Decrease of UPR- and ERAD-related proteins in Pichia pastoris during methanol-induced secretory insulin precursor production in controlled fed-batch cultures

Microbial Cell Factories

Volumn 13, Issue 1, 2014, Pages

  Vanz, Ana L ^a   Nimtz, Manfred ^b   Rinas, Ursula ^a,b  

^a LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Endoplasmic reticulum associated degradation (ERAD); Insulin precursor; Methanol metabolism; Pichia pastoris; Proteome; Two dimensional gel electrophoresis; Unfolded protein response (UPR)

Indexed keywords

BATCH CELL CULTURE TECHNIQUES; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; GLYCEROL; METHANOL; PICHIA; PROINSULIN; PROTEOME; RECOMBINANT PROTEINS; SECRETORY PATHWAY; UNFOLDED PROTEIN RESPONSE;

EID: 84893678655     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/1475-2859-13-23     Document Type: Article

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