Chitosan oligosaccharides downregulate the expression of E-selectin and ICAM-1 induced by LPS in endothelial cells by inhibiting MAP kinase signaling

International Journal of Molecular Medicine

Volumn 33, Issue 2, 2014, Pages 392-400

  Li, Yu ^b   Xu, Qingsong ^a   Wei, Peng ^a,b   Cheng, Likun ^a,b   Peng, Qiang ^a,b   Li, Shuguang ^a   Yin, Heng ^a   Du, Yuguang ^a  

^a DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Chitosan oligosaccharides; Lipopolysaccharide; Mitogen activated protein kinase; Molecular adhesion; Nuclear factor ?B

Indexed keywords

CHITOSAN; CHITOSAN OLIGOSACCHARIDE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; I KAPPA B; I KAPPA B KINASE ALPHA; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; OLIGOSACCHARIDE; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPLASM; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; INFLAMMATION; MONOCYTE; NONHUMAN; PORCINE ILIAC ARTERY ENDOTHELIAL CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANIMALS; CELL LINE; CHITOSAN; DOWN-REGULATION; E-SELECTIN; ENDOTHELIAL CELLS; INTERCELLULAR ADHESION MOLECULE-1; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; OLIGOSACCHARIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RNA, MESSENGER; SWINE;

EID: 84893720158     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1589     Document Type: Article

References (38)

