Diabetes and sepsis: Preclinical findings and clinical relevance

Diabetes Care

Volumn 34, Issue 3, 2011, Pages 771-778

  Schuetz, Philipp ^a,b,c   Castro, Pedro ^a,b,d   Shapiro, Nathan I ^a,b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; GAMMA INTERFERON; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INSULIN; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; ANTIBODY PRODUCTION; BACTERIAL CLEARANCE; COMORBIDITY; CYTOKINE PRODUCTION; DIABETES MELLITUS; DISEASE MODEL; DISEASE PREDISPOSITION; ENDOTHELIAL DYSFUNCTION; GLYCEMIC CONTROL; HUMAN; HYPERGLYCEMIA; IMMUNE RESPONSE; INFECTION SENSITIVITY; INNATE IMMUNITY; MORTALITY; MYCOBACTERIUM; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOPHYSIOLOGY; PHAGOCYTOSIS; PROGNOSIS; PSEUDOMONAS AERUGINOSA; REVIEW; SEPSIS; STREPTOCOCCUS AGALACTIAE; TH1 CELL; TREATMENT OUTCOME;

ADAPTIVE IMMUNITY; CYTOKINES; DIABETES MELLITUS; HUMANS; HYPERGLYCEMIA; IMMUNITY, INNATE; SEPSIS;

EID: 79956136689     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc10-1185     Document Type: Review

References (59)

