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Volumn 49, Issue 2, 2014, Pages 241-247

Donor TLR9 gene tagSNPs influence susceptibility to aGVHD and CMV reactivation in the allo-HSCT setting without polymorphisms in the TLR4 and NOD2 genes

Author keywords

CMV; GVHD; Hematopoietic SCT; Polymorphism; TLR9

Indexed keywords

FEMALE; GENOTYPE; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; MALE; NOD2 SIGNALING ADAPTOR PROTEIN; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; TISSUE DONORS; TOLL-LIKE RECEPTOR 4; TRANSPLANTATION CONDITIONING; TREATMENT OUTCOME;

EID: 84893783588     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2013.160     Document Type: Article
Times cited : (23)

References (46)
  • 1
    • 54049153247 scopus 로고    scopus 로고
    • TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection
    • Taylor PA, Ehrhardt MJ, Lees CJ, Panoskaltsis-Mortari A, Krieg AM, Sharpe AH et al. TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection. Blood 2008; 112: 3508-3516.
    • (2008) Blood , vol.112 , pp. 3508-3516
    • Taylor, P.A.1    Ehrhardt, M.J.2    Lees, C.J.3    Panoskaltsis-Mortari, A.4    Krieg, A.M.5    Sharpe, A.H.6
  • 2
    • 77950471448 scopus 로고    scopus 로고
    • Graft-vs-host disease: Regulation by microbe-associated molecules and innate immune receptors
    • Penack O, Holler E, van den Brink MR. Graft-vs-host disease: regulation by microbe-associated molecules and innate immune receptors. Blood 2010; 115: 1865-1872.
    • (2010) Blood , vol.115 , pp. 1865-1872
    • Penack, O.1    Holler, E.2    Van Den Brink, M.R.3
  • 3
    • 84867316465 scopus 로고    scopus 로고
    • Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation
    • Brennan TV, Lin L, Huang X, Cardona DM, Li Z, Dredge K et al. Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation. Blood 2012; 120: 2899-2908.
    • (2012) Blood , vol.120 , pp. 2899-2908
    • Brennan, T.V.1    Lin, L.2    Huang, X.3    Cardona, D.M.4    Li, Z.5    Dredge, K.6
  • 4
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001; 411: 603-606.
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3    Nicolae, D.L.4    Chen, F.F.5    Ramos, R.6
  • 7
    • 0034858551 scopus 로고    scopus 로고
    • Association of TLR4 mutations and the risk for acute GVHD after HLA-matched-sibling hematopoietic stem cell transplantation
    • Lorenz E, Schwartz DA, Martin PJ, Gooley T, Lin MT, Chien JW et al. Association of TLR4 mutations and the risk for acute GVHD after HLA-matched-sibling hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2001; 7: 384-387.
    • (2001) Biol Blood Marrow Transplant , vol.7 , pp. 384-387
    • Lorenz, E.1    Schwartz, D.A.2    Martin, P.J.3    Gooley, T.4    Lin, M.T.5    Chien, J.W.6
  • 8
    • 33644859324 scopus 로고    scopus 로고
    • Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-vs-host disease in patients who underwent an allogeneic transplantation
    • Elmaagacli AH, Koldehoff M, Hindahl H, Steckel NK, Trenschel R, Peceny R et al. Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-vs-host disease in patients who underwent an allogeneic transplantation. Transplantation 2006; 81: 247-254.
    • (2006) Transplantation , vol.81 , pp. 247-254
    • Elmaagacli, A.H.1    Koldehoff, M.2    Hindahl, H.3    Steckel, N.K.4    Trenschel, R.5    Peceny, R.6
  • 9
    • 54949144335 scopus 로고    scopus 로고
    • Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation
    • Bochud PY, Chien JW, Marr KA, Leisenring WM, Upton A, Janer M et al. Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. N Engl J Med 2008; 359: 1766-1777.
