Circadian rhythms and mood: Opportunities for multi-level analyses in genomics and neuroscience: Circadian rhythm dysregulation in mood disorders provides clues to the brain's organizing principles, and a touchstone for genomics and neuroscience Prospects & Overviews J. Z. Li

BioEssays

Volumn 36, Issue 3, 2014, Pages 305-315

  Li, Jun Z ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Circadian rhythm; Dynamics; Genetics; Integrative analysis; Mood disorder; Network; Neurobiology

Indexed keywords

ADAPTATION; ARTICLE; ATTENTION DEFICIT DISORDER; BODY MASS; BODY TEMPERATURE; BRAIN DEVELOPMENT; BRAIN FUNCTION; BRAIN REGION; CIRCADIAN RHYTHM; DEPRESSION; DNA SEQUENCE; FEEDBACK SYSTEM; FUNCTIONAL GENOMICS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOMICS; HEREDITY; HUMAN; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LOSS OF FUNCTION MUTATION; MENTAL DISEASE; MENTAL FUNCTION; MOOD; MOOD DISORDER; MULTIPLE SCLEROSIS; NERVE CELL PLASTICITY; NEUROBIOLOGY; NEUROSCIENCE; NONHUMAN; PHENOTYPE; SCHIZOPHRENIA; SEASONAL VARIATION; SENSITIVITY AND SPECIFICITY; SLEEP DISORDER; SUPRACHIASMATIC NUCLEUS; SYNAPTIC TRANSMISSION; AFFECT; BRAIN; GENETICS; MULTILEVEL ANALYSIS; PATHOPHYSIOLOGY; PHYSIOLOGY;

AFFECT; BRAIN; CIRCADIAN RHYTHM; GENOMICS; HUMANS; MOOD DISORDERS; MULTILEVEL ANALYSIS; NEUROSCIENCES;

EID: 84893752007     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.201300141     Document Type: Article

References (90)

