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Volumn 78, Issue 1-4, 2014, Pages 471-483

Comparison and correlation of in vitro, in vivo and in silico evaluations of alpha, beta and gamma cyclodextrin complexes of curcumin

Author keywords

Alpha cyclodextrin; Beta cyclodextrin; Bioavailability; Curcumin; Gamma cyclodextrin; Solubility

Indexed keywords


EID: 84893745241     PISSN: 09230750     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10847-013-0322-1     Document Type: Article
Times cited : (30)

References (45)
  • 2
    • 0026657246 scopus 로고
    • Inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation
    • 1:CAS:528:DyaK38XmsVGjsrs%3D 10.1016/0014-2999(92)90727-L
    • Huang, H.C.; Jan, T.R.; Yeh, S.F.: Inhibitory effect of curcumin, an anti-inflammatory agent, on vascular smooth muscle cell proliferation. Eur. J. Pharmacol. 221, 381-384 (1992)
    • (1992) Eur. J. Pharmacol. , vol.221 , pp. 381-384
    • Huang, H.C.1    Jan, T.R.2    Yeh, S.F.3
  • 3
    • 0035503597 scopus 로고    scopus 로고
    • The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    • 1:CAS:528:DC%2BD3MXnvVeqs7g%3D
    • Lim, G.P.; Chu, T.; Yang, F.; Beech, W.; Frautschy, S.A.; Cole, G.M.: The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J. Neurosci. 21, 8370-8377 (2001)
    • (2001) J. Neurosci. , vol.21 , pp. 8370-8377
    • Lim, G.P.1    Chu, T.2    Yang, F.3    Beech, W.4    Frautschy, S.A.5    Cole, G.M.6
  • 4
    • 0037097660 scopus 로고    scopus 로고
    • Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signalling through Janus kinase-STAT pathway in T lymphocytes
    • 1:CAS:528:DC%2BD38XksFWlsr4%3D
    • Natarajan, C.; Bright, J.J.: Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signalling through Janus kinase-STAT pathway in T lymphocytes. J. Immunol. 168, 6506-6513 (2002)
    • (2002) J. Immunol. , vol.168 , pp. 6506-6513
    • Natarajan, C.1    Bright, J.J.2
  • 5
    • 0030805998 scopus 로고    scopus 로고
    • Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action
    • 1:CAS:528:DyaK2sXls1Gjs7c%3D 10.1021/jm970190x
    • Mazumder, A.; Neamati, N.; Sunder, S.; Schulz, J.; Pertz, H.; Eich, E.; Pommier, Y.: Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action. J. Med. Chem. 40, 3057-3063 (1997)
    • (1997) J. Med. Chem. , vol.40 , pp. 3057-3063
    • Mazumder, A.1    Neamati, N.2    Sunder, S.3    Schulz, J.4    Pertz, H.5    Eich, E.6    Pommier, Y.7
  • 6
    • 0029909051 scopus 로고    scopus 로고
    • Curcumin protects against 4-hydroxy-2-trans-nonenal-induced cataract formation in rat lenses
    • 1:CAS:528:DyaK28XmvFWitL8%3D
    • Awasthi, S.; Srivastava, S.K.; Piper, J.T.; Singhal, S.S.; Chaubey, M.; Awasthi, Y.C.: Curcumin protects against 4-hydroxy-2-trans-nonenal-induced cataract formation in rat lenses. Am. J. Clin. Nutr. 64, 761-766 (1996)
    • (1996) Am. J. Clin. Nutr. , vol.64 , pp. 761-766
    • Awasthi, S.1    Srivastava, S.K.2    Piper, J.T.3    Singhal, S.S.4    Chaubey, M.5    Awasthi, Y.C.6
  • 7
    • 0037592791 scopus 로고    scopus 로고
    • Curcumin, the major component of food flavor turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis
