메뉴 건너뛰기




Volumn 31, Issue 4, 2009, Pages 692-704

Etravirine: A second-generation nonnucleoside reverse transcriptase inhibitor (NNRTI) active against NNRTI-resistant strains of HIV

Author keywords

etravirine; human immunodeficiency virus; nonnucleoside reverse transcriptase inhibitor; resistance; TMC125; treatment experienced

Indexed keywords

AMPRENAVIR PHOSPHATE; ATAZANAVIR; BENZODIAZEPINE DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; CYCLOSPORIN; DARUNAVIR; DARUNAVIR PLUS RITONAVIR; DELAVIRDINE; DISOPYRAMIDE; DOCETAXEL; EFAVIRENZ; ENFUVIRTIDE; ETRAVIRINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INDINAVIR; LIDOCAINE; MACROGOL 4000; MOXIFLOXACIN; NEVIRAPINE; PACLITAXEL; PROTEINASE INHIBITOR; QUINIDINE; RITONAVIR; RITONAVIR PLUS TIPRANAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SILDENAFIL; TACROLIMUS; TIPRANAVIR; TRICYCLIC ANTIDEPRESSANT AGENT; VINCA ALKALOID;

EID: 65549107808     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2009.04.020     Document Type: Review
Times cited : (45)

References (49)
  • 1
    • 0019873358 scopus 로고
    • Pneumocystis pneumonia-Los Angeles
    • Centers for Disease Control (CDC)
    • Centers for Disease Control (CDC). Pneumocystis pneumonia-Los Angeles. MMWR Morb Mortal Wkly Rep. 30 (1981) 250-252
    • (1981) MMWR Morb Mortal Wkly Rep. , vol.30 , pp. 250-252
  • 2
    • 58149137707 scopus 로고    scopus 로고
    • Joint United Nations Programme on HIV/AIDS, World Health Organization (UNAIDS, WHO). [UNAIDS Web site]. Accessed December 10, 2008.
    • Joint United Nations Programme on HIV/AIDS, World Health Organization (UNAIDS, WHO). Global summary of the AIDS epidemic. [UNAIDS Web site]. (December 2007). http://data.unaids.org/pub/EPISlides/2007/2007_epiupdate_en.pdf Accessed December 10, 2008.
    • (2007) Global summary of the AIDS epidemic
  • 3
    • 72849123704 scopus 로고    scopus 로고
    • Centers for Disease Control (CDC) Accessed December 10, 2008.
    • Centers for Disease Control (CDC). New estimates of US HIV prevalence (2006). http://www.cdc.gov/hiv/topics/surveillance/resources/factsheets/pdf/prevalence.pdf Accessed December 10, 2008.
    • (2006) New estimates of US HIV prevalence
  • 4
    • 0032568207 scopus 로고    scopus 로고
    • Progress and problems in the fight against AIDS
    • Hirschel B., and Francioli P. Progress and problems in the fight against AIDS. N Engl J Med 338 (1998) 906-908
    • (1998) N Engl J Med , vol.338 , pp. 906-908
    • Hirschel, B.1    Francioli, P.2
  • 5
    • 57349199622 scopus 로고    scopus 로고
    • Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents.
    • Panel on Antiretroviral Guidelines for Adults and Adolescents (AIDSinfo) Accessed December 10, 2008.
    • Panel on Antiretroviral Guidelines for Adults and Adolescents (AIDSinfo). Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. US Dept of Health and Human Services (November 3, 2008) 1-139. http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf Accessed December 10, 2008.