1. Healy D. 1987. Rhythm and blues. Neurochemical, neuropharmacological and neuropsychological implications of a hypothesis of circadian rhythm dysfunction in the affective disorders. Psychopharmacology (Berl) 93: 271-85.
2. Li JZ, Bunney BG, Meng F, Hagenauer MH, et al. 2013. Circadian patterns of gene expression in the human brain and disruption in major depressive disorder. Proc Natl Acad Sci USA 110: 9950-5.
3. Edgar N, McClung CA. 2013. Major depressive disorder: a loss of circadian synchrony? BioEssays 35: 940-4.
4. Yamazaki S, Numano R, Abe M, Hida A, et al. 2000. Resetting central and peripheral circadian oscillators in transgenic rats. Science 288: 682-5.
5. Takahashi JS, Hong HK, Ko CH, McDearmon EL. 2008. The genetics of mammalian circadian order and disorder: implications for physiology and disease. Nat Rev Genet 9: 764-75.
6. Baggs JE, Price TS, DiTacchio L, Panda S, et al. 2009. Network features of the mammalian circadian clock. PLoS Biol 7: e52.
7. Hogenesch JB, Ueda HR. 2011. Understanding systems-level properties: timely stories from the study of clocks. Nat Rev Genet 12: 407-16.
8. Muraro NI, Pirez N, Ceriani MF. 2013. The circadian system: plasticity at many levels. Neuroscience 247: 280-93.
9. Vansteensel MJ, Michel S, Meijer JH. 2008. Organization of cell and tissue circadian pacemakers: a comparison among species. Brain Res Rev 58: 18-47.
10. Liu AC, Welsh DK, Ko CH, Tran HG, et al. 2007. Intercellular coupling confers robustness against mutations in the SCN circadian clock network. Cell 129: 605-16.
11. Meijer JH, Michel S, Vanderleest HT, Rohling JH. 2010. Daily and seasonal adaptation of the circadian clock requires plasticity of the SCN neuronal network. Eur J Neurosci 32: 2143-51.
12. Buhr ED, Yoo SH, Takahashi JS. 2010. Temperature as a universal resetting cue for mammalian circadian oscillators. Science 330: 379-85.
13. Goldbeter A. 2002. Computational approaches to cellular rhythms. Nature 420: 238-45.
14. Forger DB, Peskin CS. 2003. A detailed predictive model of the mammalian circadian clock. Proc Natl Acad Sci USA 100: 14806-11.
15. Abraham U, Granada AE, Westermark PO, Heine M, et al. 2010. Coupling governs entrainment range of circadian clocks. Mol Syst Biol 6: 438.
16. Butler MP, Silver R. 2009. Basis of robustness and resilience in the suprachiasmatic nucleus: individual neurons form nodes in circuits that cycle daily. J Biol Rhythms 24: 340-52.
17. Buchman TG. 2002. The community of the self. Nature 420: 246-51.
18. Buzsaki G, Watson BO. 2012. Brain rhythms and neural syntax: implications for efficient coding of cognitive content and neuropsychiatric disease. Dialogues Clin Neurosci 14: 345-67.
19. Fujisawa S, Amarasingham A, Harrison MT, Buzsaki G. 2008. Behavior-dependent short-term assembly dynamics in the medial prefrontal cortex. Nat Neurosci 11: 823-33.
20. Uhlhaas PJ, Haenschel C, Nikolic D, Singer W. 2008. The role of oscillations and synchrony in cortical networks and their putative relevance for the pathophysiology of schizophrenia. Schizophr Bull 34: 927-43.
21. Uhlhaas PJ, Singer W. 2010. Abnormal neural oscillations and synchrony in schizophrenia. Nat Rev Neurosci 11: 100-13.
22. Miklowitz DJ, Otto MW, Frank E, Reilly-Harrington NA, et al. 2007. Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trial. Am J Psychiatry 164: 1340-7.
23. Frank E, Swartz HA, Kupfer DJ. 2000. Interpersonal and social rhythm therapy: managing the chaos of bipolar disorder. Biol Psychiatry 48: 593-604.
24. Karatsoreos IN, McEwen BS. 2011. Psychobiological allostasis: resistance, resilience and vulnerability. Trends Cogn Sci 15: 576-84.
25. Krishnan V, Nestler EJ. 2010. Linking molecules to mood: new insight into the biology of depression. Am J Psychiatry 167: 1305-20.
26. Roybal K, Theobold D, Graham A, DiNieri JA, et al. 2007. Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci USA 104: 6406-11.
27. McClung CA. 2013. How might circadian rhythms control mood? Let me count the ways. Biol Psychiatry 74: 242-9.
28. Hampp G, Albrecht U. 2008. The circadian clock and mood-related behavior. Commun Integr Biol 1: 1-3.
29. Imeri L, Opp MR. 2009. How (and why) the immune system makes us sleep. Nat Rev Neurosci 10: 199-210.
30. Raison CL, Miller AH. 2011. Is depression an inflammatory disorder? Curr Psychiatry Rep 13: 467-75.