    • 10.1038/sj.bjp.0705241
    • Ukil, A.; Maity, S.; Karmakar, S.; Datta, N.; Vedasiromoni, J.R.; Das, P.K.: Curcumin, the major component of food flavor turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis. Br. J. Pharmacol. 139, 209-218 (2005)
    • (2005) Br. J. Pharmacol. , vol.139 , pp. 209-218
    • Ukil, A.1    Maity, S.2    Karmakar, S.3    Datta, N.4    Vedasiromoni, J.R.5    Das, P.K.6
  • 8
    • 0037236792 scopus 로고    scopus 로고
    • Anticancer potential of curcumin: Preclinical and clinical studies
    • 1:CAS:528:DC%2BD3sXislaqtLo%3D
    • Aggarwal, B.B.; Kumar, A.; Bharti, A.C.: Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 23, 363-398 (2003)
    • (2003) Anticancer Res. , vol.23 , pp. 363-398
    • Aggarwal, B.B.1    Kumar, A.2    Bharti, A.C.3
  • 9
    • 0035891055 scopus 로고    scopus 로고
    • Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines
    • 1:CAS:528:DC%2BD3MXptVGmtr0%3D 10.1038/sj.onc.1204997
    • Mukhopadhyay, A.; Bueso-Ramos, C.; Chatterjee, D.; Pantazis, P.; Aggarwal, B.B.: Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene 20, 7597-7609 (2001)
    • (2001) Oncogene , vol.20 , pp. 7597-7609
    • Mukhopadhyay, A.1    Bueso-Ramos, C.2    Chatterjee, D.3    Pantazis, P.4    Aggarwal, B.B.5
  • 10
    • 0042168966 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: Correlation with suppression of COX-2, MMP-9 and cyclin D1
    • 1:CAS:528:DC%2BD3sXlvF2rtbs%3D 10.1093/carcin/bgg078
    • Shishodia, S.; Potdar, P.; Gairola, C.G.; Aggarwal, B.B.: Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1. Carcinogenesis 24, 1269-1279 (2003)
    • (2003) Carcinogenesis , vol.24 , pp. 1269-1279
    • Shishodia, S.1    Potdar, P.2    Gairola, C.G.3    Aggarwal, B.B.4
  • 11
    • 0030872976 scopus 로고    scopus 로고
    • Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines
    • 1:CAS:528:DyaK2sXksFWhtrw%3D 10.1097/00001813-199706000-00010
    • Mehta, K.; Pantazis, P.; McQueen, T.; Aggarwal, B.B.: Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. Anticancer Drugs 8, 470-481 (1997)
    • (1997) Anticancer Drugs , vol.8 , pp. 470-481
    • Mehta, K.1    Pantazis, P.2    McQueen, T.3    Aggarwal, B.B.4
  • 12
    • 0033856514 scopus 로고    scopus 로고
    • The inhibitory effect of curcumin, genistein, quercetin and cisplatin on the growth of oral cancer cells in vitro
    • 1:CAS:528:DC%2BD3cXlvVyjsLg%3D
    • Elattar, T.M.; Virji, A.S.: The inhibitory effect of curcumin, genistein, quercetin and cisplatin on the growth of oral cancer cells in vitro. Anticancer Res. 20, 1733-1738 (2000)
    • (2000) Anticancer Res. , vol.20 , pp. 1733-1738
    • Elattar, T.M.1    Virji, A.S.2
  • 13
    • 0031460545 scopus 로고    scopus 로고
    • Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway
    • 1:CAS:528:DyaK1cXks1Sjsg%3D%3D 10.1016/S0022-2143(97)90107-4
    • Hanif, R.; Qiao, L.; Shiff, S.J.; Rigas, B.: Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway. J. Lab. Clin. Med. 130, 576-584 (1997)
    • (1997) J. Lab. Clin. Med. , vol.130 , pp. 576-584
    • Hanif, R.1    Qiao, L.2    Shiff, S.J.3    Rigas, B.4
  • 14
    • 0242467932 scopus 로고    scopus 로고