    • (2008) US Dept of Health and Human Services , pp. 1-139
  • 6
    • 48949097660 scopus 로고    scopus 로고
    • Antiretroviral treatment of adult HIV infection: 2008 Recommendations of the International AIDS Society-USA panel
    • the International AIDS Society-USA
    • Hammer S.M., Eron Jr. J.J., Reiss P., et al., the International AIDS Society-USA. Antiretroviral treatment of adult HIV infection: 2008 Recommendations of the International AIDS Society-USA panel. JAMA 300 (2008) 555-570
    • (2008) JAMA , vol.300 , pp. 555-570
    • Hammer, S.M.1    Eron Jr., J.J.2    Reiss, P.3
  • 7
    • 15444380338 scopus 로고    scopus 로고
    • From 4,5,6,7-tetrahydro-5-methylimidazo [4,5,1-jk](1,4)benzodiazepin-2(1H)-one (TIBO) to etravirine (TMC125): Fifteen years of research on non-nucleoside inhibitors of HIV-1 reverse transcriptase
    • De Corte B.L. From 4,5,6,7-tetrahydro-5-methylimidazo [4,5,1-jk](1,4)benzodiazepin-2(1H)-one (TIBO) to etravirine (TMC125): Fifteen years of research on non-nucleoside inhibitors of HIV-1 reverse transcriptase. J Med Chem. 48 (2005) 1689-1696
    • (2005) J Med Chem. , vol.48 , pp. 1689-1696
    • De Corte, B.L.1
  • 8
    • 67149130842 scopus 로고    scopus 로고
    • Pooled 24-week results of DUET-1 and -2: TMC125 (etravirine; ETR) vs placebo in 1203 treatment-experienced HIV-1-infected patients
    • Chicago, Ill Abstract H-717
    • Cahn P., Haubrich R., Leider J., et al. Pooled 24-week results of DUET-1 and -2: TMC125 (etravirine; ETR) vs placebo in 1203 treatment-experienced HIV-1-infected patients. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, Ill (September 17-20, 2007) Abstract H-717
    • (2007) Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Cahn, P.1    Haubrich, R.2    Leider, J.3
  • 9
    • 0022498061 scopus 로고
    • Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV
    • di Marzo Veronese F., Copeland T.D., DeVico A.L., et al. Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV. Science 231 (1986) 1289-1291
    • (1986) Science , vol.231 , pp. 1289-1291
    • di Marzo Veronese, F.1    Copeland, T.D.2    DeVico, A.L.3
  • 10
    • 0035912717 scopus 로고    scopus 로고
    • Nonnucleo-side reverse transcriptase inhibitors are chemical enhanc- ers of dimerization of the HIV type 1 reverse transcriptase
    • Tachedjian G., Orlova M., Sarafianos S.G., et al. Nonnucleo-side reverse transcriptase inhibitors are chemical enhanc- ers of dimerization of the HIV type 1 reverse transcriptase. Proc Natl Acad Sci U S A 98 (2001) 7188-7193
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 7188-7193
    • Tachedjian, G.1    Orlova, M.2    Sarafianos, S.G.3
  • 11
    • 65549153833 scopus 로고    scopus 로고
    • Tibotec Therapeutics, Division of Ortho Biotech Products, LP, Raritan, NJ Accessed December 10, 2008
    • Intelence [package insert] (2008), Tibotec Therapeutics, Division of Ortho Biotech Products, LP, Raritan, NJ. http://www.intelence-info.com/intelence/assets/pdf/INTELENCE_PI.pdf Accessed December 10, 2008
    • (2008) Intelence [package insert]
  • 12
    • 2342620790 scopus 로고    scopus 로고
    • Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etra-virine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants
    • Das K., Clark Jr. A.D., Lewi P.J., et al. Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etra-virine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants. J Med Chem 47 (2004) 2550-2560
    • (2004) J Med Chem , vol.47 , pp. 2550-2560
    • Das, K.1    Clark Jr., A.D.2    Lewi, P.J.3
  • 13
    • 9644291579 scopus 로고    scopus 로고
    • TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleo-side reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1
    • Andries K., Azijn H., Thielemans T., et al. TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleo-side reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. Antimicrob Agents Chemo- ther 48 (2004) 4680-4686
    • (2004) Antimicrob Agents Chemo- ther , vol.48 , pp. 4680-4686
    • Andries, K.1    Azijn, H.2    Thielemans, T.3
  • 14
    • 52249114260 scopus 로고    scopus 로고
    • An update of the list of NNRTI mutations associated with decreased virologic response to etravirine (ETR): Multivariate analyses on the pooled DUET-1 and DUET-2 clinical trial data
    • Sitges, Spain Accessed December 10, 2008
    • Vingerhoets J., Peeters M., Azijn H., et al. An update of the list of NNRTI mutations associated with decreased virologic response to etravirine (ETR): Multivariate analyses on the pooled DUET-1 and DUET-2 clinical trial data. Presented at: XVII International HIV Drug Resistance Workshop. Sitges, Spain (June 10-14, 2008). http://www.natap.org/2008/ResisWksp/ResisWksp_47.htm Accessed December 10, 2008
    • (2008) Presented at: XVII International HIV Drug Resistance Workshop
    • Vingerhoets, J.1    Peeters, M.2    Azijn, H.3
  • 15
    • 26444595584 scopus 로고    scopus 로고
    • TMC125 displays a high genetic barrier to the development of resistance: Evidence from in vitro selection experiments
    • Vingerhoets J., Azijn H., Fransen E., et al. TMC125 displays a high genetic barrier to the development of resistance: Evidence from in vitro selection experiments. J Virol. 79 (2005) 12773-12782
    • (2005) J Virol. , vol.79 , pp. 12773-12782
    • Vingerhoets, J.1    Azijn, H.2    Fransen, E.3
  • 16
    • 55049102493 scopus 로고    scopus 로고
    • Combined darunavir and etravirine resistance analysis of the pooled DUET trials: When can we spare the other new classes?
