Interaction of α1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel

Circulation Research

Volumn 102, Issue 11, 2008, Pages 1378-1388

  O Uchi, Jin ^a   Sasaki, Hiroyuki ^a   Morimoto, Satoshi ^a   Kusakari, Yoichiro ^a   Shinji, Hitomi ^a   Obata, Toru ^a   Hongo, Kenichi ^a   Komukai, Kimiaki ^a   Kurihara, Satoshi ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

1 adrenoceptor; G protein; L type Ca2+ channel; PKC

Indexed keywords

ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CHANNEL L TYPE; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN; PHENYLEPHRINE; PHOSPHOLIPASE C; PROTEIN KINASE C; (2 (2',6' DIMETHOXY)PHENOXYETHYLAMINO)METHYLBENZO 1,4 DIOXANE; (2-(2',6'-DIMETHOXY)PHENOXYETHYLAMINO)METHYLBENZO-1,4-DIOXANE; ADRENERGIC RECEPTOR ALPHA(1A); ADRENERGIC RECEPTOR ALPHA(1B); ALPHA 1 ADRENERGIC RECEPTOR; DIOXANE DERIVATIVE; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; N [5 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 5,6,7,8 TETRAHYDRO 2 HYDROXY 1 NAPHTHYL]METHANESULFONAMIDE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; TETRALIN DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE CONTROL; GENE TRANSLOCATION; GENETIC LINKAGE; HEART MUSCLE CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RAT; TRANSVERSE TUBULAR SYSTEM; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; HEART VENTRICLE; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM CHANNELS, L-TYPE; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELLS, CULTURED; DIOXANES; ENZYME INHIBITORS; GTP-BINDING PROTEINS; HEART VENTRICLES; IMIDAZOLES; MYOCYTES, CARDIAC; PERTUSSIS TOXIN; PHENYLEPHRINE; PROTEIN KINASE C; PROTEIN TRANSPORT; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; SIGNAL TRANSDUCTION; TETRAHYDRONAPHTHALENES; TYPE C PHOSPHOLIPASES;

EID: 44949255104     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.107.167734     Document Type: Article

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