Year-long upregulation of connexin43 in rabbit hearts by heavy ion irradiation

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 298, Issue 3, 2010, Pages

  Amino, Mari ^a   Yoshioka, Koichiro ^a   Fujibayashi, Daisuke ^a   Hashida, Tadashi ^a   Furusawa, Yoshiya ^b   Zareba, Wojciech ^e   Ikari, Yuji ^a   Tanaka, Etsuro ^c   Mori, Hidezo ^a   Inokuchi, Sadaki ^a   Kodama, Itsuo ^d   Tanabe, Teruhisa ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

^d NAGOYA UNIVERSITY   (Japan)

^e UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Gap junctions; Long term effects; Radiation injury

Indexed keywords

CONNEXIN 43; HEAVY ION; MESSENGER RNA; TRITON X 100;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIASTOLE; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAM; GAP JUNCTION; HEART; HEART DISEASE; HEART LEFT VENTRICLE CONTRACTION; HEART LEFT VENTRICLE WALL; HEART MUSCLE; HEART MUSCLE CELL; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE SEPTUM; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; IRRADIATION; LIFE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; REAL TIME POLYMERASE CHAIN REACTION; SARCOLEMMA; TIME; UPREGULATION; WESTERN BLOTTING;

ANIMALS; CARBON; CONNEXIN 43; DOSE-RESPONSE RELATIONSHIP, RADIATION; HEART; HEART VENTRICLES; HEAVY IONS; MODELS, ANIMAL; MYOCARDIUM; RABBITS; RADIATION DOSAGE; RNA, MESSENGER; TIME FACTORS; UP-REGULATION;

EID: 77749273749     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00160.2009     Document Type: Article

References (32)

