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Volumn 72, Issue 4, 2012, Pages 525-541

Rilpivirine

Author keywords

Adis Drug Profiles; Emtricitabinerilpivirine tenofovir disoproxil fumarate; HIV infections; Rilpivirine

Indexed keywords

ABACAVIR PLUS LAMIVUDINE; ANTACID AGENT; DARUNAVIR; DIDANOSINE; EFAVIRENZ; EFAVIRENZ PLUS EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; EMTRICITABINE; ETHINYLESTRADIOL; FAMOTIDINE; FUMARIC ACID; KETOCONAZOLE; LAMIVUDINE PLUS ZIDOVUDINE; LOPINAVIR; METHADONE; MOXIFLOXACIN; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; NORETHISTERONE; OMEPRAZOLE; RILPIVIRINE; RITONAVIR; TENOFOVIR;

EID: 84857305890     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.2165/11208590-000000000-00000     Document Type: Article
Times cited : (37)

References (35)
  • 1
    • 36549011407 scopus 로고    scopus 로고
    • Joint United Nations Programme on HIV/AIDS [online] [Accessed 2011 Oct 4]
    • Joint United Nations Programme on HIV/AIDS. AIDS epidemic update [online]. Available from URL: http://www.unaids.org/en/media/unaids/ contentasssets/dataim port/pub/report/2009/jc1700-epi-update-2009-en.pdf [Accessed 2011 Oct 4].
    • AIDS Epidemic Update
  • 2
    • 84857323415 scopus 로고    scopus 로고
    • Joint United Nations Programme on HIV/AIDS [online] [Accessed 2011 Oct 4]
    • Joint United Nations Programme on HIV/AIDS. Joint action for results-UNAIDS outcome framework: business case 2009-2011 [online]. Available from URL: http://www. unaids.org/en/media/unaids/contentassets/documents/un aidspublication/2010/20110101-JC1969-Treatment-ART.en. pdf [Accessed 2011 Oct 4]
    • Joint Action for Results-UNAIDS Outcome Framework: Business Case 2009-2011
  • 3
    • 77954692660 scopus 로고    scopus 로고
    • Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society-USA Panel
    • Jul 21
    • Thompson MA, Aberg JA, Cahn P, et al. Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society-USA Panel. JAMA 2010 Jul 21; 304 (3): 321-33
    • (2010) JAMA , vol.304 , Issue.3 , pp. 321-333
    • Thompson, M.A.1    Aberg, J.A.2    Cahn, P.3
  • 4
    • 33750454570 scopus 로고    scopus 로고
    • Panel on Antiretroviral Guideline for Adults and Adolescents Department of Health and Human Services [online] [Accessed 2012 Jan 9]
    • Panel on Antiretroviral Guideline for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services [online]. Available from URL: http://aidsinfo.gov/contentfiles/AdultandAdolescentGL.pdf [Accessed 2012 Jan 9]
    • Guidelines for the Use of Antiretroviral Agents in HIV-1-infected Adults and Adolescents
  • 5
    • 38949104111 scopus 로고    scopus 로고
    • European AIDS Clinical Society (EACS) guidelines for the clinical management and treatment of HIV-infected adults
    • DOI 10.1111/j.1468-1293.2007.00533.x
    • Clumeck N, Pozniak A, Raffi F and the EACS Executive Committee. European AIDS Clinical Society (EACS) guidelines for the clinical management and treatment of HIVinfected adults. HIV Med 2008 Feb; 9 (2): 65-71 (Pubitemid 351228129)
    • (2008) HIV Medicine , vol.9 , Issue.2 , pp. 65-71
    • Clumeck, N.1    Pozniak, A.2    Raffi, F.3
  • 6
    • 52749083531 scopus 로고    scopus 로고
    • British HIV Association guidelines for the treatment of HIV-1-infected adults with antiretroviral therapy 2008. BHIVA Treatment Guidelines Writing Group