31. McCarthy MJ, Welsh DK. 2012. Cellular circadian clocks in mood disorders. J Biol Rhythms 27: 339-52.
32. Menet JS, Rosbash M. 2011. When brain clocks lose track of time: cause or consequence of neuropsychiatric disorders. Curr Opin Neurobiol 21: 849-57.
33. Akhtar RA, Reddy AB, Maywood ES, Clayton JD, et al. 2002. Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus. Curr Biol 12: 540-50.
34. Panda S, Antoch MP, Miller BH, Su AI, et al. 2002. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 109: 307-20.
35. Yan J, Wang H, Liu Y, Shao C. 2008. Analysis of gene regulatory networks in the mammalian circadian rhythm. PLoS Comput Biol 4: e1000193.
36. Yang S, Wang K, Valladares O, Hannenhalli S, et al. 2007. Genome-wide expression profiling and bioinformatics analysis of diurnally regulated genes in the mouse prefrontal cortex. Genome Biol 8: R247.
37. Zieker D, Jenne I, Koenigsrainer I, Zdichavsky M, et al. 2010. Circadian expression of clock- and tumor suppressor genes in human oral mucosa. Cell Physiol Biochem 26: 155-66.
38. Brown SA, Fleury-Olela F, Nagoshi E, Hauser C, et al. 2005. The period length of fibroblast circadian gene expression varies widely among human individuals. PLoS Biol 3: e338.
39. Akashi M, Soma H, Yamamoto T, Tsugitomi A, et al. 2010. Noninvasive method for assessing the human circadian clock using hair follicle cells. Proc Natl Acad Sci USA 107: 15643-58.
40. Hoffman AE, Zheng T, Ba Y, Stevens RG, et al. 2010. Phenotypic effects of the circadian gene Cryptochrome 2 on cancer-related pathways. BMC Cancer 10: 110.
41. Hughes ME, DiTacchio L, Hayes KR, Vollmers C, et al. 2009. Harmonics of circadian gene transcription in mammals. PLoS Genet 5: e1000442.
42. Carmichael ST. 2003. Gene expression changes after focal stroke, traumatic brain and spinal cord injuries. Curr Opin Neurol 16: 699-704.
43. Jin K, Mao XO, Eshoo MW, Nagayama T, et al. 2001. Microarray analysis of hippocampal gene expression in global cerebral ischemia. Ann Neurol 50: 93-103.
44. Li JZ, Vawter MP, Walsh DM, Tomita H, et al. 2004. Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions. Hum Mol Genet 13: 609-16.
45. Jones CR, Huang AL, Ptacek LJ, Fu YH. 2013. Genetic basis of human circadian rhythm disorders. Exp Neurol 243: 28-33.
46. Toh KL, Jones CR, He Y, Eide EJ, et al. 2001. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science 291: 1040-3.
47. Xu Y, Toh KL, Jones CR, Shin JY, et al. 2007. Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell 128: 59-70.
48. Xu Y, Padiath QS, Shapiro RE, Jones CR, et al. 2005. Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. Nature 434: 640-4.
49. He Y, Jones CR, Fujiki N, Xu Y, et al. 2009. The transcriptional repressor DEC2 regulates sleep length in mammals. Science 325: 866-70.
50. Barclay NL, Eley TC, Buysse DJ, Rijsdijk FV, et al. 2010. Genetic and environmental influences on different components of the Pittsburgh Sleep Quality Index and their overlap. Sleep 33: 659-68.
51. Genderson MR, Rana BK, Panizzon MS, Grant MD, et al. 2013. Genetic and environmental influences on sleep quality in middle-aged men: a twin study. J Sleep Res 22: 519-26.
52. Hublin C, Partinen M, Koskenvuo M, Kaprio J. 2011. Heritability and mortality risk of insomnia-related symptoms: a genetic epidemiologic study in a population-based twin cohort. Sleep 34: 957-64.
53. Gehrman PR, Meltzer LJ, Moore M, Pack AI, et al. 2011. Heritability of insomnia symptoms in youth and their relationship to depression and anxiety. Sleep 34: 1641-6.
54. Gottlieb DJ, O'Connor GT, Wilk JB. 2007. Genome-wide association of sleep and circadian phenotypes. BMC Med Genet 8: S9.
55. Byrne EM, Gehrman PR, Medland SE, Nyholt DR, et al. 2013. A genome-wide association study of sleep habits and insomnia. Am J Med Genet B Neuropsychiatr Genet 162: 439-51.
56. Allebrandt KV, Amin N, Muller-Myhsok B, Esko T, et al. 2013. A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila. Mol Psychiatry 18: 122-32.
57. Parsons MJ, Lester KJ, Barclay NL, Nolan PM, et al. 2013. Replication of genome-wide association studies (GWAS) loci for sleep in the British G1219 cohort. Am J Med Genet B Neuropsychiatr Genet 162: 431-8.
58. Hirschhorn JN, Lohmueller K, Byrne E, Hirschhorn K. 2002. A comprehensive review of genetic association studies. Genet Med 4: 45-61.
