What are the intracellular targets and intratissue target cells for radiation effects?

Radiation Research

Volumn 181, Issue 1, 2014, Pages 9-20

  Hamada, Nobuyuki ^a  

^a CENTRAL RESEARCH INSTITUTE OF ELECTRIC POWER INDUSTRY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS DNA;

ARTICLE; CATARACT; CELL DEATH; CELL SURVIVAL; CLONOGENESIS; HUMAN; IONIZING RADIATION; LINEAR ENERGY TRANSFER; MEDICINE; NONHUMAN; PRIORITY JOURNAL; RADIATION CARCINOGENESIS; RADIATION RESPONSE; RADIOBIOLOGY; X RAY;

ANIMALS; AWARDS AND PRIZES; CARCINOGENESIS; CELL DEATH; CELL NUCLEUS; CELL SURVIVAL; DNA; HUMANS; INTRACELLULAR SPACE; LINEAR ENERGY TRANSFER; RADIOBIOLOGY;

EID: 84893674701     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR13505.1     Document Type: Article

References (107)

1. Hamada N, Kodama S, Suzuki K, Watanabe M. Gap junctional intercellular communication and cellular response to heat stress. Carcinogenesis 2003; 24:1723-8.
2. ICRP. ICRP Statement on tissue reactions/Early and late effects of radiation in normal tissues and organs-threshold doses for tissue reactions in a radiation protection context. ICRP Publication 118. Ann ICRP 2012; 41(1-2):1-322.
3. Hamada N, Ogino H. Food safety regulations: what we learned from the Fukushima nuclear accident. J Environ Radioact 2012; 111:83-99.
4. Hamada N, Ogino H, Fujimichi Y. Safety regulations of food and water implemented in the first year following the Fukushima nuclear accident. J Radiat Res 2012; 53:641-71.
5. Merz S, Steinhauser G, Hamada N. Anthropogenic radionuclides in Japanese food: environmental and legal implications. Environ Sci Technol 2013; 47:1248-56.
6. Crowther JA. Some considerations relative to the action of X-rays on tissue cells. Proc R Soc Lond 1924; 96:207-11.
7. Lea DE. Actions of radiations on living cells. 2nd ed New York: Cambridge University Press; 1955.
8. Nagasawa H, Little JB. Induction of sister chromatid exchanges by extremely low doses of a-particles. Cancer Res 1992; 52:6394-6.
9. Kadhim MA, Macdonald DA, Goodhead DT, Lorimore SA, Marsden SJ, Wright EG. Transmission of chromosomal instabil-ity after plutonium a-particle irradiation. Nature 1992; 355:738-40.
10. Wu LJ, Randers-Pehrson G, Xu A, Waldren CA, Geard CR, Yu Z, et al. Targeted cytoplasmic irradiation with a particles induces mutations in mammalian cells. Proc Natl Acad Sci USA 1999; 96:4959-64.
11. Hamada N, Matsumoto H, Hara T, Kobayashi Y. Intercellular and intracellular signaling pathways mediating ionizing radiationinduced bystander effects. J Radiat Res 2007; 48:87-95.
12. Hamada N. The bystander response to heavy-ion radiation: intercellular signaling between irradiated and non-irradiated cells. Biol Sci Space 2009; 23:195-202.
13. Hamada N, Maeda M, Otsuka K, Tomita M. Signaling pathways underpinning the manifestations of ionizing radiation-induced bystander effects. Curr Mol Pharmacol 2011; 4:79-95.
14. Hamada N, Ni M, Funayama T, Sakashita T, Kobayashi Y. Temporally distinct response of irradiated normal human fibroblasts and their bystander cells to energetic heavy ions. Mutat Res 2008; 639:35-44.
15. Iwakawa M, Hamada N, Imadome K, Funayama T, Sakashita T, Kobayashi Y, et al. Expression profiles are different in carbon ion-irradiated normal human fibroblasts and their bystander cells. Mutat Res 2008; 642:57-67.
16. Kanasugi Y, Hamada N, Wada S, Funayama T, Sakashita T, Kakizaki T, et al. Role of DNA-PKcs in the bystander effect after low-or high-LET irradiation. Int J Radiat Biol 2007; 83:73-80.
17. Harada K, Nonaka T, Hamada N, Sakurai H, Hasegawa M, Funayama T, et al. Heavy-ion-induced bystander killing of human lung cancer cells: role of gap junctional intercellular communication. Cancer Sci 2009; 100:684-8.
