α1 adrenoceptor activation by norepinephrine inhibits LPS-induced cardiomyocyte TNF-α production via modulating ERK1/2 and NF-κB pathway

Journal of Cellular and Molecular Medicine

Volumn 18, Issue 2, 2014, Pages 263-273

  Yu, Xiaohui ^a   Jia, Baoyin ^a   Wang, Faqiang ^a   Lv, Xiuxiu ^a   Peng, Xuemei ^b   Wang, Yiyang ^a   Li, Hongmei ^a   Wang, Yanping ^a   Lu, Daxiang ^a   Wang, Huadong ^a  

^a MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

Author keywords

1 adrenoceptor; Cardiomyocytes; Lipopolysaccharide; Tumour necrosis factor

Indexed keywords

MUS; RATTUS;

1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)-5-(4-PYRIDYL)IMIDAZOLE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRILE; NORADRENALIN; PHENYLEPHRINE; PRAZOSIN; PROTEIN C FOS; PYRIDINE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; CARDIOMYOCYTES; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; ENDOTOXEMIA; GENE EXPRESSION REGULATION; GENETICS; HEART MUSCLE; HEART MUSCLE CELL; METABOLISM; MOUSE; NEWBORN; PATHOLOGY; RAT; SIGNAL TRANSDUCTION; TUMOUR NECROSIS FACTOR-Α; Α1-ADRENOCEPTOR;

CARDIOMYOCYTES; LIPOPOLYSACCHARIDE; TUMOUR NECROSIS FACTOR-Α; Α1-ADRENOCEPTOR;

ADRENERGIC ALPHA-1 RECEPTOR AGONISTS; ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ANIMALS; ANIMALS, NEWBORN; BUTADIENES; ENDOTOXEMIA; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; IMIDAZOLES; LIPOPOLYSACCHARIDES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCARDIUM; MYOCYTES, CARDIAC; NF-KAPPA B; NITRILES; NOREPINEPHRINE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENYLEPHRINE; PRAZOSIN; PROTO-ONCOGENE PROTEINS C-FOS; PYRIDINES; RATS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84893684043     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12184     Document Type: Article

References (42)

