Effects of acute exercise and chronic exercise on the liver leptin-AMPK-ACC signaling pathway in rats with type 2 diabetes

Journal of Diabetes Research

Volumn 2013, Issue , 2013, Pages

  Yi, Xuejie ^a,b   Cao, Shicheng ^a   Chang, Bo ^b   Zhao, Dalin ^b   Gao, Haining ^b   Wan, Yihan ^b   Shi, Jiaojiao ^b   Wei, Wei ^b   Guan, Yifu ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b SHENYANG SPORT UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEPTIN;

ANIMAL; ANIMAL EXPERIMENT; ARTICLE; CHEMICALLY INDUCED DISORDER; EXPERIMENTAL DIABETES MELLITUS; LIVER; MALE; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TIME;

ACETYL-COA CARBOXYLASE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; LEPTIN; LIVER; MALE; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84893740051     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2013/946432     Document Type: Article

References (54)

1. Petersen K. F., Oral E. A., Dufour S., Befroy D., Ariyan C., Yu C., Cline G. W., DePaoli A. M., Taylor S. I., Gorden P., Shulman G. I., Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. Journal of Clinical Investigation 2002 109 10 1345 1350 2-s2.0-0036114844 10.1172/JCI200215001 (Pubitemid 34546899)
2. Oral E. A., Simha V., Ruiz E., Andewelt A., Premkumar A., Snell P., Wagner A. J., DePaoli A. M., Reitman M. L., Taylor S. I., Gorden P., Garg A., Leptin-replacement therapy for lipodystrophy. The New England Journal of Medicine 2002 346 8 570 578 2-s2.0-0037148928 10.1056/NEJMoa012437 (Pubitemid 34438818)
3. Friedman J. M., Modern science versus the stigma of obesity. Nature Medicine 2004 10 6 563 569 2-s2.0-2942716780 10.1038/nm0604-563 (Pubitemid 38796839)
4. Mapfei M., Halaas J., Ravussin E., Pratley R. E., Lee G. H., Zhangs Y., Fei H., Kim S., Lallone R., Ranganathan S., Kern P. A., Friedman J. M., Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Medicine 1995 1 11 1155 1161 2-s2.0-0028845877
5. Widjaja A., Stratton I. M., Horn R., Holman R. R., Turner R., Brabant G., UKPDS 20: plasma leptin, obesity, and plasma insulin in type 2 diabetic subjects. Journal of Clinical Endocrinology and Metabolism 1997 82 2 654 657 2-s2.0-0031031624 10.1210/jc.82.2.654 (Pubitemid 27068646)
6. Heymsfield S. B., Greenberg A. S., Fujioka K., Dixon R. M., Kushner R., Hunt T., Lubina J. A., Patane J., Self B., Hunt P., McCamish M., Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. Journal of the American Medical Association 1999 282 16 1568 1575 2-s2.0-0032747280 10.1001/jama.282.16.1568 (Pubitemid 29504050)
7. Sriwijitkamol A., Coletta D. K., Wajcberg E., Balbontin G. B., Reyna S. M., Barrientes J., Eagan P. A., Jenkinson C. P., Cersosimo E., DeFronzo R. A., Sakamoto K., Musi N., Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response study. Diabetes 2007 56 3 836 848 2-s2.0-33847399214 10.2337/db06-1119 (Pubitemid 46348486)
8. Jeukendrup A. E., Regulation of fat metabolism in skeletal muscle. Annals of the New York Academy of Sciences 2002 967 217 235 2-s2.0-0036291378 (Pubitemid 34721908)
9. Mullen K. L., Pritchard J., Ritchie I., Snook L. A., Chabowski A., Bonen A., Wright D., Dyck D. J., Adiponectin resistance precedes the accumulation of skeletal muscle lipids and insulin resistance in high-fat-fed rats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2009 296 2 R243 R251 2-s2.0-61949190996 10.1152/ajpregu.90774.2008
10. Yi X. J., Wang H., Li Q. P., Exercise on the sexual development and the fat leptin receptor mRNA expression in the high-fat die female rats. Zhongguo Ying Yong Sheng Li Xue Za Zhi 2009 25 4 454 542
11. Fuentes T., Ara I., Guadalupe-Grau A., Larsen S., Stallknecht B., Olmedillas H., Santana A., Helge J. W., Calbet J. A. L., Guerra B., Leptin receptor 170 kDa (OB-R170) protein expression is reduced in obese human skeletal muscle: a potential mechanism of leptin resistance. Experimental Physiology 2010 95 1 160 171 2-s2.0-74049113378 10.1113/expphysiol.2009.049270
