Cell-selective intracellular drug delivery using doxorubicin and α-helical peptides conjugated to gold nanoparticles

Biomaterials

Volumn 35, Issue 10, 2014, Pages 3480-3487

  Park, Hyejin ^a   Tsutsumi, Hiroshi ^a   Mihara, Hisakazu ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Cell internalization; Drug delivery; Nanoparticles; Peptides

Indexed keywords

CELL INTERNALIZATION; CELL PENETRATING PEPTIDES (CPPS); CELL-SELECTIVITY; DRUG DELIVERY SYSTEM; GOLD NANOPARTICLES; GOLD NANOSPHERES; INTRACELLULAR DRUG DELIVERY; POTENTIAL RESEARCHES;

CELL DEATH; CELL MEMBRANES; DRUG DELIVERY; GOLD; NANOPARTICLES;

PEPTIDES;

DOXORUBICIN; GOLD NANOPARTICLE;

ALPHA HELIX; ARTICLE; CELL ACTIVITY; CELL DEATH; CELL NUCLEUS; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; INTERNALIZATION; PARTICLE SIZE; PRIORITY JOURNAL;

CELL INTERNALIZATION; DRUG DELIVERY; NANOPARTICLES; PEPTIDES;

CELL LINE, TUMOR; DOXORUBICIN; DRUG DELIVERY SYSTEMS; GOLD; HUMANS; METAL NANOPARTICLES; MICROSCOPY, FLUORESCENCE; PEPTIDES;

EID: 84893643000     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.12.094     Document Type: Article

References (38)