    • Mexico City, Mexico Accessed December 10, 2008
    • Haubrich R., Schapiro J.M., Vinger-hoets J., et al. Combined darunavir and etravirine resistance analysis of the pooled DUET trials: When can we spare the other new classes?. Presented at: XVII International AIDS Conference. Mexico City, Mexico (August 3-8, 2008). http://www.tibotec.com/content/congresses/www.tibotec.com/Haubrich_TMC125_pDUET_Ran.pdf Accessed December 10, 2008
    • (2008) Presented at: XVII International AIDS Conference
    • Haubrich, R.1    Schapiro, J.M.2    Vinger-hoets, J.3
  • 17
    • 34347327010 scopus 로고    scopus 로고
    • Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-Week results from a randomized, double-blind, placebo-controlled trial
    • the DUET-1 Study Group
    • Madruga J.V., Cahn P., Grinsztejn B., et al., the DUET-1 Study Group. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-Week results from a randomized, double-blind, placebo-controlled trial. Lancet 370 (2007) 29-38
    • (2007) Lancet , vol.370 , pp. 29-38
    • Madruga, J.V.1    Cahn, P.2    Grinsztejn, B.3
  • 18
    • 34347354196 scopus 로고    scopus 로고
    • Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-Week results from a randomized, double-blind, placebo-controlled trial
    • the DUET-2 Study Group
    • Lazzarin A., Campbell T., Clotet B., et al., the DUET-2 Study Group. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-Week results from a randomized, double-blind, placebo-controlled trial. Lancet 370 (2007) 39-48
    • (2007) Lancet , vol.370 , pp. 39-48
    • Lazzarin, A.1    Campbell, T.2    Clotet, B.3
  • 19
    • 54549118264 scopus 로고    scopus 로고
    • Prevalence of etravirine-associated mutations in clinical samples with resistance to nevirapine and efa-virenz
    • Llibre J.M., Santos J.R., Puig T., et al. Prevalence of etravirine-associated mutations in clinical samples with resistance to nevirapine and efa-virenz. J Antimicrob Chemother 62 (2008) 909-913
    • (2008) J Antimicrob Chemother , vol.62 , pp. 909-913
    • Llibre, J.M.1    Santos, J.R.2    Puig, T.3
  • 20
    • 65549161656 scopus 로고    scopus 로고
    • Substantial improvement of oral bioavailability of TMC125 using new tablet formulations in healthy volunteers
    • Rio de Janeiro, Brazil Accessed December 10, 2008
    • Scholler M., Hoetelmans R., Beets G., et al. Substantial improvement of oral bioavailability of TMC125 using new tablet formulations in healthy volunteers. Presented at: 3rd International AIDS Conference. Rio de Janeiro, Brazil (July 24-27, 2005). http://www.natap.org/2005/ias/ias_17.htm Accessed December 10, 2008
    • (2005) Presented at: 3rd International AIDS Conference
    • Scholler, M.1    Hoetelmans, R.2    Beets, G.3
  • 21
    • 34250854707 scopus 로고    scopus 로고
    • Pharmacokinetics and antiretro-viral response to darunavir/ritonavir and etravirine combination in patients with high-level viral resistance
    • Boffito M., Winston A., Jackson A., et al. Pharmacokinetics and antiretro-viral response to darunavir/ritonavir and etravirine combination in patients with high-level viral resistance. AIDS 21 (2007) 1449-1455
    • (2007) AIDS , vol.21 , pp. 1449-1455
    • Boffito, M.1    Winston, A.2    Jackson, A.3
  • 22
    • 49949101117 scopus 로고    scopus 로고
    • Pharmacokinetics and pharma-codynamics of the NNRTI etravir-ine (ETR; TMC125) in treatment-experienced HIV-1-infected patients: Pooled 24-week results of DUET-1 and DUET-2
    • Boston, Mass Accessed December 10, 2008