1. Fernandes CJ Jr, de Assuncao MS. Myocardial dysfunction in sepsis: a large, unsolved puzzle. Crit Care Res Pract. 2012; 2012: 896430. Doi: 10.1155/2012/896430.
2. Zhang T, Feng Q. Nitric oxide and calcium signaling regulate myocardial tumor necrosis factor-α expression and cardiac function in sepsis. Can J Physiol Pharmacol. 2010; 88: 92-104.
3. Natanson C, Eichenholz PW, Danner RL, et al. Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock. J Exp Med. 1989; 169: 823-32.
4. Cain BS, Meldrum DR, Dinarello CA, et al. Tumor necrosis factor-alpha and interleukin-1beta synergistically depress human myocardial function. Crit Care Med. 1999; 27: 1309-18.
5. Vincent JL, Bakker J, Marécaux G, et al. Administration of anti-TNF antibody improves left ventricular function in septic shock patients. Results of a pilot study. Chest. 1992; 101: 810-5.
6. Herbertson MJ, Werner HA, Goddard CM, et al. Anti-tumor necrosis factor-alpha prevents decreased ventricular contractility in endotoxemic pigs. Am J Respir Crit Care Med. 1995; 152: 480-8.
7. Opal SM. Endotoxins and other sepsis triggers. Contrib Nephrol. 2010; 167: 14-24.
8. Panaro MA, Gagliardi N, Saponaro C, et al. Toll-like receptor 4 mediates LPS-induced release of nitric oxide and tumor necrosis factor-alpha by embryonal cardiomyocytes: biological significance and clinical implications in human pathology. Curr Pharm Des. 2010; 16: 766-74.
9. Fujihara M, Muroi M, Tanamoto K, et al. Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex. Pharmacol Ther. 2003; 100: 171-94.
10. Tavener SA, Kubes P. Cellular and molecular mechanisms underlying LPS-associated myocyte impairment. Am J Physiol Heart Circ Physiol. 2006; 290: H800-6.
11. Boyd JH, Mathur S, Wang Y, et al. Toll-like receptor stimulation in cardiomyocytes decreases contractility and initiates an NF-kappa B dependent inflammatory response. Cardiovasc Res. 2006; 72: 384-93.
12. Fallach R, Shainberg A, Avlas O, et al. Cardiomyocyte Toll-like receptor 4 is involved in heart dysfunction following septic shock or myocardial ischemia. J Mol Cell Cardiol. 2010; 48: 1236-44.
13. Kumar V, Sharma A. Is neuroimmunomodulation a future therapeutic approach for sepsis? Int Immunopharmacol. 2010; 10: 9-17.
14. Groves AC, Griffiths J, Leung F, et al. Plasma catecholamines in patients with serious postoperative infection. Ann Surg. 1973; 178: 102-7.
15. Benedict CR, Grahame-Smith DG. Plasma noradrenaline and adrenaline concentrations and dopamine-beta-hydroxylase activity in patients with shock due to septicaemia, trauma and haemorrhage. Q J Med. 1978; 47: 1-20.
16. Hahn PY, Wang P, Tait SM, et al. Sustained elevation in circulating catecholamine levels during polymicrobial sepsis. Shock. 1995; 4: 269-73.
17. Miksa M, Das P, Zhou M, et al. Pivotal role of the alpha (2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsis. PLoS ONE. 2009; 4: e5504. Doi: 10.1371/journal.pone.0005504.
18. Huang JL, Zhang YL, Wang CC, et al. Enhanced phosphorylation of MAPKs by NE promotes TNF-α production by macrophage through α adrenergic receptor. Inflammation. 2012; 35: 527-34.
19. Chottová DM, Slavíková J. Adrenergic regulation of the mammalian heart. Cesk Fysiol. 2011; 60: 14-9.
20. Puskarich MA. Emergency management of severe sepsis and septic shock. Curr Opin Crit Care. 2012; 18: 295-300.
21. Lv X, Yu X, Wang Y, et al. Berberine inhibits doxorubicin-triggered cardiomyocyte apoptosis via attenuating mitochondrial dysfunction and increasing Bcl-2 expression. PLoS ONE. 2012; 7: e47351. Doi: 10.1371/journal.pone.0047351.
22. Wang YY, Li HM, Wang HD, et al. Pretreatment with berberine and yohimbine protects against LPS-induced myocardial dysfunction via inhibition of cardiac I-[kappa]B[alpha] phosphorylation and apoptosis in mice. Shock. 2011; 35: 322-8.
23. Singal T, Dhalla NS, Tappia PS. Regulation of c-Fos and c-Jun gene expression by phospholipase C activity in adult cardiomyocytes. Mol Cell Biochem. 2009; 327: 229-39.
24. Peng T, Zhang T, Lu X, et al. JNK1/c-fos inhibits cardiomyocyte TNF-alpha expression via a negative crosstalk with ERK and p38 MAPK in endotoxaemia. Cardiovasc Res. 2009; 81: 733-41.
25. Huang MH, Bahl JJ, Wu Y, et al. Neuroendocrine properties of intrinsic cardiac adrenergic cells in fetal rat heart. Am J Physiol Heart Circ Physiol. 2005; 288: H497-503.
26. Peng T, Lu X, Lei M, et al. Endothelial nitric-oxide synthase enhances lipopolysaccharide-stimulated tumor necrosis factor-alpha expression via cAMP-mediated p38 MAPK pathway in cardiomyocytes. J Biol Chem. 2003; 278: 8099-105.
27. Peng T, Lu X, Feng Q. Pivotal role of gp91phox-containing NADH oxidase in lipopolysaccharide-induced tumor necrosis factor-alpha expression and myocardial depression. Circulation. 2005; 111: 1637-44.
28. Peng T, Lu X, Feng Q. NADH oxidase signaling induces cyclooxygenase-2 expression during lipopolysaccharide stimulation in cardiomyocytes. FASEB J. 2005; 19: 293-5.
29. Geoghegan-Morphet N, Burger D, Lu X, et al. Role of neuronal nitric oxide synthase in lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal mouse cardiomyocytes. Cardiovasc Res. 2007; 75: 408-16.
30. Turrell HE, Rodrigo GC, Norman RI, et al. Phenylephrine preconditioning involves modulation of cardiac sarcolemmal K(ATP) current by PKC delta, AMPK and p38 MAPK. J Mol Cell Cardiol. 2011; 51: 370-80.
31. Pucéat M, Hilal-Dandan R, Strulovici B, et al. Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes. J Biol Chem. 1994; 269: 16938-44.
32. Rao VU, Shiraishi H, McDermott PJ. PKC-epsilon regulation of extracellular signal-regulated kinase: a potential role in phenylephrine-induced cardiocyte growth. Am J Physiol Heart Circ Physiol. 2004; 286: H2195-203.
33. Clerk A, Sugden PH. Signaling through the extracellular signal-regulated kinase 1/2 cascade in cardiac myocytes. Biochem Cell Biol. 2004; 82: 603-9.
34. 2 prevents proteasomal degradation of c-Fos in cardiomyocytes. J Biol Chem. 2004; 279: 33567-74.
35. Hall G, Singh IS, Hester L, et al. Inhibitor-kappa B kinase-beta regulates LPS-induced TNF-alpha production in cardiac myocytes through modulation of NF-kappa B p65 subunit phosphorylation. Am J Physiol Heart Circ Physiol. 2005; 289: H2103-11.
36. Wright G, Singh IS, Hasday JD, et al. Endotoxin stress-response in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expression. Am J Physiol Heart Circ Physiol. 2002; 282: H872-9.
37. 2+ channel. Circ Res. 2008; 102: 1378-88.
38. Zhang T, Lu X, Li J, et al. Inhibition of Na/K-ATPase promotes myocardial tumor necrosis factor-alpha protein expression and cardiac dysfunction via calcium/mTOR signaling in endotoxemia. Basic Res Cardiol. 2012; 107: 254. Doi: 10.1007/s00395-012-0254-8.
39. Tan J, Maass DL, White DJ, et al. Effects of burn injury on myocardial signaling and cytokine secretion: possible role of PKC. Am J Physiol Regul Integr Comp Physiol. 2007; 292: R887-96.
40. Ock S, Ahn J, Lee SH, et al. Receptor activator of nuclear factor-κB ligand is a novel inducer of myocardial inflammation. Cardiovasc Res. 2012; 94: 105-14.
41. Peng T, Lu X, Lei M, et al. Inhibition of p38 MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival in endotoxemia. Cardiovasc Res. 2003; 59: 893-900.
42. Haudek SB, Spencer E, Bryant DD, et al. Overexpression of cardiac I-kappa B alpha prevents endotoxin-induced myocardial dysfunction. Am J Physiol Heart Circ Physiol. 2001; 280: H962-8.