Mutations in subunit interface and B-cell Epitopes improve Antileukemic activities of Escherichia Coli asparaginase-II:Evaluation of Immunogenicity in Mice

Journal of Biological Chemistry

Volumn 289, Issue 6, 2014, Pages 3555-3570

  Mehta, Ranjit Kumar ^a   Verma, Shikha ^b   Pati, Rashmirekha ^a   Sengupta, Mitali ^a   Khatua, Biswajit ^c   Jena, Rabindra Kumar ^d   Sethy, Sudha ^d   Kar, Santosh K ^a   Mandal, Chitra ^c   Roehm, Klaus H ^b   Sonawane, Avinash ^a  

^a KIIT UNIVERSITY   (India)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^d Sriram Chandra Bhanj Medical College   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINASE; CYTOTOXICITY; E. COLI; ENZYME MUTATION; ESCHERICHIA COLI; IMMUNOGENICITY; LEUKEMIA; LEUKEMIC CELLS; LYMPHOMA; MICE; MICROBIOLOGY;

AMINO ACID SUBSTITUTION; ANIMALS; ANTINEOPLASTIC AGENTS; ASPARAGINASE; BCL-X PROTEIN; CASPASE 3; CELL LINE, TUMOR; CYTOCHROMES C; EPITOPES, B-LYMPHOCYTE; ESCHERICHIA COLI PROTEINS; FEMALE; HUMANS; MALE; MICE; MICE, INBRED BALB C; MUTAGENESIS; MUTATION, MISSENSE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA;

EID: 84893659684     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.486530     Document Type: Article

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