Effect of hyperglycaemia on inflammatory and stress responses and clinical outcome of pneumonia in non-critical-care inpatients: Results from an observational cohort study

Diabetologia

Volumn 57, Issue 2, 2014, Pages 275-284

  Schuetz, Philipp ^a   Friedli, Natalie ^a   Grolimund, Eva ^a   Kutz, Alexander ^a   Haubitz, Sebastian ^a   Christ Crain, Mirjam ^b   Thomann, Robert ^c   Zimmerli, Werner ^c   Hoess, Claus ^d   Henzen, Christoph ^c   Mueller, Beat ^a  

^a University Department of Internal Medicine   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c Buergerspital Solothurn ^*  (Switzerland)

^d Kantonsspital Muensterlingen   (Switzerland)

Author keywords

Biomarker response; Diabetes; Glucose; Hyperglycaemia; Outcome; Pneumonia

Indexed keywords

C REACTIVE PROTEIN; GLUCOSE; INSULIN; PROADRENOMEDULLIN; PROCALCITONIN;

ADVERSE OUTCOME; AGED; ARTICLE; CAUSE OF DEATH; COHORT ANALYSIS; COMMUNITY ACQUIRED PNEUMONIA; DIABETIC PATIENT; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; HOSPITAL ADMISSION; HOSPITAL PATIENT; HUMAN; HYPERGLYCEMIA; INFLAMMATION; INSULIN TREATMENT; INTENSIVE CARE UNIT; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK FACTOR; SECONDARY ANALYSIS; STRESS; TREATMENT OUTCOME;

AGED; ANTI-BACTERIAL AGENTS; BIOLOGICAL MARKERS; BLOOD GLUCOSE; BODY MASS INDEX; C-REACTIVE PROTEIN; CALCITONIN; COMMUNITY-ACQUIRED INFECTIONS; DIABETES MELLITUS; FEMALE; HOSPITALIZATION; HUMANS; HYPERGLYCEMIA; INFLAMMATION; LEUKOCYTE COUNT; MALE; PNEUMONIA; PROGNOSIS; PROSPECTIVE STUDIES; PROTEIN PRECURSORS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; STRESS, PHYSIOLOGICAL;

EID: 84893659046     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-3112-9     Document Type: Article

References (50)

