Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 3, 2014, Pages 917-922

  Côté, Bernard ^a   Burch, Jason D ^a   Asante Appiah, Ernest ^a   Bayly, Chris ^a   Bédard, Leanne ^a   Blouin, Marc ^a   Campeau, Louis Charles ^a   Cauchon, Elizabeth ^a   Chan, Manuel ^a   Chefson, Amandine ^a   Coulombe, Nathalie ^a   Cromlish, Wanda ^a   Debnath, Smita ^a   Deschênes, Denis ^a   Dupont Gaudet, Kristina ^a   Falgueyret, Jean Pierre ^a   Forget, Robert ^a   Gagné, Sébastien ^a   Gauvreau, Danny ^a   Girardin, Melina ^a   Guiral, Sébastien ^a   Langlois, Eric ^a   Li, Chun Sing ^a   Nguyen, Natalie ^a   Papp, Rob ^a   Plamondon, Serge ^a   Roy, Amélie ^a   Roy, Stéphanie ^a   Seliniotakis, Ria ^a   St Onge, Miguel ^a   Ouellet, Stéphane ^a   Tawa, Paul ^a   Truchon, Jean François ^a   Vacca, Joe ^a   Wrona, Marc ^a   Yan, Youwei ^b   Ducharme, Yves ^a   more..

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

HIV; Inhibitor; Non nucleoside reverse transcriptase; Pyridone; Triazolinone

Indexed keywords

DORAVIRINE;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; VIRUS MUTANT; VIRUS RESISTANCE;

HIV; INHIBITOR; NON-NUCLEOSIDE REVERSE TRANSCRIPTASE; PYRIDONE; TRIAZOLINONE;

ANIMALS; ANTI-HIV AGENTS; CELLS, CULTURED; CRYSTALLOGRAPHY, X-RAY; DOGS; DRUG DISCOVERY; DRUG RESISTANCE, VIRAL; HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; MUTATION; PYRIDONES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE INHIBITORS; TRIAZOLES;

EID: 84893653923     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.12.070     Document Type: Article

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