    • Kakuda T.N., Wade J.R., Snoeck E., et al. Pharmacokinetics and pharma-codynamics of the NNRTI etravir-ine (ETR; TMC125) in treatment-experienced HIV-1-infected patients: Pooled 24-week results of DUET-1 and DUET-2. Presented at: 15th Conference on Retroviruses and Opportunistic Infections. Boston, Mass (February 3-6, 2008). http://www.hivandhepatitis.org/2008icr/croi/docs/posters/Kakuda2.pdf Accessed December 10, 2008
    • (2008) Presented at: 15th Conference on Retroviruses and Opportunistic Infections
    • Kakuda, T.N.1    Wade, J.R.2    Snoeck, E.3
  • 27
    • 51649083570 scopus 로고    scopus 로고
    • A pharmacokinetic study of etravirine (TMC125) co-administered with ranitidine and omeprazole in HIV-negative volunteers
    • Schöller-Gyüre M., Kakuda T.N., De Smedt G., et al. A pharmacokinetic study of etravirine (TMC125) co-administered with ranitidine and omeprazole in HIV-negative volunteers. Br J Clin Pharmacol 66 (2008) 508-516
    • (2008) Br J Clin Pharmacol , vol.66 , pp. 508-516
    • Schöller-Gyüre, M.1    Kakuda, T.N.2    De Smedt, G.3
  • 28
    • 54749118543 scopus 로고    scopus 로고
    • Effects of different meal compositions and fasted state on the oral bioavailability of etravirine
    • Schöller-Gyüre M., Boffito M., Pozniak A.L., et al. Effects of different meal compositions and fasted state on the oral bioavailability of etravirine. Pharmacotherapy 28 (2008) 1215-1222
    • (2008) Pharmacotherapy , vol.28 , pp. 1215-1222
    • Schöller-Gyüre, M.1    Boffito, M.2    Pozniak, A.L.3
  • 29
    • 73549100330 scopus 로고    scopus 로고
    • Pharmacokinetics of etravirine are not affected by sex, age, race, treatment duration or use of enfuvirtide in HIV-1-infected subjects
    • Mexico City, Mexico Accessed December 10, 2008
    • Kakuda T.N., Schöller-Gyüe M., Peeters M., et al. Pharmacokinetics of etravirine are not affected by sex, age, race, treatment duration or use of enfuvirtide in HIV-1-infected subjects. Presented at: XVII International AIDS Conference. Mexico City, Mexico (August 3-8, 2008). http://www.medadvocates.org/resources/conferences/international_aids_conferences/17/etravirine/aa17KakudaPoster_FINAL.pdf Accessed December 10, 2008
    • (2008) Presented at: XVII International AIDS Conference
    • Kakuda, T.N.1    Schöller-Gyüe, M.2    Peeters, M.3
  • 30
    • 65549100382 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics ofTMC125 in HIV-infected patients with non-nucleoside reverse transcriptase inhibitor and protease inhibitor resistance: TMC125-C223
    • Los Angeles, Calif
    • Kakuda T.N., Schöller-Gyüre M., Peeters M., et al. Pharmacokinetics and pharmacodynamics ofTMC125 in HIV-infected patients with non-nucleoside reverse transcriptase inhibitor and protease inhibitor resistance: TMC125-C223. Presented at: 14th Conference on Retroviruses and Opportunistic Infections. Los Angeles, Calif (February 25-28, 2007)
    • (2007) Presented at: 14th Conference on Retroviruses and Opportunistic Infections
    • Kakuda, T.N.1    Schöller-Gyüre, M.2    Peeters, M.3
  • 31
    • 12144289848 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of TMC125 as 7-day monothera-py in antiretroviral naive, HIV-1 infected subjects
    • Gruzdev B., Rakhmanova A., Dou-bovskaya E., et al. A randomized, double-blind, placebo-controlled trial of TMC125 as 7-day monothera-py in antiretroviral naive, HIV-1 infected subjects. AIDS 17 (2003) 2487-2494
    • (2003) AIDS , vol.17 , pp. 2487-2494