    • (2008) N Engl J Med , vol.359 , pp. 1766-1777
    • Bochud, P.Y.1    Chien, J.W.2    Marr, K.A.3    Leisenring, W.M.4    Upton, A.5    Janer, M.6
  • 10
    • 20044386782 scopus 로고    scopus 로고
    • Cyclosporine A and mycophenolate mofetil vs cyclosporine A and methotrexate for graftvs-host disease prophylaxis after stem cell transplantation from HLA-identical siblings
    • Neumann F, Graef T, Tapprich C, Vaupel M, Steidl U, Germing U et al. Cyclosporine A and mycophenolate mofetil vs cyclosporine A and methotrexate for graftvs-host disease prophylaxis after stem cell transplantation from HLA-identical siblings. Bone Marrow Transplant 2005; 35: 1089-1093.
    • (2005) Bone Marrow Transplant , vol.35 , pp. 1089-1093
    • Neumann, F.1    Graef, T.2    Tapprich, C.3    Vaupel, M.4    Steidl, U.5    Germing, U.6
  • 11
    • 63349095025 scopus 로고    scopus 로고
    • Prospective trial of mycophenolate mofetil-cyclosporine A prophylaxis for acute GVHD after G-CSF stimulated allogeneic bone marrow transplantation with HLA-identical sibling donors in patients with severe aplastic anemia and hematological malignancies
    • Ostronoff F, Ostronoff M, Souto-Maior AP, Domingues M, Sucupira A, Manso DA et al. Prospective trial of mycophenolate mofetil-cyclosporine A prophylaxis for acute GVHD after G-CSF stimulated allogeneic bone marrow transplantation with HLA-identical sibling donors in patients with severe aplastic anemia and hematological malignancies. Clin Transplant 2009; 23: 33-38.
    • (2009) Clin Transplant , vol.23 , pp. 33-38
    • Ostronoff, F.1    Ostronoff, M.2    Souto-Maior, A.P.3    Domingues, M.4    Sucupira, A.5    Manso, D.A.6
  • 12
    • 77956459654 scopus 로고    scopus 로고
    • MTX or mycophenolate mofetil with CsA as GVHD prophylaxis after reduced-intensity conditioning PBSCT from HLA-identical siblings
    • Pinana JL, Valcarcel D, Fernandez-Aviles F, Martino R, Rovira M, Barba P et al. MTX or mycophenolate mofetil with CsA as GVHD prophylaxis after reduced-intensity conditioning PBSCT from HLA-identical siblings. Bone Marrow Transplant 2010; 45: 1449-1456.
    • (2010) Bone Marrow Transplant , vol.45 , pp. 1449-1456
    • Pinana, J.L.1    Valcarcel, D.2    Fernandez-Aviles, F.3    Martino, R.4    Rovira, M.5    Barba, P.6
  • 13
    • 53049090390 scopus 로고    scopus 로고
    • Combination of mycophenolate mofetil with cyclosporine A and methotrexate as acute GVHD prophylaxis after unrelated donor allogeneic bone marrow transplantation
    • Huang H, Lin M, Meng H, Qian W, Jin J, Huang J et al. [Combination of mycophenolate mofetil with cyclosporine A and methotrexate as acute GVHD prophylaxis after unrelated donor allogeneic bone marrow transplantation]. Zhonghua Xue Ye Xue Za Zhi 2001; 22: 76-78.
    • (2001) Zhonghua Xue Ye Xue Za Zhi , vol.22 , pp. 76-78
    • Huang, H.1    Lin, M.2    Meng, H.3    Qian, W.4    Jin, J.5    Huang, J.6
  • 14
    • 0036527599 scopus 로고    scopus 로고
    • Prophylaxis of acute graft-vs-host disease after allogeneic bone marrow transplantation by mycophenolate mofetil in a murine model
    • Huang H, Zheng W, Lin M, Fu J, Zhang R. [Prophylaxis of acute graft-vs-host disease after allogeneic bone marrow transplantation by mycophenolate mofetil in a murine model]. Zhonghua Xue Ye Xue Za Zhi 2002; 23: 191-193.