    • Cox-2 is needed but not sufficient for apoptosis induced by Cox- selective inhibitors in colon cancer cells
    • 10.1023/A:1026199929747
    • Aggarwal, B.B.; Swaroop, P.; Protiva, P.; Raj, S.V.; Shirin, H.; Holt, P.R.: Cox-2 is needed but not sufficient for apoptosis induced by Cox- selective inhibitors in colon cancer cells. Apoptosis 8, 649-654 (2003)
    • (2003) Apoptosis , vol.8 , pp. 649-654
    • Aggarwal, B.B.1    Swaroop, P.2    Protiva, P.3    Raj, S.V.4    Shirin, H.5    Holt, P.R.6
  • 15
    • 33746197963 scopus 로고    scopus 로고
    • Multiple molecular targets in cancer chemoprevention by curcumin
    • 1:CAS:528:DC%2BD28Xpt1Cns74%3D 10.1208/aapsj080352
    • Thangapazham, R.L.; Sharma, A.; Maheshwari, R.K.: Multiple molecular targets in cancer chemoprevention by curcumin. AAPS J. 8, E443-E449 (2006)
    • (2006) AAPS J. , vol.8
    • Thangapazham, R.L.1    Sharma, A.2    Maheshwari, R.K.3
  • 16
    • 2142784187 scopus 로고    scopus 로고
    • Biological properties of curcumin-cellular and molecular mechanisms of action
    • 1:CAS:528:DC%2BD2cXjslSmsb0%3D 10.1080/10408690490424702
    • Joe, B.; Vijaykumar, M.; Lokesh, B.R.: Biological properties of curcumin-cellular and molecular mechanisms of action. Crit. Rev. Food Sci. Nutr. 44, 97-111 (2004)
    • (2004) Crit. Rev. Food Sci. Nutr. , vol.44 , pp. 97-111
    • Joe, B.1    Vijaykumar, M.2    Lokesh, B.R.3
  • 17
    • 77955665447 scopus 로고    scopus 로고
    • Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake
    • 1:CAS:528:DC%2BC3cXhtVeku7nP 10.1016/j.bcp.2010.06.022
    • Yadav, V.R.; Prasad, S.; Kannappan, R.; Ravindran, J.; Chaturvedi, M.M.; Vaahtera, L.; Parkkinen, J.; Aggarwal, B.B.: Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake. Biochem. Pharmacol. 80, 1021-1032 (2010)
    • (2010) Biochem. Pharmacol. , vol.80 , pp. 1021-1032
    • Yadav, V.R.1    Prasad, S.2    Kannappan, R.3    Ravindran, J.4    Chaturvedi, M.M.5    Vaahtera, L.6    Parkkinen, J.7    Aggarwal, B.B.8
  • 18
    • 0037026270 scopus 로고    scopus 로고
    • Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: Solubility, chemical and photochemical stability
    • 1:CAS:528:DC%2BD38XmsVahsrg%3D 10.1016/S0378-5173(02)00323-X
    • Tonnesen, H.H.; Masson, M.; Loftsson, T.: Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: solubility, chemical and photochemical stability. Int. J. Pharm. 244, 127-135 (2002)
    • (2002) Int. J. Pharm. , vol.244 , pp. 127-135
    • Tonnesen, H.H.1    Masson, M.2    Loftsson, T.3
  • 19
    • 37549051274 scopus 로고    scopus 로고
    • Bioavailability of curcumin: Problems and promises
    • 1:CAS:528:DC%2BD2sXht12gsrnF 10.1021/mp700113r
    • Anand, P.; Kunnumakkara, A.B.; Newman, R.A.; Aggarwal, B.B.: Bioavailability of curcumin: problems and promises. Mol. Pharm. 4, 807-818 (2007)
    • (2007) Mol. Pharm. , vol.4 , pp. 807-818
    • Anand, P.1    Kunnumakkara, A.B.2    Newman, R.A.3    Aggarwal, B.B.4
  • 20
    • 0029819323 scopus 로고    scopus 로고
    • Pharmaceutical applications of cyclodextrins: 1. Drug solubilization and stabilization
    • 10.1021/js950534b