1. Mourya VK, Inamdar NN and Choudhari YM: Chitooligosaccharides: Synthesis, characterization and applications. Polym Sci Ser A 53: 583-612, 2011.
2. Xu WH, Jiang CQ, Kong XY, Liang Y, Rong M and Liu WS: Chitooligosaccharides and N-acetyl-D-glucosamine stimulate peripheral blood mononuclear cell-mediated antitumor immune responses. Mol Med Rep 6: 385-390, 2012.
3. Liu HT, He JL, Li WM, et al: Chitosan oligosaccharides protect human umbilical vein endothelial cells from hydrogen peroxide-induced apoptosis. Carbohydr Polym 80: 1062-1071, 2010.
4. Zhang JN, Dang YB, Li S, et al: The effects of chitosan oligosaccharide on the activation of murine spleen CD11c(+) dendritic cells via toll-like receptor 4. Carbohydr Polym 83: 1075-1081, 2011.
5. Yousef M, Pichyangkura R, Soodvilai S, Chatsudthipong V and Muanprasat C: Chitosan oligosaccharide as potential therapy of inflammatory bowel disease: Therapeutic efficacy and possible mechanisms of action. Pharmacol Res 66: 66-79, 2012.
6. Ji Q, Deng J, Yu X, Xu Q, Wu H and Pan J: Modulation of pro-inflammatory mediators in LPS-stimulated human periodontal ligament cells by chitosan and quaternized chitosan. Carbohydr Polym 92: 824-829, 2013.
7. Chu X, Ci X, Wei M, et al: Licochalcone A inhibits lipopolysaccharide- induced inflammatory response in vitro and in vivo. J Agric Food Chem 60: 3947-3954, 2012.
8. Chen G, Li J, Ochani M, et al: Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14-and TNF-dependent mechanisms. J Leukoc Biol 76: 994-1001, 2004.
9. Hu Y, Chen X, Duan H, Hu Y and Mu X: Chinese herbal medicinal ingredients inhibit secretion of IL-6, IL-8, E-selectin and TXB(2) in LPS-induced rat intestinal microvascular endothelial cells. Immunopharmacol Immunotoxicol 31: 550-555, 2009.
10. Zou LY, Yang SL, Champattanachai V, et al: Glucosamine improves cardiac function following trauma-hemorrhage by increased protein O-GlcNAcylation and attenuation of NF-?B signaling. Am J Physiol Heart Circ Physiol 296: H515-H523, 2009.
11. Yan WS, Zhao KS, Jiang Y, et al: Role of p38 MAPK in ICAM-1 expression of vascular endothelial cells induced by lipopolysaccharide. Shock 17: 433-438, 2002.
12. Tanigawa N, Hagiwara M, Tada H, et al: Acacetin inhibits expression of E-selectin on endothelial cells through regulation of the MAP kinase signaling pathway and activation of NF-?B. Immunopharmacol Immunotoxicol 35: 471-477, 2013.
13. Pina-Canseco Mdel S, Paez-Arenas A, Masso F, et al: Protein C activation peptide inhibits the expression of ICAM-1, VCAM-1, and interleukin-8 induced by TNF-a in human dermal microvascular endothelial cells. Folia Histochem Cytobiol 50: 407-413, 2012.
14. Shreeniwas R, Koga S, Karakurum M, et al: Hypoxia-mediated induction of endothelial cell interleukin-1 alpha. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface. J Clin Invest 90: 2333-2339, 1992.
15. Qiao Y, Ruan YY, Xiong CN, et al: Chitosan oligosaccharides suppressant LPS binding to TLR4/MD-2 receptor complex. Carbohydr Polym 82: 405-411, 2010.
16. Yomogida S, Hua J, Sakamoto K and Nagaoka I: Glucosamine suppresses interleukin-8 production and ICAM-1 expression by TNF-a-stimulated human colonic epithelial HT-29 cells. Int J Mol Med 22: 205-211, 2008.
17. Egorina EM, Sovershaev TA, Hansen JB and Sovershaev MA: BMP-2 inhibits TF expression in human monocytes by shutting down MAPK signaling and AP-1 transcriptional activity. Thromb Res 129: E106-E111, 2012.
18. Hippenstiel S, Soeth S, Kellas B, et al: Rho proteins and the p38-MAPK pathway are important mediators for LPS-induced interleukin-8 expression in human endothelial cells. Blood 95: 3044-3051, 2000.
19. Bahar B, O'Doherty JV, Maher S, McMorrow J and Sweeney T: Chitooligosaccharide elicits acute inflammatory cytokine response through AP-1 pathway in human intestinal epithelial-like (Caco-2) cells. Mol Immunol 51: 283-291, 2012.
20. Simunek J, Brandysova V, Koppova I and Simunek J Jr: The antimicrobial action of chitosan, low molar mass chitosan, and chitooligosaccharides on human colonic bacteria. Folia Microbiol (Praha) 57: 341-345, 2012.
21. Zhang H, Du Y, Yu X, Mitsutomi M and Aiba S: Preparation of chitooligosaccharides from chitosan by a complex enzyme. Carbohydr Res 320: 257-260, 1999.
22. Dou J, Tan C, Du Y, Bai X, Wang K and Ma X: Effects of chitooligosaccharides on rabbit neutrophils in vitro. Carbohydr Polym 69: 209-213, 2007.
23. Shan Y, Lin N, Yang X, et al: Sulphoraphane inhibited the expressions of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 through MyD88-dependent toll-like receptor-4 pathway in cultured endothelial cells. Nutr Metab Cardiovasc Dis 22: 215-222, 2012.
24. Lush CW, Cepinskas G and Kvietys PR: LPS tolerance in human endothelial cells: Reduced PMN adhesion, E-selectin expression, and NF-kappa B mobilization. Am J Physiol Heart Circ Physiol 278: H853-H861, 2000.
25. Junkins RD, MacNeil AJ, Wu Z, McCormick C and Lin TJ: Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections. J Immunol 190: 5178-5186, 2013.
26. Viatour P, Merville MP, Bours V and Chariot A: Phosphorylation of NF-kappaB and IkappaB proteins: Implications in cancer and inflammation. Trends Biochem Sci 30: 43-52, 2005.
27. Luco S, Delmas O, Vidalain PO, Tangy F, Weil R and Bourhy H: RelAp43, a member of the NF-?B family involved in innate immune response against Lyssavirus infection. PLoS Pathog 8: E1003060, 2012.
28. Wu B, Yao H, Wang S and Xu R: DAPK1 modulates a curcumin-induced G2/M arrest and apoptosis by regulating STAT3, NF-?B, and caspase-3 activation. Biochem Biophys Res Commun 434: 75-80, 2013.
29. Park EJ, Cheenpracha S, Chang LC and Pezzuto JM: Suppression of cyclooxygenase-2 and inducible nitric oxide synthase expression by epimuqubilin A via IKK/I?B/NF-?B pathways in lipopolysaccharide-stimulated RAW 264.7 cells. Phytochem Lett 4: 426-431, 2011.
30. O'Connell MA, Bennett BL, Mercurio F, Manning AM and Mackman N: Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells. J Biol Chem 273: 30410-30414, 1998.
31. Murayama R, Kobayashi M, Takeshita A, et al: MAPKs, activator protein-1 and nuclear factor-kappa B mediate production of interleukin-1 beta-stimulated cytokines, prostaglandin E-2 and MMP-1 in human periodontal ligament cells. J Periodont Res 46: 568-575, 2011.
32. Liu HT, Li WM, Xu G, et al: Chitosan oligosaccharides attenuate hydrogen peroxide-induced stress injury in human umbilical vein endothelial cells. Pharmacol Res 59: 167-175, 2009.
33. Vo TS, Kong CS and Kim SK: Inhibitory effects of chitooligosaccharides on degranulation and cytokine generation in rat basophilic leukemia RBL-2H3 cells. Carbohydr Polym 84: 649-655, 2011.
34. Bianchi G, D'Amico G, Varone L, Sozzani S, Mantovani A and Allavena P: In vitro studies on the trafficking of dendritic cells through endothelial cells and extra-cellular matrix. Dev Immunol 7: 143-153, 2000.
35. Ogawa H, Rafiee P, Heidemann J, et al: Mechanisms of endotoxin tolerance in human intestinal microvascular endothelial cells. J Immunol 170: 5956-5964, 2003.
36. Albelda SM, Smith CW and Ward PA: Adhesion molecules and inflammatory injury. FASEB J 8: 504-512, 1994.
37. Ju Y, Hua J, Sakamoto K, Ogawa H and Nagaoka I: Modulation of TNF-a-induced endothelial cell activation by glucosamine, a naturally occurring amino monosaccharide. Int J Mol Med 22: 809-815, 2008.
38. Binion DG, Heidemann J, Li MS, Nelson VM, Otterson MF and Rafiee P: Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK/NF-kappa B: Inhibitory role of curcumin. Am J Physiol Gastrointest Liver Physiol 297: G259-G268, 2009.