    • (2002) Zhonghua Xue Ye Xue Za Zhi , vol.23 , pp. 191-193
    • Huang, H.1    Zheng, W.2    Lin, M.3    Fu, J.4    Zhang, R.5
  • 15
    • 79952628198 scopus 로고    scopus 로고
    • Immunosuppressive cytokine gene polymorphisms and outcome after related and unrelated hematopoietic cell transplantation in a chinese population
    • Xiao H, Cao W, Lai X, Luo Y, Shi J, Tan Y et al. Immunosuppressive cytokine gene polymorphisms and outcome after related and unrelated hematopoietic cell transplantation in a chinese population. Biol Blood Marrow Transplant 2011; 17: 542-549.
    • (2011) Biol Blood Marrow Transplant , vol.17 , pp. 542-549
    • Xiao, H.1    Cao, W.2    Lai, X.3    Luo, Y.4    Shi, J.5    Tan, Y.6
  • 16
    • 79952537288 scopus 로고    scopus 로고
    • Relationship between TNFA, TNFB and TNFRII gene polymorphisms and outcome after unrelated hematopoietic cell transplantation in a Chinese population
    • Xiao HW, Lai XY, Luo Y, Shi JM, Tan YM, He JS et al. Relationship between TNFA, TNFB and TNFRII gene polymorphisms and outcome after unrelated hematopoietic cell transplantation in a Chinese population. Bone Marrow Transplant 2011; 46: 400-407.
    • (2011) Bone Marrow Transplant , vol.46 , pp. 400-407
    • Xiao, H.W.1    Lai, X.Y.2    Luo, Y.3    Shi, J.M.4    Tan, Y.M.5    He, J.S.6
  • 17
    • 84870448146 scopus 로고    scopus 로고
    • Genetic variations in T-cell activation and effector pathways modulate alloimmune responses after allogeneic hematopoietic stem cell transplantation in patients with hematologic malignancies
    • Xiao H, Luo Y, Lai X, Fu S, Shi J, Tan Y et al. Genetic variations in T-cell activation and effector pathways modulate alloimmune responses after allogeneic hematopoietic stem cell transplantation in patients with hematologic malignancies. Haematologica 2012; 97: 1804-1812.
    • (2012) Haematologica , vol.97 , pp. 1804-1812
    • Xiao, H.1    Luo, Y.2    Lai, X.3    Fu, S.4    Shi, J.5    Tan, Y.6
  • 18
    • 33646591889 scopus 로고    scopus 로고
    • Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: Effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination
    • Holler E, Rogler G, Brenmoehl J, Hahn J, Herfarth H, Greinix H et al. Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination. Blood 2006; 107: 4189-4193.
    • (2006) Blood , vol.107 , pp. 4189-4193
    • Holler, E.1    Rogler, G.2    Brenmoehl, J.3    Hahn, J.4    Herfarth, H.5    Greinix, H.6
  • 19
    • 34948899807 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors
    • Mayor NP, Shaw BE, Hughes DA, Maldonado-Torres H, Madrigal JA, Keshav S et al. Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors. J Clin Oncol 2007; 25: 4262-4269.
    • (2007) J Clin Oncol , vol.25 , pp. 4262-4269
    • Mayor, N.P.1    Shaw, B.E.2    Hughes, D.A.3    Maldonado-Torres, H.4    Madrigal, J.A.5    Keshav, S.6
  • 20
    • 77951721712 scopus 로고    scopus 로고
    • Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel diseaseassociated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation
    • Nguyen Y, Al-Lehibi A, Gorbe E, Li E, Haagenson M, Wang T et al. Insufficient evidence for association of NOD2/CARD15 or other inflammatory bowel diseaseassociated markers on GVHD incidence or other adverse outcomes in T-replete, unrelated donor transplantation. Blood 2010; 115: 3625-3631.