    • Loftson, T.; Brewster, M.E.: Pharmaceutical applications of cyclodextrins: 1. Drug solubilization and stabilization. J. Pharm. Sci. 85, 1017-1025 (1996)
    • (1996) J. Pharm. Sci. , vol.85 , pp. 1017-1025
    • Loftson, T.1    Brewster, M.E.2
  • 21
    • 1942470488 scopus 로고    scopus 로고
    • E.M.: Cyclodextrins and their uses: A review
    • 10.1016/S0032-9592(03)00258-9
    • Del Valle, Martin: E.M.: cyclodextrins and their uses: a review. Process Biochem. 39, 1033-1046 (2004)
    • (2004) Process Biochem. , vol.39 , pp. 1033-1046
    • Del Valle, M.1
  • 22
    • 70449520196 scopus 로고    scopus 로고
    • Effect of cyclodextrin complexation of curcumin on its solubility and antiangiogenic and anti-inflammatory activity in rat colitis model
    • 10.1208/s12249-009-9264-8
    • Vivek, R.Y.; Sarasija, S.; Kshama, D.; Seema, Y.: Effect of cyclodextrin complexation of curcumin on its solubility and antiangiogenic and anti-inflammatory activity in rat colitis model. AAPS Pharm. Sci. Tech. 10, 752-762 (2009)
    • (2009) AAPS Pharm. Sci. Tech. , vol.10 , pp. 752-762
    • Vivek, R.Y.1    Sarasija, S.2    Kshama, D.3    Seema, Y.4
  • 23
    • 67349198514 scopus 로고    scopus 로고
    • Investigation of inclusion complex of trazodone hydrochloride with hydroxypropyl-β-cyclodextrin
    • 10.1016/j.carbpol.2009.01.033
    • Wieslawa, M.; Magdalena, Z.: Investigation of inclusion complex of trazodone hydrochloride with hydroxypropyl-β-cyclodextrin. Carbohydr. Polym. 77, 482-488 (2009)
    • (2009) Carbohydr. Polym. , vol.77 , pp. 482-488
    • Wieslawa, M.1    Magdalena, Z.2
  • 24
    • 34047187407 scopus 로고    scopus 로고
    • Water soluble progesterone-hydroxypropyl-b-cyclodextrin complex for injectable formulations
    • 1:CAS:528:DC%2BD2sXjs12ks7c%3D 10.1007/s10847-006-9174-2
    • Zoppetti, G.; Puppini, N.; Pizzutti, M.; Fini, A.; Giovani, T.; Comini, S.: Water soluble progesterone-hydroxypropyl-b-cyclodextrin complex for injectable formulations. J. Incl. Phenom. Macrocycl. Chem. 57, 283-288 (2007)
    • (2007) J. Incl. Phenom. Macrocycl. Chem. , vol.57 , pp. 283-288
    • Zoppetti, G.1    Puppini, N.2    Pizzutti, M.3    Fini, A.4    Giovani, T.5    Comini, S.6
  • 25
    • 1442310829 scopus 로고    scopus 로고
    • Solubility enhancement of celecoxib using β-cyclodextrin inclusion complexes
    • 10.1016/j.ejpb.2003.10.020
    • Swati, R.; Sanjay, K.: Solubility enhancement of celecoxib using β-cyclodextrin inclusion complexes. Euro. J. Pharma. Biopharm. 57, 263-267 (2004)
    • (2004) Euro. J. Pharma. Biopharm. , vol.57 , pp. 263-267
    • Swati, R.1    Sanjay, K.2
  • 28
    • 77958500768 scopus 로고    scopus 로고
    • Crystal structure of an essential enzyme in seed starch degradation: Barley limit dextrinase in complex with cyclodextrins
    • 10.1016/j.jmb.2010.09.031
    • Christensen, M.B.V.; Abouhachem, M.; Svensson, B.; Henriksen, A.: Crystal structure of an essential enzyme in seed starch degradation: barley limit dextrinase in complex with cyclodextrins. J. Mol. Bio. 405, 739-750 (2010)
    • (2010) J. Mol. Bio. , vol.405 , pp. 739-750
    • Christensen, M.B.V.1    Abouhachem, M.2    Svensson, B.3    Henriksen, A.4
  • 29
    • 34247115617 scopus 로고    scopus 로고