    • Gruzdev, B.1    Rakhmanova, A.2    Dou-bovskaya, E.3
  • 32
    • 12144287763 scopus 로고    scopus 로고
    • An open-label assessment of TMC 125-a new, next-generation NNRTI, for 7 days in HIV-1 infected individuals with NNRTI resistance
    • Gazzard B.G., Pozniak A.L., Rosenbaum W., et al. An open-label assessment of TMC 125-a new, next-generation NNRTI, for 7 days in HIV-1 infected individuals with NNRTI resistance. AIDS 17 (2003) F49-F54
    • (2003) AIDS , vol.17
    • Gazzard, B.G.1    Pozniak, A.L.2    Rosenbaum, W.3
  • 33
    • 52449097524 scopus 로고    scopus 로고
    • Safety, tolerability, and preliminary efficacy of 48 weeks of etravirine therapy in a phase IIb doseranging study involving treatment-experienced patients with HIV-1 infection
    • the TMC125-C203 Study Group
    • Montaner J., Yeni P., Clumeck N.N., et al., the TMC125-C203 Study Group. Safety, tolerability, and preliminary efficacy of 48 weeks of etravirine therapy in a phase IIb doseranging study involving treatment-experienced patients with HIV-1 infection. Clin Infect Dis 47 (2008) 969-978
    • (2008) Clin Infect Dis , vol.47 , pp. 969-978
    • Montaner, J.1    Yeni, P.2    Clumeck, N.N.3
  • 34
    • 34147134958 scopus 로고    scopus 로고
    • Efficacy and safety of etra-virine (TMC125) in patients with highly resistant HIV-1: Primary 24- week analysis
    • the TMC125-C223 Writing Group
    • Nadler J.P., Berger D.S., Blick G., et al., the TMC125-C223 Writing Group. Efficacy and safety of etra-virine (TMC125) in patients with highly resistant HIV-1: Primary 24- week analysis. AIDS 21 (2007) F1-F10
    • (2007) AIDS , vol.21
    • Nadler, J.P.1    Berger, D.S.2    Blick, G.3
  • 35
    • 43749121302 scopus 로고    scopus 로고
    • DUET-1: Week 48 results of a Phase III randomized double-blind trial to evaluate the efficacy and safety of etravirine (ETR; TMC125) versus pla- cebo in 612 treatment-experienced HIV-1-infected patients
    • the DUET-1 Study Group. Boston, Mass Accessed December 10, 2008
    • Haubrich R., Cahn P., Grinsztejn B., et al., the DUET-1 Study Group. DUET-1: Week 48 results of a Phase III randomized double-blind trial to evaluate the efficacy and safety of etravirine (ETR; TMC125) versus pla- cebo in 612 treatment-experienced HIV-1-infected patients. Presented at: 15th Conference on Retroviruses and Opportunistic Infections. Boston, Mass (February 3-6, 2008). http:// www.natap.org/2008/CROI/croi_38.htm Accessed December 10, 2008
    • (2008) Presented at: 15th Conference on Retroviruses and Opportunistic Infections
    • Haubrich, R.1    Cahn, P.2    Grinsztejn, B.3
  • 36
    • 43749103048 scopus 로고    scopus 로고
    • DUET-2: Week 48 results of a Phase III randomized double-blind trial to evaluate the efficacy and safety of etravirine (ETRl TMC125) versus placebo in 591 treatment-experienced HIV-1-infected patients
    • Boston, Mass Abstract 791
    • Johnson M., Campbell T., Clotet B., et al. DUET-2: Week 48 results of a Phase III randomized double-blind trial to evaluate the efficacy and safety of etravirine (ETRl TMC125) versus placebo in 591 treatment-experienced HIV-1-infected patients. Presented at: 15th Conference on Retroviruses and Opportunistic Infections. Boston, Mass (February 3-6, 2008) Abstract 791
    • (2008) Presented at: 15th Conference on Retroviruses and Opportunistic Infections
    • Johnson, M.1    Campbell, T.2    Clotet, B.3
  • 37
    • 52749089298 scopus 로고    scopus 로고
    • TMC125 safety and tol-erability in treatment-experienced, HIV infected patients-pooled DUET trial data