1. Delamaire M, Maugendre D, Moreno M, Le Goff MC, Allannic H, Genetet B (1997) Impaired leucocyte functions in diabetic patients. Diabet Med 14:29-34
2. Alexiewicz JM, Kumar D, Smogorzewski M, Klin M, Massry SG (1995) Polymorphonuclear leukocytes in non-insulin-dependent diabetes mellitus: abnormalities in metabolism and function. Ann Intern Med 123:919-924
3. Schuetz P, Castro P, Shapiro NI (2011) Diabetes and sepsis: preclinical findings and clinical relevance. Diabetes Care 34:771-778
4. Liberatore RR Jr, Barbosa SF, Alkimin M et al (2005) Is immunity in diabetic patients influencing the susceptibility to infections? Immunoglobulins, complement and phagocytic function in children and adolescents with type 1 diabetes mellitus. Pediatr Diabetes 6:206-212
5. Spatz M, Eibl N, Hink S et al (2003) Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T cells. Cell Immunol 221:15-26
6. Edwards MS, Fuselier PA (1983) Enhanced susceptibility of mice with streptozotocin-induced diabetes to type II group B streptococcal infection. Infect Immun 39:580-585
7. Lepper PM, Ott S, Nuesch E et al (2012) Serum glucose levels for predicting death in patients admitted to hospital for community acquired pneumonia: prospective cohort study. BMJ 344:e3397
8. Esper AM, Moss M, Martin GS (2009) The effect of diabetes mellitus on organ dysfunction with sepsis: an epidemiological study. Crit Care 13:R18
9. Moss M, Guidot DM, Steinberg KP et al (2000) Diabetic patients have a decreased incidence of acute respiratory distress syndrome. Crit Care Med 28:2187-2192
10. Thomsen RW, Hundborg HH, Lervang HH, Johnsen SP, Sorensen HT, Schonheyder HC (2004) Diabetes and outcome of community-acquired pneumococcal bacteremia: a 10-year population-based cohort study. Diabetes Care 27:70-76
11. Graham BB, Keniston A, Gajic O, Trillo Alvarez CA, Medvedev S, Douglas IS (2010) Diabetes mellitus does not adversely affect outcomes from a critical illness. Crit Care Med 38:16-24
12. Van den Berghe G, Wilmer A, Hermans G et al (2006) Intensive insulin therapy in the medical ICU. N Engl J Med 354:449-461
13. van den Berghe G, Wouters P, Weekers F et al (2001) Intensive insulin therapy in critically ill patients. N Engl J Med 345:1359-1367
14. Investigators N-SS, Finfer S, Chittock DR et al (2009) Intensive versus conventional glucose control in critically ill patients. N Engl J Med 360:1283-1297
15. Schuetz P, Kennedy M, Lucas JM et al (2012) Initial management of septic patients with hyperglycemia in the noncritical care inpatient setting. Am J Med 125:670-678
16. Schuetz P, Christ-Crain M, Wolbers M et al (2007) Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trial. BMC Health Serv Res 7:102
17. Schuetz P, Christ-Crain M, Thomann R et al (2009) Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial. JAMA 302:1059-1066
18. Schuetz P, Wolbers M, Christ-Crain M et al (2010) Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections. Crit Care 14:R106
19. Schuetz P, Suter-Widmer I, Chaudri A et al (2011) Prognostic value of procalcitonin in community-acquired pneumonia. Eur Respir J 37:384-392
20. Renaud B, Schuetz P, Claessens YE, Labarere J, Albrich W, Mueller B (2012) Proadrenomedullin improves risk of early admission to ICU score for predicting early severe community-acquired pneumonia. Chest 142:1447-1454
21. Mimoz O, Benoist JF, Edouard AR, Assicot M, Bohuon C, Samii K (1998) Procalcitonin and C-reactive protein during the early posttraumatic systemic inflammatory response syndrome. Intensive Care Med 24:185-188
22. Guertler C, Wirz B, Christ-Crain M, Zimmerli W, Mueller B, Schuetz P (2011) Inflammatory responses predict long-term mortality risk in community-acquired pneumonia. Eur Respir J 37:1439-1446
23. Umpierrez GE, Hellman R, Korytkowski MT et al (2012) Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 97:16-38
24. Calverley PM, Walker P (2003) Chronic obstructive pulmonary disease. Lancet 362:1053-1061
25. Gonzales R, Sande MA (2000) Uncomplicated acute bronchitis. Ann Intern Med 133:981-991
26. Niederman MS, Mandell LA, Anzueto A et al (2001) Guidelines for the management of adults with community-acquired pneumonia. Diagnosis, assessment of severity, antimicrobial therapy, and prevention. Am J Respir Crit Care Med 163:1730-1754
27. Woodhead M, Blasi F, Ewig S et al (2005) Guidelines for the management of adult lower respiratory tract infections. Eur Respir J 26:1138-1180
28. Lim WS, van der Eerden MM, Laing R et al (2003) Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study. Thorax 58:377-382
29. Kornum JB, Thomsen RW, Riis A, Lervang HH, Schonheyder HC, Sorensen HT (2007) Type 2 diabetes and pneumonia outcomes: a population-based cohort study. Diabetes Care 30:2251-2257
30. McAlister FA, Majumdar SR, Blitz S, Rowe BH, Romney J, Marrie TJ (2005) The relation between hyperglycemia and outcomes in 2,471 patients admitted to the hospital with community-acquired pneumonia. Diabetes Care 28:810-815
31. Moghissi ES, Korytkowski MT, DiNardo M et al (2009) American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. Diabetes Care 32:1119-1131
32. Stegenga ME, Vincent JL, Vail GM et al (2010) Diabetes does not alter mortality or hemostatic and inflammatory responses in patients with severe sepsis. Crit Care Med 38:539-545
33. Christ-Crain M, Muller B (2007) Biomarkers in respiratory tract infections: diagnostic guides to antibiotic prescription, prognostic markers and mediators. Eur Respir J 30:556-573
34. Cerami A (1992) Inflammatory cytokines. Clin Immunol Immunopathol 62:S3-S10
35. Hofbauer KH, Schoof E, Kurtz A, Sandner P (2002) Inflammatory cytokines stimulate adrenomedullin expression through nitric oxide-dependent and -independent pathways. Hypertension 39:161-167
36. Moshage HJ, Roelofs HM, van Pelt JF et al (1988) The effect of interleukin-1, interleukin-6 and its interrelationship on the synthesis of serum amyloid A and C-reactive protein in primary cultures of adult human hepatocytes. Biochem Biophys Res Commun 155:112-117
37. Redl H, Schlag G, Togel E, Assicot M, Bohuon C (2000) Procalcitonin release patterns in a baboon model of trauma and sepsis: relationship to cytokines and neopterin. Crit Care Med 28:3659-3663
38. Redl H, Schiesser A, Togel E, Assicot M, Bohuon C (2001) Possible role of TNF on procalcitonin release in a baboon model of sepsis. Shock 16:25-27
39. Ulich TR, del Castillo J, Keys M, Granger GA (1987) Recombinant human alpha lymphotoxin (tumor necrosis factor-beta) induces peripheral neutrophilia and lymphopenia in the rat. Am J Pathol 128:5-12
40. Ulich TR, del Castillo J, Keys M, Granger GA, Ni RX (1987) Kinetics and mechanisms of recombinant human interleukin 1 and tumor necrosis factor-alpha-induced changes in circulating numbers of neutrophils and lymphocytes. J Immunol 139:3406-3415
41. Ulich TR, del Castillo J, Guo KZ (1989) In vivo hematologic effects of recombinant interleukin-6 on hematopoiesis and circulating numbers of RBCs and WBCs. Blood 73:108-110
42. Dungan KM, Braithwaite SS, Preiser JC (2009) Stress hyperglycaemia. Lancet 373:1798-1807
43. Ishihara M, Kagawa E, Inoue I et al (2007) Impact of admission hyperglycemia and diabetes mellitus on short- and long-term mortality after acute myocardial infarction in the coronary intervention era. Am J Cardiol 99:1674-1679
44. Andrews RC, Walker BR (1999) Glucocorticoids and insulin resistance: old hormones, new targets. Clin Sci (Lond) 96:513-523
45. Gelfand RA, Matthews DE, Bier DM, Sherwin RS (1984) Role of counterregulatory hormones in the catabolic response to stress. J Clin Invest 74:2238-2248
46. Dandona P, Aljada A, Mohanty P et al (2001) Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J Clin Endocrinol Metab 86:3257-3265
47. Das UN (2001) Is insulin an antiinflammatory molecule? Nutrition 17:409-413
48. Garg R, Chaudhuri A, Munschauer F, Dandona P (2006) Hyperglycemia, insulin, and acute ischemic stroke: a mechanistic justification for a trial of insulin infusion therapy. Stroke 37:267-273
49. Donnino MW, Cocchi MN, Howell M et al (2009) Statin therapy is associated with decreased mortality in patients with infection. Acad Emerg Med 16:230-234
50. Umpierrez GE, Smiley D, Jacobs S et al (2011) Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes undergoing general surgery (RABBIT 2 surgery). Diabetes Care 34:256-261