    • Gazzard BG. British HIV Association guidelines for the treatment of HIV-1-infected adults with antiretroviral therapy 2008. BHIVA Treatment Guidelines Writing Group. HIV Med 2008; 9 (8): 563-608
    • (2008) HIV Med , vol.9 , Issue.8 , pp. 563-608
    • Gazzard, B.G.1
  • 7
    • 74549195545 scopus 로고    scopus 로고
    • Nonnucleoside reverse transcriptase inhibitor resistance and the role of the second-generation agents
    • Jan
    • Adams J, Patel N, Mankaryous N, et al. Nonnucleoside reverse transcriptase inhibitor resistance and the role of the second-generation agents. Ann Pharmacother 2010 Jan; 44 (1): 157-65
    • (2010) Ann Pharmacother , vol.44 , Issue.1 , pp. 157-165
    • Adams, J.1    Patel, N.2    Mankaryous, N.3
  • 8
    • 70049100021 scopus 로고    scopus 로고
    • HIV-1 resistance to firstand second-generation non-nucleoside reverse transcriptase inhibitors
    • Ghosn J, Chaix ML, Delaugerre C. HIV-1 resistance to firstand second-generation non-nucleoside reverse transcriptase inhibitors. AIDS Rev 2009; 11 (3): 165-73
    • (2009) AIDS Rev , vol.11 , Issue.3 , pp. 165-173
    • Ghosn, J.1    Chaix, M.L.2    Delaugerre, C.3
  • 9
    • 84857335338 scopus 로고    scopus 로고
    • Boehringer-Ingelheim [online] [Accessed 2011 Dec 9]
    • Boehringer-Ingelheim. Viramune-(nevirapine tablets/oral suspension): US prescribing information [online]. Available from URL: http://www.accessdata.fda. gov/drugsatfda-docs/label/2011/020636s039-020933s030lbl.pdf [Accessed 2011 Dec 9]
    • Viramune-(nevirapine Tablets/oral Suspension): US Prescribing Information
  • 10
    • 55049127766 scopus 로고    scopus 로고
    • Etravirine
    • Deeks ED, Keating GM. Etravirine. Drugs 2008; 68 (16): 2357-72
    • (2008) Drugs , vol.68 , Issue.16 , pp. 2357-72
    • Deeks, E.D.1    Keating, G.M.2
  • 11
    • 84856540624 scopus 로고    scopus 로고
    • Tibotec Pharmaceuticals [online] [Accessed 2011 Sep 26]
    • Tibotec Pharmaceuticals. Edurant-(rilpivirine) tablets: US prescribing information [online]. Available from URL: http://www.accessdata.fda.gov/ drugsatfda-docs/label/2011/202022s000lbl.pdf [Accessed 2011 Sep 26]
    • Edurant-(rilpivirine) Tablets: US Prescribing Information
  • 12
    • 84857253222 scopus 로고    scopus 로고
    • European Medicines Agency [online] [Accessed2011 Dec 9]
    • European Medicines Agency. Edurant-25 mg film-coated tablets: summary of product characteristics [online]. Available from URL: http://www.ema.europa.eu/ docs/en-GB/document-library/EPAR-Product-Information/human/002264/WC500118874. pdf [Accessed2011 Dec 9]
    • Edurant-25 Mg Film-coated Tablets: Summary of Product Characteristics
  • 13
    • 0242363266 scopus 로고    scopus 로고
    • Mitochondrial toxicity of NRTI antiviral drugs: An integrated cellular perspective
    • Lewis W, Day BJ, Copeland WC. Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective. Nat Rev Drug Discov 2003 Oct; 2 (10): 812-22 (Pubitemid 37361813)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.10 , pp. 812-822
    • Lewis, W.1    Day, B.J.2    Copeland, W.C.3
  • 14
    • 75749118495 scopus 로고    scopus 로고
    • TMC278 a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI) active against wild-type and NNRTI-resistant HIV-1
    • Feb