    • Structural basis for cyclodextrin recognition by Thermoactinomyces vulgaris cyclo/maltodextrin-binding protein
    • 1:CAS:528:DC%2BD2sXltVeisr0%3D 10.1111/j.1742-4658.2007.05753.x
    • Tonozuka, T.; Sogawa, A.; Yamada, M.; Matsumoto, N.; Yoshida, H.; Kamitori, S.; Ichikawa, K.; Mizuno, M.; Nishikawa, A.; Sakano, Y.: Structural basis for cyclodextrin recognition by Thermoactinomyces vulgaris cyclo/maltodextrin-binding protein. FEBS J. 274, 2109-2120 (2007)
    • (2007) FEBS J. , vol.274 , pp. 2109-2120
    • Tonozuka, T.1    Sogawa, A.2    Yamada, M.3    Matsumoto, N.4    Yoshida, H.5    Kamitori, S.6    Ichikawa, K.7    Mizuno, M.8    Nishikawa, A.9    Sakano, Y.10
  • 30
    • 49149147973 scopus 로고
    • Iterative partial equalization of orbital electro negativity a rapid access to atomic charges
    • 1:CAS:528:DyaL3MXhslCjtbs%3D 10.1016/0040-4020(80)80168-2
    • Gasteiger, J.; Marsili, M.: Iterative partial equalization of orbital electro negativity a rapid access to atomic charges. Tetrahedron 36, 3219-3228 (1980)
    • (1980) Tetrahedron , vol.36 , pp. 3219-3228
    • Gasteiger, J.1    Marsili, M.2
  • 32
    • 33846446220 scopus 로고
    • Restart procedures for conjugate gradient method program
    • 10.1007/BF01593790
    • Powell, M.J.D.: Restart procedures for conjugate gradient method program. Math. Prog. 12, 241-254 (1977)
    • (1977) Math. Prog. , vol.12 , pp. 241-254
    • Powell, M.J.D.1
  • 33
    • 84893731839 scopus 로고    scopus 로고
    • SYBYL7.1, Tripos Associates INC: S. Henley Rd.; St. Louis, MO631444, USA. (1699)
    • SYBYL7.1, Tripos Associates INC: S. Henley Rd.; St. Louis, MO631444, USA. (1699)
  • 35
    • 41549126609 scopus 로고    scopus 로고
    • In vitro-in vivo correlation: From theory to application
    • 1:CAS:528:DC%2BD28Xot1yjsLg%3D
    • Emami, J.: In vitro-in vivo correlation: from theory to application. J. Pharm. Pharmaceut. Sci. 9, 169-189 (2006)
    • (2006) J. Pharm. Pharmaceut. Sci. , vol.9 , pp. 169-189
    • Emami, J.1
  • 36
    • 70449528133 scopus 로고    scopus 로고
    • Preparation and evaluation of inclusion complex of lipid lowering drug lovastatin with β-cyclodextrin
    • 10.3329/dujps.v6i1.340
    • Patel, R.P.; Patel, M.M.: Preparation and evaluation of inclusion complex of lipid lowering drug lovastatin with β-cyclodextrin. Dhaka Univ. J. Pharm. Sci. 6, 25-36 (2007)
    • (2007) Dhaka Univ. J. Pharm. Sci. , vol.6 , pp. 25-36
    • Patel, R.P.1    Patel, M.M.2
  • 38
    • 10444279209 scopus 로고    scopus 로고
    • Cyclodextrin-based pharmaceutics: Past, present and future
    • 10.1038/nrd1576
    • Mark, E.D.; Marcus, E.B.: Cyclodextrin-based pharmaceutics: past, present and future. Nat. Rev. Drug Discov. 3, 1023-1035 (2004)
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 1023-1035
    • Mark, E.D.1    Marcus, E.B.2
  • 39
    • 84865663965 scopus 로고    scopus 로고
    • Water soluble complexes of curcumin with cyclodextrin: Characterization by FT-Raman spectroscopy
    • 10.1016/j.vibspec.2012.05.002
    • Krishna Mohan, P.R.; Sreelakshmi, G.; Muraleedharan, C.V.; Joseph, R.: Water soluble complexes of curcumin with cyclodextrin: characterization by FT-Raman spectroscopy. Vib. Spectrosc. 62, 77-84 (2012)
