Developing heatable microfluidic chip to generate gelatin emulsions and microcapsules

Microfluidics and Nanofluidics

Volumn 15, Issue 6, 2013, Pages 775-784

  Yeh, Chia Hsien ^a   Chen, Ke Rong ^a   Lin, Yu Cheng ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Gelatin emulsions; Heatable microfluidic chip; Microheater; Uniform; Vitamin C

Indexed keywords

CONTROLLED DRUG DELIVERY; EMULSIFICATION; EMULSIONS; FLUIDIC DEVICES; HEATING EQUIPMENT; MICROELECTROMECHANICAL DEVICES; MICROFLUIDICS; TARGETED DRUG DELIVERY;

EXTERNAL ENVIRONMENTS; FLOW-FOCUSING DEVICES; MICROFLUIDIC CHIP; MICROHEATER; THERMAL CONDITION; THERMO-SENSITIVE HYDROGEL; UNIFORM; VITAMIN C;

OSTWALD RIPENING;

EID: 84893687916     PISSN: 16134982     EISSN: 16134990     Source Type: Journal    
DOI: 10.1007/s10404-013-1193-x     Document Type: Article

References (43)

1. Adamson DN, Mustafi D, Zhang JXJ, Zheng B, Ismagilov RF (2006) Production of arrays of chemically distinct nanolitre plugs via repeated splitting in microfluidic devices. Lab Chip 6:1178-1186
2. Anna SL, Bontoux N, Stone HA (2003) Formation of dispersions using flow focusing in microchannels. Appl Phys Lett 82:364-366
3. Asai A (1991) Bubble dynamics in boiling under high heat flux pulse heating. J Heat Transf 113:973-979
4. Bruschi ML, Cardoso MLC, Lucchesi MB, Gremião MPD (2003) Gelatin microparticles containing propolis obtained by spraydrying technique: preparation and characterization. Int J Pharm 264:45-55
5. Butler MF, Paul YF, Pudney DA (2003) Mechanism and kinetics of the crosslinking reaction between biopolymers containing primary amine groups and genipin. J Polym Sci Part A Polym Chem 41:3941-3953
6. Choi CH, Jung JH, Rhee YW, Kim DP, Shim SE, Lee CS (2007) Generation of monodisperse alginate microbeads and in situ encapsulation of cell in microfluidic device. Biomed Microdevices 9:855-862
7. Djabourov M, Papon P (1983) Influence of thermal treatments on the structure and stability of gelatin gels. Polymer 24:524-537
8. Gombotz WR, Wee SF (1998) Protein release from alginate matrices. Adv Drug Deliv Rev 31:267-285
9. Hoesli CA, Raghuram K, Kiang RLJ, Mocinecova D, Hu X, Johnson JD, Lacik I, Kieffer TJ, Piret JM (2011) Pancreatic cell immobilization in alginate beads produced by emulsion and internal gelation. Biotechnol Bioeng 108:424-434
10. Huang KS, Lai TH, Lin YC (2006a) Manipulating the generation of Ca-alginate microspheres using microfluidic channels as a carrier of gold nanoparticles. Lab Chip 6:954-957
11. Huang KS, Lai TH, Lin YC (2006b) Using a microfluidic chip and internal gelation reaction for monodisperse calcium alginate microparticles generation. Front Biosci 12:3061-3067
12. Huang KS, Lu K, Yeh CS, Chung SR, Lin CH, Yang CH, Dong YS (2009) Microfluidic controlling monodisperse microdroplet for 5-fluorouracil loaded genipin-gelatin microcapsules. J Controlled Release 137:15-19
13. Hung LH, Teh SY, Jester J, Lee AP (2010) PLGA micro/nanosphere synthesis by droplet microfluidic solvent evaporation and extraction approaches. Lab Chip 10:1820-1825
14. Kawakatsu T, Tragardh G, Tragardh Ch, Nakajima M, Oda N, Yonemoto T (2001) The effect of the hydrophobicity of microchannels and components in water and oil phases on droplet formation in microchannel water-in-oil emulsification. Colloids Surf 179:29-37
15. Kikuchi A, Okano T (2002) Pulsatile drug release control using hydrogels. Adv Drug Deliv Rev 54:53-77
16. Kopp MU, de Mello AJ, Manz A (1998) Chemical amplification: continuous-flow PCR on a chip. Science 280:1046-1048
17. Kushibiki T, Tomoshige R, Fukunaka Y, Kakemi M, Tabata Y (2003) In vivo release and gene expression of plasmid DNA by hydrogels of gelatin with different cationization extents. J Controlled Release 90:207-216
18. Lagally ET, Emrich CA, Mathies RA (2001) Fully integrated PCR capillary electrophoresis microsystem for DNA analysis. Lab Chip 1:102-107
19. Lan WJ, Li SW, Xu JH, Luo GS (2010) One-step synthesis of chitosan-silica hybrid microspheres in a microfluidic device. Biomed Microdevices 12:1087-1095
20. Li W, Nie Z, Zhang H, Paquet C, Seo M, Garstecki P, Kumacheva E (2007) Screening of the effect of surface energy of microchannels on microfluidic emulsification. Langmuir 23:8010-8014