    • AzijnH, Tirry I,Vingerhoets J, et al. TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1. Antimicrob Agents Chemother 2010 Feb; 54 (2): 718-27
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.2 , pp. 718-727
    • Azijn, H.1    Tirry, I.2    Vingerhoets, J.3
  • 16
    • 83655163698 scopus 로고    scopus 로고
    • Genotypic and phenotypic characterization of HIV-1 isolates obtained from patients on rilpivirine therapy experiencing virologic failure in the phase 3 ECHO and THRIVE studies: 48-week analysis
    • Jan 1
    • Rimsky L, Vingerhoets J, Van Eygen V, et al. Genotypic and phenotypic characterization of HIV-1 isolates obtained from patients on rilpivirine therapy experiencing virologic failure in the phase 3 ECHO and THRIVE studies: 48-week analysis. J Acquir Immune Defic Syndr 2012 Jan 1; 59 (1): 39-46
    • (2012) J Acquir Immune Defic Syndr , vol.59 , Issue.1 , pp. 39-46
    • Rimsky, L.1    Vingerhoets, J.2    Van Eygen, V.3
  • 17
    • 73649148381 scopus 로고    scopus 로고
    • Efficacy and safety of TMC278 in antiretroviral-naive HIV-1 patients: Week 96 results of a phase IIb randomized trial
    • Jan 2
    • Pozniak AL, Morales-Ramirez J, Katabira E, et al. Efficacy and safety of TMC278 in antiretroviral-naive HIV-1 patients: week 96 results of a phase IIb randomized trial. AIDS 2010 Jan 2; 24 (1): 55-65
    • (2010) AIDS , vol.24 , Issue.1 , pp. 55-65
    • Pozniak, A.L.1    Morales-Ramirez, J.2    Katabira, E.3
  • 18
    • 79960381844 scopus 로고    scopus 로고
    • Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatmentnaive adults infected with HIV-1 (ECHO): A phase 3 randomised double-blind active-controlled trial
    • Jul 16
    • Molina JM, Cahn P, Grinsztejn B, et al. Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatmentnaive adults infected with HIV-1 (ECHO): a phase 3 randomised double-blind active-controlled trial. Lancet 2011 Jul 16; 378 (9787): 238-46
    • (2011) Lancet , vol.378 , Issue.9787 , pp. 238-246
    • Molina, J.M.1    Cahn, P.2    Grinsztejn, B.3
  • 19
    • 79960358849 scopus 로고    scopus 로고
    • Rilpivirine versus efavirenz with two background nucleoside or nucleotide reverse transcriptase inhibitors in treatment-naive adults infected with HIV-1 (THRIVE): A phase 3 randomised non-inferiority trial
    • Jul 16
    • Cohen CJ, Andrade-Villanueva J, Clotet B, et al. Rilpivirine versus efavirenz with two background nucleoside or nucleotide reverse transcriptase inhibitors in treatment-naive adults infected with HIV-1 (THRIVE): a phase 3, randomised, non-inferiority trial. Lancet 2011 Jul 16; 378 (9787): 229-37
    • (2011) Lancet , vol.378 , Issue.9787 , pp. 229-237
    • Cohen, C.J.1    Andrade-Villanueva, J.2    Clotet, B.3
  • 20
    • 83655195760 scopus 로고    scopus 로고
    • Effect of intrinsic and extrinsic factors on the pharmacokinetics of TMC278 in antiretroviral naive HIV-1-infected patients in ECHO and THRIVE [abstract no. P186]
    • Nov 7-11; Glasgow
    • Crauwels HM, van Schaik E, van Heeswijk RPG, et al. Effect of intrinsic and extrinsic factors on the pharmacokinetics of TMC278 in antiretroviral naive, HIV-1-infected patients in ECHO and THRIVE [abstract no. P186]. 10th International Congress on Drug Therapy in HIV Infection; 2010 Nov 7-11; Glasgow
    • (2010) 10th International Congress on Drug Therapy in HIV Infection
