Physiological response of Pichia pastoris GS115 to methanol-induced high level production of the Hepatitis B surface antigen: Catabolic adaptation, stress responses, and autophagic processes

Microbial Cell Factories

Volumn 11, Issue , 2012, Pages

  Vanz, Ana Leticia ^a   Lünsdorf, Heinrich ^b   Adnan, Ahmad ^b,c   Nimtz, Manfred ^b   Gurramkonda, Chandrasekhar ^b,d   Khanna, Navin ^d   Rinas, Ursula ^a,b  

^a LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c GC UNIVERSITY   (Pakistan)

^d INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

Aox1 promoter; Autophagy; Carbon metabolism; ER stress; Pichia pastoris; Proteome

Indexed keywords

ALCOHOL OXIDASE; GLYCEROL; HEPATITIS B SURFACE ANTIGEN; METHANOL; PEROXIREDOXIN; REACTIVE OXYGEN METABOLITE;

ALCOHOL METABOLISM; ALCOHOL OXIDATION; ARTICLE; AUTOPHAGY; CATABOLISM; CELL COUNT; CELL SIZE; CELL STRUCTURE; CELL VACUOLE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; FED BATCH CULTURE; FUNGUS GROWTH; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PICHIA PASTORIS; PROTEIN DEGRADATION; PROTEIN UNFOLDING; UPREGULATION;

AUTOPHAGY; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; FUNGAL PROTEINS; GLYCEROL; HEPATITIS B SURFACE ANTIGENS; METHANOL; MOLECULAR CHAPERONES; OXIDATIVE STRESS; PEROXIREDOXINS; PICHIA; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN DISULFIDE-ISOMERASES; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; UNFOLDED PROTEIN RESPONSE; VACUOLES;

EUKARYOTA; HEPATITIS B VIRUS; PICHIA PASTORIS;

EID: 84864564106     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/1475-2859-11-103     Document Type: Article

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