1. Amino M, Yoshioka K, Tanabe T, Tanaka E, Mori H, Furusawa Y, Zareba W, Yamazaki M, Nakagawa H, Honjo H, Yasui K, Kamiya K, Kodama I. Heavy ion radiation up-regulates connexin43 and ameliorates the arrhythmogenic substrates in rabbit hearts after myocardial infarction. Cardiovasc 72: 412-421, 2006.
2. Azzam EI, Toledo SM, Little JB. Expression of connexin 43 is highly sensitive to ionizing radiation and other environmental stresses. Cancer Res 63: 7128-7135, 2003.
3. Azzam EI, Toledo SM, Little JB. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from α-particle irradiated to nonirradiated cells. Proc Natl Acad Sci USA 98: 473-478, 2001.
4. Bruce AF, Rothery S, Dupont E, Severs NJ. Gap junction remodelling in human heart failure is associated with increased interaction of connexin43 with ZO-1. Cardiovasc Res 77: 757-765, 2008.
5. Buxton AE, Lee KL, DiCarlo L, Gold MR, Greer GS, Prystowsky EN, O'Toole MF, Tang A, Fisher JD, Coromilas J, Talajic M, Hafley G. A randomized study of prevention of sudden death in patients with coronary artery disease. Multicenter Unsustained Tachycardia Trial Investigators. N Engl J Med 341: 1882-1890, 1999.
6. Camelliti P, Borg TK, Kohl P. Structural and functional characterization of cardiac fibroblasts. Cardiovasc Res 65: 40-51, 2005.
7. Fast VG, Kléber AG. Role of wavefront curvature in propagation of cardiac impulse. Cardiovasc Res 33: 258-271, 1997.
8. Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL. Radiation injury. In: Harrison's Principles of Internal Medicine (17th ed.), edited by Hahn SM and Glastein E. Desoto, TX: McGraw-Hill, 2008, part 15.
9. Godemann F, Butter C, Lampe F, Linden M, Schlegl M, Schultheiss HP, Behrens S. Pacing disorders and agoraphobia: side effects of treatment with an implantable cardioverter/defibrillator. Clin Cardiol 27: 321-326, 2004.
10. Goldberg Z, Lehnert BE. Radiation-induced effects in unirradiated cells: a review and implications in cancer. Int J Oncol 21: 337-349, 2002.
11. Gros DB, Jongsma HJ. Connexins in mammalian heart function. Bioessays 18: 719-730, 1996.
12. Gyenes G. Radiation-induced ischemic heart disease in breast cancer. Acta Oncol 37: 241-246, 1998.
13. Hamada N, Matsumoto H, Hara T, Kobayashi Y. Intercellular and intracellular signaling pathways mediating ionizing radiation-induced bystander effects. J Radiat Res 48: 87-95, 2007.
14. Hei TK, Zhou H, Ivanov VN, Hong M, Lieberman HB, Brenner DJ, Amundson SA, Geard CR. Mechanism of radiation-induced bystander effects: a unifying model. J Pharm Pharmacol 60: 943-950, 2008.
15. Honjo H, Boyett MR, Coppen SR, Takagishi Y, Opthof T, Severs NJ, Kodama I. Heterogeneous expression of connexins in rabbit sinoatrial node cells: correlation between connexin isotype and cell size. Cardiovasc Res 5: 89-96, 2002.
16. Hucker WJ, McCain ML, Laughner JI, Iaizzo PA, Efimov IR. Connexin 43 expression delineates two discrete pathways in the human atrioventricular junction. Anat Rec 291: 204-215, 2008.
17. Jongsma HJ, Wilders R. Gap junctions in cardiovascular disease. Circ Res 86: 1193-1197, 2000.
18. Kam R, Garan H, McGovern BA, Ruskin JN, Harthorne JW. Transient right bundle branch block causing R wave attenuation postdefibrillation. Pacing Clin Electrophysiol 20: 130-131, 1997.
19. Kleber AG, Rudy Y. Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol Rev 84: 431-488, 2004.
20. Lee DS, Green LD, Liu PP, Dorian P, Newman DM, Grant Tu JV FC, Alter DA. Effectiveness of implantable defribrillators for preventing arrhythmic events and death: a meta-analysis. J Am Coll Cardiol 41: 1573-1582, 2003.
21. Littlefield R, Fowler VM. Defining actin filament length in striated muscle: rulers and caps or dynamic stability? Annu Rev Cell Dev Biol 14: 487-525, 1998.
22. Matsumoto H, Tomita M, Otsuka K, Hatashita M. A new paradime in radioadaptive response developing from micribeam research. J Radiat Res 50: 67-79, 2009.
23. Mesnil M, Piccoli C, Tiraby G, Willecke K, Yamasaki H. Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins. Proc Natl Acad Sci USA 93: 1831-1835, 1996.
24. Myerburg RJ, Interian Simmons JA Jr, Castellanos A. Sudden cardiac death. In: Cardiac Electrophysiology: From Cell to Bedside (4th ed.), edited by Zipes DP and Jalife J. Philadelphia: Saunders, 2009, p. 720-731.
25. Padilla D, Menéndez P, García M, Villarejo P, Cubo T, Gambí D, Pardo R, Martín J. Immunohistochemical expression of epidermal growth factor and its prognostic value for gastrointestinal stromal tumors. Rev Esp Enferm Dig 100: 752-757, 2008.
26. Problems associated with the effects of low dose of ionizing radiations.
27. Rohr S. Role of gap junctions in the propagation of the cardiac action potential. Cardiovasc Res 62: 309-322, 2004.
28. Severs NJ, Bruce AF, Dupont E, Rothery S. Remodelling of gap junctions and connexin expression in diseased myocardium. Cardiovasc Res 80: 9-19, 2008.
29. Swerdlow AJ, Higgins CD, Smith P, Cunningham D, Hancock BW, Horwich A, Hoskin PJ, Lister A, Radford JA, Rohatiner AZ, Linch DC. Myocardial infarction mortality risk after treatment for Hodgkin disease: a collaborative British cohort study. J Natl Cancer Inst 99: 206-214, 2007.
30. Tokano T, Bach D, Chang J, Davis J, Souza JJ, Zivin A, Knight BP, Goyal R, Man KC, Morady F, Strickberger SA. Effect of ventricular shock strength on cardiac hemodynamics. J Cardiovasc Electrophysiol 9: 791-797, 1998.
31. Torikoshi M, Minohara S, Kanematsu N, Komori M, Kanazawa M, Noda K, Miyahara N, Itoh H, Endo M, Kanai T. Irradiation system for HIMAC. J Radiat 48: A15-A25, 2007.
32. Zivin A, Souza J, Pelosi F, Flemming M, Knight BP, Goyal R, Morady F, Strickberger SA. Relationship between shock energy and postdefibrillation ventricular arrhythmias in patients with implantable defibrillators. J Cardiovasc Electrophysiol 10: 370-377, 1999.