Synthesis and biological evaluation of novel 2,4-disubstituted quinazoline analogues as GPR119 agonists

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 5, 2013, Pages 1349-1356

  Pham, Tuan Anh N ^a   Yang, Zunhua ^a,b   Fang, Yuanying ^a   Luo, Jun ^a   Lee, Jongkook ^a   Park, Haeil ^a  

^a Kangwon National University   (South Korea)

^b JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Azabicyclic amines; GPR119 agonist; Quinazoline analogues; Type 2 diabetes

Indexed keywords

2 (9 BENZYL 3,9 DIAZABICYCLO[4.2.1]NONAN 3 YL) 6,7 DIMETHOXY N [4 (METHYLSULFONYL)PHENYL] QUINAZOLIN 4 AMINE; 2 CHLORO 4 (2 FLUORO 4 METHYLSULFONYLPHENYLAMINO) 6,7 DIMETHOXYQUINAZOLINE; 2 CHLORO 4 (4 METHYLSULFONYLPHENYLAMINO) 6,7 DIMETHOXYQUINAZOLINE; 4 (9 BENZYL 3,9 DIAZABICYCLO[4.2.1]NONAN 3 YL) 2 CHLORO 6,7 DIMETHOXYQUINAZOLINE; 4 (9 BENZYL 3,9 DIAZABICYCLO[4.2.1]NONAN 3 YL) 6,7 DIMETHOXY N [4 (METHYL SULFONYL)]QUINAZOLIN 2 AMINE; ANTIDIABETIC AGENT; CARBOXYLIC ACID DERIVATIVE; G PROTEIN COUPLED RECEPTOR; N OLEOYLETHANOLAMINE; PROTEIN GPR119; QUINAZOLINE DERIVATIVE; TERT BUTYL 3 (2 CHLORO 6,7 DIMETHOXYQUINAZOLIN 4 YLOXY) 8 AZABICYCLO[3.2.1]OCTANE 8 CARBOXYLATE; TERT BUTYL 3 [(2 CHLORO 6,7 DIMETHOXYQUINAZOLIN 4 YLAMINO)METHYL] 8 AZABICYCLO[3.2.1]OCTANE 8 CARBOXYLATE; TERT BUTYL 3 [4 [2 FLUORO 4 (METHYLSULFONYL)PHENYLAMINO] 6,7 DIMETHOXYQUINAZOLIN 2 YLAMINO] 8 AZABICYCLO[3.2.1]OCTANE 8 CARBOXYLATE; TERT BUTYL 3 [4 [[2 FLUORO 4 (METHYLSULFONYL)PHENYLAMINO]6,7 DIMETHOXYQUINAZOLIN 2 YLAMINO]METHYL] 8 AZABICYCLO[3.2.1]OCTANE 8 CARBOXYLATE; TERT BUTYL 3 [6,7 DIMETHOXY 2 [4 (METHYLSULFONYL)PHENYLAMINO]QUINAZOLIN 4 YL] 3,9 DIAZABICYCLO[4.2.1]NONANE 9 CARBOXYLATE; TERT BUTYL 3 [6,7 DIMETHOXY 2 [4 (METHYLSULFONYL)PHENYLAMINO]QUINAZOLIN 4 YLAMINO] 8 AZABICYCLO[3.2.1]OCTANE 8 CARBOXYLATE; TERT BUTYL 3 [[6,7 DIMETHOXY 4 [4 (METHYLSULFONYL)PHENYLAMINO]QUINAZOLIN 2 YLAMINO]METHYL] 8 AZABICYCLO[3.2.1]OCTANE 8 CARBOXYLATE; TERT BUTYL 3 [[6,7 DIMETHOXY 4 [4 (METHYLSULFONYL)PHENYLAMINO]QUINAZOLIN 2 YLAMINO]METHYL] 8 AZABICYCLOP[3.2.1]OCTANE 8 CARBOXYLATE; TERT BUTYL 4 (2 CHLORO 6,7 DIMETHOXYQUINAZOLIN 4 YLOXY)PIPERIDINE 1 CARBOXYLATE; TERT BUTYL 4 [(2 CHLORO 6,7 DIMETHOXYQUINAZOLIN 4 YLOXY)METHYL]PIPERIDINE 1 CARBOXYLATE; TERT BUTYL 4 [2 [2 FLUORO [4 (METHYLSULFONYL)PHENYLAMINO] 6,7 DIMETHOXYQUINAZOLIN 4 YLOXY]]PIPERIDINE 1 CARBOXYLATE; TERT BUTYL 4 [2 [2 FLUORO [4 (METHYLSULFONYL)PHENYLAMINO]6,7 DIMETHOXYQUINAZOLIN 4 YLOXY]METHYL]PIPERIDINE 1 CARBOXYLATE; TERT BUTYL 4 [4 [2 FLUORO 4 (METHYLSULFONYL)PHENYLAMINO] 6,7 DIMETHOXYQUINAZOLIN 2 YLOXY]PIPERIDINE 1 CARBOXYLATE; TERT BUTYL 4 [4 [[2 FLUORO 4 (METHYLSULFONYL)PHENYLAMINO]6,7 DIMETHOXYQUINAZOLIN 2 YLOXY]METHYL]PIPERIDINE 1 CARBOXYLATE; TERT BUTYL 4 [6,7 DIMETHOXY 2 [4 (METHYLSULFONYL)PHENYLAMINO]QUINAZOLIN 4 YLOXY]PIPERIDINE 1 CARBOXYLATE; TERT BUTYL 4 [6,7 DIMETHOXY 4 [4 (METHYLSULFONYL)PHENYLAMINO]QUINAZOLIN 2 YLOXY]PIPERIDINE 1 CARBOXYLATE; TERT BUTYL 4 [[6,7 DIMETHOXY 2 [4 (METHYLSULFONYL)PHENYLAMINO]QUINAZOLIN 4 YLOXY]METHYL]PIPERIDINE 1 CARBOXYLATE; TERT BUTYL 4 [[6,7 DIMETHOXY 4 [4 (METHYLSULFONYL)PHENYLAMINO]QUINAZOLIN 2 YLOXY]METHYL]PIPERIDINE 1 CARBOXYLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

AMINES; AZA COMPOUNDS; BICYCLO COMPOUNDS; DRUG EVALUATION, PRECLINICAL; HUMANS; PROTEIN BINDING; QUINAZOLINES; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873709105     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.12.013     Document Type: Article

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