    • Crauwels, H.M.1    Van Schaik, E.2    Van Heeswijk, R.P.G.3
  • 21
    • 84857344237 scopus 로고    scopus 로고
    • Absorption metabolism and excretion of TMC278 a nextgeneration non-nucleoside reverse transcriptase inhibitor (NNRTI) after a single oral dose of 150 mg in healthy male volunteers [abstract no. PE7.1/3]
    • Nov 11-14; Cologne
    • Lachau-Durand S, Mamidi RNVS, Cuyckens F, et al. Absorption, metabolism and excretion of TMC278, a nextgeneration non-nucleoside reverse transcriptase inhibitor (NNRTI), after a single oral dose of 150 mg in healthy male volunteers [abstract no. PE7.1/3]. 12th European AIDS Conference; 2009 Nov 11-14; Cologne
    • (2009) 12th European AIDS Conference
    • Lachau-Durand, S.1    Mamidi, R.N.V.S.2    Cuyckens, F.3
  • 22
    • 84888365357 scopus 로고    scopus 로고
    • Pharmacokinetic interaction study between TMC278 a nextgeneration nonnucleoside reverse transcriptase inhibitor (NNRTI) and the contraceptives norethindrone plus ethinylestradiol [abstract no. PE4.3/3]
    • Nov 11-14; Cologne
    • Crauwels H, van Heeswijk R, Cornelis L, et al. Pharmacokinetic interaction study between TMC278, a nextgeneration nonnucleoside reverse transcriptase inhibitor (NNRTI), and the contraceptives norethindrone plus ethinylestradiol [abstract no. PE4.3/3]. 12th European AIDS Conference; 2009 Nov 11-14; Cologne
    • (2009) 12th European AIDS Conference
    • Crauwels, H.1    Van Heeswijk, R.2    Cornelis, L.3
  • 23
    • 84877599461 scopus 로고    scopus 로고
    • Pharmacokinetic interaction study between TMC278 a nextgeneration non-nucleoside reverse transcriptase inhibitor and methadone [abstract no. WEPE0089]
    • Jul 18-23; Vienna
    • Crauwels H, van Heeswijk R, Vandevoorde A, et al. Pharmacokinetic interaction study between TMC278, a nextgeneration non-nucleoside reverse transcriptase inhibitor, and methadone [abstract no. WEPE0089]. 18th International AIDS Conference; 2010 Jul 18-23; Vienna
    • (2010) 18th International AIDS Conference
    • Crauwels, H.1    Van Heeswijk, R.2    Vandevoorde, A.3
  • 24
    • 84857251288 scopus 로고    scopus 로고
    • The pharmacokinetic interaction between omeprazole and TMC278, an investigational non-nucleoside reverse transcriptase inhibitor [abstract P239]
    • Nov 10
    • Crauwels HM, van Heeswijk RPG, Kestens D, et al. The pharmacokinetic interaction between omeprazole and TMC278, an investigational non-nucleoside reverse transcriptase inhibitor [abstract P239]. J Int AIDS Soc 2008 Nov 10; 11 Suppl. 1
    • (2008) J Int AIDS Soc , vol.11 , Issue.SUPPL. 1
    • Crauwels, H.M.1    Van Heeswijk, R.P.G.2    Kestens, D.3
  • 25
    • 79960372015 scopus 로고    scopus 로고
    • Bioequivalence of the co-formulation of emtricitabine/rilpivirine/ tenofovir DF [abstract no. LBPE17]
    • Jul 18-23; Vienna
    • Mathias A, Menning M, Wei X, et al. Bioequivalence of the co-formulation of emtricitabine/rilpivirine/tenofovir DF [abstract no. LBPE17]. 18th International AIDS Conference; 2010 Jul 18-23; Vienna
    • (2010) 18th International AIDS Conference
    • Mathias, A.1    Menning, M.2    Wei, X.3
  • 26
    • 77951210910 scopus 로고    scopus 로고
    • Pharmacokinetics and disposition of rilpivirine (TMC278) nanosuspension as a long-acting injectable antiretroviral formulation
    • May