59. Lohmueller KE, Pearce CL, Pike M, Lander ES, et al. 2003. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 33: 177-82.
60. Ripke S, Wray NR, Lewis CM, Hamilton SP, et al. 2013. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry 18: 497-511.
61. Psychiatric GWAS Consortium Bipolar Disorder Working Group. 2011. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet 43: 977-83.
62. Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium. 2011. Genome-wide association study identifies five new schizophrenia loci. Nat Genet 43: 969-76.
63. Ripke S, O'Dushlaine C, Chambert K, Moran JL, et al. 2013. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet 45: 1150-9.
64. Purcell SM, Wray NR, Stone JL, Visscher PM, et al. 2009. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460: 748-52.
65. Bush WS, Sawcer SJ, de Jager PL, Oksenberg JR, et al. 2010. Evidence for polygenic susceptibility to multiple sclerosis - the shape of things to come. Am J Hum Genet 86: 621-5.
66. Speliotes EK, Willer CJ, Berndt SI, Monda KL, et al. 2010. Association analyses of 249, 796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42: 937-48.
67. Smoller JW, Craddock N, Kendler K, Lee PH, et al. 2013. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 381: 1371-9.
68. Lee SH, Ripke S, Neale BM, Faraone SV, et al. 2013. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 45: 984-94.
69. McClellan J, King MC. 2010. Genetic heterogeneity in human disease. Cell 141: 210-7.
70. Hirschhorn JN. 2009. Genomewide association studies - illuminating biologic pathways. N Engl J Med 360: 1699-701.
71. Visscher PM, Brown MA, McCarthy MI, Yang J. 2012. Five years of GWAS discovery. Am J Hum Genet 90: 7-24.
72. [Anonymous]. 2005. Framework for a fully powered risk engine. Nat Genet 37: 1153.
73. Ramanan VK, Shen L, Moore JH, Saykin AJ. 2012. Pathway analysis of genomic data: concepts, methods, and prospects for future development. Trends Genet 28: 323-32.
74. Wang K, Li M, Hakonarson H. 2010. Analysing biological pathways in genome-wide association studies. Nat Rev Genet 11: 843-54.
75. Schadt EE. 2009. Molecular networks as sensors and drivers of common human diseases. Nature 461: 218-23.
76. Sullivan PF. 2012. Puzzling over schizophrenia: schizophrenia as a pathway disease. Nat Med 18: 210-1.
77. Gulsuner S, Walsh T, Watts AC, Lee MK, et al. 2013. Spatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical network. Cell 154: 518-29.
78. Perry C, Mackay-Sim A, Feron F, McGrath J. 2002. Olfactory neural cells: an untapped diagnostic and therapeutic resource. The 2000 Ogura Lecture. Laryngoscope 112: 603-7.
79. Yang S, Van Dongen HP, Wang K, Berrettini W, et al. 2009. Assessment of circadian function in fibroblasts of patients with bipolar disorder. Mol Psychiatry 14: 143-55.
80. Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C, et al. 2011. Modelling schizophrenia using human induced pluripotent stem cells. Nature 473: 221-5.
81. Deboer T, van Diepen HC, Ferrari MD, Van den Maagdenberg AM, et al. 2013. Reduced sleep and low adenosinergic sensitivity in cacna1a R192Q mutant mice. Sleep 36: 127-36.
82. Royer S, Zemelman BV, Losonczy A, Kim J, et al. 2012. Control of timing, rate and bursts of hippocampal place cells by dendritic and somatic inhibition. Nat Neurosci 15: 769-75.
83. Abe M, Herzog ED, Yamazaki S, Straume M, et al. 2002. Circadian rhythms in isolated brain regions. J Neurosci 22: 350-6.
84. Guilding C, Piggins HD. 2007. Challenging the omnipotence of the suprachiasmatic timekeeper: are circadian oscillators present throughout the mammalian brain? Eur J Neurosci 25: 3195-216.
85. Aston-Jones G, Chen S, Zhu Y, Oshinsky ML. 2001. A neural circuit for circadian regulation of arousal. Nat Neurosci 4: 732-8.
86. Smith DF, Jakobsen S. 2013. Molecular neurobiology of depression: PET findings on the elusive correlation with symptom severity. Front Psychiatry 4: 8.
87. Waddington CH. 1959. Canalization of development and genetic assimilation of acquired characters. Nature 183: 1654-5.
88. McGrath JJ, Hannan AJ, Gibson G. 2011. Decanalization, brain development and risk of schizophrenia. Transl Psychiatry 1: e14.
89. Adam D. 2013. Mental health: on the spectrum. Nature 496: 416-48.
90. Hyman SE. 2012. Revolution stalled. Sci Transl Med 4: 155cm11.