Design and synthesis of pyridone inhibitors of non-nucleoside reverse transcriptase

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 24, 2011, Pages 7344-7350

  Gomez, Robert ^a   Jolly, Samson ^a   Williams, Theresa ^a   Tucker, Thomas ^a   Tynebor, Robert ^a   Vacca, Joe ^a   McGaughey, Georgia ^a   Lai, Ming Tain ^a   Felock, Peter ^a   Munshi, Vandna ^a   Destefano, Daniel ^a   Touch, Sinoeun ^a   Miller, Mike ^a   Yan, Youwei ^a   Sanchez, Rosa ^a   Liang, Yuexia ^a   Paton, Brenda ^a   Wan, Bang Lin ^a   Anthony, Neville ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

HIV; Non nucleoside reverse transcriptase inhibitor; Pyridinone; Pyridone

Indexed keywords

ANTIVIRUS AGENT; ARYL ETHER; DIPYRONE; ETHER; LERSIVIRINE; MK 4965; MK 6186; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RILPIVIRINE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; VIRUS STRAIN;

BINDING SITES; CELL LINE; COMPUTER SIMULATION; DRUG DESIGN; ENZYME ACTIVATION; HIV; HIV REVERSE TRANSCRIPTASE; HUMANS; PROTEIN STRUCTURE, TERTIARY; PYRAZOLES; PYRIDINES; PYRIDONES; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 81255192088     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.027     Document Type: Article

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