1. Edwards MS, Fuselier PA. Enhanced susceptibility of mice with streptozotocin-induced diabetes to type II group B streptococcal infection. Infect Immun 1983;39:580-585 (Pubitemid 13188334)
2. Kitahara Y, Ishibashi T, Harada Y, Takamoto M, Tanaka K. Reduced resistance to Pseudomonas septicaemia in diabetic mice. Clin Exp Immunol 1981;43:590-598 (Pubitemid 11130425)
3. Martens GW, Arikan MC, Lee J, Ren F, Greiner D, Kornfeld H. Tuberculosis susceptibility of diabetic mice. Am J Respir Cell Mol Biol 2007;37:518-524 (Pubitemid 350058182)
4. Yamashiro S, Kawakami K, Uezu K, et al. Lower expression of Th1-related cytokines and inducible nitric oxide synthase in mice with streptozotocin- induced diabetes mellitus infected with Mycobacterium tuberculosis. Clin Exp Immunol 2005;139:57-64 (Pubitemid 40066129)
5. Delamaire M, Maugendre D, Moreno M, Le Goff MC, Allannic H, Genetet B. Impaired leucocyte functions in diabetic patients. Diabet Med 1997;14:29-34 (Pubitemid 27019919)
6. Alexiewicz JM, Kumar D, Smogorzewski M, Klin M, Massry SG. Polymorphonuclear leukocytes in non-insulin-dependent diabetes mellitus: abnormalities in metabolism and function. Ann Intern Med 1995;123:919-924
7. Stegenga ME, van der Crabben SN, Blümer RM, et al. Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia. Blood 2008;112:82-89
8. Stegenga ME, van der Crabben SN, Dessing MC, et al. Effect of acute hyperglycaemia and/or hyperinsulinaemia on proinflammatory gene expression, cytokine production and neutrophil function in humans. Diabet Med 2008;25:157-164 (Pubitemid 351293406)
9. Graves DT, Naguib G, Lu H, Leone C, Hsue H, Krall E. Inflammation is more persistent in type 1 diabetic mice. J Dent Res 2005;84:324-328 (Pubitemid 43822013)
10. Geerlings SE, Brouwer EC, Van Kessel KC, Gaastra W, Stolk RP, Hoepelman AI. Cytokine secretion is impaired in women with diabetes mellitus. Eur J Clin Invest 2000;30:995-1001
11. Amano H, Yamamoto H, Senba M, et al. Impairment of endotoxin-induced macrophage inflammatory protein 2 gene expression in alveolar macrophages in streptozotocin-induced diabetes in mice. Infect Immun 2000;68:2925-2929 (Pubitemid 30253873)
12. Spatz M, Eibl N, Hink S, et al. Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. Cell Immunol 2003;221:15-26
13. Rubinstein R, Genaro AM, Motta A, Cremaschi G, Wald MR. Impaired immune responses in streptozotocin-induced type I diabetes inmice. Involvement of high glucose. Clin Exp Immunol 2008;154:235-246
14. Liberatore RR Jr, Barbosa SF, Alkimin MG, et al. Is immunity in diabetic patients influencing the susceptibility to infections? Immunoglobulins, complement and phagocytic function in children and adolescents with type 1 diabetes mellitus. Pediatr Diabetes 2005;6:206-212 (Pubitemid 43013628)
15. Lapolla A, Tonani R, Fedele D, et al. Non-enzymatic glycation of IgG: an in vivo study. Horm Metab Res 2002;34:260-264 (Pubitemid 34666590)
16. Beam TR Jr. Pneumococcal vaccination in diabetes. JAMA 1981;245:920-921
17. Dandona P, Aljada A, Mohanty P, et al. Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J Clin Endocrinol Metab 2001;86:3257-3265 (Pubitemid 32674120)
18. Das UN. Is insulin an antiinflammatory molecule? Nutrition 2001;17:409-413
19. Campos SP, Baumann H. Insulin is a prominent modulator of the cytokine-stimulated expression of acute-phase plasma protein genes. Mol Cell Biol 1992;12:1789-1797
20. Viardot A, Grey ST, Mackay F, Chisholm D. Potential antiinflammatory role of insulin via the preferential polarization of effector T cells toward a T helper 2 phenotype. Endocrinology 2007;148:346-353 (Pubitemid 46021467)
21. Hansen TK, Thiel S, Wouters PJ, Christiansen JS, Van den Berghe G. Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels. J Clin Endocrinol Metab 2003;88:1082-1088 (Pubitemid 36337759)
22. Marfella R, Nappo F, De Angelis L, Siniscalchi M, Rossi F, Giugliano D. The effect of acute hyperglycaemia on QTc duration in healthy man. Diabetologia 2000;43:571-575 (Pubitemid 30322074)
23. Vachharajani V, Russell JM, Scott KL, et al. Obesity exacerbates sepsis-induced inflammation and microvascular dysfunction in mouse brain. Microcirculation 2005;12:183-194 (Pubitemid 40485631)
24. Matsumoto K, Sera Y, Miyake S, Ueki Y. Serum levels of adhesion molecules correlate with insulin resistance. Atherosclerosis 2002;161:243-244 (Pubitemid 34214842)
25. Langouche L, Vanhorebeek I, Vlasselaers D, et al. Intensive insulin therapy protects the endothelium of critically ill patients. J Clin Invest 2005;115:2277-2286 (Pubitemid 41134169)
26. Zuran I, Poredos P, Skale R, Voga G, Gabrscek L, Pareznik R. Intensive insulin treatment improves forearm blood flow in critically ill patients: a randomized parallel design clinical trial. Crit Care 2009;13:R198
27. Wheat LJ. Infection and diabetes mellitus. Diabetes Care 1980;3:187-197 (Pubitemid 10079181)
28. Smitherman KO, Peacock JE Jr. Infectious emergencies in patients with diabetes mellitus. Med Clin North Am 1995;79:53-77
29. Zhao Y, Ye W, Le TK, Boye KS, Holcombe JH, Swindle R. Comparing clinical and economic characteristics between commercially-insured patients with diabetic neuropathy and demographically-matched diabetic controls. Curr Med Res Opin 2009;25:585-597
30. Boyko EJ, Fihn SD, Scholes D, Abraham L, Monsey B. Risk of urinary tract infection and asymptomatic bacteriuria among diabetic and nondiabetic postmenopausal women. Am J Epidemiol 2005;161:557-564 (Pubitemid 40349911)