18. Hino M, Hamada N, Tajika Y, Funayama T, Morimura Y, Sakashita T, et al. Heavy ion irradiation induces autophagy in irradiated C2C12 myoblasts and their bystander cells. J Electron Microsc 2010; 59:495-501.
19. Hamada N, Funayama T, Wada S, Sakashita T, Kakizaki T, Ni M, et al. LET-dependent survival of irradiated normal human fibroblasts and their descendents. Radiat Res 2006; 166:24-30.
20. Hamada N, Hara T, Omura-Minamisawa M, Funayama T, Sakashita T, Sora S, et al. The survival of heavy ion-irradiated Bcl-2 overexpressing radioresistant tumor cells and their progeny. Cancer Lett 2008; 268:76-81.
21. Tanaka A, Nakatani Y, Hamada N, Jinno-Oue A, Shimizu N, Wada S, et al. Ionising irradiation alters the dynamics of human long interspersed nuclear elements 1 (LINE1) retrotransposon. Mutagenesis 2012; 27:599-607.
22. Rastogi S, Coates PJ, Lorimore SA, Wright EG. Bystander-type effects mediated by long-lived inflammatory signaling in irradiated bone marrow. Radiat Res 2012; 177:244-50.
23. Puck TT, Marcus PI. Action of X-rays on mammalian cells. J Exp Med 1956; 103:653-66.
24. Hamada N, Hara T, Funayama T, Sakashita T, Kobayashi Y. Energetic heavy ions accelerate differentiation in the descendants of irradiated normal human diploid fibroblasts. Mutat Res 2008; 637:190-6.
25. Hamada N. Recent insights into the biological action of heavyion radiation. J Radiat Res 2009; 50:1-9.
26. Sakashita T, Hamada N, Kawaguchi I, Ouchi NB, Hara T, Kobayashi Y, et al. A framework for analysis of abortive colony size distributions using a model of branching processes in irradiated normal human fibroblasts. PLoS ONE 2013 Jul 23; 8(7):e70291. PubMed PMID: 23894635.
27. Sakashita T, Hamada N, Kawaguchi I, Hara T, Kobayashi Y, Saito K. A branching process model for the analysis of abortive colony size distributions in carbon ion-irradiated normal human fibroblasts. J Radiat Res 2014; 55:Forthcoming.
28. Withers HR, Elkind MM. Radiosensitivity and fractionation response of crypt cells of mouse jejunum. Radiat Res 1969; 38:598-613.
29. Withers HR, Elkind MM. Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation. Int J Radiat Biol 1970; 17:261-7.
30. Potten CS. Radiation, the ideal cytotoxic agent for studying the cell biology of tissues such as the small intestine. Radiat Res 2004; 161:123-36.
31. Yamauchi M, Otsuka K, Kondo H, Hamada N, Tomita M, Takahashi M, et al. A novel in vitro survival assay of small intestinal stem cells after exposure to ionising radiation. J Radiat Res 2014; 55:Forthcoming.
32. Niwa O. Roles of stem cells in tissue turnover and radiation carcinogenesis. Radiat Res 2010; 174:833-9.
33. Barcellos-Hoff MH, Ravani SA. Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. Cancer Res 2000; 60:1254-60.
34. Mancuso M, Pasquali E, Leonardi S, Tanori M, Rebessi S, Di Majo V, et al. Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellum. Proc Natl Acad Sci USA 2008; 105:12445-50.
35. Portess DI, Bauer G, Hill MA, O'Neill P. Low-dose irradiation of nontransformed cells stimulates the selective removal of precancerous cells via intercellular induction of apoptosis. Cancer Res 2007; 67:1246-53.
36. Fry RJM, Lesher S, Kohn HI. Estimation of time of generation of living cells. Nature 1961; 191:290-1.
37. Fry RJM, Lesher S, Sallese A, Staffeldt E. The generation cycle of duodenal crypt cells of mice exposed to 220 roentgens of cobalt-60 c irradiation per day. Radiat Res 1963; 19:628-35.
38. Otsuka K, Hamada N, Magae J, Matsumoto H, Hoshi Y, Iwasaki T. Ionizing radiation leads to the replacement and de novo production of colonic Lgr5\+ stem cells. Radiat Res 2013; 179:637-46.
39. Hamada N, Schettino G, Kashino G, Vaid M, Suzuki K, Kodama S, et al. Histone H2AX phosphorylation in normal human cells irradiated with focused ultrasoft X rays: evidence for chromatin movement during repair. Radiat Res 2006; 166:31-8.
