Vitamin C suppresses cell death in MCF-7 human breast cancer cells induced by tamoxifen

Journal of Cellular and Molecular Medicine

Volumn 18, Issue 2, 2014, Pages 305-313

  Subramani, Tamilselvan ^a   Yeap, Swee Keong ^a   Ho, Wan Yang ^a   Ho, Chai Ling ^a   Omar, Abdul Rahman ^a   Aziz, Suraini Abdul ^a   Rahman, Nik Mohd Afizan Nik Abd ^a   Alitheen, Noorjahan Banu ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Apoptosis; Breast cancer; Free radical; Lipid peroxidation; ROS; Tamoxifen; Vitamin C

Indexed keywords

ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; ASCORBIC ACID; CASPASE 8; DEHYDROASCORBIC ACID; FAS LIGAND; FASLG PROTEIN, HUMAN; FREE RADICAL; LIPOCORTIN 5; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; TAMOXIFEN; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; BREAST CANCER; CELL DEATH; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENETICS; HUMAN; LIPID PEROXIDATION; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; ROS; TUMOR CELL LINE;

APOPTOSIS; BREAST CANCER; FREE RADICAL; LIPID PEROXIDATION; ROS; TAMOXIFEN; VITAMIN C;

ANNEXIN A5; ANTINEOPLASTIC AGENTS, HORMONAL; CASPASE 8; CELL DEATH; CELL LINE, TUMOR; DEHYDROASCORBIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; FAS LIGAND PROTEIN; FEMALE; HUMANS; LIPID PEROXIDATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; PROPIDIUM; REACTIVE OXYGEN SPECIES; TAMOXIFEN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84893700328     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12188     Document Type: Article

References (43)

