A click chemistry approach to pleuromutilin derivatives. Part 3: Extended footprinting analysis and excellent MRSA inhibition for a derivative with an adenine phenyl side chain

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 4, 2014, Pages 1043-1046

  Dreier, Ida ^a   Hansen, Lykke H ^a   Nielsen, Poul ^a   Vester, Birte ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Antibiotics; Chemical footprinting; Click chemistry; MRSA inhibition; Pleuromutilin derivatives

Indexed keywords

ANTIBIOTICS; CHEMICAL FOOTPRINTING; CLICK CHEMISTRY; MRSA INHIBITION; PLEUROMUTILIN DERIVATIVES;

ADENINE; ANTI-BACTERIAL AGENTS; CLICK CHEMISTRY; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84893724606     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.01.019     Document Type: Article

References (17)

1. H.A. Kirst Expert Opin. Drug. Disc. 8 2013 479
2. F. Kavanagh, A. Hervey, and W.J. Robbins Proc. Nat. Acad. Sci. USA 37 1951 570
3. R.S. Daum, S. Kar, and P. Kirkpatrich Nat. Rev. Drug. Disc. 6 2007 865
4. S.M. Poulsen, M. Karlsson, L.B. Johansson, and B. Vester Mol. Microbiol. 41 2001 1091
5. K.S. Long, L.H. Hansen, L. Jakobsen, and B. Vester Antimicrob. Agents Chemother. 50 2006 1458
6. F. Schlunzen, E. Pyetan, P. Fucini, A. Yonath, and J.M. Harms Mol. Microbiol. 54 2004 1287
7. C. Davidovich, A. Bashan, T. Auerbach-Nevo, R.D. Yaggie, R.R. Gontarek, and A. Yonath Proc. Nat. Acad. Sci. U.S.A. 104 2007 4291
8. G. Gurel, G. Blaha, P.B. Moore, and T.A. Steitz J. Mol. Biol. 389 2009 146
9. R. Novak Ann. NY Acad. Sci. 1241 2011 71
10. Y.Z. Tang, Y.H. Liu, and J.X. Chen Mini Rev. Med. Chem. 12 2012 53
11. X.Y. Wang, Y. Ling, H. Wang, J.H. Yu, J.M. Tang, H. Zheng, X. Zhao, D.G. Wang, G.T. Chen, W.Q. Qiu, and J.H. Tao Bioorg. Med. Chem. Lett. 22 2012 6166
12. R. Shang, Y. Liu, Z. Xin, W. Guo, Z. Guo, B. Hao, and L. Jianping Eur. J. Med. Chem. 63 2013 231
13. L. Lolk, J. Pøhlsgaard, A.S. Jepsen, L.H. Hansen, H. Nielsen, S.I. Steffansen, L. Sparving, A.B. Nielsen, B. Vester, and P. Nielsen J. Med. Chem. 51 2008 4957
14. I. Dreier, S. Kumar, H. Søndergaard, M.L. Rasmussen, L.H. Hansen, N.H. List, J. Kongsted, B. Vester, and P. Nielsen J. Med. Chem. 55 2012 2067
15. V.V. Rostovtsev, L.G. Green, V.V. Fokin, and K.B. Sharpless Angew. Chem., Int. Ed. 41 2002 2596
16. C.W. Tornøe, C. Christensen, and M. Meldal J. Org. Chem. 67 2002 3057
17. K.S. Long, J. Poehlsgaard, C. Kehrenberg, S. Schwarz, and B. Vester Antimicrob. Agents Chemother. 50 2006 2500