Discovery and optimization of arylsulfonyl 3-(pyridin-2-yloxy)anilines as novel GPR119 agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 12, 2013, Pages 3609-3613

  Zhang, Jian ^a   Li, An Rong ^a   Yu, Ming ^a   Wang, Yingcai ^a   Zhu, Jiang ^a   Kayser, Frank ^a   Medina, Julio C ^a   Siegler, Karen ^a   Conn, Marion ^a   Shan, Bei ^a   Grillo, Mark P ^a   Eksterowicz, John ^a   Coward, Peter ^a   Liu, Jiwen ^a  

^a AMGEN INC   (United States)

Author keywords

GPR119 agonist; Metabolic stability; SAR optimization; Type 2 diabetes

Indexed keywords

ANILINE DERIVATIVE; ARYLSULFONYL 3 (PYRIDIN 2 YLOXY)ANILINE DERIVATIVE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 119; METHYL GROUP; PYRIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DRUG CLEARANCE; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LIVER MICROSOME; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANILINE COMPOUNDS; ANIMALS; DIABETES MELLITUS, TYPE 2; DRUG DISCOVERY; HUMANS; MICE; MODELS, MOLECULAR; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84878111023     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.04.014     Document Type: Article

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