    • (2012) Vib. Spectrosc. , vol.62 , pp. 77-84
    • Krishna Mohan, P.R.1    Sreelakshmi, G.2    Muraleedharan, C.V.3    Joseph, R.4
  • 40
    • 79952238275 scopus 로고    scopus 로고
    • Bioavailability enhancement of curcumin by complexation with phosphatidyl choline
    • 1:CAS:528:DC%2BC3MXislOkt74%3D 10.1002/jps.22393
    • Gupta, N.K.; Dixit, V.K.: Bioavailability enhancement of curcumin by complexation with phosphatidyl choline. J. Pharm. Sci. 100, 1987-1995 (2011)
    • (2011) J. Pharm. Sci. , vol.100 , pp. 1987-1995
    • Gupta, N.K.1    Dixit, V.K.2
  • 41
    • 0036266936 scopus 로고    scopus 로고
    • Characterization of raloxifene glucuronidation in vitro: Contribution of intestinal metabolism to pre-systemic clearance
    • 1:CAS:528:DC%2BD38XktFSlsbk%3D 10.1124/dmd.30.6.694
    • Kemp, D.C.; Fan, P.W.; Stevens, J.C.: Characterization of raloxifene glucuronidation in vitro: contribution of intestinal metabolism to pre-systemic clearance. Drug Metab. Dispos. 30, 694-700 (2002)
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 694-700
    • Kemp, D.C.1    Fan, P.W.2    Stevens, J.C.3
  • 42
    • 36148994703 scopus 로고    scopus 로고
    • Pharmacokinetics of raloxifene in male Wistar-Hannover rats: Influence of complexation with hydroxybutenyl-beta-cyclodextrin
    • 1:CAS:528:DC%2BD2sXhtlWmsLbK 10.1016/j.ijpharm.2007.06.002
    • Wempe, M.F.; Wacher, V.J.; Ruble, K.M.; Ramsey, M.G.; Edgar, K.J.; Buchanan, N.L.; Buchanan, C.M.: Pharmacokinetics of raloxifene in male Wistar-Hannover rats: influence of complexation with hydroxybutenyl-beta- cyclodextrin. Int. J. Pharm. 346, 25-37 (2008)
    • (2008) Int. J. Pharm. , vol.346 , pp. 25-37
    • Wempe, M.F.1    Wacher, V.J.2    Ruble, K.M.3    Ramsey, M.G.4    Edgar, K.J.5    Buchanan, N.L.6    Buchanan, C.M.7
  • 43
    • 80052846753 scopus 로고    scopus 로고
    • In vitro-in vivo correlation: Perspectives on model development
    • 1:CAS:528:DC%2BC3MXhtFOmtrrP 10.1016/j.ijpharm.2011.01.010
    • Lu, Y.; Kim, S.; Park, K.: In vitro-in vivo correlation: perspectives on model development. Int. J. Pharm. 418, 142-148 (2011)
    • (2011) Int. J. Pharm. , vol.418 , pp. 142-148
    • Lu, Y.1    Kim, S.2    Park, K.3
  • 44
    • 44949089872 scopus 로고    scopus 로고
    • In vitro-in vivo correlation: Importance of dissolution in IVIVC
    • Cardot, J.M.; Beyssac, E.; Alric, M.: In vitro-in vivo correlation: importance of dissolution in IVIVC. Disso. Tech. 15-16 (2007)
    • (2007) Disso. Tech. , pp. 15-16
    • Cardot, J.M.1    Beyssac, E.2    Alric, M.3
  • 45
    • 82955228962 scopus 로고    scopus 로고
    • Preparation and characterization of Pioglitazone cyclodextrin inclusion complexes
    • 10.4103/0975-1483.90234
    • Vinay, P.; Raghu, G.; Kusum, D.; Roopa, S.P.; Sarasija, S.: Preparation and characterization of Pioglitazone cyclodextrin inclusion complexes. J. Young. Pharma. 3, 267-274 (2011)
    • (2011) J. Young. Pharma. , vol.3 , pp. 267-274
    • Vinay, P.1    Raghu, G.2    Kusum, D.3    Roopa, S.P.4    Sarasija, S.5


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