12. Steinberg G. R., Dyck D. J., Calles-Escandon J., Tandon N. N., Luiken J. J. F. P., Glatz J. F. C., Bonen A., Chronic leptin administration decreases fatty acid uptake and fatty acid transporters in rat skeletal muscle. Journal of Biological Chemistry 2002 277 11 8854 8860 2-s2.0-0037088653 10.1074/jbc.M107683200 (Pubitemid 34952953)
13. Bandyopadhyay G. K., Yu J. G., Ofrecio J., Olefsky J. M., Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. Diabetes 2006 55 8 2277 2285 2-s2.0-33749370466 10.2337/db06-0062 (Pubitemid 44743625)
14. Vozarova B., Stefan N., Lindsay R. S., Saremi A., Pratley R. E., Bogardus C., Antonio Tataranni P., High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes. Diabetes 2002 51 6 1889 1895 2-s2.0-0036263238 (Pubitemid 34564303)
15. Chiang D. J., Pritchard M. T., Nagy L. E., Obesity, diabetes mellitus, and liver fibrosis. American Journal of Physiology-Gastrointestinal and Liver Physiology 2011 300 5 G697 G702 2-s2.0-79955551252 10.1152/ajpgi.00426.2010
16. Lazo M., Clark J. M., The epidemiology of nonalcoholic fatty liver disease: a global perspective. Seminars in Liver Disease 2008 28 4 339 350 2-s2.0-56649123256 10.1055/s-0028-1091978
17. Lautamäki R., Borra R., Iozzo P., Komu M., Lehtimäki T., Salmi M., Jalkanen S., Airaksinen K. E. J., Knuuti J., Parkkola R., Nuutila P., Liver steatosis coexists with myocardial insulin resistance and coronary dysfunction in patients with type 2 diabetes. American Journal of Physiology-Endocrinology and Metabolism 2006 291 2 E282 E290 2-s2.0-33745856570 10.1152/ajpendo.00604. 2005 (Pubitemid 44035287)
18. Krawczewski Carhuatanta K. A., Demuro G., Tschöp M. H., Pfluger P. T., Benoit S. C., Obici S., Voluntary exercise improves high-fat diet-induced leptin resistance independent of adiposity. Endocrinology 2011 152 7 2655 2664 2-s2.0-79959444288 10.1210/en.2010-1340
19. Sari R., Balci M. K., Balci N., Karayalcin U., Acute effect of exercise on plasma leptin level and insulin resistance in obese women with stable caloric intake. Endocrine Research 2007 32 1-2 9 17 2-s2.0-40449115424 10.1080/07435800701670070 (Pubitemid 351411680)
20. Zhao J., Tian Y., Xu J., Liu D., Wang X., Zhao B., Endurance exercise is a leptin signaling mimetic in hypothalamus of Wistar rats. Lipids in Health and Disease 2011 10, article 225 2-s2.0-82455168243 10.1186/1476-511X-10-225
21. Patterson C. M., Bouret S. G., Dunn-Meynell A. A., Levin B. E., Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2009 296 3 R537 R548 2-s2.0-64149099887 10.1152/ajpregu.90859.2008
22. Ruderman N. B., Park H., Kaushik V. K., Dean D., Constant S., Prentki M., Saha A. K., AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise. Acta Physiologica Scandinavica 2003 178 4 435 442 2-s2.0-0042160131 10.1046/j.1365-201X.2003.01164.x (Pubitemid 36960435)
23. Cao S., Li B., Yi X., Chang B., Zhu B., Lian Z., Zhang Z., Zhao G., Liu H., Zhang H., Effects of exercise on AMPK signaling and downstream components to PI3K in rat with type 2 diabetes. PLoS ONE 2012 7 12 e51709
24. Srinivasan K., Viswanad B., Asrat L., Kaul C. L., Ramarao P., Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacological Research 2005 52 4 313 320 2-s2.0-23844504364 10.1016/j.phrs.2005.05.004 (Pubitemid 41175991)
25. Zhang M., Lv X.-Y., Li J., Xu Z.-G., Chen L., The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. Experimental Diabetes Research 2008 2008 9 704045 2-s2.0-65549131015 10.1155/2008/704045
26. Luciano E., Carneiro E. M., Carvalho C. R., Carvalheira J. B., Peres S. B., Reis M. A., Saad M. J., Boschero A. C., Velloso L. A., Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the phosphatidylinositol 3-kinase/Akt-1 pathway. European Journal of Endocrinology 2002 147 1 149 157 (Pubitemid 34814752)
27. Chibalin A. V., Yu M., Ryder J. W., Song X. M., Galuska D., Krook A., Wallberg-Henriksson H., Zierath J. R., Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: differential effects on insulin-receptor substrates 1 and 2. Proceedings of the National Academy of Sciences of the United States of America 2000 97 1 38 43 2-s2.0-0034602675 10.1073/pnas.97.1.38 (Pubitemid 30055780)