    • van't Klooster G, Hoeben E, Borghys H, et al. Pharmacokinetics and disposition of rilpivirine (TMC278) nanosuspension as a long-acting injectable antiretroviral formulation. Antimicrob Agents Chemother 2010 May; 54 (5): 2042-50
    • (2010) Antimicrob Agents Chemother , vol.54 , Issue.5 , pp. 2042-50
    • Van'T Klooster, G.1    Hoeben, E.2    Borghys, H.3
  • 27
    • 84871651718 scopus 로고    scopus 로고
    • Pooled week 96 efficacy resistance and safety results from the doubleblind randomised phase III trials comparing rilpivirine (RPV) versus efavirenz (EFV) in treatment-naive HIV-1-infected adults [abstract no. TULBPE032]
    • Jul 17-20; Rome
    • Cohen C, Molina J-M, Cassetti I, et al. Pooled week 96 efficacy, resistance and safety results from the doubleblind, randomised, phase III trials comparing rilpivirine (RPV) versus efavirenz (EFV) in treatment-naive, HIV-1-infected adults [abstract no. TULBPE032]. 6th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention; 2011 Jul 17-20; Rome
    • (2011) 6th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention
    • Cohen, C.1    Molina, J.-M.2    Cassetti, I.3
  • 28
    • 84876416632 scopus 로고    scopus 로고
    • Generalized additive modelling of virologic response to the NNRTIs rilpivirine (RPV TMC278) and efavirenz (EFV) in treatment-naive HIV-infected patients: Pooled week 48 data from ECHO and THRIVE [abstract plus poster no. PS12/7]
    • Oct 12-15; Belgrade
    • Brochot A, Vis P, Corbett C, et al. Generalized additive modelling of virologic response to the NNRTIs rilpivirine (RPV, TMC278) and efavirenz (EFV) in treatment-naive HIV-infected patients: pooled week 48 data from ECHO and THRIVE [abstract plus poster no. PS12/7]. 13th European AIDS Conference; 2011 Oct 12-15; Belgrade
    • (2011) 13th European AIDS Conference
    • Brochot, A.1    Vis, P.2    Corbett, C.3
  • 29
    • 84857298056 scopus 로고    scopus 로고
    • TMC278 shows favorable tolerability and non-inferior efficacy compared to efavirenz over 192 weeks in HIV-1-infected treatment-naive patients [abstract]
    • Jun 20-22; Brescia
    • Wilkin A, Pozniak AL, Morales-Ramirez J, et al. TMC278 shows favorable tolerability and non-inferior efficacy compared to efavirenz over 192 weeks in HIV-1-infected treatment-naive patients [abstract]. 2nd Italian Conference on AIDS and Retroviruses; 2010 Jun 20-22; Brescia
    • (2010) 2nd Italian Conference on AIDS and Retroviruses
    • Wilkin, A.1    Pozniak, A.L.2    Morales-Ramirez, J.3
  • 30
    • 84857331413 scopus 로고    scopus 로고
    • Efficacy and safety of TMC278 in treatment-naive HIV-1-infected patients with HBV/HCV coinfection enrolled in the phase III ECHO and THRIVE trials [abstract no. P210]
    • Nov 7-11; Glasgow
    • Nelson M, Amaya G, Clumeck N, et al. Efficacy and safety of TMC278 in treatment-naive, HIV-1-infected patients with HBV/HCV coinfection enrolled in the phase III ECHO and THRIVE trials [abstract no. P210]. 10th International Congress on Drug Therapy in HIV Infection; 2010 Nov 7-11; Glasgow
    • (2010) 10th International Congress on Drug Therapy in HIV Infection
    • Nelson, M.1    Amaya, G.2    Clumeck, N.3
  • 31
    • 83655201824 scopus 로고    scopus 로고