    • (2010) Blood , vol.115 , pp. 3625-3631
    • Nguyen, Y.1    Al-Lehibi, A.2    Gorbe, E.3    Li, E.4    Haagenson, M.5    Wang, T.6
  • 22
    • 0037090071 scopus 로고    scopus 로고
    • Definitions of cytomegalovirus infection and disease in transplant recipients
    • Ljungman P, Griffiths P, Paya C. Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis 2002; 34: 1094-1097.
    • (2002) Clin Infect Dis , vol.34 , pp. 1094-1097
    • Ljungman, P.1    Griffiths, P.2    Paya, C.3
  • 23
    • 34547622486 scopus 로고    scopus 로고
    • Competing risk analysis using R: An easy guide for clinicians
    • Scrucca L, Santucci A, Aversa F. Competing risk analysis using R: an easy guide for clinicians. Bone Marrow Transplant 2007; 40: 381-387.
    • (2007) Bone Marrow Transplant , vol.40 , pp. 381-387
    • Scrucca, L.1    Santucci, A.2    Aversa, F.3
  • 24
    • 0033616908 scopus 로고    scopus 로고
    • Estimation of failure probabilities in the presence of competing risks: New representations of old estimators
    • Gooley TA, Leisenring W, Crowley J, Storer BE. Estimation of failure probabilities in the presence of competing risks: new representations of old estimators. Stat Med 1999; 18: 695-706.
    • (1999) Stat Med , vol.18 , pp. 695-706
    • Gooley, T.A.1    Leisenring, W.2    Crowley, J.3    Storer, B.E.4
  • 25
    • 0037289001 scopus 로고    scopus 로고
    • Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): Frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. Ethnic groups and exploratory case-control disease association studies
    • Lazarus R, Klimecki WT, Raby BA, Vercelli D, Palmer LJ, Kwiatkowski DJ et al. Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies. Genomics 2003; 81: 85-91.
    • (2003) Genomics , vol.81 , pp. 85-91
    • Lazarus, R.1    Klimecki, W.T.2    Raby, B.A.3    Vercelli, D.4    Palmer, L.J.5    Kwiatkowski, D.J.6
  • 26
    • 2342558523 scopus 로고    scopus 로고
    • Antitumor applications of stimulating toll-like receptor 9 with CpG oligodeoxynucleotides
    • Krieg AM. Antitumor applications of stimulating toll-like receptor 9 with CpG oligodeoxynucleotides. Curr Oncol Rep 2004; 6: 88-95.
    • (2004) Curr Oncol Rep , vol.6 , pp. 88-95
    • Krieg, A.M.1
  • 27
    • 37849002321 scopus 로고    scopus 로고
    • Toll-like receptor 9 (TLR9) agonists in the treatment of cancer
    • Krieg AM. Toll-like receptor 9 (TLR9) agonists in the treatment of cancer. Oncogene 2008; 27: 161-167.
    • (2008) Oncogene , vol.27 , pp. 161-167
    • Krieg, A.M.1
  • 29
    • 49649085838 scopus 로고    scopus 로고
    • Mechanisms underlying blockade of allograft acceptance by TLR ligands
    • Porrett PM, Yuan X, LaRosa DF, Walsh PT, Yang J, Gao W et al. Mechanisms underlying blockade of allograft acceptance by TLR ligands. J Immunol 2008; 181: 1692-1699.
    • (2008) J Immunol , vol.181 , pp. 1692-1699
    • Porrett, P.M.1    Yuan, X.2    Larosa, D.F.3    Walsh, P.T.4    Yang, J.5    Gao, W.6
  • 30
    • 77954733523 scopus 로고    scopus 로고
    • MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-vs-host disease
    • Heimesaat MM, Nogai A, Bereswill S, Plickert R, Fischer A, Loddenkemper C et al. MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-vs-host disease. Gut 2010; 59: 1079-1087.
    • (2010) Gut , vol.59 , pp. 1079-1087
    • Heimesaat, M.M.1    Nogai, A.2    Bereswill, S.3    Plickert, R.4    Fischer, A.5    Loddenkemper, C.6
  • 31
    • 0041402777 scopus 로고    scopus 로고
    • Toll-like receptors and innate antiviral responses
    • Vaidya SA, Cheng G. Toll-like receptors and innate antiviral responses. Curr Opin Immunol 2003; 15: 402-407.