    • San Diego, Calif
    • Haubrich R., Schechter M., Walms-ley S., et al. TMC125 safety and tol-erability in treatment-experienced, HIV infected patients-pooled DUET trial data. Presented at: 45th Annual Meeting of the Infectious Diseases Society of America. San Diego, Calif (October 4-7, 2007). CKey={D712B83E-A1E0-4C21-B9E9-D1445F892115}& MKey={2BC0388C-EE56-4FA2-A529-EC8 2E2C73 62A}&AKey={45 6A 1804-CC97-4677-BF53-D872148C 9EF7}& SKey={07A115CE-07- A8-4EB9-A4CC-D64DFF340C90}. Accessed December 10, 2008 http:// www.abstractsonline.com/viewer/ viewAbstract.asp
    • (2007) Presented at: 45th Annual Meeting of the Infectious Diseases Society of America
    • Haubrich, R.1    Schechter, M.2    Walms-ley, S.3
  • 38
    • 44649109705 scopus 로고    scopus 로고
    • Etravirine has no effect on QT and corrected QT interval in HIVnegative volunteers
    • Peeters M., Janssen K., Kakuda T.N., et al. Etravirine has no effect on QT and corrected QT interval in HIVnegative volunteers. Ann Pharmaco- ther 42 (2008) 757-765
    • (2008) Ann Pharmaco- ther , vol.42 , pp. 757-765
    • Peeters, M.1    Janssen, K.2    Kakuda, T.N.3
  • 39
    • 34547742407 scopus 로고    scopus 로고
    • TMC125 in combination with other medications: Summary of drug-drug interaction studies
    • Glasgow, UK Accessed December 10, 008
    • Kakuda T.N., Schöller-Gyüre M., Woodfall B., et al. TMC125 in combination with other medications: Summary of drug-drug interaction studies. Presented at: 8th International Congress on Drug Therapy in HIV Infection. Glasgow, UK (November 12-16, 2006). http://www.tibotec.com/content/congresses/www.tibotec.com/Kakuda_TMC125_DDI.pdf Accessed December 10, 008
    • (2006) Presented at: 8th International Congress on Drug Therapy in HIV Infection
    • Kakuda, T.N.1    Schöller-Gyüre, M.2    Woodfall, B.3
  • 42
    • 33746966338 scopus 로고    scopus 로고
    • Significant decrease in TMC125 exposures when co-administered with tipranavir boosted with ritona-vir in healthy subjects
    • Denver, Col Accessed December 10, 2008
    • Schöller M., Kraft M., Hoetelmans R., et al. Significant decrease in TMC125 exposures when co-administered with tipranavir boosted with ritona-vir in healthy subjects. Presented at: 13th Conference on Retroviruses and Opportunistic Infections. Denver, Col (February 5-8, 2006). http://www.retroconference.org/2006/Abstracts/27489.HTM Accessed December 10, 2008
    • (2006) Presented at: 13th Conference on Retroviruses and Opportunistic Infections
    • Schöller, M.1    Kraft, M.2    Hoetelmans, R.3
  • 43
    • 0031975185 scopus 로고    scopus 로고
    • Update: Clinically significant cytochrome P-450 drug interactions
    • Michalets E.L. Update: Clinically significant cytochrome P-450 drug interactions. Pharmacotherapy. 18 (1998) 84-112
    • (1998) Pharmacotherapy. , vol.18 , pp. 84-112
    • Michalets, E.L.1
  • 44
    • 78649232766 scopus 로고    scopus 로고
    • Bioavail-ability of the 100mg etravirine tablet dispersed in water and of the 25mg pediatric tablet formulation
    • Mexico City, Mexico Accessed December 10, 2008
    • Schöller-Gyüre M., Kakuda T.N., Van Solingen-Ristea R.M., et al. Bioavail-ability of the 100mg etravirine tablet dispersed in water and of the 25mg pediatric tablet formulation. Presented at: XVII International AIDS Conference. Mexico City, Mexico (August 3-8, 2008). http://www.iasociety.org/abstractmaterial/AIDS2008/AbstractPlus/AbsDoc_6021_2.pdf Accessed December 10, 2008
