A click chemistry approach to pleuromutilin derivatives, part 2: Conjugates with acyclic nucleosides and their ribosomal binding and antibacterial activity

Journal of Medicinal Chemistry

Volumn 55, Issue 5, 2012, Pages 2067-2077

  Dreier, Ida ^a   Kumar, Surender ^a,b   Søndergaard, Helle ^a   Rasmussen, Maria Louise ^a   Hansen, Lykke Haastrup ^a   List, Nanna Holmgaard ^a   Kongsted, Jacob ^a   Vester, Birte ^a   Nielsen, Poul ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b KURUKSHETRA UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

22 (1,2,3 TRIAZOL 1 YL) 22 DEOXYPLEUROMUTILIN; 22 [4 (2 THYMIN 1 YL)ETHOXYMETHYL) 1,2,3 TRIAZOL 1 YL] 22 DEOXYPLEUROMUTILIN; 22 [4 (2R (URACIL 1 YL) 4S HYDROXY 5R HYDROXYMETHYL)TETRAHYDROFURAN 3R YLMETHYL) 1,2,3 TRIAZOL 1 YL] 22 DEOXYPLEUTOMUTILIN; 22 [4 (3 (ADENIN 9 YL)PHENYL) 1,2,3 TRIAZOL 1 YL] 22 DEOXYPLEUROMUTILIN; 22 [4 (3 (ADENIN 9 YL)PROPEN 1 YL) 1,2,3 TRIAZOL 1 YL] 22 DEOXYPLEUROMUTILIN; 22 [4 (3 (THYMIN 1 YL)PROPEN 1 YL) 1,2,3 TRIAZOL 1 YL] 22 DEOXYPLEUROMUTILIN; 22 [4 (4 (ADENIN 9 YL)PHENYL) 1,2,3 TRIAZOL 1 YL] 22 DEOXYPLEUROMUTILIN; 22 [4 (ADENIN 9 YLMETHOXYMETHYL) 1,2,3 TRIAZOL 1 YL] 22 DEOXYPLEUROMUTILIN; 22 [4 (BENZYLOXYMETHYL) 1,2,3 TRIAZOL 1 YL] 22 DEOXYPLEUROMUTILIN; 22 [4 (THYMIN 1 YLMETHOXYMETHYL) 1,2,3 TRIAZOL 1 YL] 22 DEOXYPLEUROMUTILIN; 22 [5 (3 (ADEN 9 YL)PROPYL) 1,2,3 TRIAZOL 1 YL] 22 DEOXYPLEUROMUTILIN; ACYCLIC NUCLEOSIDE; CARBENE; NUCLEIC ACID BASE; OXYGEN; PHENYL GROUP; PLEUROMUTILIN; RETAPAMULIN; TERPENOID DERIVATIVE; TIAMULIN; UNCLASSIFIED DRUG; VALNEMULIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BINDING AFFINITY; CLICK CHEMISTRY; CONTROLLED STUDY; DRUG CONFORMATION; DRUG CONJUGATION; ESCHERICHIA COLI; GROWTH INHIBITION; HYDROPHILICITY; MOLECULAR MODEL; NONHUMAN; PROTEIN FOOTPRINTING; RIBOSOME;

ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; BINDING SITES; CLICK CHEMISTRY; DITERPENES; ESCHERICHIA COLI; LISTERIA; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEOSIDES; PEPTIDYL TRANSFERASES; RIBOSOMES; RNA, BACTERIAL; RNA, RIBOSOMAL, 23S; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863242788     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201266b     Document Type: Article

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