Initial management of septic patients with hyperglycemia in the noncritical care inpatient setting

American Journal of Medicine

Volumn 125, Issue 7, 2012, Pages 670-678

  Schuetz, Philipp ^a   Kennedy, Maura ^a   Lucas, Jason M ^a   Howell, Michael D ^a   Aird, William C ^b   Yealy, Donald M ^c   Shapiro, Nathan I ^a,b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b Center for Vascular Biology Research   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Diabetes; Hyperglycemia; Noncritical care; Sepsis; Severe sepsis

Indexed keywords

GLUCOSE; INSULIN;

ADULT; AGE; ARTICLE; DIABETES MELLITUS; DIABETIC PATIENT; DISEASE SEVERITY; FEMALE; HIGH RISK PATIENT; HOSPITAL ADMISSION; HOSPITAL PATIENT; HUMAN; HYPERGLYCEMIA; INSULIN TREATMENT; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PATIENT CARE; PRIORITY JOURNAL; PROGNOSIS; RISK ASSESSMENT; SEPSIS;

ADULT; AGED; AGED, 80 AND OVER; BLOOD GLUCOSE; BOSTON; DIABETES COMPLICATIONS; FEMALE; HOSPITAL MORTALITY; HOSPITALIZATION; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; INTENSIVE CARE; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; REGRESSION ANALYSIS; SEPSIS;

EID: 84862645058     PISSN: 00029343     EISSN: 15557162     Source Type: Journal    
DOI: 10.1016/j.amjmed.2012.03.001     Document Type: Article

References (20)

1. Brunkhorst FM, Engel C, Bloos F, et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med. 2008;358: 125-139.
2. Finfer S, Chittock DR, Su SY, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360:1283-1297.
3. Van den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006;354:449-461.
4. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001;345:1359-1367.
5. Kavanagh BP, McCowen KC. Clinical practice. Glycemic control in the ICU. N Engl J Med. 2010;363:2540-2546.
6. Ata A, Lee J, Bestle SL, et al. Postoperative hyperglycemia and surgical site infection in general surgery patients. Arch Surg. 2010; 145:858-864.
7. Patel KL. Impact of tight glucose control on postoperative infection rates and wound healing in cardiac surgery patients. J Wound Ostomy Continence Nurs. 2008;35:397-404; quiz 5-6.
8. Umpierrez GE, Smiley D, Jacobs S, et al. Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes undergoing general surgery (RABBIT 2 surgery). Diabetes Care. 2011;34:256-261.
9. Schuetz P, Castro P, Shapiro NI. Diabetes and sepsis: preclinical findings and clinical relevance. Diabetes Care. 2011;34:771-778.
10. Falguera M, Pifarre R, Martin A, et al. Etiology and outcome of community-acquired pneumonia in patients with diabetes mellitus. Chest. 2005;128:3233-3239.
11. McAlister FA, Majumdar SR, Blitz S, et al. The relation between hyperglycemia and outcomes in 2,471 patients admitted to the hospital with community-acquired pneumonia. Diabetes Care. 2005;28:810-815.
12. Frisch A, Chandra P, Smiley D, et al. Prevalence and clinical outcome of hyperglycemia in the perioperative period in noncardiac surgery. Diabetes Care. 2010;33:1783-1788.
13. Umpierrez GE, Isaacs SD, Bazargan N, et al. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab. 2002;87:978-982.
14. Schuetz P, Jones AE, Howell MD, et al. Diabetes is not associated with increased mortality in emergency department patients with sepsis. Ann Emerg Med. 2011;58:438-444.
15. Shapiro NI, Howell MD, Talmor D, et al. Serum lactate as a predictor of mortality in emergency department patients with infection. Ann Emerg Med. 2005;45:524-528.
16. Egi M, Bellomo R, Stachowski E, et al. The interaction of chronic and acute glycemia with mortality in critically ill patients with diabetes. Crit Care Med. 2011;39:105-111.
17. Finney SJ, Zekveld C, Elia A, Evans TW. Glucose control and mortality in critically ill patients. Jama. 2003;290:2041-2047.
18. Shapiro NI, Wolfe RE, Moore RB, et al. Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule. Crit Care Med. 2003;31:670-675.
19. Economic costs of diabetes in the U.S. In 2007. Diabetes Care. 2008;31:596-615.
20. Moghissi ES, Korytkowski MT, DiNardo M, et al. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. Diabetes Care. 2009;32:1119-1131.