40. Abremski K, Hoess R. Bacteriophage P1 site-specific recombination. Purification and properties of the Cre recombinase protein. J Biol Chem 1984; 259:1509-14.
41. Feil R, Wagner J, Metzger D, Chambon P. Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains. Biochem Biophys Res Commun 1997; 237:752-7.
42. Shoemaker AR, Gould KA, Luongo C, Moser AR, Dove WF. Studies of neoplasia in the Min mouse. Biochim Biophys Acta 1997; 1332:F25-48.
43. Heidenreich WF, Saran A, Atkinson M, Pazzaglia S. A mechanistic model for medulloblastoma induction in mice. Radiat Res 2013; 179:610-4.
44. Saran A. Basal cell carcinoma and the carcinogenic role of aberrant Hedgehog signaling. Future Oncol 2010; 6:1003-14.
45. Kaplan HS, Brown MB. A quantitative dose-response study of lymphoid-tumor development in irradiated C57 black mice. J Natl Cancer Inst 1952; 13:185-208.
46. Chang PY, Bjornstad KA, Rosen CJ, McNamara MP, Mancini R, Goldstein LE, et al. Effects of iron ions, protons and X rays on human lens cell differentiation. Radiat Res 2005; 164:531-9.
47. Chalupeecky H. Uber die wirkung der röntgenstrahlen auf das Auge und die haut. Zentralbl Augenheilkd 1897; 21:234-71.
48. Rohrschneider W. Experimentelle untersuchungen über die veränderungen normaler augengewebe nach röntgenbestrahlung. III. Mitteilung: Veränderungen der lines, der netzhaut und des sehnerven nach röntgenbestrahlung. Albrecht von Graefes Arch Klin Exp Ophthalmol 1929; 122:282-98.
49. Rollins W. Notes on x-light. The effect of x-light on the crystalline lens. Boston Med Surg J 1903; 148:364-5.
50. Cogan DG, Martin SF, Kimura SJ. Atom bomb cataracts. Science 1949; 110:654-5.
51. Abelson PH, Kruger PG. Cyclotron-induced radiation cataracts. Science 1949; 110:655-7.
52. ICRP. International recommendations on radiological protection. Br J Radiol 1951; 24:46-53.
53. Radiology 1951; 56:431-9. (n.b., the same contents were published in two different journals)
54. ICRP. Recommendations of the International Commission on Radiological Protection. Br J Radiol 1955; 28 Suppl 6:1-92.
55. ICRP. Recommendations of the International Commission on Radiological Protection. ICRP Publication 6. Oxford: Pergamon Press; 1964.
56. ICRP. The 2007 Recommendations of the International Commission on Radiological Protection. ICRP Publication 103. Ann ICRP 2007; 37(2-4):1-332.
57. ICRP. Radiosensitivity and spatial distribution of dose. ICRP Publication 14. Oxford: Pergamon Press; 1969.
58. ICRP. RBE for deterministic effects. ICRP Publication 58. Ann ICRP 1990; 20(4):1-57.
59. ICRP. Relative biological effectiveness (RBE), quality factor (Q), and radiation weighting factor (wR). ICRP Publication 92. Ann ICRP 2003; 33(4):1-117.
60. Cogan DG, Dreisler KK. Minimal amount of X-ray exposure causing lens opacities in the human eye. Arch Ophthalmol 1953; 50:30-4.
61. Britten MJA, Halnan KE, Meredith WJ. Radiation cataract-new evidence on radiation dosage to the lens. Br J Radiol 1966; 39:612-7.
62. Merriam GR Jr, Focht EF. A clinical study of radiation cataracts and the relationship to dose. Am J Roentgenol 1957; 77:759-85.
63. Nakashima E, Neriishi K, Minamoto A. A reanalysis of atomicbomb cataract data, 2000-2002: a threshold analysis. Health Phys 2006; 90:154-60.
64. Neriishi K, Nakashima E, Minamoto A, Fujiwara S, Akahoshi M, Mishima HK, et al. Postoperative cataract cases among atomic bomb survivors: radiation dose response and threshold. Radiat Res 2007; 168:404-8.
65. ICRP. 1990 recommendations of the International Commission on Radiological Protection. ICRP Publication 60. Ann ICRP 1991; 21(1-3):1-201.