    • Change in vitamin D levels smaller and risk of development of severe vitamin D deficiency lower among HIV-1-infected, treatment-naive adults receiving TMC278 compared with efavirenz: 48-week results from the phase III ECHO trial [abstract no. O-1014]
    • Feb 27-Mar 2; Boston (MA)
    • Wohl D, Doroana M, Orkin C, et al. Change in vitamin D levels smaller and risk of development of severe vitamin D deficiency lower among HIV-1-infected, treatment-naive adults receiving TMC278 compared with efavirenz: 48-week results from the phase III ECHO trial [abstract no. O-1014]. 18th Conference on Retroviruses and Opportunistic Infections; 2011 Feb 27-Mar 2; Boston (MA)
    • (2011) 18th Conference on Retroviruses and Opportunistic Infections
    • Wohl, D.1    Doroana, M.2    Orkin, C.3
  • 32
    • 84857341758 scopus 로고    scopus 로고
    • Rilpivirine (RPV, TMC278) tolerability over the first 12 weeks of treatment in the phase 3 ECHO and THRIVE studies [abstract no. H2-805]
    • Sep 17-20; Chicago (IL)
    • Rashbaum B, Girard P, Rachlis A, et al. Rilpivirine (RPV, TMC278) tolerability over the first 12 weeks of treatment in the phase 3 ECHO and THRIVE studies [abstract no. H2-805]. 51st Interscience Conference on Antimicrobial Agents and Chemotherapy; 2011 Sep 17-20; Chicago (IL)
    • (2011) 51st Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Rashbaum, B.1    Girard, P.2    Rachlis, A.3
  • 33
    • 84857331399 scopus 로고    scopus 로고
    • Neurologic and psychiatric safety profile of TMC278 compared with EFV in treatment-naive HIV-1+ patients: ECHO and THRIVE trials at 48 weeks [abstract no. 420]
    • Feb 27-Mar 2; Boston (MA)
    • Mills A, Antinori A, Clotet B, et al. Neurologic and psychiatric safety profile of TMC278 compared with EFV in treatment-naive HIV-1+ patients: ECHO and THRIVE trials at 48 weeks [abstract no. 420]. 18th Conference on Retroviruses and Opportunistic Infections; 2011 Feb 27-Mar 2; Boston (MA)
    • (2011) 18th Conference on Retroviruses and Opportunistic Infections
    • Mills, A.1    Antinori, A.2    Clotet, B.3
  • 34
    • 84857344221 scopus 로고    scopus 로고
    • Lipid profiles of TMC278 and EFV in treatment-naive HIV-1+ patients: Pooled week-48 data from the randomized double-blind phase III ECHO and THRIVE trials [abstract no. 819]
    • Feb 27-Mar 2; Boston (MA)
    • Arribas J, Andrade-Villanueva J, Bellos N, et al. Lipid profiles of TMC278 and EFV in treatment-naive HIV-1+ patients: pooled week-48 data from the randomized double-blind phase III ECHO and THRIVE trials [abstract no. 819]. 18th Conference on Retroviruses and Opportunistic Infections; 2011 Feb 27-Mar 2; Boston (MA)
    • (2011) 18th Conference on Retroviruses and Opportunistic Infections
    • Arribas, J.1    Andrade-Villanueva, J.2    Bellos, N.3
  • 35
    • 84857316569 scopus 로고    scopus 로고
    • TMC278 25mg qd has no effect on correctedQT (QTC) interval inHIV-negative volunteers [abstract no. 285]
    • Oct 29-Nov 1; Philadelphia (PA)
    • Vanveggel S, Buelens A, Crauwels H, et al. TMC278 25mg qd has no effect on correctedQT (QTC) interval inHIV-negative volunteers [abstract no. 285]. 47th Annual Meeting of the Infectious Diseases Society of America; 2009 Oct 29-Nov 1; Philadelphia (PA)
    • (2009) 47th Annual Meeting of the Infectious Diseases Society of America
    • Vanveggel, S.1    Buelens, A.2    Crauwels, H.3


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