Novel pleuromutilin derivatives as antibacterial agents: Synthesis, biological evaluation and molecular docking studies

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 19, 2012, Pages 6166-6172

  Wang, Xinyang ^a   Ling, Yong ^a   Wang, Hui ^b   Yu, Jianghe ^b   Tang, Junming ^c   Zheng, Heng ^b   Zhao, Xi ^a   Wang, Donggeng ^a   Chen, Guangtong ^a   Qiu, Wenqian ^a   Tao, Jinhua ^a  

^a NANTONG MEDICAL COLLEGE   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c HENAN NORMAL UNIVERSITY   (China)

Author keywords

2 Amino 1,3 thiazole; Antibacterial activity; Pleuromutilin derivatives; Resistant Gram positive pathogens

Indexed keywords

AMOXICILLIN; PLEUROMUTILIN; TIAMULIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN;

ANTI-BACTERIAL AGENTS; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; METHICILLIN RESISTANCE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STAPHYLOCOCCUS EPIDERMIDIS; STRUCTURE-ACTIVITY RELATIONSHIP;

POSIBACTERIA;

EID: 84866354312     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.021     Document Type: Article

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