28. Laemmli U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970 227 5259 680 685 2-s2.0-0014949207 10.1038/227680a0
29. Tanaka S., Hayashi T., Toyoda T., Hamada T., Shimizu Y., Hirata M., Ebihara K., Masuzaki H., Hosoda K., Fushiki T., Nakao K., High-fat diet impairs the effects of a single bout of endurance exercise on glucose transport and insulin sensitivity in rat skeletal muscle. Metabolism 2007 56 12 1719 1728 2-s2.0-35848951395 10.1016/j.metabol.2007.07.017 (Pubitemid 350060940)
30. Petersen K. F., Shulman G. I., Etiology of insulin resistance. American Journal of Medicine 2006 119 5 S10 S16 2-s2.0-33645074450 10.1016/j.amjmed.2006. 01.009
31. Hsiao P.-J., Kuo K.-K., Shin S.-J., Yang Y.-H., Lin W.-Y., Yang J.-F., Chiu C.-C., Chuang W.-L., Tsai T.-R., Yu M.-L., Significant correlations between severe fatty liver and risk factors for metabolic syndrome. Journal of Gastroenterology and Hepatology 2007 22 12 2118 2123 2-s2.0-36348948428 10.1111/j.1440-1746.2006.04698.x (Pubitemid 350145601)
32. Targher G., Arcaro G., Non-alcoholic fatty liver disease and increased risk of cardiovascular disease. Atherosclerosis 2007 191 2 235 240 2-s2.0-33947108446 10.1016/j.atherosclerosis.2006.08.021 (Pubitemid 46400718)
33. Fabbrini E., Sullivan S., Klein S., Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 2010 51 2 679 689 2-s2.0-75449094816 10.1002/hep.23280
34. Speliotes E. K., Massaro J. M., Hoffmann U., Vasan R. S., Meigs J. B., Sahani D. V., Hirschhorn J. N., O'Donnell C. J., Fox C. S., Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham heart study. Hepatology 2010 51 6 1979 1987 2-s2.0-77952680758 10.1002/hep.23593
35. Fabbrini E., Magkos F., Mohammed B. S., Pietka T., Abumrad N. A., Patterson B. W., Okunade A., Klein S., Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proceedings of the National Academy of Sciences of the United States of America 2009 106 36 15430 15435 2-s2.0-70349326750 10.1073/pnas.0904944106
36. Shimabukuro M., Koyama K., Chen G., Wang M. Y., Tried F., Lee Y., Newqard C. B., Unqer R. H., Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proceedings of the National Academy of Sciences of the United States of America 1997 94 9 4637 4641 (Pubitemid 27194295)
37. Unger R. H., The Physiology of Cellular Liporegulation. Annual Review of Physiology 2003 65 333 347 2-s2.0-0037636366 10.1146/annurev.physiol.65.092101. 142622 (Pubitemid 38249157)
38. Palou M., Priego T., Sánchez J., Villegas E., Rodríguez A. M., Palou A., Picó C., Sequential changes in the expression of genes involved in lipid metabolism in adipose tissue and liver in response to fasting. Pflugers Archiv European Journal of Physiology 2008 456 5 825 836 2-s2.0-45649083309 10.1007/s00424-008-0461-1
39. Minokoshi Y., Alquier T., Furukawa H., Kim Y.-B., Lee A., Xue B., Mu J., Foufelle F., Ferré P., Birnbaum M. J., Stuck B. J., Kahn B. B., AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004 428 6982 569 574 2-s2.0-1842484296 10.1038/nature02440 (Pubitemid 38480541)
40. Miyamoto L., Ebihara K., Kusakabe T., Aotani D., Yamamoto-Kataoka S., Sakai T., Aizawa-Abe M., Yamamoto Y., Fujikura J., Hayashi T., Hosoda K., Nakao K., Leptin activates hepatic 5′-AMP-activated protein kinase through sympathetic nervous system and ?1-adrenergic receptor:a potential mechanism for improvement of fatty liver in lipodystrophy by leptin. The Journal of Biological Chemistry 2012 287 48 40441 40447
41. Yu X., McCorkle S., Wang M., Lee Y., Li J., Saha A. K., Unger R. H., Ruderman N. B., Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. Diabetologia 2004 47 11 2012 2021 2-s2.0-12144271041 10.1007/s00125-004-1570-9 (Pubitemid 40110213)
