The A allele of the rs1990760 Polymorphism in the IFIH1 gene is associated with protection for arterial hypertension in type 1 diabetic patients and with expression of this gene in human mononuclear cells

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Bouças, Ana P ^a,b   Brondani, Letícia A ^a,b   Souza, Bianca M ^a,b   Lemos, Natália E ^b   De Oliveira, Fernanda S ^a   Canani, Luis H ^b   Crispim, Daisy ^a,b  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALLELES; BLOOD PRESSURE; BRAZIL; CASE-CONTROL STUDIES; DEAD-BOX RNA HELICASES; DIABETES MELLITUS, TYPE 1; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERTENSION; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, GENETIC;

EID: 84893623120     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083451     Document Type: Article

References (51)

1. American Diabetes Association (2013) Diagnosis and classification of diabetes mellitus. Diabetes care 36 Suppl 1: S67-74.
2. Pirot P, Cardozo AK, Eizirik DL (2008) Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes. Arq Bras Endocrinol Metabol 52: 156-165.
3. Knip M, Veijola R, Virtanen SM, Hyoty H, Vaarala O, et al. (2005) Environmental triggers and determinants of type 1 diabetes. Diabetes 54: 125-136.
4. Steck A, Rewers M (2011) Genetics of type 1 diabetes. Clin Chem 57: 176-185.
5. Jaïdane Sauter, Sane Goffard, Gharbi, etal. (2010) Enteroviruses and type 1 diabetes: towards a better understanding of the relationship. Rev Med Virol 20: 265-280.
6. Hober Sane, Jaidane Riedweg, Goffard, etal. (2012) Immunology in the clinic review series; focus on type 1 diabetes and viruses: role of antibodies enhancing the infection with Coxsackievirus-B in the pathogenesis of type 1 diabetes. Clin Exp Immunol: 47-51.
7. Filippi C, von Herrath M (2008) Viral trigger for type 1 diabetes: pros and cons. Diabetes 57: 2863-2871.
8. Yoon J, Austin M, Onodera T, Notkins A (1979) Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med 300: 1173-1179. (Pubitemid 9191515)
9. Dotta F, Censini S, van Halteren AG, Marselli L, Masini M, et al. (2007) Coxsackie B4 virus infection of b cells and natural killer cell insulitis in recentonset type 1 diabetic patients. Proc Natl Acad Sci U S A 104: 5115-5120. (Pubitemid 47186185)
10. Elshebani A, Olsson A, Westman J, Tuvemo T, Korsgren O, et al. (2007) Effects on isolated human pancreatic islet cells after infection with strains of enterovirus isolated at clinical presentation of type 1 diabetes. Virus Res 124.
11. Eizirik DL, Colli ML, Ortis F (2009) The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol 5: 219-226.
12. Kumar H, Kawai T, Akira S (2009) Pathogen recognition in the innate immune response. Biochem J 420: 1-16.
13. Wilkins C, Gale MJ (2010) Recognition of viruses by cytoplasmic sensors. Curr Opin Immunol 22.
14. Randall RE, Goodbourn S (2008) Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol 89: 1-47.
15. Nejentsev S, Walker N, Riches D, Egholm M, Todd JA (2009) Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 324: 387-389.
16. Liu S, Wang H, Jin Y, Podolsky R, Reddy MV, et al. (2009) IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells. Hum Mol Genet 18: 358-365.
17. Yang H, Wang Z, Xu K, Gu R, Chen H, et al. (2012) IFIH1 gene polymorphisms in type 1 diabetes: Genetic association analysis and genotype-phenotype correlation in Chinese Han population. Autoimmunity 45: 226-232.
18. Canani L, Costa L, Crispim D, Gonçalves Dos Santos K, Roisenberg I, et al. (2005) The presence of allele D of angiotensin-converting enzyme polymorphism is associated with diabetic nephropathy in patients with less than 10 years duration of Type 2 diabetes. Diabet Med 22: 1167-1172. (Pubitemid 41224175)
19. Wilkinson CP, Ferris FL 3rd, Klein RE, Lee PP, Agardh CD, et al. (2003) Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 110: 1677-1682. (Pubitemid 37025422)
20. American Diabetes Association (2004) Nephropathy in diabetes. Diabetes Care 27: 79-83.
21. Camargo JL, Zelmanovitz T, Paggi A, Friedman R, Gross JL (1998) Accuracy of conversion formulae for estimation of glycohaemoglobin. Scand J Clin Lab Invest 58: 521-528. (Pubitemid 28506517)
22. Camargo JL, Lara GM, Wendland AE, Gross JL, de Azevedo MJ (2008) Agreement of different immunoassays for urinary albumin measurement. Clin Chem 54: 925-927. (Pubitemid 351671613)
23. Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, et al. (2009) The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem 55: 611-622.
24. Higuchi R, Fockler C, Dollinger G, Watson R (1993) Kinetic PCR analysis: real-time monitoring of DNA amplification reactions. Biotechnology (N Y) 11: 1026-1030. (Pubitemid 23254023)