    • (2003) Curr Opin Immunol , vol.15 , pp. 402-407
    • Vaidya, S.A.1    Cheng, G.2
  • 32
    • 0842328805 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9
    • Krug A, Luker GD, Barchet W, Leib DA, Akira S, Colonna M. Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood 2004; 103: 1433-1437.
    • (2004) Blood , vol.103 , pp. 1433-1437
    • Krug, A.1    Luker, G.D.2    Barchet, W.3    Leib, D.A.4    Akira, S.5    Colonna, M.6
  • 33
    • 0042123694 scopus 로고    scopus 로고
    • Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    • Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 2003; 198: 513-520.
    • (2003) J Exp Med , vol.198 , pp. 513-520
    • Lund, J.1    Sato, A.2    Akira, S.3    Medzhitov, R.4    Iwasaki, A.5
  • 34
    • 12144286763 scopus 로고    scopus 로고
    • Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
    • Tabeta K, Georgel P, Janssen E, Du X, Hoebe K, Crozat K et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci USA 2004; 101: 3516-3521.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3516-3521
    • Tabeta, K.1    Georgel, P.2    Janssen, E.3    Du, X.4    Hoebe, K.5    Crozat, K.6
  • 35
    • 34250627117 scopus 로고    scopus 로고
    • Putative association of a TLR9 promoter polymorphism with atopic eczema
    • Novak N, Yu CF, Bussmann C, Maintz L, Peng WM, Hart J et al. Putative association of a TLR9 promoter polymorphism with atopic eczema. Allergy 2007; 62: 766-772.
    • (2007) Allergy , vol.62 , pp. 766-772
    • Novak, N.1    Yu, C.F.2    Bussmann, C.3    Maintz, L.4    Peng, W.M.5    Hart, J.6
  • 36
    • 34347262069 scopus 로고    scopus 로고
    • Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population
    • Tao K, Fujii M, Tsukumo S, Maekawa Y, Kishihara K, Kimoto Y et al. Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population. Ann Rheum Dis 2007; 66: 905-909.
    • (2007) Ann Rheum Dis , vol.66 , pp. 905-909
    • Tao, K.1    Fujii, M.2    Tsukumo, S.3    Maekawa, Y.4    Kishihara, K.5    Kimoto, Y.6
  • 37
    • 33847021903 scopus 로고    scopus 로고
    • Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection
    • Bochud PY, Hersberger M, Taffe P, Bochud M, Stein CM, Rodrigues SD et al. Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection. AIDS 2007; 21: 441-446.
    • (2007) AIDS , vol.21 , pp. 441-446
    • Bochud, P.Y.1    Hersberger, M.2    Taffe, P.3    Bochud, M.4    Stein, C.M.5    Rodrigues, S.D.6
  • 38
    • 70349115053 scopus 로고    scopus 로고
    • Improved outcome of hematopoietic SCT in patients with homozygous gene variant of Toll-like receptor 9
    • Elmaagacli AH, Koldehoff M, Beelen DW. Improved outcome of hematopoietic SCT in patients with homozygous gene variant of Toll-like receptor 9. Bone Marrow Transplant 2009; 44: 295-302.
    • (2009) Bone Marrow Transplant , vol.44 , pp. 295-302
    • Elmaagacli, A.H.1    Koldehoff, M.2    Beelen, D.W.3
  • 39
    • 79955927350 scopus 로고    scopus 로고
    • Toll-like receptor 9 NOD2 and IL23R gene polymorphisms influenced outcome in AML patients transplanted from HLA-identical sibling donors
    • Elmaagacli AH, Steckel N, Ditschkowski M, Hegerfeldt Y, Ottinger H, Trenschel R et al. Toll-like receptor 9, NOD2 and IL23R gene polymorphisms influenced outcome in AML patients transplanted from HLA-identical sibling donors. Bone Marrow Transplant 2011; 46: 702-708.