    • (2008) Presented at: XVII International AIDS Conference
    • Schöller-Gyüre, M.1    Kakuda, T.N.2    Van Solingen-Ristea, R.M.3
  • 45
    • 0034919021 scopus 로고    scopus 로고
    • Highly active antiretroviral therapy: Pharmacoeconomic issues in the management of HIV infection
    • Sendi P., Palmer A.J., Gafni A., and Battegay M. Highly active antiretroviral therapy: Pharmacoeconomic issues in the management of HIV infection. Pharmaco Economics. 19 (2001) 709-713
    • (2001) Pharmaco Economics. , vol.19 , pp. 709-713
    • Sendi, P.1    Palmer, A.J.2    Gafni, A.3    Battegay, M.4
  • 46
    • 62549145125 scopus 로고    scopus 로고
    • Analysis of US costs of full virologic suppression for treatment-experienced, HIV- infected patients in the DUET trials
    • Mexico City, Mexico Abstract TUPE0241
    • Martin S., and Hill A.M. Analysis of US costs of full virologic suppression for treatment-experienced, HIV- infected patients in the DUET trials. Presented at: XVII International AIDS Conference. Mexico City, Mexico (August 3-8, 2008) Abstract TUPE0241
    • (2008) Presented at: XVII International AIDS Conference
    • Martin, S.1    Hill, A.M.2
  • 47
    • 84864221306 scopus 로고    scopus 로고
    • Impact of etravirine on hospitalizations and hospital-related costs: 48-Week findings from pooled DUET trials
    • Mexico City, Mexico Accessed December 10, 2008
    • Gebo K., Martin S., Corbett C., and De Smedt G. Impact of etravirine on hospitalizations and hospital-related costs: 48-Week findings from pooled DUET trials. Presented at: XVII International AIDS Conference. Mexico City, Mexico (August 3-8, 2008). http://www.medadvocates.org/resources/conferences/international_aids_conferences/17/etravirine/aaa17GeboPoster_FINAL.pdf Accessed December 10, 2008
    • (2008) Presented at: XVII International AIDS Conference
    • Gebo, K.1    Martin, S.2    Corbett, C.3    De Smedt, G.4
  • 48
    • 55049098133 scopus 로고    scopus 로고
    • High rate of viro-logic success with raltegravir plus etravirine and darunavir/ritonavir in treatment-experienced patients with multidrug-resistant virus: Results of the ANRS 139 TRIO trial
    • Mexico City, Mexico Accessed April 10, 2009
    • Yazdanpanah Y., Fagard C., Descamps D., et al. High rate of viro-logic success with raltegravir plus etravirine and darunavir/ritonavir in treatment-experienced patients with multidrug-resistant virus: Results of the ANRS 139 TRIO trial. XVII International AIDS Conference. Mexico City, Mexico (2008). http://www.hivandhepatitis.com/2008icr/AIDS2008/docs/081508_a.html Accessed April 10, 2009
    • (2008) XVII International AIDS Conference
    • Yazdanpanah, Y.1    Fagard, C.2    Descamps, D.3
  • 49
    • 65549125212 scopus 로고    scopus 로고
    • The impact of background regimen on virologic response to etravirine: Pooled 48-week analysis of DUET-1 and DUET-2
    • Mexico City, Mexico Accessed December 10, 2008
    • Di Perri G., Madruga J.V., Sathasivam K., et al. The impact of background regimen on virologic response to etravirine: Pooled 48-week analysis of DUET-1 and DUET-2. Presented at: XVII International AIDS Conference. Mexico City, Mexico (August 3-8, 2008). http://www.medadvocates.org/resources/conferences/international_aids_conferences/17/etravirine/aa171DiPerriPoster_FINAL.pdf Accessed December 10, 2008
    • (2008) Presented at: XVII International AIDS Conference
    • Di Perri, G.1    Madruga, J.V.2    Sathasivam, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.