25. Applied Biosystems (2004) Relative Quantitation of Gene Expression Experimental Design and Analysis: Relative Standard Curve Method and Comparative ct Method (DeltaDelta-ct). Guide to Performing Relative Quantitation of Gene Expression Using Real-time Quantitative PCR.
26. Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151: 264-269, W264.
27. Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, et al. (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 283: 2008-2012. (Pubitemid 30214957)
28. Wells GA, Shea B, O'Connell D, Peterson J, Welch V, et al. The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomized studies in meta-analysis. Available: http://www.medicine.mcgill.ca/rtamblyn/Readings.
29. Minelli C, Thompson JR, Abrams KR, Thakkinstian A, Attia J (2005) The choice of a genetic model in the meta-analysis of molecular association studies. Int J Epidemiol 34: 1319-1328. (Pubitemid 41819539)
30. Zintzaras E, Lau J (2008) Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches. J Clin Epidemiol 61: 634-645. (Pubitemid 351766746)
31. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21: 1539-1558. (Pubitemid 34746062)
32. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327: 557-560. (Pubitemid 37088507)
33. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315: 629-634. (Pubitemid 27387172)
34. American Diabetes Association (2010) Standards of Medical Care in Diabetes - 2010. Diabetes Care 33: S11-S61.
35. Smyth DJ, Cooper JD, Bailey R, Field S, Burren O, et al. (2006) A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet 38: 617-619. (Pubitemid 43927300)
36. Jermendy A, Szatmari I, Laine AP, Lukacs K, Horvath KH, et al. (2010) The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations. Diabetologia 53: 98-102.
37. Schulte BM, Bakkers J, Lanke KHW, Melchers WJG, Westerlaken C, et al. (2010) Detection of enterovirus RNA in peripheral blood mononuclear cells of type 1 diabetic patients beyond the stage of acute infection. Viral Immunology 23: 99-104.
38. Chistiakov DA (2010) Interferon induced with helicase C domain 1 (IFIH1) and virus-induced autoimmunity: a review. Viral Immunol 23: 3-15.
39. Concannon P, Onengut-Gumuscu S, Todd JA, Smyth DJ, Pociot F, et al. (2008) A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. Diabetes 57: 2858-2861.
40. Cen H, Wang W, Leng RX, Wang TY, Pan HF, et al. (2013) Association of IFIH1 rs1990760 polymorphism with susceptibility to autoimmune diseases: A meta-analysis. Autoimmunity 46: 455-462.
41. McCartney SA, Vermi W, Lonardi S, Rossini C, Otero K, et al. (2011) RNA sensor-induced type I IFN prevents diabetes caused by a beta cell-tropic virus in mice. J Clin Invest 121: 1497-1507.
42. Harrison DG, Guzik TJ, Lob HE, Madhur MS, Marvar PJ, et al. (2011) Inflammation, immunity, and hypertension. Hypertension 57: 132-140.
43. Verlohren S, Muller DN, Luft FC, Dechend R (2009) Immunology in hypertension, preeclampsia, and target-organ damage. Hypertension 54: 439-443.
44. Schiffrin EL (2010) T lymphocytes: a role in hypertension? Curr Opin Nephrol Hypertens 19: 181-186.
45. De Ciuceis C, Amiri F, Brassard P, Endemann DH, Touyz RM, et al. (2005) Reduced vascular remodeling, endothelial dysfunction, and oxidative stress in resistance arteries of angiotensin II-infused macrophage colony-stimulating factor-deficient mice: evidence for a role in inflammation in angiotensin-induced vascular injury. Arterioscler Thromb Vasc Biol 25: 2106-2113. (Pubitemid 41416308)
46. Ko EA, Amiri F, Pandey NR, Javeshghani D, Leibovitz E, et al. (2007) Resistance artery remodeling in deoxycorticosterone acetate-salt hypertension is dependent on vascular inflammation: evidence from m-CSF-deficient mice. Am J Physiol Heart Circ Physiol 292: H1789-1795. (Pubitemid 46572403)
47. White FN, Grollman A (1964) Autoimmune Factors Associated with Infarction of the Kidney. Nephron 1: 93-102.
48. Leibowitz A, Schiffrin EL (2011) Immune mechanisms in hypertension. Curr Hypertens Rep 13: 465-472.
49. Luft FC, Dechend R, Muller DN (2012) Immune mechanisms in angiotensin II-induced target-organ damage. Ann Med 44 Suppl 1: S49-54.
50. Chatterjee P, Weaver LE, Doersch KM, Kopriva SE, Chiasson VL, et al. (2012) Placental Toll-like receptor 3 and Toll-like receptor 7/8 activation contributes to preeclampsia in humans and mice. PLoS One 7: e41884.
51. Chatterjee P, Weaver LE, Chiasson VL, Young KJ, Mitchell BM (2011) Do double-stranded RNA receptors play a role in preeclampsia? Placenta 32: 201-205.