1. Baum M. Adjuvant endocrine therapy in postmenopausal women with early breast cancer: where are we now? Eur J Cancer. 2005; 41: 1667-77.
2. Mandlekar S, Kong AN. Mechanisms of tamoxifen-induced apoptosis. Apoptosis. 2001; 6: 469-77.
3. Moreira PI, Custodio J, Morena A, et al. Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure. J Biol Chem. 2006; 281: 10143-52.
4. Han P, Kang JH, Li HL, et al. Antiproliferation and apoptosis induced by tamoxifen in human bile duct carcinoma QBC939 cells via upregulated p53 expression. Biochem Biophys Res Commun. 2009; 385: 251-6.
5. Moriai R, Tsuji N, Moriai M, et al. Survivin plays as a resistant factor against taxoxifen-induced apoptosis in human breast cancer cells. Breast Cancer Res Treat. 2009; 117: 261-71.
6. de Medina P, Favre G, Poirot M. Multiple targeting by the antitumor drug tamoxifen: a structure-activity study. Curr Med Chem Anticanc Agents. 2004; 4: 491-508.
7. de Medina P, Payre BL, Bernad J, et al. Tamoxifen is a potent inhibitor of cholesterol esterification and prevents the formation of foam cells. J Pharmacol Exp Ther. 2004; 308: 1165-73.
8. Payre B, de Medina P, Boubekeur N, et al. Microsomal antiestrogen-binding site ligands induce growth control and differentiation of human breast cancer cells through the modulation of cholesterol metabolism. Mol Cancer Ther. 2008; 7: 3707-18.
9. de Medina P, Paillasse MR, Ségala G, et al. Importance of cholesterol and oxysterols metabolism in the pharmacology of tamoxifen and other AEBS ligands. Chem Phys Lipids. 2011; 164: 432-7.
10. Head KA. Ascorbic acid in the prevention and treatment of cancer. Altern Med Rev. 1998; 3: 174-86.
11. Lutzky J, Astor MB, Taub RN, et al. Role of glutathione and dependent enzymes in anthracycline-resistant HL60/AR cells. Cancer Res. 1989; 49: 4120-5.
12. Cossarizza A, Franceschi C, Monti D, et al. Protective effect of N-acetylcysteine in tumor necrosis factor-α-induced apoptosis in U937 cells: the role of mitochondria. Exp Cell Res. 1995; 220: 232-40.
13. Vera JC, Rivas CI, Fischbarg J, et al. Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid. Nature. 1993; 364: 79-82.
14. Vera JC, Rivas CI, Velasquez FV, et al. Resolution of the facilitated transport of dehydroascorbic acid from its intracellular accumulation as ascorbic acid. J Biol Chem. 1995; 270: 23706-12.
15. Moriarty MJ, Mulgrew S, Malone JR, et al. Results and analysis of tumour levels of ascorbic acid. Ir J Med Sci. 1977; 146: 74-8.
16. de Medina P, Silvente-Poirot S, Poirot M. Tamoxifen and AEBS ligands induced apoptosis and autophagy in breast cancer cells through the stimulation of sterol accumulation. Autophagy. 2009; 5: 1066-7.
17. Segala G, de Medina P, Iuliano L, et al. 5, 6-Epoxy-cholesterols contribute to the anticancer pharmacology of Tamoxifen in breast cancer cells. Biochem Pharmacol. 2013; 86: 175-89.
18. Buettner GR, Jurkiewicz BA. Catalytic metals, ascorbate and free radicals: combinations to avoid. Radiat Res. 1996; 145: 532-41.
19. Clement MV, Ramalingam J, Long LH, et al. The in vitro cytotoxicity of ascorbate depends on the culture medium used to perform the assay and involves hydrogen peroxide. Antioxid Redox Signal. 2001; 3: 157-63.
20. Ihara H, Matsumoto N, Shino Y, et al. An automated assay for measuring serum ascorbic acid with use of 4-hydroxy-2, 2, 6, 6-tetramethylpiperidinyloxy, free radical and o-phenylenediamine. Clin Chim Acta. 2000; 301: 193-204.
21. Ihara H, Shino Y, Aoki Y, et al. A simple and rapid method for the routine assay of total ascorbic acid in serum and plasma using ascorbate oxidase and o-phenylenediamine. J Nutr Sci Vitaminol. 2000; 46: 321-4.
22. Frank J, Kelleher DK, Pompella A, et al. Enhancement of oxidative cell injury and antitumor effects of localized 44 degrees C hyperthermia upon combination with respiratory hyperoxia and xanthine oxidase. Cancer Res. 1998; 58: 2693-8.
23. Jentzsch AM, Bachmann H, Furst P, et al. Improved analysis of malondialdehyde in human body fluids. Free Radic Biol Med. 1996; 20: 251-6.
24. Marklund S, Marklund G. Involvement of superoxide anion radical in autooxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 1974; 47: 469-74.
25. Karasavvas N, Carcamo JM, Stratis G, et al. Vitamin C protects HL60 and U266 cells from arsenic toxicity. Blood. 2005; 105: 4004-12.
26. Welch RW, Wang Y, Crossman A Jr, et al. Accumulation of vitamin C (ascorbate) and its oxidized metabolite dehydroascorbic acid occurs by separate mechanisms. J Biol Chem. 1995; 270: 12584-92.
27. Wells WW, Xu DP. Dehydroascorbate reduction. J Bioenerg Biomembr. 1994; 26: 369-77.
28. Guaiquil VH, Vera JC, Golde DW. Mechanism of vita- min C inhibition of cell death induced by oxidative stress in glutathione-depleted HL-60 cells. J Biol Chem. 2001; 276: 40955-61.
29. Marchetti P, Hirsch T, Zamzami N, et al. Mitochondrial permeability transition triggers lymphocyte apoptosis. J Immunol. 1996; 157: 4830-6.
30. Zamzami N, Marchetti P, Castedo M, et al. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med. 1995; 182: 367-77.
31. Budihardjo I, Oliver H, Lutter M, et al. Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol. 1999; 15: 269-90.
32. Srinivasula SM, Ahmad M, Fernandes-Alnemri T, et al. Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc Natl Acad Sci USA. 1996; 93: 14486-91.
33. Richardson MA, Sanders T, Palmer JL, et al. Complementary/alternative medicine use in a comprehensive cancer center and the implications for oncology. J Clin Oncol. 2000; 18: 2505-14.
34. Vera JC, Rivas CI, Zhang RH, et al. Human HL-60 myeloid leukemia cells transport dehydroascorbic acid via the glucose transporters and accumulate reduced ascorbic acid. Blood. 1994; 84: 1628-34.
35. Lesperance ML, Olivotto IA, Forde N, et al. Mega-dose vitamins and minerals in the treatment of non-metastatic breast cancer: an historical cohort study. Breast Cancer Res Treat. 2002; 76: 137-43.
36. Li L, Lorenzo PS, Bogi K, et al. Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector. Mol Cell Biol. 1999; 19: 8547-58.
37. Morgan PE, Dean RT, Davies MJ. Protective mechanisms against peptide and protein peroxides generated by singlet oxygen. Free Radic Biol Med. 2004; 36: 484-96.
38. Philpott NJ, Turner AJ, Scopes J, et al. The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques. Blood. 1996; 87: 2244-51.
39. Langemann H, Torhorst J, Kabiersch A, et al. Quantitative determination of water- and lipid-soluble antioxidants in neoplastic and non-neoplastic human breast tissue. Int J Cancer. 1989; 43: 1169-73.
40. de Medina P, Payre B, Boubekeur N, et al. Ligands of the antiestrogen-binding site induce active cell death and autophagy in human breast cancer cells through the modulation of cholesterol metabolism. Cell Death Differ. 2009; 16: 1372-84.
41. de Medina P, Paillasse MR, Segala G, et al. Identification and pharmacological characterization of cholesterol-5, 6-epoxide hydrolase as a target for tamoxifen and AEBS ligands. Proc Natl Acad Sci USA. 2010; 107: 13520-5.
42. Decaudin D, Geley S, Hirsch T, et al. Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. Cancer Res. 1997; 57: 62-7.
43. Costantini P, Jacotot E, Decaudin D, et al. Mitochondrion as a novel target of anticancer chemotherapy. J Natl Cancer Inst. 2000; 92: 1042-53.