    • (2011) Bone Marrow Transplant , vol.46 , pp. 702-708
    • Elmaagacli, A.H.1    Steckel, N.2    Ditschkowski, M.3    Hegerfeldt, Y.4    Ottinger, H.5    Trenschel, R.6
  • 40
    • 2942530690 scopus 로고    scopus 로고
    • Influence of coinfecting pathogens on HIV expression: Evidence for a role of Toll-like receptors
    • Bafica A, Scanga CA, Schito M, Chaussabel D, Sher A. Influence of coinfecting pathogens on HIV expression: evidence for a role of Toll-like receptors. J Immunol 2004; 172: 7229-7234.
    • (2004) J Immunol , vol.172 , pp. 7229-7234
    • Bafica, A.1    Scanga, C.A.2    Schito, M.3    Chaussabel, D.4    Sher, A.5
  • 41
    • 7644230107 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides block human immunodeficiency virus type 1 replication in human lymphoid tissue infected ex vivo
    • Schlaepfer E, Audige A, von Beust B, Manolova V, Weber M, Joller H et al. CpG oligodeoxynucleotides block human immunodeficiency virus type 1 replication in human lymphoid tissue infected ex vivo. J Virol 2004; 78: 12344-12354.
    • (2004) J Virol , vol.78 , pp. 12344-12354
    • Schlaepfer, E.1    Audige, A.2    Von Beust, B.3    Manolova, V.4    Weber, M.5    Joller, H.6
  • 42
    • 33644555213 scopus 로고    scopus 로고
    • TLR7/8 triggering exerts opposing effects in acute vs latent HIV infection
    • Schlaepfer E, Audige A, Joller H, Speck RF. TLR7/8 triggering exerts opposing effects in acute vs latent HIV infection. J Immunol 2006; 176: 2888-2895.
    • (2006) J Immunol , vol.176 , pp. 2888-2895
    • Schlaepfer, E.1    Audige, A.2    Joller, H.3    Speck, R.F.4
  • 43
    • 0034307339 scopus 로고    scopus 로고
    • The Toll receptor family and microbial recognition
    • Medzhitov R, Janeway Jr. C. The Toll receptor family and microbial recognition. Trends Microbiol 2000; 8: 452-456.
    • (2000) Trends Microbiol , vol.8 , pp. 452-456
    • Medzhitov, R.1    Janeway Jr., C.2
  • 44
    • 33846611019 scopus 로고    scopus 로고
    • TLR9 ligand enhances proliferation of rat CD4\+ T cell and modulates suppressive activity mediated by CD4\+ CD25\+ T cell
    • Chiffoleau E, Heslan JM, Heslan M, Louvet C, Condamine T, Cuturi MC. TLR9 ligand enhances proliferation of rat CD4\+ T cell and modulates suppressive activity mediated by CD4\+ CD25\+ T cell. Int Immunol 2007; 19: 193-201.
    • (2007) Int Immunol , vol.19 , pp. 193-201
    • Chiffoleau, E.1    Heslan, J.M.2    Heslan, M.3    Louvet, C.4    Condamine, T.5    Cuturi, M.C.6
  • 45
    • 34848856815 scopus 로고    scopus 로고
    • Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself
    • Li JL, Song WR, Czerwinski DK, Varghese B, Uematsu S, Akira S et al. Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself. J Immunol 2007; 179: 2493-2500.
    • (2007) J Immunol , vol.179 , pp. 2493-2500
    • Li, J.L.1    Song, W.R.2    Czerwinski, D.K.3    Varghese, B.4    Uematsu, S.5    Akira, S.6
  • 46
    • 65349153756 scopus 로고    scopus 로고
    • T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy
    • Houot R, Levy R. T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy. Blood 2009; 113: 3546-3552.
    • (2009) Blood , vol.113 , pp. 3546-3552
    • Houot, R.1    Levy, R.2


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