31. Shah BR, Hux JE. Quantifying the risk of infectious diseases for people with diabetes. Diabetes Care 2003;26:510-513 (Pubitemid 36929083)
32. Benfield T, Jensen JS, Nordestgaard BG. Influence of diabetes and hyperglycaemia on infectious disease hospitalisation and outcome. Diabetologia 2007;50:549-554 (Pubitemid 46215497)
33. Dooley KE, Chaisson RE. Tuberculosis and diabetes mellitus: convergence of two epidemics. Lancet Infect Dis 2009;9:737-746
34. Kung HC, Wang JL, Chang SC, et al. Community-onset candidemia at a university hospital, 1995-2005. J Microbiol Immunol Infect 2007;40:355-363
35. Fine MJ, Smith MA, Carson CA, et al. Prognosis and outcomes of patients with community-acquired pneumonia. A meta-analysis. JAMA 1996;275:134-141
36. Thomsen RW, Hundborg HH, Lervang HH, Johnsen SP, Schønheyder HC, Sørensen HT. Diabetes mellitus as a risk and prognostic factor for community-acquired bacteremia due to enterobacteria: a 10-year, population-based study among adults. Clin Infect Dis 2005;40:628-631 (Pubitemid 40270239)
37. Kornum JB, Thomsen RW, Riis A, Lervang HH, Schønheyder HC, Sørensen HT. Type 2 diabetes and pneumonia outcomes: a population-based cohort study. Diabetes Care 2007;30:2251-2257 (Pubitemid 47359027)
38. Kaplan V, Angus DC, Griffin MF, et al. Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United States. Am J Respir Crit Care Med 2002;165:766-772 (Pubitemid 34229645)
39. McAlister FA, Majumdar SR, Blitz S, Rowe BH, Romney J, Marrie TJ. The relation between hyperglycemia and outcomes in 2,471 patients admitted to the hospital with community-acquired pneumonia. Diabetes Care 2005;28:810-815 (Pubitemid 40434478)
40. Tsai CL, Lee CC, Ma MH, et al. Impact of diabetes on mortality among patients with community-acquired bacteremia. J Infect 2007;55:27-33
41. Vincent JL, Preiser JC, Sprung CL, Moreno R, Sakr Y. Insulin-treated diabetes is not associated with increased mortality in critically ill patients. Crit Care 2010;14:R12
42. Stegenga ME, Vincent JL, Vail GM, et al. Diabetes does not alter mortality or hemostatic and inflammatory responses in patients with severe sepsis. Crit Care Med 2009;38:539-545
43. Esper AM, Moss M, Martin GS. The effect of diabetes mellitus on organ dysfunction with sepsis: an epidemiological study. Crit Care 2009;13:R18
44. Moss M, Guidot DM, Steinberg KP, et al. Diabetic patients have a decreased incidence of acute respiratory distress syndrome. Crit Care Med 2000;28:2187-2192 (Pubitemid 30604414)
45. Thomsen RW, Hundborg HH, Lervang HH, Johnsen SP, Sørensen HT, Schønheyder HC. Diabetes and outcome of community-acquired pneumococcal bacteremia: a 10-year population-based cohort study. Diabetes Care 2004;27:70-76 (Pubitemid 38196712)
46. Graham BB, Keniston A, Gajic O, Trillo Alvarez CA, Medvedev S, Douglas IS. Diabetes mellitus does not adversely affect outcomes from a critical illness. Crit Care Med 2010;38:16-24
47. Peake SL, Moran JL, Ghelani DR, Lloyd AJ, Walker MJ. The effect of obesity on 12-month survival following admission to intensive care: a prospective study. Crit Care Med 2006;34:2929-2939 (Pubitemid 44808734)
48. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001;345:1359-1367
49. Capes SE, Hunt D, Malmberg K, Gerstein HC. Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet 2000;355:773-778 (Pubitemid 30128815)
50. Van den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy in the medical ICU. N Engl J Med 2006;354:449-461 (Pubitemid 43200296)
51. Brunkhorst FM, Engel C, Bloos F, et al.; German Competence Network Sepsis (SepNet). Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008;358:125-139
52. Finfer S, Chittock DR, Su SY, et al.; NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009;360:1283-1297
53. Li Volti S, Caruso-Nicoletti M, Biazzo F, et al. Hyporesponsiveness to intradermal administration of hepatitis B vaccine in insulin dependent diabetes mellitus. Arch Dis Child 1998;78:54-57 (Pubitemid 28177584)
54. Okon EB, Chung AW, Rauniyar P, et al. Compromised arterial function in human type 2 diabetic patients. Diabetes 2005;54:2415-2423 (Pubitemid 41134270)
55. Gómez JM, Vila R, Catalina P, Soler J, Badimón L, Sahún M. The markers of inflammation and endothelial dysfunction in correlation with glycated haemoglobin are present in type 2 diabetes mellitus patients but not in their relatives. Glycoconj J 2008;25:573-579
56. Boden G, Vaidyula VR, Homko C, Cheung P, Rao AK. Circulating tissue factor procoagulant activity and thrombin generation in patients with type 2 diabetes: effects of insulin and glucose. J Clin Endocrinol Metab 2007;92:4352-4358 (Pubitemid 350074756)
57. Kornum JB, Thomsen RW, Riis A, Lervang HH, Schønheyder HC, Sørensen HT. Diabetes, glycemic control, and risk of hospitalization with pneumonia: a population-based case-control study. Diabetes Care 2008;31:1541-1545
58. Thomsen RW, Hundborg HH, Lervang HH, Johnsen SP, Schønheyder HC, Sørensen HT. Risk of community-acquired pneumococcal bacteremia in patients with diabetes: a population-based case-control study. Diabetes Care 2004;27:1143-1147 (Pubitemid 38579780)
59. Michalia M, Kompoti M, Koutsikou A, et al. Diabetes mellitus is an independent risk factor for ICU-acquired bloodstream infections. Intensive Care Med 2009;35:448-454