21. Li W, Young EWK, Seo M, Nie Z, Garstecki P, Simmons CA, Kumacheva E (2008) Simultaneous generation of droplets with different dimensions in parallel integrated microfluidic droplet generators. Soft Matter 4:258-262
22. Link DR, Mongrain EG, Duri A, Sarrazin F, Cheng Z, Cristobal G, Marquez M, Weitz DA (2006) Electric control of droplets in microfluidic devices. Angew Chem 118:2618-2622
23. Liu K, Ding HJ, Liu J, Chen Y, Zhao XZ (2006) Shape-controlled production of biodegradable calcium alginate gel microparticles using a novel microfluidic device. Langmuir 22:9453-9457
24. Murshed SMS, Tan SH, Nguyen NT, Wong TN, Yobas L (2009) Microdroplet formation of water and nanofluids in heat-induced microfluidic T junction. Microfluid Nanofluid 6:253-259
25. Nisisako T, Torii T, Takahashi T, Takizawa Y (2006) Synthesis of monodisperse bicolored Janus particles with electrical anisotropy using a microfluidic co-flow system. Adv Mater 18:1152-1156
26. Owen MJ, Smith PJ (1994) Plasma treatment of polydimethysiloxane. J Adhes Sci Technol 8:1063-1075
27. Rao VS, Kripesh V, Yoon SW, Tay AAO (2006) A thick photoresist process for advanced wafer level packaging applications using JSR THB-151N negative tone UV photoresist. J Micromech Microeng 16:1841-1846
28. Roy S, Pal M, Gupta BK (1992) Indomethacin-loaded microspheres: design and preparation by a multiple-emulsification technique and their in vitro evaluation. Pharm Res 9:1132-1136
29. Serra C, Berton N, Bouquey M, Prat L, Hadziioannou G (2007) A predictive approach of the influence of the operating parameters on the size of polymer particles synthesized in a simplified microfluidic system. Langmuir 23:7745-7750
30. Sivakumar M, Rao KP (2003) Preparation, characterization, and in vitro release of gentamicin from coralline hydroxyapatite-alginate composite microspheres. Biomaterials 23:3175-3181
31. Srivastava AK, Ridhurkar DN, Wadhwa S (2005) Floating microspheres of cimetidine: formulation, characterization and in vitro evaluation. Acta Pharm 55:277-285
32. Vandervoort J, Ludwig A (2004) Preparation and evaluation of drugloaded gelatin nanoparticles for topical ophthalmic use. Eur J Pharm Biopharm 57:251-261
33. Wang LY, Ma GH, Su ZG (2005) Preparation of uniform sized chitosan microspheres by membrane emulsification technique and application as a carrier of protein drug. J Controlled Release 106:62-75
34. Xu Q, Hashimoto M, Dang TT, Hoare T, Kohane DS, Whitesides GM, Langer R, Andersonl DG (2009) Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flowfocusing device for controlled drug delivery. Small 5:1575-1581
35. Yang LJ, Wang JM, Huang YL (2004) The micro ion drag pump using indium-tin-oxide (ITO) electrodes to resist aging. Sens Actuators A Phys 111:118-122
36. Yang CH, Huang KS, Lin PW, Lin YC (2007) Using a cross-flow microfluidic chip and external crosslinking reaction for monodisperse TPP-chitosan microparticles. Sens Actuators B Chem 124:510-516
37. Yeh CH, Lin YC (2009) Using a cross-flow microfluidic chip for monodisperse UV-photopolymerized microparticles. Microfluid Nanofluid 6:277-283
38. Yeh CH, Zhao Q, Lee SJ, Lin YC (2009) Using a T junction microfluidic chip for monodisperse calcium alginate microparticles and encapsulation of nanoparticles. Sens Actuators A Phys 151:231-236
39. Yeh CH, Lin PW, Lin YC (2010) Chitosan microfiber fabrication using a microfluidic chip and its application to cell cultures. Microfluid Nanofluid 8:115-121
40. Yeh CH, Chen YC, Lin YC (2011) Generation of droplets with different concentrations by using gradient-microfluidic droplet generator. Microfluid Nanofluid 11:245-253
41. Yeh CH, Lee MH, Lin YC (2012) Using an electro-spraying microfluidic chip to produce uniform emulsions under a directcurrent electric field. Microfluid Nanofluid 12:475-484
42. Young S, Wong M, Tabata Y, Mikos G (2005) Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J Controlled Release 109:256-274
43. Zheng B, Roach LS, Ismagilov RF (2003) Screening of protein crystallization conditions on a microfluidic chip using nanolitersize droplets. J Am Chem Soc 125:11170-11171