42. Krawczewski Carhuatanta K. A., Demuro G., Tschöp M. H., Pfluger P. T., Benoit S. C., Obici S., Voluntary exercise improves high-fat diet-induced leptin resistance independent of adiposity. Endocrinology 2011 152 7 2655 2664 2-s2.0-79959444288 10.1210/en.2010-1340
43. Gauthier M.-S., Couturier K., Charbonneau A., Lavoie J.-M., Effects of introducing physical training in the course of a 16-week high-fat diet regimen on hepatic steatosis, adipose tissue fat accumulation, and plasma lipid profile. International Journal of Obesity 2004 28 8 1064 1071 2-s2.0-3242888007 10.1038/sj.ijo.0802628 (Pubitemid 38998714)
44. Steinberg G. R., Smith A. C., Wormald S., Malenfant P., Collier C., Dyck D. J., Endurance training partially reverses dietary-induced leptin resistance in rodent skeletal muscle. American Journal of Physiology-Endocrinology and Metabolism 2004 286 1 E57 E63 2-s2.0-0348048486 (Pubitemid 38036610)
45. Roselli-Rehfuss L., Mountjoy K. G., Robbins L. S., Mortrud M. T., Low M. J., Tatro J. B., Entwistle M. L., Simerly R. B., Cone R. D., Identification of a receptor for γ melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proceedings of the National Academy of Sciences of the United States of America 1993 90 19 8856 8860 2-s2.0-0027436690 10.1073/pnas.90.19.8856 (Pubitemid 23306409)
46. Steinberg G. R., Smith A. C., Wormald S., Malenfant P., Collier C., Dyck D. J., Endurance training partially reverses dietary-induced leptin resistance in rodent skeletal muscle. American Journal of Physiology-Endocrinology and Metabolism 2004 286 1 E57 E63 2-s2.0-0348048486 (Pubitemid 38036610)
47. Yasari S., Wang D., Prud'homme D., Jankowski M., Gutkowska J., Lavoie J.-M., Exercise training decreases plasma leptin levels and the expression of hepatic leptin receptor-a, -b, and -e in rats. Molecular and Cellular Biochemistry 2009 324 1-2 13 20 2-s2.0-61549106934 10.1007/s11010-008-9979-y
48. Zhao J., Tian Y., Xu J., Liu D., Wang X., Zhao B., Endurance exercise is a leptin signaling mimetic in hypothalamus of Wistar rats. Lipids in Health and Disease 2011 10, article 225 2-s2.0-82455168243 10.1186/1476-511X-10-225
49. Olmedillas H., Sanchis-Moysi J., Fuentes T., Guadalupe-Grau A., Ponce-González J. G., Morales-Alamo D., Santana A., Dorado C., Calbet J. A. L., Guerra B., Muscle hypertrophy and increased expression of leptin receptors in the musculus triceps brachii of the dominant arm in professional tennis players. European Journal of Applied Physiology 2010 108 4 749 758 2-s2.0-77950865754 10.1007/s00421-009-1281-5
50. Ritchie I. R. W., Gulli R. A., Stefanyk L. E., Harasim E., Chabowski A., Dyck D. J., Restoration of skeletal muscle leptin response does not precede the exercise-induced recovery of insulin-stimulated glucose uptake in high-fat-fed rats. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2011 300 2 R492 R500 2-s2.0-79551563331 10.1152/ajpregu.00602.2010
51. Takekoshi K., Fukuhara M., Quin Z., Nissato S., Isobe K., Kawakami Y., Ohmori H., Long-term exercise stimulates adenosine monophosphate-activated protein kinase activity and subunit expression in rat visceral adipose tissue and liver. Metabolism 2006 55 8 1122 1128 2-s2.0-33745713517 10.1016/j.metabol.2006.04.007
52. Little J. P., Safdar A., Cermak N., Tarnopolsky M. A., Gibala M. J., Acute endurance exercise increases the nuclear abundance of PGC-1 α in trained human skeletal muscle. American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2010 298 4 R912 R917 2-s2.0-77949856117 10.1152/ajpregu.00409.2009
53. Lee-Young R. S., Koufogiannis G., Canny B. J., McConell G. K., Acute exercise does not cause sustained elevations in AMPK signaling or expression. Medicine and Science in Sports and Exercise 2008 40 8 1490 1494 2-s2.0-58149347843 10.1249/MSS.0b013e318173a037
54. Koh H.-J., Hirshman M. F., He H., Li Y., Manabe Y., Balschi J. A., Goodyear L. J., Adrenaline is a critical mediator of acute exercise-induced AMP-activated protein kinase activation in adipocytes. Biochemical Journal 2007 403 3 473 481 2-s2.0-34247853279 10.1042/BJ20061479 (Pubitemid 46706975)