1. Gupta B., Levchenko T.S., Torchilin V.P. Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides. Adv Drug Deliv Rev 2005, 57:637-651.
2. Thomas C.E., Ehrhardt A., Kay M.A. Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet 2003, 4:346-358.
3. Niidome T., Huang L. Gene therapy progress and prospects: nonviral vectors. Gene Ther 2002, 9:1647-1652.
4. Lindgren M., Hällbrink M., Prochiantz A., Langel U. Cell-penetrating peptides. Trends Pharmacol Sci 2000, 21:99-103.
5. Xia H., Mao Q., Davidson B.L. The HIV Tat protein transduction domain improves the biodistribution of beta-glucuronidase expressed from recombinant viral vectors. Nat Biotechnol 2001, 19:640-644.
6. Sebbage V. Review cell-penetrating peptides and their therapeutic applications. Bio-horizons 2009, 2:64-72.
7. Snyder E.L., Dowdy S.F. Cell penetrating peptides in drug delivery. Pharm Res 2004, 21:389-393.
8. Song L., Varma C.A., Verhoeven J.W., Tanke H.J. Influence of the triplet excited state on the photobleaching kinetics of fluorescein in microscopy. Biophys J 1996, 70:2959-2968.
9. Song L., van Gijlswijk R.P., Young I.T., Tanke H.J. Influence of fluorochrome labeling density on the photobleaching kinetics of fluorescein in microscopy. Cytometry 1997, 27:213-223.
10. Bernas T., Zarebski M., Cook R.R., Dobrucki J.W., Cook P.R. Minimizing photobleaching during confocal microscopy of fluorescent probes bound to chromatin: role of anoxia and photon flux. J Microsc 2004, 215:281-296.
11. Song S., Qin Y., He Y., Huang Q., Fan C., Chen H.Y. Functional nanoprobes for ultrasensitive detection of biomolecules. Chem Soc Rev 2010, 39:4234-4243.
12. Zrazhevskiy P., Sena M., Gao X. Designing multifunctional quantum dots for bioimaging, detection, and drug delivery. Chem Soc Rev 2010, 39:4326-4354.
13. Khlebtsov N., Dykman L. Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies. Chem Soc Rev 2011, 40:1647-1671.
14. Corr S.A., Rakovich Y.P., Gun'ko Yurii K. Multifunctional magnetic-fluorescent nanocomposites for biomedical applications. Nanoscale Res Lett 2008, 3:87-104.
15. Usui K., Tomizaki K., Mihara H. Protein-fingerprint data mining of a designed α-helical peptide array. Mol Biosyst 2006, 2:417.
16. Usui K., Kakiyama T., Tomizaki K.Y., Mie M., Kobatake E., Mihara H. Cell fingerprint patterns using designed α-helical peptides to screen for cell-specific toxicity. Bioorg Med Chem Lett 2011, 21:6281-6284.
17. Usui K., Tomizaki K.-Y., Mihara H. Screening of α-helical peptide ligands controlling a calcineurin-phosphatase activity. Bioorg Med Chem Lett 2007, 17:167-171.
18. Usui K., Kikuchi T., Mie M., Kobatake E., Mihara H. Systematic screening of the cellular penetration of designed alpha-helix peptides. Bioorg Med Chem 2013, 21:2560-2567.
19. Park H., Tsutsumi H., Mihara H. Cell penetration and cell-selective drug delivery using α-helix peptides conjugated with gold nanoparticles. Biomaterials 2013, 34:4872-4879.
20. Tkachenko A.G., Xie H., Coleman D., Glomm W., Ryan J., Anderson M.F., et al. Multifunctional gold nanoparticle-peptide complexes for nuclear targeting. J Am Chem Soc 2003, 125:4700-4701.
21. Kang B., Mackey M.A., El-Sayed M.A. Nuclear targeting of gold nanoparticles in cancer cells induces DNA damage, causing cytokinesis arrest and apoptosis. J Am Chem Soc 2010, 132:1517-1519.
22. Xie W., Wang L., Zhang Y., Su L., Shen A., Tan J., et al. Nuclear targeted nanoprobe for single living cell detection by surface-enhanced Raman scattering. Bioconjug Chem 2009, 20:768-773.
23. Oyelere A.K., Chen P.C., Huang X., El-Sayed I.H., El-Sayed M.A. Peptide-conjugated gold nanorods for nuclear targeting. Bioconjug Chem 2007, 18:1490-1497.
24. Qian W., Huang X., Kang B., El-Sayed M a. Dark-field light scattering imaging of living cancer cell component from birth through division using bioconjugated gold nanoprobes. J Biomed Opt 2011, 15:046025.
25. Gao W., Chan J.M., Farokhzad O.C. pH-Responsive nanoparticles for drug delivery. Mol Pharm 2010, 7:1913-1920.
26. Jiang T., Zhang Z., Zhang Y., Lv H., Zhou J., Li C., et al. Dual-functional liposomes based on pH-responsive cell-penetrating peptide and hyaluronic acid for tumor-targeted anticancer drug delivery. Biomaterials 2012, 33:9246-9258.
27. Urano Y., Asanuma D., Hama Y., Koyama Y., Barrett T., Kamiya M., et al. Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes. Nat Med 2009, 15:104-109.
28. Oh E., Delehanty J.B., Sapsford K.E., Susumu K., Goswami R., Blanco-Canosa J.B., et al. Cellular uptake and fate of PEGylated gold nanoparticles is dependent on both cell-penetration peptides and particle size. ACS Nano 2011, 5:6434-6448.
29. Thurn K.T., Brown E.M.B., Wu A., Vogt S., Lai B., Maser J., et al. Nanoparticles for applications in cellular imaging. Nanoscale Res Lett 2007, 2:430-441.
30. Huang K., Ma H., Liu J., Huo S., Kumar A., Wei T., et al. Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivo. ACS Nano 2012, 6:4483-4493.
31. Kojima C., Kono K., Maruyama K., Takagishi T. Synthesis of polyamidoamine dendrimers having poly(ethylene glycol) grafts and their ability to encapsulate anticancer drugs. Bioconjug Chem 2000, 11:910-917.
32. Kono K., Kojima C., Hayashi N., Nishisaka E., Kiura K., Watarai S., et al. Preparation and cytotoxic activity of poly(ethylene glycol)-modified poly(amidoamine) dendrimers bearing adriamycin. Biomaterials 2008, 29:1664-1675.
33. Wang F., Wang Y.C., Dou S., Xiong M.H., Sun T.M., Wang J. Doxorubicin-tethered responsive gold nanoparticles facilitate intracellular drug delivery for overcoming multidrug resistance in cancer cells. ACS Nano 2011, 5:3679-3692.
34. Frens G. Controlled nucleation for the regulation of the particle size in monodisperse gold suspensions. Nat Phys Sci 1973, 241:20-22.
35. Chan W.C., White P.D. Fmoc solid phase peptide synthesis 2000, 41-76. Oxford University Press, New York.
36. Niidome T., Yamagata M., Okamoto Y., Akiyama Y., Takahashi H., Kawano T., et al. PEG-modified gold nanorods with a stealth character for in vivo applications. J Control Release 2006, 114:343-347.
37. Veronese F.M., Pasut G. PEGylation, successful approach to drug delivery. Drug Discov Today 2005, 10:1451-1458.
38. Zuco V., Supono R., Righetti S.C., Cleris L., Marchesi E., Gambacorti-Passerini C., et al. Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells. Cancer Lett 2002, 175:17-25.