66. Di Paola M, Bianchi M, Baarli J. Lens opacification in mice exposed to 14-MeV neutrons. Radiat Res 1978; 73:340-50.
67. Worgul BV, Smilenov L, Brenner DJ, Junk A, Zhou W, Hall EJ. Atm heterozygous mice are more sensitive to radiation-induced cataracts than are their wild-type counterparts. Proc Natl Acad Sci USA 2002; 99:9836-9.
68. Neriishi K, Hayashi T, Nakashima E, Imai K, Nakachi K. ATM haplotypes and radiosensitivity in A-bomb survivors-preliminary trial using existing data at RERF. Abstract Book of Radiation Cataractogenesis Workshop 2009 Hiroshima, Japan: RERF; 2009.
69. Goldmann H, Liechti A. Experimentelle untersuchungen über die genese des röntgenstars. Albrecht von Graefes Arch Ophthalmol 1938; 138:722-36.
70. Alter AJ, Leinfelder PJ. Roentgen-ray cataract. Effects of shielding of the lens and ciliary body. Arch Ophthalmol 1953; 49:257-60.
71. Worgul BV, Rothstein H. Radiation cataract and mitosis. Ophthalmic Res 1975; 7:21-32.
72. Oka M, Toyoda C, Kaneko Y, Nakazawa Y, Aizu-Yokota E, Takehana M. Characterization and localization of side population cells in the lens. Mol Vis 2010; 16:945-53.
73. Yang C, Yang Y, Brennan L, Bouhassira EE, Kantorow M, Cvekl A. Efficient generation of lens progenitor cells and lentoid bodies from human embryonic stem cells in chemically defined conditions. FASEB J 2010; 24:3274-83.
74. Hamada N, Fujimichi Y, Nomura T, Iwasaki T. Dose limits for exposure to ionizing radiation: past, present and future. Emerging issues in radiogenic cataracts and cardiovascular disease. J Radiat Res in press.
75. Fry RJM. Deterministic effects. Health Phys 2001; 80:338-43.
76. Shimizu Y, Pierce DA, Preston DL, Mabuchi K. Studies of the mortality of atomic bomb survivors. Report 12, part II. Noncancer mortality: 1950-1990. Radiat Res 1999; 152:374-89.
77. Fry RJM. The question of thresholds for carcinogenesis. Cancer Invest 1989; 7:299-300.
78. Preston DL, Ron E, Tokuoka S, Funamoto S, Nishi N, Soda M, et al. Solid cancer incidence in atomic bomb survivors: 1958-1998. Radiat Res 2007; 168:1-64.
79. Samartzis D, Nishi N, Hayashi M, Cologne J, Cullings HM, Kodama K, et al. Exposure to ionizing radiation and development of bone sarcoma: new insights based on atomic-bomb survivors of Hiroshima and Nagasaki. J Bone Joint Surg Am 2011; 93:1008-15.
80. ICRP. Recommendations of the International Commission on Radiological Protection. ICRP Publication 26. Ann ICRP 1977; 1(3):1-53.
81. Tatsukawa Y, Cologne JB, Hsu WL, Yamada M, Ohishi W, Hida A, et al. Radiation risk of individual multifactorial diseases in offspring of the atomic-bomb survivors: a clinical health study. J Radiol Prot 2013; 33:281-293.
82. Little MP, Goodhead DT, Bridges BA, Bouffler SD. Evidence relevant to untargeted and transgenerational effects in the offspring of irradiated parents. Mutat Res 2013; 753:50-67.
83. Tsuruoka C, Furusawa Y, Anzai K, Okayasu R, Suzuki M. Rejoining kinetics of G1-PCC breaks induced by different heavyion beams with a similar LET value. Mutat Res 2010; 701:47-51.
84. George KA, Hada M, Chappell L, Cucinotta FA. Biological effectiveness of accelerated particles for the induction of chromosome damage: track structure effects. Radiat Res 2013; 180:25-33.
85. Hino M, Wada S, Tajika Y, Morimura Y, Hamada N, Funayama T, et al. Heavy ion microbeam irradiation induces ultrastructural changes in isolated single fibers of skeletal muscle. Cell Struct Funct 2007; 32:51-6.
86. Hino M, Hamada N, Tajika Y, Funayama T, Morimura Y, Sakashita T, et al. Insufficient membrane fusion in dysferlindeficient muscle fibers after heavy-ion irradiation. Cell Struct Funct 2009; 34:11-5.
87. Hamada N, Imaoka T, Masunaga S, Ogata T, Okayasu R, Takahashi A, et al. Recent advances in the biology of heavy-ion cancer therapy. J Radiat Res 2010; 51:365-83.
