez TL, Burnett BG, Stanescu HC, et al (2010) Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C. Nat Genet 42:170-174
-
(2010)
Nat Genet
, vol.42
, pp. 170-174
-
-
Landoure, G.1
Zdebik, A.A.2
Martinez, T.L.3
Burnett, B.G.4
Stanescu, H.C.5
-
48
-
-
77951717570
-
Dominant TRPV4 mutations in nonlethal and lethal metatropic dysplasia
-
1:CAS:528:DC%2BC3cXnsFylurg%3D 20425821 10.1002/ajmg.a.33392
-
Camacho N, Krakow D, Johnykutty S, Katzman PJ, Pepkowitz S, Vriens J, Nilius B, Boyce BF, Cohn DH (2010) Dominant TRPV4 mutations in nonlethal and lethal metatropic dysplasia. Am J Med Genet A 152A:1169-1177
-
(2010)
Am J Med Genet A
, vol.152
, pp. 1169-1177
-
-
Camacho, N.1
Krakow, D.2
Johnykutty, S.3
Katzman, P.J.4
Pepkowitz, S.5
Vriens, J.6
Nilius, B.7
Boyce, B.F.8
Cohn, D.H.9
-
49
-
-
50049122815
-
TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts
-
1:CAS:528:DC%2BD1cXhtFeju77E 18762026 10.1016/j.cmet.2008.08.002
-
Masuyama R, Vriens J, Voets T, Karashima Y, Owsianik G, Vennekens R, Lieben L, Torrekens S, Moermans K, Vanden Bosch A, Bouillon R, Nilius B, Carmeliet G (2008) TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts. Cell Metab 8:257-265
-
(2008)
Cell Metab
, vol.8
, pp. 257-265
-
-
Masuyama, R.1
Vriens, J.2
Voets, T.3
Karashima, Y.4
Owsianik, G.5
Vennekens, R.6
Lieben, L.7
Torrekens, S.8
Moermans, K.9
Vanden Bosch, A.10
Bouillon, R.11
Nilius, B.12
Carmeliet, G.13
-
50
-
-
78649443616
-
RANKL-induced TRPV2 expression regulates osteoclastogenesis via calcium oscillations
-
1:CAS:528:DC%2BC3cXhsVyhsLjN 20980052 10.1016/j.ceca.2010.09.010
-
Kajiya H, Okamoto F, Nemoto T, Kimachi K, Toh-Goto K, Nakayana S, Okabe K (2010) RANKL-induced TRPV2 expression regulates osteoclastogenesis via calcium oscillations. Cell Calcium 48:260-269
-
(2010)
Cell Calcium
, vol.48
, pp. 260-269
-
-
Kajiya, H.1
Okamoto, F.2
Nemoto, T.3
Kimachi, K.4
Toh-Goto, K.5
Nakayana, S.6
Okabe, K.7
-
51
-
-
0038609734
-
Structural determinant of TRPV1 desensitization interacts with calmodulin
-
1:CAS:528:DC%2BD3sXlt1WqtL8%3D 12808128 10.1073/pnas.1337252100
-
Numazaki M, Tominaga T, Takeuchi K, Murayama N, Toyooka H, Tominaga M (2003) Structural determinant of TRPV1 desensitization interacts with calmodulin. Proc Natl Acad Sci USA 100:8002-8006
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 8002-8006
-
-
Numazaki, M.1
Tominaga, T.2
Takeuchi, K.3
Murayama, N.4
Toyooka, H.5
Tominaga, M.6
-
52
-
-
77957726026
-
2+-dependent desensitization of TRPV2 channels is mediated by hydrolysis of phosphatidylinositol 4,5-bisphosphate
-
1:CAS:528:DC%2BC3cXhtlars7bE 3001133 20926660 10.1523/JNEUROSCI.2108-10. 2010
-
2+-dependent desensitization of TRPV2 channels is mediated by hydrolysis of phosphatidylinositol 4,5-bisphosphate. J Neurosci 30:13338-13347
-
(2010)
J Neurosci
, vol.30
, pp. 13338-13347
-
-
Mercado, J.1
Gordon-Shaag, A.2
Zagotta, W.N.3
Gordon, S.E.4
-
53
-
-
79960358181
-
Molecular mechanisms of calmodulin action on TRPV5 and modulation by parathyroid hormone
-
3133394 21576356 10.1128/MCB.01319-10
-
de Groot T, Kovalevskaya NV, Verkaart S, Schilderink N, Felici M, van der Hagen EA, Bindels RJ, Vuister GW, Hoenderop JG (2011) Molecular mechanisms of calmodulin action on TRPV5 and modulation by parathyroid hormone. Mol Cell Biol 31:2845-2853
-
(2011)
Mol Cell Biol
, vol.31
, pp. 2845-2853
-
-
De Groot, T.1
Kovalevskaya, N.V.2
Verkaart, S.3
Schilderink, N.4
Felici, M.5
Van Der Hagen, E.A.6
Bindels, R.J.7
Vuister, G.W.8
Hoenderop, J.G.9
-
54
-
-
30044448541
-
Calmodulin is a critical regulator of osteoclastic differentiation, function, and survival
-
1:CAS:528:DC%2BD28XivV2lsA%3D%3D 16216008 10.1002/jcb.20659
-
Seales EC, Micoli KJ, McDonald JM (2006) Calmodulin is a critical regulator of osteoclastic differentiation, function, and survival. J Cell Biochem 97:45-55
-
(2006)
J Cell Biochem
, vol.97
, pp. 45-55
-
-
Seales, E.C.1
Micoli, K.J.2
McDonald, J.M.3
-
55
-
-
23844504243
-
Fas binding to calmodulin regulates apoptosis in osteoclasts
-
1:CAS:528:DC%2BD2MXns1SltLg%3D 1351015 15965236 10.1074/jbc.M500710200
-
Wu X, Ahn EY, McKenna MA, Yeo H, McDonald JM (2005) Fas binding to calmodulin regulates apoptosis in osteoclasts. J Biol Chem 280:29964-29970
-
(2005)
J Biol Chem
, vol.280
, pp. 29964-29970
-
-
Wu, X.1
Ahn, E.Y.2
McKenna, M.A.3
Yeo, H.4
McDonald, J.M.5
-
56
-
-
84864140546
-
Calcium/calmodulin-signaling supports TRPV4 activation in osteoclasts and regulates bone mass
-
1:CAS:528:DC%2BC38XhtVequ7%2FP 22492541 10.1002/jbmr.1629
-
Masuyama R, Mizuno A, Komori H, Kajiya H, Uekawa A, Kitaura H, Okabe K, Ohyama K, Komori T (2012) Calcium/calmodulin-signaling supports TRPV4 activation in osteoclasts and regulates bone mass. J Bone Miner Res 27:1708-1721
-
(2012)
J Bone Miner Res
, vol.27
, pp. 1708-1721
-
-
Masuyama, R.1
Mizuno, A.2
Komori, H.3
Kajiya, H.4
Uekawa, A.5
Kitaura, H.6
Okabe, K.7
Ohyama, K.8
Komori, T.9
|