88. Jinno-Oue A, Shimizu N, Hamada N, Wada S, Tanaka A, Shinagawa M, et al. Irradiation with carbon ion beams induces apoptosis, autophagy, and cellular senescence in a human gliomaderived cell line. Int J Radiat Oncol Biol Phys 2010; 76:229-41.
89. Fry RJM, Powers-Risius P. Alpen EL, Ainsworth EJ. High-LET radiation carcinogenesis. Radiat Res 1985; 104:S188-95.
90. Blakely EA. What makes particle radiation so effective? Health Phys 2012; 103:508-28.
91. Takahashi Y, Teshima T, Kawaguchi N, Hamada Y, Mori S, Madachi A, et al. Heavy ion irradiation inhibits in vitro angiogenesis even at sublethal dose. Cancer Res 2003; 63:4253-7.
92. Ogata T, Teshima T, Kagawa K, Hishikawa Y, Takahashi Y, Kawaguchi A, et al. Particle irradiation suppresses metastatic potential of cancer cells. Cancer Res 2005; 65:113-20.
93. Takahashi A, Matsumoto H, Yuki K, Yasumoto J, Kajiwara A, Aoki M, et al. High-LET radiation enhanced apoptosis but not necrosis regardless of p53 status. Int J Radiat Oncol Biol Phys 2004; 60:591-7.
94. Masunaga S, Ando K, Uzawa A, Hirayama R, Furusawa Y, Koike S, et al. Radiobiologic significance of response of intratumor quiescent cells in vivo to accelerated carbon ion beams compared with c-rays and reactor neutron beams. Int J Radiat Oncol Biol Phys 2008; 70:221-8.
95. Hamada N, Hara T, Omura-Minamisawa M, Funayama T, Sakashita T, Sora S, et al. Energetic heavy ions overcome tumor radioresistance caused by overexpression of Bcl-2. Radiother Oncol 2008; 89:231-6.
96. Okada T, Kamada T, Tsuji H, Mizoe JE, Baba M, Kato S, et al. Carbon ion radiotherapy: clinical experiences at National Institute of Radiological Science (NIRS). J Radiat Res 2010; 51:355-64.
97. Hamada N, Kataoka K, Sora S, Hara T, Omura-Minamisawa M, Funayama T, et al. The small-molecule Bcl-2 inhibitor HA14-1 sensitizes cervical cancer cells, but not normal fibroblasts, to heavy-ion radiation. Radiother Oncol 2008; 89:227-30.
98. Takahashi A, Ota I, Tamamoto T, Asakawa I, Nagata Y, Nakagawa H, et al. p53-dependent hyperthermic enhancement of tumour growth inhibition by X-ray or carbon-ion beam irradiation. Int J Hyperthermia 2003; 19:145-53.
99. Oohira G, Yamada S, Ochiai T, Matsubara H, Okazumi S, Ando K, et al. Growth suppression of esophageal squamous cell carcinoma induced by heavy carbon-ion beams combined with p53 gene transfer. Int J Oncol 2004; 25:563-9.
100. Amino M, Yoshioka K, Fujibayashi D, Hashida T, Furusawa Y, Zareba W, et al. Year-long upregulation of connexin43 in rabbit hearts by heavy ion irradiation. Am J Physiol Heart Circ Physiol 2010; 298:H1014-21.
101. Terato H, Tanaka R, Nakaarai Y, Nohara T, Doi Y, Iwai S, et al. Quantitative analysis of isolated and clustered DNA damage induced by c-rays, carbon ion beams, and iron ion beams. J Radiat Res 2008; 49:133-46.
102. Hada M, Georgakilas AG. Formation of clustered DNA damage after high-LET irradiation: a review. J Radiat Res 2008; 49:203-10.
103. Brenner DJ, Medvedovsky C, Huang Y, Worgul BV. Accelerated heavy particles and the lens. VIII. Comparisons between the effects of acute low doses of iron ions (190 keV/lm) and argon ions (88 keV/lm). Radiat Res 1993; 133:198-203.
104. Worgul BV, Medvedovsky C, Huang Y, Marino SA, Randers-Pehrson G, Brenner DJ. Quantitative assessment of the cataractogenic potential of very low doses of neutrons. Radiat Res 1996; 145:343-9.
105. Hall EJ, Giaccia A. Radiobiology for the radiologist. 7th ed Philadelphia: Lippincott Williams & Wilkins; 2011.
106. Suda K, Mitsudomi T. Unintentional weakness of cancers: the MEK/ERK pathway as a double-edged sword. Mol Cancer Res 2013; 11:1125-8.
107. Shimura T, Fukumoto M, Kunugita N. The role of cyclin D1 in response to long-term exposure to ionizing radiation. Cell Cycle 2013; 12:773-82.